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dr. K.P. (Kevin) Kenna

dr. K.P. (Kevin) Kenna

Associate Professor

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Research Output (45)

The Effect of SMN Gene Dosage on ALS Risk and Disease Severity

Moisse Matthieu, Zwamborn Ramona A J, van Vugt Joke, van der Spek Rick, van Rheenen Wouter, Kenna Brendan, Van Eijk Kristel, Kenna Kevin, Corcia Philippe, Couratier Philippe, Vourc'h Patrick, Hardiman Orla, McLaughin Russell, Gotkine Marc, Drory Vivian, Ticozzi Nicola, Silani Vincenzo, de Carvalho Mamede, Mora Pardina Jesús S, Povedano Monica, Andersen Peter M, Weber Markus, Başak Nazli A, Chen Xiao, Eberle Michael A, Al-Chalabi Ammar, Shaw Chris, Shaw Pamela J, Morrison Karen E, Landers John E, Glass Jonathan D, Robberecht Wim, van Es Michael, van den Berg Leonard, Veldink Jan, Van Damme Philip, Apr 2021, In: Annals of Neurology. 89 , p. 686-697 12 p.

Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

Dewan Ramita, Chia Ruth, Ding Jinhui, Hickman Richard A, Stein Thor D, Abramzon Yevgeniya, Ahmed Sarah, Sabir Marya S, Portley Makayla K, Tucci Arianna, Ibáñez Kristina, Shankaracharya F N U, Keagle Pamela, Rossi Giacomina, Caroppo Paola, Tagliavini Fabrizio, Waldo Maria L, Johansson Per M, Nilsson Christer F, Rowe James B, Benussi Luisa, Binetti Giuliano, Ghidoni Roberta, Jabbari Edwin, Viollet Coralie, Glass Jonathan D, Singleton Andrew B, Silani Vincenzo, Ross Owen A, Ryten Mina, Torkamani Ali, Tanaka Toshiko, Ferrucci Luigi, Resnick Susan M, Pickering-Brown Stuart, Brady Christopher B, Kowal Neil, Hardy John A, Van Deerlin Vivianna, Vonsattel Jean Paul, Harms Matthew B, Morris Huw R, Ferrari Raffaele, Landers John E, Chiò Adriano, Gibbs J Raphael, Dalgard Clifton L, Scholz Sonja W, Traynor Bryan J, , , Kenna Kevin, , , , , , 3 Feb 2021, In: Neuron. 109 , p. 448-460.e4

Erratum:Rare variant burden analysis within enhancers identifies CAV1 as an ALS risk gene (Cell Reports (2020) 33(9), (S2211124720314455), (10.1016/j.celrep.2020.108456))

Cooper-Knock Johnathan, Zhang Sai, Kenna Kevin P, Moll Tobias, Franklin John P, Allen Samantha, Nezhad Helia Ghahremani, Iacoangeli Alfredo, Yacovzada Nancy Y, Eitan Chen, Hornstein Eran, Elhaik Eran, Celadova Petra, Bose Daniel, Farhan Sali, Fishilevich Simon, Lancet Doron, Morrison Karen E, Shaw Christopher E, Al-Chalabi Ammar, Veldink Jan H, Kirby Janine, Snyder Michael P, Shaw Pamela J, 2 Feb 2021, In: Cell Reports. 34

Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy

Schijven Dick, Stevelink Remi, McCormack Mark, van Rheenen Wouter, Luykx Jurjen J., Koeleman Bobby P.C., Veldink Jan H., , , Kenna Kevin 1 Jan 2020, In: Neurobiology of Aging. 92 , p. 153.e1-153.e5

ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization

Tazelaar Gijs H P, Boeynaems Steven, De Decker Mathias, van Vugt Joke J F A, Kool Lindy, Goedee H Stephan, McLaughlin Russell L, Sproviero William, Iacoangeli Alfredo, Moisse Matthieu, Jacquemyn Maarten, Daelemans Dirk, Dekker Annelot M, van der Spek Rick A, Westeneng Henk-Jan, Kenna Kevin P, Assialioui Abdelilah, Da Silva Nica, Povedano Mónica, Pardina Jesus S Mora, Hardiman Orla, Salachas François, Millecamps Stéphanie, Vourc'h Patrick, Corcia Philippe, Couratier Philippe, Morrison Karen E, Shaw Pamela J, Shaw Christopher E, Pasterkamp R Jeroen, Landers John E, Van Den Bosch Ludo, Robberecht Wim, Al-Chalabi Ammar, van den Berg Leonard H, Van Damme Philip, Veldink Jan H, van Es Michael A, 2020, In: Brain communications. 2 , p. 1-13

