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prof. dr. F.P.J.G. (Floris) Lafeber

prof. dr. F.P.J.G. (Floris) Lafeber

Full Professor
prof. dr. F.P.J.G. (Floris) Lafeber
  • Rheumatology & Clinical Immunology

Biography

Biography

Floris Lafeber (1961) is professor of ‘Experimental Rheumatology’ at the UMC Utrecht. He studied Biology at the University of Nijmegen (NL; graduated Nov 1984) and did his PhD at this University in collaboration with the Univerity of Leiden (NL), with a visit of three months at the department of Physiology, Univ. of Ottawa (Canada) (graduated April 1988).  He is scientifically active in the field of ‘Regenerative Medicine’ and ‘Immunology’.

Currently, his main research interest is in 1) Implementation of joint distraction in the treatment of knee osteoarthritis; 2) The potential of IL4-10 synerkine in control of cartilage damage, inflammation, and pain in osteoarthritis (and haemophilic arthropathy); 3) The prediction of progression and response to treatment in osteoarthritis, rheumatoid arthritis, and haemophilic arthropathy.

Floris Lafeber is (co-)author of over 300 peer-reviewed papers (H-index 48), of which more than half in the top 10% of the field. He co-supervised 30 PhD students with several additionally scheduled. He has several patent (provisional) in the fields described above, and gained over his career for more than 15 million Euros research funding from the Dutch Arthritis Association, government, and industry. At present he is manager of research and head of research laboratory of the department of Rheumatology & Clinical Immunology, UMCU (3 days/week)

Side Activities

Manager Research of the Division of Internal Medicine & Dermatology (2018 - present) 1 day/week

Member of the steering committee of APPROACH within IMI (2015-2021)

Member of: OsteoArthritis Research Society International (OARSI); Orthopaedic Research Society (ORS); and International Cartilage Repair Society (ICRS) (present)

Member of the Advisory Board Biobanking (2019-present)

Consultant: SynerkinePharma BV

Reviewer for several international journals and funding agencies

 

Research Output (430)

Using real-world data to dynamically predict flares during tapering of biological DMARDs in rheumatoid arthritis:development, validation, and potential impact of prediction-aided decisions

van der Leeuw Matthijs S., Messelink Marianne A., Tekstra Janneke, Medina Ojay, van Laar Jaap M., Haitjema Saskia, Lafeber Floris, Veris-van Dieren Josien J., van der Goes Marlies C., den Broeder Alfons A., Welsing Paco M.J. 23 Mar 2022, In: Arthritis research & therapy. 24 , p. 1-11

GaitSmart motion analysis compared to commonly used function outcome measures in the IMI-APPROACH knee osteoarthritis cohort

van Helvoort Eefje M, Hodgins D, Mastbergen Simon C, Marijnissen Anne C A, Kloppenburg M, Blanco Fransisco J, Haugen Ida K, Berenbaum F, Lafeber Floris P J G, Welsing Paco M J Mar 2022, In: PLoS ONE. 17 , p. 1-13

Neuropathic pain in the IMI-APPROACH knee osteoarthritis cohort:prevalence and phenotyping

van Helvoort Eefje Martine, Welsing Paco M J, Jansen Mylène P, Gielis Willem Paul, Loef Marieke, Kloppenburg Margreet, Blanco Francisco, Haugen Ida K, Berenbaum Francis, Bay-Jensen Anne-C, Ladel Christoph, Lalande Agnes, Larkin Jonathan, Loughlin John, Mobasheri Ali, Weinans Harrie, Lafeber Floris, Eijkelkamp Niels, Mastbergen Simon Dec 2021, In: RMD Open. 7 , p. 1-9

Cartilage collagen structure upon knee joint distraction and high tibial osteotomy as measured with T2-mapping MRI - post-hoc analyses of two RCTs

Jansen M.P., Mastbergen S.C., Wirth W., Spruijt S., Custers R.J.H., Heerwaarden R.J. Van, Lafeber F.P.J.G. 20 Oct 2021, In: Osteoarthritis Imaging. 1 , p. 1-8

Baseline clinical characteristics of predicted structural and pain progressors in the IMI-APPROACH knee OA cohort

van Helvoort Eefje Martine, Ladel Christoph, Mastbergen Simon, Kloppenburg Margreet, Blanco Francisco J., Haugen Ida K., Berenbaum Francis, Bacardit Jaume, Widera Pawel, Welsing Paco M.J., Lafeber Floris 23 Aug 2021, In: RMD Open. 7 , p. 1-7

Comparison between 2D radiographic weight-bearing joint space width and 3D MRI non-weight-bearing cartilage thickness measures in the knee using non-weight-bearing 2D and 3D CT as an intermediary

Jansen Mylène P., Mastbergen Simon C., Eckstein Felix, van Heerwaarden Ronald J., Spruijt Sander, Lafeber Floris P.J.G. 21 Aug 2021, In: Therapeutic Advances in Chronic Disease . 12 , p. 1-11

Dorsal root ganglia macrophages maintain osteoarthritis pain

Raoof Ramin, Gil Christian Martin, Lafeber Floris P.J.G., De Visser Huub, Prado Judith, Versteeg Sabine, Pascha Mirte N., Heinemans Anne L.P., Adolfs Youri, Pasterkamp Jeroen, Wood John N., Mastbergen Simon C., Eijkelkamp Niels 16 Aug 2021, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 41 , p. 8249-8261 13 p.

Cartilage repair activity during joint-preserving treatment may be accompanied by osteophyte formation

Jansen Mylène P., Mastbergen Simon C., Watt Fiona E., Willemse Elske J., Vincent Tonia L., Spruijt Sander, Emans Pieter J., Custers Roel J.H., van Heerwaarden Ronald J., Lafeber Floris P.J.G. 3 Aug 2021, In: Applied Sciences (Switzerland). 11 , p. 1-13

Relationship between motion, using the GaitSmartTM system, and radiographic knee osteoarthritis:an explorative analysis in the IMI-APPROACH cohort

van Helvoort Eefje M., Hodgins Diana, Mastbergen Simon C., Marijnissen Anne Karien, Guehring Hans, Loef Marieke, Kloppenburg Margreet, Blanco Francisco, Haugen Ida K., Berenbaum Francis, Lafeber Floris P.J.G., Welsing Paco M.J. 2 Aug 2021, In: Rheumatology (Oxford, England). 60 , p. 3588-3597 10 p.

On-demand treatment with the iron chelator deferasirox is ineffective in preventing blood-induced joint damage in haemophilic mice

Pulles Astrid E, van Vulpen Lize F D, Coeleveld Katja, Mastbergen Simon C, Schutgens Roger E G, Lafeber Floris P J G 27 May 2021, In: Haemophilia. 27 , p. 648-656 9 p.

All research output

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