dr. R.M. (Roelie) Wösten-van Asperen

dr. R.M. (Roelie) Wösten-van Asperen

Associate Professor
dr. R.M. (Roelie) Wösten-van Asperen
  • IC patient care

Research Programs

Child Health



Roelie Wösten-van Asperen  is a pediatric-intensivist at the PICU of the Wilhelmina Children’s Hospital in Utrecht. She started her fellowship in pediatric intensive care in 2002. After finalization of her fellowship, she has been a consultant pediatric intensivist in the Emma Children’s Hospital/Academic Medical Center, Amsterdam. In 2011, she defended her thesis ‘The role of the renin-angiotensin system in acute lung injury’ at the University of Amsterdam.

After almost 15 years (in January 2016), she moved from the PICU of the Emma Children’s Hospital to the PICU of the Wilhelmina Children’s Hospital in Utrecht. Together with Prof. Marry van den Heuvel of the Princess Máxima Center for Pediatric Oncology, she started a research group on pediatric cancer patients at the PICU.

She is currently chair of the PICU Oncology Kids in Europe Research group (POKER), a research consortium comprising of 21 PICU’s which are adhered to large pediatric oncological centers in 11 different countries (Austria, Belgium, Denmark, Germany, France, Italy, Poland, Spain, Switzerland, the Netherlands, and the UK). Our mission is to improve our understanding and our ability to appropriately treat these patients, thereby improving outcomes of children with cancer who are admitted to the PICU. 



1988-1993 Medical Biology, Groningen University, Groningen, The Netherlands Degree: MSc (cum laude)

1991-1995 Medicine, Groningen University, Groningen, The Netherlands. Degree: MSc (cum laude)

1995-1997 Medical Degree Groningen University, Groningen, The Netherlands. Degree: MD (cum laude)

1997-2002 Training in pediatrics, University of Leiden (1997-1999) and University of Groningen (2000-2002), The Netherlands

2002-2006 Fellowship pediatric intensive care medicine, Emma Children’s Hospital/Academic Medical Center, Amsterdam, The Netherlands

2005-2011 PhD ‘The role of the renin angiotensin system in acute lung injury’, University of Amsterdam, Amsterdam, The Netherlands



Pediatric cancer patients at the PICU: identifying prognostic factors influencing PICU admission and outcome of pediatric cancer patients.


Side Activities

Chair of POKER (PICU Oncology Kids in Europe Research group) research consortium of ESPNIC (European Society of Paediatric & Neonatol Intensive Care).

Member of European Society of Paediatric & Neonatol Intensive Care


Fellowship and Awards

Funding as Co-PI:

2012 Academic Medical Center Graduate School Scholarship: Impact of age on the pulmonary renin-angiotensin system in acute respiratory distress syndrome (Euro 205K)

2017 Research grant supported by KiKa: Identifying the critically ill pediatric cancer patient. (Euro 590K)

Research Output (50)

Oscillometry:a substitute of spirometry in children with neuromuscular diseases?

Veldhoen Esther S, Roos Johan H, Bekkema Rolien, Ludo van der Pol W, Tinnevelt Marcel H B, Verweij-van den Oudenrijn Laura P, Wösten-van Asperen Roelie M, Hulzebos Erik H J, Wijngaarde Camiel A, Kors van der Ent C 26 Apr 2022, In: Pediatric Pulmonology. 57 , p. 1618-1624 7 p.

Short-term effect of air stacking and mechanical insufflation-exsufflation on lung function in patients with neuromuscular diseases

Veldhoen Esther S, Vercoelen Femke, Ros Leandra, Verweij-van den Oudenrijn Laura P, Wösten-van Asperen Roelie M, Hulzebos Erik Hj, Bartels Bart, Gaytant Michael A, van der Ent Kors, Ludo van der Pol W 21 Apr 2022, In: Chronic Respiratory Disease. 19

Natural history of respiratory muscle strength in spinal muscular atrophy:a prospective national cohort study

Veldhoen Esther S., Wijngaarde Camiel A., Hulzebos Erik H.J., Wösten-van Asperen Roelie M., Wadman Renske I., van Eijk Ruben P.A., Asselman Fay Lynn, Stam Marloes, Otto Louise A.M., Cuppen Inge, Scheijmans Feline E.V., den Oudenrijn Laura P.Verweij van, Bartels Bart, Gaytant Michael A., van der Ent Cornelis K., van der Pol W. Ludo 21 Feb 2022, In: Orphanet Journal of Rare Diseases. 17 , p. 1-11

