prof. dr. J.M. (Jaap) van Laar

prof. dr. J.M. (Jaap) van Laar

Full Professor
prof. dr. J.M. (Jaap) van Laar
  • Rheumatology & Clinical Immunology



Jacob M. van Laar is Professor at the Department of Rheumatology and Clinical Immunology at UMC Utrecht, the Netherlands. After obtaining his MD and PhD degrees at Leiden University, he specialised in Internal Medicine and Rheumatology in Leiden University Medical Center and worked at the Department of Rheumatology as clinical academic in various roles from 1997-2007, interrupted by a postdoctoral research fellowship at the National Institute of Arthritis and Musculoskeletal and Skin Diseases in Bethesda, USA. From 2007 until 2013 he held a Chair in Clinical Rheumatology at Newcastle University, and post as honorary consultant rheumatologist at The James Cook University Hospital, Middlesbrough, UK. He has been working as Professor of Rheumatology at UMC Utrecht since 1 November 2013. His main research interests involve clinical and pathogenetic aspects of systemic sclerosis and rheumatoid arthritis, aimed at improving the outcome of patients with rheumatic diseases by innovative clinical-translational research.

Side Activities

Founding Member Stichting ARCH

Member Scientific Advisory Board Edith Busch Stiftung

Member of EUSTAR (EULAR Scleroderma Trials and Research)

Ad hoc basis: expert advice Central Board of Appeal, Medical Ethics Committee Noord Brabant, liability disputes; consultancies pharmaceutical companies (; postgraduate teaching (including Artrose Instituut Nederland); patient consultations (Reumazorg Zuid-West Nederland).



Fellowship and Awards

Marie Parijs award for pioneering work in the field of clinical stem cell research in rheumatic autoimmune diseases (2002, Leiden University Medical Center)

ZonMW Clinical Fellow (2007)

Fellow of the Royal College of Physicians Edinburgh (2009)

NVLE Award (2015) 

Research Output (318)

Anti-thymocyte globulin exposure in patients with diffuse cutaneous systemic sclerosis undergoing autologous haematopoietic stem cell transplantation

Chiu Yu Hsiang, Drijver Anouk, Admiraal Rick, van Rhenen Anna, Nierkens Stefan, van Laar Jacob M., Spierings Julia Oct 2023, In: Journal of Scleroderma and Related Disorders. 8 , p. 241-246 6 p.

Association of endothelial to mesenchymal transition and cellular senescence with fibrosis in skin biopsies of systemic sclerosis patients:a cross-sectional study

Chiu Yu Hsiang, Spierings Julia, van Laar Jacob M., de Vries-Bouwstra Jeska K., van Dijk Marijke, Goldschmeding Roel 9 Jun 2023, In: Clinical and Experimental Rheumatology. 41 , p. 1612-1617 6 p.

Concomitant prednisone may alleviate methotrexate side-effects in rheumatoid arthritis patients

van der Leeuw Matthijs S., Tekstra Janneke, van Laar Jacob M., Welsing Paco M.J. 17 May 2023, In: BMC Rheumatology. 7 6 p.

Using real-world data to dynamically predict flares during tapering of biological DMARDs in rheumatoid arthritis:development, validation, and potential impact of prediction-aided decisions

van der Leeuw Matthijs S., Messelink Marianne A., Tekstra Janneke, Medina Ojay, van Laar Jaap M., Haitjema Saskia, Lafeber Floris, Veris-van Dieren Josien J., van der Goes Marlies C., den Broeder Alfons A., Welsing Paco M.J. Dec 2022, In: Arthritis research & therapy. 24 , p. 1-11

Regulatory T cells in psoriatic arthritis:an IL-17A-producing, Foxp3<sup>int</sup>CD161 + RORγt + ICOS + phenotype, that associates with the presence of ADAMTSL5 autoantibodies

Pouw J. N.Juliëtte, Nordkamp M. A.M.Michel Olde, van Kempen T. Tessa, Concepcion A. N.Arno, van Laar J. M.Jacob, van Wijk F. Femke, Spierings J. Julia, Leijten E. F.A.Emmerik, Boes M. Marianne Dec 2022, In: Scientific Reports. 12

Classification of rheumatoid arthritis into active or inactive with a modified Disease Activity score, for future use as a treat-to-target tool, with a HandScan score replacing joint counts

Verhoeven Maxime M.A., Westgeest Anton A.A., Tekstra Janneke, van Laar Jacob M., Lafeber Floris P.J.G., Welsing Paco M.J., Jacobs Johannes W.G. 1 Nov 2022, In: Clinical and Experimental Rheumatology. 40 , p. 2018-2022 5 p.

Mechanisms underlying DMARD inefficacy in difficult-to-treat rheumatoid arthritis:a narrative review with systematic literature search

Roodenrijs Nadia M.T., Welsing Paco M.J., van Roon Joël, Schoneveld Jan L.M., van der Goes Marlies C., Nagy György, Townsend Michael J., van Laar Jacob M. 30 Aug 2022, In: Rheumatology (Oxford, England). 61 , p. 3552-3566 15 p.

Positron Emission Tomography to Improve Assessment of Interstitial Lung Disease in Patients With Systemic Sclerosis Eligible for Autologous Stem Cell Transplantation

Broens Bo, van der Laken Conny J, Zwezerijnen Gerben J C, Nossent Esther J, Meijboom Lilian J, Spierings Julia, de Vries-Bouwstra Jeska K, van Laar Jacob M, Voskuyl Alexandre E 5 Jul 2022, In: Frontiers in Immunology. 13

Microarray analysis of autoantibodies can identify future Systemic Lupus Erythematosus patients

Brunekreef Tammo E, Reteig Leon C, Limper Maarten, Haitjema Saskia, Dias Jorge, Mathsson-Alm Linda, van Laar Jacob M, Otten Henny G Jun 2022, In: Human Immunology. 83 , p. 509-514 6 p.

Endothelial to mesenchymal transition and senescence are part of the fibrotic pathogenesis in systemic sclerosis

Chiu Yu-Hsiang, Spierings Julia, van Laar Jaap, de Vries-Bouwstra Jeska, van Dijk Marijke, Goldschmeding Roel May 2022,

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical uses cookies

This website uses cookies This website displays videos from, among others, YouTube. Such parties place cookies (third-party cookies). If you do not want these cookies, you can indicate that here. We also place cookies ourselves to improve our site.

Read more about the cookie policy

Agree No, rather not