dr. Z. Sebestyen

dr. Z. Sebestyen

Associate Professor
dr. Z. Sebestyen
  • Center for Translational Immunology (CTI) Research



  1. Biograpy: Obtained his PhD in Hungary at University of Debrecen, where he became fascinated by biophysical techniques that he learned to use to study molecular interactions in living cells. He was further trained in the Babraham Institute In Cambridge (UK) and later at the ErasmusMC in Rotterdam (NL) where he as postdoctoral fellow has studied the molecular needs of genetic engineering of T cells for the immunotherapy of cancer. He continued his career at the UMCU in Utrecht, where he was appointed in 2014 as staff member of Section Applied within the Laboratory of Translational Immunology. He is currently focusing on the developement of novel gamma delta T cell-based immunotherapies and the better understanding of innate T cell and tumour cell interactions.  Reserach interest:  Tumour recognition of innate immune cells, Immune receptors , Genetic engineering

Research Output (28)

Basics of advanced therapy medicinal product development in academic pharma and the role of a GMP simulation unit

Johanna I., Daudeij A., Devina F., Nijenhuis C., Nuijen B., Romberg B., de Haar C., Haanen J., Dolstra H., Bremer E., Sebestyen Z., Straetemans T., Jedema I., Kuball J. Dec 2023, In: Immuno-Oncology and Technology. 20 9 p.

CRISPR screens decode cancer cell pathways that trigger γδ T cell detection

Mamedov Murad R, Vedova Shane, Freimer Jacob W, Sahu Avinash Das, Ramesh Amrita, Arce Maya M, Meringa Angelo D, Ota Mineto, Chen Peixin Amy, Hanspers Kristina, Nguyen Vinh Q, Takeshima Kirsten A, Rios Anne C, Pritchard Jonathan K, Kuball Jürgen, Sebestyen Zsolt, Adams Erin J, Marson Alexander 30 Aug 2023, In: Nature. 621 , p. 188-195 8 p.

Serpin B9 controls tumor cell killing by CAR T cells

Kimman Thomas, Slomp Anne, Martens Anne, Grabherr Sarah, Li Shuang, van Diest Eline, Meeldijk Jan, Kuball Jurgen, Minnema Monique C., Eldering Eric, Bovenschen Niels, Sebestyén Zsolt, Peperzak Victor 17 Mar 2023, In: Journal for ImmunoTherapy of Cancer. 11

Strategies to improve γδTCRs engineered T-cell therapies for the treatment of solid malignancies

Meringa A D, Hernández-López P, Cleven A, de Witte M, Straetemans T, Kuball J, Beringer D X, Sebestyen Z 2023, In: Frontiers in Immunology. 14 , p. 1-7

Uncovering the mode of action of engineered T cells in patient cancer organoids

Dekkers Johanna F., Alieva Maria, Cleven Astrid, Keramati Farid, Wezenaar Amber K.L., van Vliet Esmée J., Puschhof Jens, Brazda Peter, Johanna Inez, Meringa Angelo D., Rebel Heggert G., Buchholz Maj Britt, Barrera Román Mario, Zeeman Amber L., de Blank Sam, Fasci Domenico, Geurts Maarten H., Cornel Annelisa M., Driehuis Else, Millen Rosemary, Straetemans Trudy, Nicolasen Mara J.T., Aarts-Riemens Tineke, Ariese Hendrikus C.R., Johnson Hannah R., van Ineveld Ravian L., Karaiskaki Froso, Kopper Oded, Bar-Ephraim Yotam E., Kretzschmar Kai, Eggermont Alexander M.M., Nierkens Stefan, Wehrens Ellen J., Stunnenberg Henk G., Clevers Hans, Kuball Jürgen, Sebestyen Zsolt, Rios Anne C. 25 Jul 2022, In: Nature Biotechnology. 41 , p. 60-69 10 p.

γ9δ2 T-Cell Expansion and Phenotypic Profile Are Reflected in the CDR3δ Repertoire of Healthy Adults

Vyborova Anna, Janssen Anke, Gatti Lucrezia, Karaiskaki Froso, Yonika Austin, van Dooremalen Sanne, Sanders Jasper, Beringer Dennis X, Straetemans Trudy, Sebestyen Zsolt, Kuball Jürgen 7 Jul 2022, In: Frontiers in Immunology. 13 , p. 1-13

The Role of γδ T Cells as a Line of Defense in Viral Infections after Allogeneic Stem Cell Transplantation:Opportunities and Challenges

Janssen Anke, van Diest Eline, Vyborova Anna, Schrier Lenneke, Bruns Anke, Sebestyen Zsolt, Straetemans Trudy, de Witte Moniek, Kuball Jürgen Jan 2022, In: Viruses. 14 , p. 1-15

Gamma delta TCR anti-CD3 bispecific molecules (GABs) as novel immunotherapeutic compounds

Van Diest Eline, Hernández López Patricia, Meringa Angelo D., Vyborova Anna, Karaiskaki Froso, Heijhuurs Sabine, Gumathi Bormin Jan, Van Dooremalen Sanne, Nicolasen Mara J.T., Gatti Lucrezia C.D.E., Johanna Inez, Straetemans Trudy, Sebestyén Zsolt, Beringer Dennis X., Kuball Jürgen 23 Nov 2021, In: Journal for ImmunoTherapy of Cancer. 9 , p. 1-15

Adding Help to an HLA-A*24:02 Tumor-Reactive gamma delta TCR Increases Tumor Control

Johanna Inez, Hernández-López Patricia, Heijhuurs Sabine, Scheper Wouter, Bongiovanni Laura, de Bruin Alain, Beringer Dennis X., Oostvogels Rimke, Straetemans Trudy, Sebestyen Zsolt, Kuball Jürgen 25 Oct 2021, In: Frontiers in Immunology. 12 , p. 1-12

Characterization and modulation of anti-alpha beta TCR antibodies and their respective binding sites at the beta TCR chain to enrich engineered T cells

Kierkels Guido J J, van Diest Eline, Hernández-López Patricia, Scheper Wouter, de Bruin Anja C M, Frijlink Elselien, Aarts-Riemens Tineke, van Dooremalen Sanne F J, Beringer Dennis X, Oostvogels Rimke, Kramer Lovro, Straetemans Trudy, Uckert Wolfgang, Sebestyén Zsolt, Kuball Jürgen 10 Sep 2021, In: Molecular Therapy - Methods and Clinical Development. 22 , p. 388-400 13 p.

All research output

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