drs. K.P. (Krzysztof) Trzcinski
drs. K.P. (Krzysztof) Trzcinski
- Infectious Diseases Research 4
Research Programs
Biography
Biography
Dr Krzysztof Trzciński, is a microbiologist and Principal Investigator in the Respiratory Infections Research Group at the University Medical Centre Utrecht (UMCU).
Before taking up the position of Associate Professor at the Department of Pedatric Immunology and Infectious Diseases at UMCU in 2009, he worked as a Senior Research Scientist at Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
His main area of interest is Streptococcus pneumoniae (pneumococcus), whether it be a respiratory pathogen, or human commensal. Despite available vaccines targeting pneumococcal disease, S. pneumoniae remains one of the top causes of death due to bacterial respiratory infections.
In his work, Dr Trzciński focuses on innate and acquired immune responses to natural colonization with S. pneumoniae, as well as mechanisms maintaining the diversity of pneumococcal capsular types (serotypes) circulating and causing disease in the human population. He is using both experimental and epidemiological approaches in his research. With his work, he contributed to the discovery that naturally acquired mucosal immunity to pneumococcal colonization is largely antibody-independent (Trzciński et al. Infect.Immun. 2005), yet antigen-specific (Trzciński et al. Infect.Immun. 2008), while transcending serotypes (Malley et al. PNAS 2005). These findings opened new opportunities in developing vaccines (Li et al. PLoS Path. 2012). Also, utilizing pneumococcal strains that differ only by serotype (Trzciński et al. App.Env.Microbiol. 2003), he and his co-workers showed that simple characteristics of the capsular polysaccharide allow predictions of prevalence of a serotype in carriage (Weinberger et al. PLoS Path. 2009, Li et al. Infect.Immun. 2013, Trzciński et al. MBio 2015) and invasiveness in disease (Hyams et al. Infect.Immun. 2013), and that capsular characteristics could be linked to variations in S. pneumoniae resistance to certain immune responses: opsonin-independent killing of pneumococci by neutrophils (Weinberger et al. PLoS Path. 2009) and the deposition of complement and opsonophagocytosis (Melin et al. Infect. Immun. 2010a; Melin et al. Infect.Immun. 2010b, Hyams et al. Infect.Immun. 2013). He also contributed to better understanding the factors mediating interaction between pneumoocci and other pathogens colonizing the upper respiratory tract, Staphylococcus aureus in particular (Regev-Yochay et al. J.Bac. 2006, Selva et al. PNAS 2009).
Currently, he is developing enhanced methods for pneumococcal colonization detection, and for studying multi-serotype carriage (Trzciński et al. PLoS ONE, 2013, Wyllie et al. PLoS ONE 2014, Krone et al. PLoS ONE 2015, Trzciński et al. MBio 2015, Miellet et al. CID 2021, Miellet et al. Front.Microbiol. 2022).
With his work, Dr Trzciński aims to broaden our understanding of the interactions between S. pneumoniae and the host during colonization and infection, and enhance the knowledge necessary to assess accurately the effects of preventative strategies targeting pneumococcal disease.
