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dr. F. (Floris) Groenendaal

dr. F. (Floris) Groenendaal

Associate Professor - medical
dr. F. (Floris) Groenendaal
  • Birth Center Neonatology - Medical

Biography

Biography

Floris Groenendaal finished Medical School of the Erasmus University Rotterdam in 1984. From 1984 1986 he worked at the Institute of Physiology I (Neurophysiology) of the Erasmus University Rotterdam and defended his PhD thesis: "Perinatal hypoxia and visual functions in infants and children" in January 1988. From 1986 to 1991 he was trained in paediatrics in the Sophia Children’s Hospital in Rotterdam. His fellowship neonatology was spent at the Sophia Children’s Hospital, Rotterdam, and the Wilhelmina Children’s Hospital, Utrecht.

Since April 1993 he is consultant neonatology at the Wilhelmina Children’s Hospital/University Medical Center, Utrecht, The Netherlands. At present he is associate professor of neonatology.

In 1994 he was funded by the Ter Meulen Fund to spend his post-doc period at the Department of Physiology of the University of Pennsylvania, Philadelphia, USA. The main focus of his scientific research is: early detection of neonatal brain injury (including MR techniques) and neuroprotection. Under his guidance hypothermia was introduced as standard therapy for neonates with perinatal asphyxia in the Netherlands in 2008. Meanwhile, in collaboration with the NIDOD laboratory of the UMC Utrecht novel therapeutic  strategies have been developed and tested in animal models.

He has been involved in many PhD studies, and has obtained grants from different sources. Publications cited in PubMed include more than 250 papers.

He is member of many professional societies.

Research line

Neonatal neuroprotection

Most recent key publications

1: Harteman JC et al. Diffusion-weighted imaging changes in cerebral watershed distribution following neonatal encephalopathy are not invariably associated with an adverse outcome. Dev Med Child Neurol. 2013;55:642-53
2: Harteman JC et al. Placental pathology in full-term infants with hypoxic-ischemic neonatal encephalopathy and association with magnetic resonance imaging pattern of brain injury. J Pediatr. 2013;163:968-95
3: Van den Heuvel MP et al. The Neonatal Connectome During Preterm Brain Development. Cereb Cortex. 2015;25:3000-13
4: Kersbergen K et al. Microstructural brain development between 30 and 40 weeks corrected age in a longitudinal cohort of extremely preterm infants. Neuroimage. 2014;103:214-24
5: Alderliesten T et al. Neuroprotection by argon ventilation after perinatal asphyxia: a safety study in newborn piglets. PLoS One. 2014;9:e113575

Side Activities

•          Invited speaker on many international courses and symposia

•          Co-inventor of 2-iminobiotin for neonatal neuroprotection

•          Expert witness in several legal cases

•          Reviewer for many international scientific journals

Fellowship and Awards

- Ter Meulen Fonds, KNAW, Amsterdam 1993

- Sterproject Neurowetenschappen Universitair Medisch Centrum Utrecht 1995

- NWO AGIKO-stipendium 920-03-039

- Hersenstichting Nederland (Brain Foundation of the Netherlands) 10F02.07

- Dr.W.M.Phelps-Stichting voor Spastici 03.016

- Wilhelmina Kinderziekenhuis Onderzoekfonds 2003

- NWO ZonMW Doelmatigheidsonderzoek ‘Selection of preterm neonates at risk for neurodevelopmental disorders by segmentation of the brain using MRI’ 945-27-022

- Excellence in Academic Medicine, UniversityMedicalCenter Utrecht 2009-2010.