Characteristics and Outcome of Children with Wilms Tumor Requiring Intensive Care Admission in First Line Therapy

Steur Anouk, Raymakers-Janssen Paulien A.M.A., Kneyber Martin C.J., Dijkstra Sandra, van Woensel Job B.M., van Waardenburg Dick A., van de Ven Cornelis P., van der Steeg Alida F.W., Wijnen Marc, Lilien Marc R., de Krijger Ronald R., van Tinteren Harm, Littooij Annemieke S., Janssens Geert O., Peek Annemarie M.L., Tytgat Godelieve A.M., Mavinkurve-Groothuis Annelies M., van Grotel Martine, van den Heuvel-Eibrink Marry M., Wösten-Van Asperen Roelie M. 14 Feb 2022, In: Cancers. 14

Letter in response to:A Systematic review literature searches must be comprehensive and reproducible if their conclusions are to drive the research agenda and clinical practice changes

De Man M A C P, Wösten-van Asperen R M, de Weerth C, van den Hoogen A 31 Jan 2022, In: Acta Paediatrica. 111 , p. 897-898 2 p.

Paediatric Acute Respiratory Distress Syndrome Neuromuscular Blockade study (PAN-study):a phase IV randomised controlled trial of early neuromuscular blockade in moderate-to-severe paediatric acute respiratory distress syndrome

Rudolph Michelle W, Slager Sjoerdtje, Burgerhof Johannes G M, van Woensel Job B M, Alffenaar Jan-Willem C, Wösten-van Asperen Roelie M, de Hoog Matthijs, IJland Marloes M, Kneyber Martin C J, 31 Jan 2022, In: Trials. 23

Role of extracorporeal membrane oxygenation in pediatric cancer patients:a systematic review and meta-analysis of observational studies

Slooff Valerie, Hoogendoorn Rianne, Nielsen Jeppe Sylvest Angaard, Pappachan John, Amigoni Angela, Caramelli Fabio, Aziz Omer, Wildschut Enno, Verbruggen Sascha, Crazzolara Roman, Dohna-Schwake Christian, Potratz Jenny, Willems Jef, Llevadias Judit, Moscatelli Andrea, Montaguti Alessia, Bottari Gabriella, Di Nardo Matteo, Schlapbach Luregn, Wösten-van Asperen Roelie, 29 Jan 2022, In: Annals of Intensive Care. 12

Short term effect and effect on rate of lung function decline after surgery for neuromuscular or syndromic scoliosis

Veldhoen Esther S, de Vries Anneloes, Schlosser Tom P C, Kruyt Moyo C, van Eijk Ruben P A, Tersmette Joyce M, Hulzebos Erik H, van der Pol Ludo W, Wösten-van Asperen Roelie M, van der Ent Cornelis K 2022, In: Pediatric Pulmonology. 57 , p. 1303-1309 7 p.

The predictive performance and impact of pediatric early warning systems in hospitalized pediatric oncology patients—A systematic review

Soeteman Marijn, Lekkerkerker Caroline W., Kappen Teus H., Tissing Wim J., Nieuwenhuis Edward E., Wösten-van Asperen Roelie M. 2022, In: Pediatric Blood and Cancer. 69

Extracorporeal membrane oxygenation in children receiving haematopoietic cell transplantation and immune effector cell therapy:an international and multidisciplinary consensus statement

Di Nardo Matteo, Ahmad Ali H., Merli Pietro, Zinter Matthew S., Lehman Leslie E., Rowan Courtney M., Steiner Marie E., Hingorani Sangeeta, Angelo Joseph R., Abdel-Azim Hisham, Khazal Sajad J., Shoberu Basirat, McArthur Jennifer, Bajwa Rajinder, Ghafoor Saad, Shah Samir H., Sandhu Hitesh, Moody Karen, Brown Brandon D., Mireles Maria E., Steppan Diana, Olson Taylor, Raman Lakshmi, Bridges Brian, Duncan Christine N., Choi Sung Won, Swinford Rita, Paden Matt, Fortenberry James D., Peek Giles, Tissieres Pierre, De Luca Daniele, Locatelli Franco, Corbacioglu Selim, Kneyber Martin, Franceschini Alessio, Nadel Simon, Kumpf Matthias, Loreti Alessandra, Wösten-Van Asperen Roelie, Gawronski Orsola, Brierley Joe, MacLaren Graeme, Mahadeo Kris M. 9 Dec 2021, In: The Lancet. Child & adolescent health. 6 , p. 116-128 13 p.

All research output

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