prof. dr. F.P.J.G. (Floris) Lafeber

prof. dr. F.P.J.G. (Floris) Lafeber

Full Professor
prof. dr. F.P.J.G. (Floris) Lafeber
  • Rheumatology & Clinical Immunology



Floris Lafeber (1961) is professor of ‘Experimental Rheumatology’ at the UMC Utrecht. He studied Biology at the University of Nijmegen (NL; graduated Nov 1984) and did his PhD at this University in collaboration with the Univerity of Leiden (NL), with a visit of three months at the department of Physiology, Univ. of Ottawa (Canada) (graduated April 1988).  He is scientifically active in the field of ‘Regenerative Medicine’ and ‘Immunology’.

Currently, his main research interest is in 1) Implementation of joint distraction in the treatment of knee osteoarthritis; 2) The potential of IL4-10 synerkine in control of cartilage damage, inflammation, and pain in osteoarthritis (and haemophilic arthropathy); 3) The prediction of progression and response to treatment in osteoarthritis, rheumatoid arthritis, and haemophilic arthropathy.

Floris Lafeber is (co-)author of over 300 peer-reviewed papers (H-index 48), of which more than half in the top 10% of the field. He co-supervised 30 PhD students with several additionally scheduled. He has several patent (provisional) in the fields described above, and gained over his career for more than 15 million Euros research funding from the Dutch Arthritis Association, government, and industry. At present he is manager of research and head of research laboratory of the department of Rheumatology & Clinical Immunology, UMCU (3 days/week)

Side Activities

Manager Research of the Division of Internal Medicine & Dermatology (2018 - present) 1 day/week

Member of the steering committee of APPROACH within IMI (2015-2021)

Member of: OsteoArthritis Research Society International (OARSI); Orthopaedic Research Society (ORS); and International Cartilage Repair Society (ICRS) (present)

Member of the Advisory Board Biobanking (2019-present)

Consultant: SynerkinePharma BV

Reviewer for several international journals and funding agencies


Research Output (441)

Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort

Roemer Frank W, Jansen Mylène, Marijnissen Anne C A, Guermazi Ali, Heiss Rafael, Maschek Susanne, Lalande Agnes, Blanco Francisco J, Berenbaum Francis, van de Stadt Lotte A, Kloppenburg Margreet, Haugen Ida K, Ladel Christoph H, Bacardit Jaume, Wisser Anna, Eckstein Felix, Lafeber Floris P J G, Weinans Harrie H, Wirth Wolfgang 17 Nov 2022, In: BMC Musculoskeletal Disorders. 23

Classification of rheumatoid arthritis into active or inactive with a modified Disease Activity score, for future use as a treat-to-target tool, with a HandScan score replacing joint counts

Verhoeven Maxime M.A., Westgeest Anton A.A., Tekstra Janneke, van Laar Jacob M., Lafeber Floris P.J.G., Welsing Paco M.J., Jacobs Johannes W.G. 1 Nov 2022, In: Clinical and Experimental Rheumatology. 40 , p. 2018-2022 5 p.

TOFA-PREDICT study protocol:a stratification trial to determine key immunological factors predicting tofacitinib efficacy and drug-free remission in psoriatic arthritis (PsA)

Kleinrensink Nienke J., Perton Frank T., Pouw Juliëtte N., Vincken Nanette L.A., Hartgring Sarita A.Y., Jansen Mylène P., Arbabi Saeed, Foppen Wouter, de Jong Pim A., Tekstra Janneke, Leijten Emmerik F.A., Spierings Julia, Lafeber Floris P.J.G., Welsing Paco M.J., Heijstek Marloes W., 10 Oct 2022, In: BMJ Open. 12 , p. 1-11

Subchondral bone changes after joint distraction treatment for end stage knee osteoarthritis

Mastbergen S C, Ooms A, Turmezei T D, MacKay J W, Van Heerwaarden R J, Spruijt S., Lafeber F P J G, Jansen M P Jul 2022, In: Osteoarthritis and Cartilage. 30 , p. 965-972 8 p.

The fear for adverse bleeding and cardiovascular events in hemophilia patients using (non-)selective non-steroidal anti-inflammatory drugs:A systematic review reporting on safety

van Bergen E. D.P., Monnikhof M., Lafeber F. P.J.G., Schutgens R. E.G., Mastbergen S. C., van Vulpen L. F.D. 24 Jun 2022, In: Blood Reviews. 56

Prediction Aided Tapering In rheumatoid arthritis patients treated with biOlogicals (PATIO):protocol for a randomized controlled trial

Messelink Marianne A., van der Leeuw Matthijs S., den Broeder Alfons A., Tekstra Janneke, van der Goes Marlies C., Heijstek Marloes W., Lafeber Floris, Welsing Paco M.J. 16 Jun 2022, In: Trials. 23

CCL5 Release by CCR9+ CD8 T Cells:A Potential Contributor to Immunopathology of Primary Sjögren’s Syndrome

Hinrichs Anneline C., Blokland Sofie L.M., Kruize Aike A., Lafeber Floris P.J., Leavis Helen L., van Roon Joel A.G. 1 Jun 2022, In: Frontiers in Immunology. 13 , p. 1-10

Predicted and actual 2-year structural and pain progression in the IMI-APPROACH knee osteoarthritis cohort

van Helvoort Eefje M, Jansen Mylène P, Marijnissen Anne C A, Kloppenburg Margreet, Blanco Francisco J, Haugen Ida K, Berenbaum Francis, Bay-Jensen Anne-Christine C, Ladel Christoph, Lalande Agnes, Larkin Jonathan, Loughlin John, Mobasheri Ali, Weinans Harrie H, Widera Pawel, Bacardit Jaume, Welsing Paco M J, Lafeber Floris P J G 16 May 2022, In: Rheumatology (Oxford, England). 62 , p. 147-157 11 p.

Using real-world data to dynamically predict flares during tapering of biological DMARDs in rheumatoid arthritis:development, validation, and potential impact of prediction-aided decisions

van der Leeuw Matthijs S., Messelink Marianne A., Tekstra Janneke, Medina Ojay, van Laar Jaap M., Haitjema Saskia, Lafeber Floris, Veris-van Dieren Josien J., van der Goes Marlies C., den Broeder Alfons A., Welsing Paco M.J. 23 Mar 2022, In: Arthritis research & therapy. 24 , p. 1-11

GaitSmart motion analysis compared to commonly used function outcome measures in the IMI-APPROACH knee osteoarthritis cohort

van Helvoort Eefje M, Hodgins D, Mastbergen Simon C, Marijnissen Anne C A, Kloppenburg M, Blanco Fransisco J, Haugen Ida K, Berenbaum F, Lafeber Floris P J G, Welsing Paco M J Mar 2022, In: PLoS ONE. 17 , p. 1-13

All research output

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