Side Activities
MSD, Advisory Boards (from 2019 onwards), payments always to UMC Utrecht (>€2200,-)
Pfizer, speaker (2018), payment to UMC Utrecht (>€2200,-)
Pfizer, Advisory Board (2017), payment to UMC Utrecht (<€2200,-)
Fellowship and Awards
2000 British Society for Antimicrobial Chemotherapy Research Fellowship
1999 European Respiratory Society Research Fellowship
1998 Royal Society/NATO Research Fellowship
1997 Award of the European Congress of Clinical Microbiology and Infectious Diseases, Lausanne, Switzerland
1994 European Society of Clinical Microbiology and Infectious Diseases Young Scientist Research Fellowship
Research Output (85)
Kremer Philip H C, Ferwerda Bart, Bootsma Hester J, Rots Nienke Y, Wijmenga-Monsuur Alienke J, Sanders Elisabeth A M, Trzciński Krzysztof, Wyllie Anne L, Turner Paul, van der Ende Arie, Brouwer Matthijs C, Bentley Stephen D, van de Beek Diederik, Lees John A 26 Jul 2022, In: eLife. 2022 , p. 1-20
Kolodziej L M, van Lelyveld S F L, Haverkort M E, Mariman R, Sluiter-Post J G C, Badoux P, de Koff E M, Koole J C D, Miellet W R, Swart A N, Coipan E C, Meijer A, Sanders E A M, Trzciński K, Euser S M, Eggink D, van Houten M A 15 May 2022, In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 75 , p. e10-e19
Miellet Willem R., van Veldhuizen Janieke, Litt David, Mariman Rob, Wijmenga-Monsuur Alienke J., Badoux Paul, Nieuwenhuijsen Tessa, Thombre Rebecca, Mayet Sanaa, Eletu Seyi, Sheppard Carmen, van Houten Marianne Alice, Rots Nynke Y., Miller Elizabeth, Fry Norman K., Sanders Elisabeth A.M., Trzciński Krzysztof 18 Apr 2022, In: Frontiers in Microbiology. 13
Wróbel-Pawelczyk Izabela, Ronkiewicz Patrycja, Wanke-Rytt Monika, Rykowska Dominika, Górska-Kot Aneta, Włodkowska Katarzyna, Topczewska-Cabanek Agnieszka, Jackowska Teresa, Chruszcz Joanna, Marchut Walentyna, Mastalerz-Migas Agnieszka, Korzeniewski Krzysztof, Gastoł Karolina, Gromek Marta, Jankowska-Sasin Katarzyna, Karpierz Katarzyna, Okarska-Napierała Magdalena, Pokorna-Kałwak Dagmara, Polit Agata, Robakiewicz Julia, Rygalski Maciej, Siwonia Anna, Strzałka Martyna, Szenborn Leszek, Szwejkowska Martyna, Szymańska-Toczek Zofia, Zaleska Izabela, Żołnierowicz Katarzyna, Skoczyńska Anna, Trzciński Krzysztof, 7 Apr 2022, In: Scientific Reports. 12
Man Irene, Bogaards Johannes A, Makwana Kishan, Trzciński Krzysztof, Auranen Kari 15 Mar 2022, In: Statistics in Medicine. 41 , p. 981-993 13 p.
Miellet Willem R., Mariman Rob, Pluister Gerlinde, de Jong Lieke J., Grift Ivo, Wijkstra Stijn, van Logchem Elske M., van Veldhuizen Janieke, Immink Marie Monique, Wijmenga-Monsuur Alienke J., Rots Nynke Y., Sanders Elisabeth A.M., Bosch Thijs, Trzciński Krzysztof 30 Nov 2021, In: Scientific Reports. 11 , p. 1-9
Miellet Willem R., Van Veldhuizen Janieke, Nicolaie Mioara A., Mariman Rob, Bootsma Hester J., Bosch Thijs, Rots Nynke Y., Sanders Elisabeth A.M., Van Beek Josine, Trzciński Krzysztof 1 Nov 2021, In: Clinical Infectious Diseases. 73 , p. E2680-E2689
Arends D. W., Miellet W. R., Langereis J. D., Ederveen T. H.A., van der Gaast–de Jongh C. E., van Scherpenzeel M., Knol M. J., van Sorge N. M., Lefeber D. J., Trzcinski K., Sanders E. A.M., Dorfmueller H. C., Bootsma H. J., de Jonge M. I. 15 Oct 2021, In: Infection and Immunity. 89 , p. 1-14
Grant Lindsay R., Slack Mary P.E., Yan Qi, Trzciński Krzysztof, Barratt Jane, Sobczyk Elizabeth, Appleby James, Cané Alejandro, Jodar Luis, Isturiz Raul E., Gessner Bradford D. Jun 2021, In: Expert Review of Vaccines. 20 , p. 691-705 15 p.
Arguedas Adriano, Trzciński Krzysztof, O’Brien Katherine L., Ferreira Daniela M., Wyllie Anne L., Weinberger Daniel, Danon Leon, Pelton Stephen I., Azzari Chiara, Hammitt Laura L., Sá-Leão Raquel, Brandileone Maria Cristina C., Saha Samir, Suaya Jose, Isturiz Raul, Jodar Luis, Gessner Bradford D. 2 Apr 2020, In: Expert Review of Vaccines. 19 , p. 353-366 14 p.