The project MinE databrowser:bringing large-scale whole-genome sequencing in ALS to researchers and the public

van der Spek Rick A A, van Rheenen Wouter, Pulit Sara L, Kenna Kevin P, van den Berg Leonard H, Veldink Jan H, Aug 2019, In: Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 20 , p. 432-440 9 p.

Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS

Baron Desiree M, Matheny Tyler, Lin Yen-Chen, Leszyk John D, Kenna Kevin, Gall Katherine V, Santos David P, Tischbein Maeve, Funes Salome, Hayward Lawrence J, Kiskinis Evangelos, Landers John E, Parker Roy, Shaffer Scott A, Bosco Daryl A 1 Jul 2019, In: Human molecular genetics. 28 , p. 2143-2160 18 p.

ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function

de Majo Martina, Topp Simon D, Smith Bradley N, Nishimura Agnes L, Chen Han-Jou, Gkazi Athina Soragia, Miller Jack, Wong Chun Hao, Vance Caroline, Baas Frank, Ten Asbroek Anneloor L M A, Kenna Kevin P, Ticozzi Nicola, Redondo Alberto Garcia, Esteban-Pérez Jesús, Tiloca Cinzia, Verde Federico, Duga Stefano, Morrison Karen E, Shaw Pamela J, Kirby Janine, Turner Martin R, Talbot Kevin, Hardiman Orla, Glass Jonathan D, de Belleroche Jacqueline, Gellera Cinzia, Ratti Antonia, Al-Chalabi Ammar, Brown Robert H, Silani Vincenzo, Landers John E, Shaw Christopher E Nov 2018, In: Neurobiology of Aging. 71 , p. 266.e1-266.e10

Project MinE:study design and pilot analyses of a large-scale whole-genome sequencing study in amyotrophic lateral sclerosis

Project Mine Als Sequencing Consortium Mine Als Sequencing Consortium, Pulit Sara L., Dekker Annelot M., Al Khleifat Ahmad, Brands William J., Iacoangeli Alfredo, Kenna Kevin P., Kavak Ersen, Kooyman Maarten, McLaughlin Russell L., Middelkoop Bas, Moisse Matthieu, Schellevis Raymond D., Shatunov Aleksey, Sproviero William, Tazelaar Gijs H.P., van der Spek Rick A.A., van Doormaal Perry T.C., van Eijk Kristel R., van Vugt Joke, Basak A. Nazli, Blair Ian P., Glass Jonathan D., Hardiman Orla, Hide Winston, Landers John E., Mora Jesus S., Morrison Karen E., Newhouse Stephen, Robberecht Wim, Shaw Christopher E., Shaw Pamela J., van Damme Philip, van Es Michael A., Wray Naomi R., Al-Chalabi Ammar, van Den Berg Leonard H., Veldink Jan H. 1 Oct 2018, In: European Journal of Human Genetics. 26 , p. 1537–1546 10 p.

Association of NIPA1 repeat expansions with amyotrophic lateral sclerosis in a large international cohort

Tazelaar Gijs H P, Dekker Annelot M, van Vugt Joke J F A, van der Spek Rick A, Westeneng Henk-Jan, Kool Lindy J B G, Kenna Kevin P, van Rheenen Wouter, Pulit Sara L, McLaughlin Russell L, Sproviero William, Iacoangeli Alfredo, Hübers Annemarie, Brenner David, Morrison Karen E, Shaw Pamela J, Shaw Christopher E, Panadés Monica Povedano, Mora Pardina Jesus S, Glass Jonathan D, Hardiman Orla, Al-Chalabi Ammar, van Damme Philip, Robberecht Wim, Landers John E, Ludolph Albert C, Weishaupt Jochen H, van den Berg Leonard H, Veldink Jan H, van Es Michael A, 22 Sep 2018, In: Neurobiology of Aging. 74 , p. 234.e9-234.e15

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