- NWO ZonMW Priority Medicines For Children: Pharmacokinetics and Pharmacodynamics of Medication in Asphyxiated Newborns During Controlled Hypothermia. PharmaCoolNationalMulticenter Study. 40-41500-98-9002

- NWO ZonMW Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain 40-41400-98-1103

- ZonMW 2012: Organisatie en evaluatie van het perinataal Regio Consortium Utrecht: een samenwerkingsverband voor zorg en kennisoverdracht rondom zwangerschap en geboorte project: 50-50200-98-005

- ZonMW 2012: Towards risk-guided intergrated and tailored care; Early prediction of pregnancy complications to improve perinatal outcomes.  50-50200-98-060

Research Output (588)

Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy

Annink Kim V, de Vries Linda S, Groenendaal Floris, Eijsermans Rian M J C, Mocking Manouk, van Schooneveld Monique M J, Dudink Jeroen, van Straaten Henrica L M, Benders Manon J N L, Lequin Maarten, van der Aa Niek E dec 2021, In: Scientific Reports. 11

A novel neonatal encephalopathy rating scale

Groenendaal Floris, van der Aa Niek nov 2021, In: Journal of Pediatrics. 238 , p. 338-342 5 p.

Nutritional intake, white matter integrity, and neurodevelopment in extremely preterm born infants

Hortensius Lisa M., Janson Els, van Beek Pauline E., Groenendaal Floris, Claessens Nathalie H.P., Swanenburg de Veye Henriette F.N., Eijsermans Maria J.C., Koopman-Esseboom Corine, Dudink Jeroen, van Elburg Ruurd M., Benders Manon J.N.L., Tataranno Maria Luisa, van der Aa Niek E. 27 sep 2021, In: Nutrients. 13

A prospective population-based multicentre study on the impact of maternal body mass index on adverse pregnancy outcomes:Focus on normal weight

van Hoorn Fieke, de Wit Leon, van Rossem Lenie, Jambroes Marielle, Groenendaal Floris, Kwee Anneke, Lamain-de Ruiter Marije, Franx Arie, van Rijn Bas B, Koster Maria P H, Bekker Mireille N sep 2021, In: PLoS ONE. 16 , p. e0257722

Implementation of a first-trimester prognostic model to improve screening for gestational diabetes mellitus

van Hoorn Fieke, Koster Maria P H, Kwee Anneke, Groenendaal Floris, Franx Arie, Bekker Mireille N, 13 apr 2021, In: BMC Pregnancy and Childbirth. 21

Early Acute Kidney Injury in Preterm and Term Neonates:Incidence, Outcome, and Associated Clinical Features

Gallo Dario, de Bijl-Marcus Karen A, Alderliesten Thomas, Lilien Marc, Groenendaal Floris 29 mrt 2021, In: Neonatology. 118 , p. 174-179 6 p.

Pathophysiology of Cerebral Hyperperfusion in Term Neonates With Hypoxic-Ischemic Encephalopathy:A Systematic Review for Future Research

Kleuskens Dianne G, Gonçalves Costa Filipe, Annink Kim V, van den Hoogen Agnes, Alderliesten Thomas, Groenendaal Floris, Benders Manon J N, Dudink Jeroen 2 feb 2021, In: Frontiers in Pediatrics. 9 , p. 631258

Isoprostanes as Biomarker for White Matter Injury in Extremely Preterm Infants

Coviello Caterina, Perrone Serafina, Buonocore Giuseppe, Negro Simona, Longini Mariangela, Dani Carlo, de Vries Linda S, Groenendaal Floris, Vijlbrief Daniel C, Benders Manon J N L, Tataranno Maria Luisa 15 jan 2021, In: Frontiers in Pediatrics. 8

Background incidence rates of adverse pregnancy outcomes in the Netherlands:Data of 2006-2018

Immink Maarten M, Koole Sanne, Bekker Mireille N, Groenendaal Floris, Kemmeren Jeanet M, de Melker Hester E, van der Maas Nicoline A T jan 2021, In: European Journal of Obstetrics, Gynecology and Reproductive Biology. 256 , p. 274-280 7 p.

Timing of Intervention for Post-Hemorrhagic Ventricular Dilatation:An Ongoing Debate

Cizmeci Mehmet N, Groenendaal Floris, de Vries Linda S 2021, In: The Journal of Pediatrics. 234 , p. 14-16 3 p.

All research output

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