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dr. S. (Stefan) Nierkens

dr. S. (Stefan) Nierkens

Associate Professor
dr. S. (Stefan) Nierkens
  • Center for Translational Immunology (CTI) Research

Biography

Biography

Dr. Stefan Nierkens (PhD) is Associate Professor and Medical Immunologist, accredited according to guidelines of the College of Medical Immunologists of the Dutch Society of Immunology, in the UMC Utrecht and Princess Máxima Center for Pediatric Oncology. Within the ISO15189-accredited laboratory his focus areas are Hemato-oncology, Immune monitoring, Cell and functional diagnostics, and Serology.

Dr. Nierkens is Associate Professor Pediatric Tumor Immunology and HCT and focusses on the development of innovative immunotherapy treatment strategies (based on dendritic cells and gene-engineered T cells) to improve the outcome of pediatric cancers (e.g. acute leukemia and neuroblastoma). Furthermore, his lab (12 fte) focuses on the combination of advanced immune monitoring and PK-PD modeling to provide predictable immune reconstitution after hematopoietic cell transplantation.

 

Side Activities

Advisory Board / Consultancy / Speaker: Sobi, Medimmune, GamidaCell, Olink

 

Fellowship and Awards

KWF fellowship

Kika

ZonMW-TAS

VillaJoep

Ammodo

Research Output (172)

Heterozygous Variants in the DNA-binding Domain of c-Myb May Affect Normal B/T Cell Development

Smits Bas M., Hartley Taila, Dünnebach Ester, Bartels Marije, Boycott Kim M., Kernohan Kirstin D., Dyment David A., Giltay Jacques C., Haddad Elie, Jarinova Olga, Van Montfrans Joris, Van Royen-Kerkhof Annet, Van Der Veken Lars T., De Witte Moniek, Nierkens Stefan, Pham-Huy Anne, Leavis Helen L. 21 Oct 2022, In: HemaSphere. 6 , p. E774

Clinical features and immune-related protein patterns of anti-MDA5 positive clinically amyopathic dermatomyositis Dutch patients

Hensgens Marjolein P.M., Delemarre Eveline M., Drylewicz Julia, Voortman Mareye, Krol Roline M., Dalm Virgil A.S.H., Miedema Jelle R., Wiertz Ivo, Grutters Jan, Limper Maarten, Nierkens Stefan, Leavis Helen L. 6 Oct 2022, In: Rheumatology (Oxford, England). 61 , p. 4087-4096 10 p.

Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes

Sengupta Satyaki, Das Sanjukta, Crespo Angela C, Cornel Annelisa M, Patel Anand G, Mahadevan Navin R, Campisi Marco, Ali Alaa K, Sharma Bandana, Rowe Jared H, Huang Hao, Debruyne David N, Cerda Esther D, Krajewska Malgorzata, Dries Ruben, Chen Minyue, Zhang Shupei, Soriano Luigi, Cohen Malkiel A, Versteeg Rogier, Jaenisch Rudolf, Spranger Stefani, Romee Rizwan, Miller Brian C, Barbie David A, Nierkens Stefan, Dyer Michael A, Lieberman Judy, George Rani E 22 Sep 2022, In: Nature Cancer. 3 , p. 1228-1246 19 p.

Naive T Cells in Graft Versus Host Disease and Graft Versus Leukemia:Innocent or Guilty?

Dekker Linde, Sanders Evy, Lindemans Caroline A., de Koning Coco, Nierkens Stefan 20 Jun 2022, In: Frontiers in Immunology. 13 , p. 1-10

Hematologic malignancies following immune checkpoint inhibition for solid tumors

van Eijs Mick J.M., van der Wagen Lotte E., Mous Rogier, Leguit Roos J., van de Corput Lisette, van Lindert Anne S.R., Suelmann Britt B.M., Kamphuis Anna M., Nierkens Stefan, Suijkerbuijk Karijn P.M. 13 Jun 2022, In: Cancer Immunology, Immunotherapy. 72 , p. 249-255 7 p.

Gene Editing of Checkpoint Molecules in Cord Blood-Derived Dendritic Cells and CD8<sup>+</sup>T Cells Using CRISPR-Cas9

Lo Presti Vania, Cutilli Alessandro, Dogariu Yvonne, Müskens Konradin F., Dünnebach Ester, Van Den Beemt Denise A.M.H., Cornel Annelisa M., Plantinga Maud, Nierkens Stefan 8 Jun 2022, In: CRISPR Journal. 5 , p. 435-444 10 p.

Immune monitoring and treatment in immune-mediated inflammatory diseases

van Wijk Femke, de Bruin Marjolein, Leavis Helen, Nierkens Stefan 7 Jun 2022, In: Nature Communications. 13 , p. 1-1

Recurrent respiratory syncytial virus infection in a CD14 deficient patient

Besteman Sjanna B, Phung Emily, Raeven Henriette H M, Amatngalim Gimano D, Rumpret Matevž, Crabtree Juliet, Schepp Rutger M, Rodenburg Lisa W, Siemonsma Susanna G, Verleur Nile, van Slooten Rianne, Duran Karen, van Haaften Gijs, Beekman Jeffrey M, Chang Lauren A, Meyaard Linde, van der Bruggen Tjomme, Berbers Guy A M, Derksen Nicole, Nierkens Stefan, Morabito Kaitlyn M, Ruckwardt Tracy J, Kurt-Jones Evelyn A, Golenbock Douglas, Graham Barney S, Bont Louis J 16 Apr 2022, In: The Journal of infectious diseases. 226 , p. 258-269 12 p.

Fludarabine exposure predicts outcome after CD19 CAR T-cell therapy in children and young adults with acute leukemia

Dekker Linde, Calkoen Friso G., Jiang Yilin, Blok Hilly, Veldkamp Saskia R., De Koning Coco, Spoon Maike, Admiraal Rick, Hoogerbrugge Peter, Vormoor Britta, Vormoor H. Josef, Visscher Henk, Bierings Marc, Van Der Vlugt Marieke, Van Tinteren Harm, Nijstad A. Laura, Huitema Alwin D.R., Van Der Elst Kim C.M., Pieters Rob, Lindemans Caroline A., Nierkens Stefan 12 Apr 2022, In: Blood Advances. 6 , p. 1969-1976 8 p.

A Toolkit for Profiling the Immune Landscape of Pediatric Central Nervous System Malignancies

Rozowsky Jacob S, Meesters-Ensing Joyce I, Lammers Julie A S, Belle Muriël L, Nierkens Stefan, Kranendonk Mariëtte E G, Kester Lennart A, Calkoen Friso G, van der Lugt Jasper 7 Apr 2022, In: Frontiers in Immunology. 13 , p. 1-19

All research output

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