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dr. S. (Stefan) Nierkens

dr. S. (Stefan) Nierkens

Associate Professor
dr. S. (Stefan) Nierkens
  • Central Diagnostic Laboratory
  • Center for Translational Immunology (CTI) Research

Biography

Biography

Dr. Stefan Nierkens (PhD) is Associate Professor and Medical Immunologist, accredited according to guidelines of the College of Medical Immunologists of the Dutch Society of Immunology, in the UMC Utrecht and Princess Máxima Center for Pediatric Oncology. Within the ISO15189-accredited laboratory his focus areas are Hemato-oncology, Immune monitoring, Cell and functional diagnostics, and Serology.

Dr. Nierkens is Associate Professor Pediatric Tumor Immunology and HCT and focusses on the development of innovative immunotherapy treatment strategies (based on dendritic cells and gene-engineered T cells) to improve the outcome of pediatric cancers (e.g. acute leukemia and neuroblastoma). Furthermore, his lab (12 fte) focuses on the combination of advanced immune monitoring and PK-PD modeling to provide predictable immune reconstitution after hematopoietic cell transplantation.

 

Side Activities

Advisory Board / Consultancy / Speaker: Sobi, Medimmune, GamidaCell, Olink

 

Fellowship and Awards

KWF fellowship

Kika

ZonMW-TAS

VillaJoep

Ammodo

Research Output (154)

In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center

Rümke Lidewij W, Groenveld Femke C, van Os Yvonne M G, Praest Patrique, Tanja Anniek A N, de Jong Dorien T C M, Symons Jori, Schuurman Rob, Reinders Tessa, Hofstra L Marije, Nierkens Stefan, Thijsen Steven F T, Heron Michiel, Lebbink Robert-Jan, Beekman Jeffrey M, Nijhuis Monique, Wensing Annemarie M J 1 Jan 2022, In: Open forum infectious diseases. 9 , p. ofab553

Lymphoid and myeloid immune cell reconstitution after nicotinamide-expanded cord blood transplantation

de Koning Coco, Tao Weiyang, Lacna Amelia, van Veghel Karin, Horwitz Mitchell E., Sanz Guillermo, Jagasia Madan H., Wagner John E., Stiff Patrick J., Hanna Rabi, Cilloni Daniela, Valcárcel David, Peled Tony, Galamidi Cohen Einat, Goshen Uri, Pandit Aridaman, Lindemans Caroline A., Jan Boelens Jaap, Nierkens Stefan Nov 2021, In: Bone Marrow Transplantation. 56 , p. 2826-2833 8 p.

Anti-GD2 IgA kills tumors by neutrophils without antibody-associated pain in the preclinical treatment of high-risk neuroblastoma

Evers Mitchell, Stip Marjolein, Keller Kaylee, Willemen Hanneke, Nederend Maaike, Jansen Marco, Chan Chilam, Budding Kevin, Nierkens Stefan, Valerius Thomas, Meyer-Wentrup Friederike, Eijkelkamp Niels, Leusen Jeanette 29 Oct 2021, In: Journal for ImmunoTherapy of Cancer. 9 , p. 1-14

Serum Biomarker Profile Including CCL1, CXCL10, VEGF, and Adenosine Deaminase Activity Distinguishes Active From Remotely Acquired Latent Tuberculosis

Delemarre Eveline M, van Hoorn Laura, Bossink Aik W J, Drylewicz Julia, Joosten Simone A, Ottenhoff Tom H M, Akkerman Onno W, Goletti Delia, Petruccioli Elisa, Navarra Assunta, van den Broek Brigitte T A, Paardekooper Sanne P A, van Haeften Ineke, Koenderman Leo, Lammers Jan-Willem J, Thijsen Steven F T, Hofland Regina W, Nierkens Stefan 7 Oct 2021, In: Frontiers in Immunology. 12 , p. 1-12

Unraveling heterogeneity in pediatric atopic dermatitis::identification of serum biomarker based patient clusters

Bakker D., de Graaf M., Nierkens S., Delemarre E., Knol E., van Wijk F., de Bruin-Weller M., Drylewicz J., Thijs J. Oct 2021, In: Journal of Investigative Dermatology. 141 , p. S189-S189

Long-term effect of hematopoietic cell transplantation on systemic inflammation in patients with mucopolysaccharidoses

van den Broek Brigitte T A, Lindemans Caroline A, Boelens Jaap Jan, Delemarre Eveline M, Drylewicz Julia, Verhoeven-Duif Nanda, van Hasselt Peter M, Nierkens Stefan 24 Aug 2021, In: Blood Advances. 5 , p. 3092-3101 10 p.

Patterns of Immune Activation in HIV and Non HIV Subjects and Its Relation to Cardiovascular Disease Risk

Vos Alinda G., Dodd Caitlin N., Delemarre Eveline M., Nierkens Stefan, Serenata Celicia, Grobbee Diederick E., Klipstein-Grobusch Kerstin, Venter W. D. Francois 5 Jul 2021, In: Frontiers in Immunology. 12 , p. 1-9

Efficient lentiviral transduction method to gene modify cord blood CD8<sup>+</sup> T cells for cancer therapy applications

Lo Presti Vania, Cornel Annelisa M., Plantinga Maud, Dünnebach Ester, Kuball Jurgen, Boelens Jaap Jan, Nierkens Stefan, van Til Niek P. 11 Jun 2021, In: Molecular Therapy - Methods and Clinical Development. 21 , p. 357-368 12 p.

BIOMARKERS FOR CONNECTIVE TISSUE DISEASE-ASSOCIATED INTERSTITIAL LUNG DISEASE: A PILOT STUDY

Chiu Y. H., Voortman M., Delemarre E. M., Nierkens S., De Jong P., Hoesein F. Mohamed, Van Laar J. M., Spierings J. Jun 2021, In: Annals of the Rheumatic Diseases. 80 , p. 1430-1431

Immune Monitoring during Therapy Reveals Activitory and Regulatory Immune Responses in High-Risk Neuroblastoma

Szanto Celina L, Cornel Annelisa M, Tamminga Sara M, Delemarre Eveline M, de Koning Coco C H, van den Beemt Denise A M H, Dunnebach Ester, Tas Michelle L, Dierselhuis Miranda P, Tytgat Lieve G A M, van Noesel Max M, Kraal Kathelijne C J M, Boelens Jaap-Jan, Huitema Alwin D R, Nierkens Stefan 1 May 2021, In: Cancers. 13 18 p.

All research output

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