dr. L.A.A. (Lodewijk) Brosens

dr. L.A.A. (Lodewijk) Brosens

Associate Professor - medical
dr. L.A.A. (Lodewijk) Brosens
  • Department of Pathology

Research Programs

Strategic Program Cancer



2015-present: Associate professor of pathology, gastrointestinal and endocrine pathology, UMC Utrecht.

2014-2015: Post-doctoral research fellow department of pathology Johns Hopkins Hospital, Baltimore

2013: Pathologist, gastrointestinal pathology, Academic Medical Center Amsterdam

2008-2013: Pathology residency

2008: PhD, Gastrointestinal polyposis syndromes, clinical and molecular aspects of Familial Adenomatous Polyposis en Juvenile Polyposis, Utrecht University

2006: M.D. University of Amsterdam

2004: MSc. Biomedical Science, Vrije Universiteit, Amsterdam

2003-2004: Research fellow Departments of Pathology and Gastroenterology, Johns Hopkins Hospital, Baltimore

Side Activities

Member of the scientific committee Dutch Pancreatic Cancer Group (DPCG)

Member of scientific council pancreas parel (nationwide biobank)

Member of scientific committee LWH Foundation

Member of Dutch working group on Barrett's esophagus

WHO Classification of Tumours 5Th Edition - Tumours of the Digestive System, co-author

WHO Classification of Tumours 5Th Edition - Endocrine and Neuroendocrine tumours Tumours, co-author

Associate Editor BMC Cancer

Pathologist RadboudUMC (0,2 fte) gastrointestinal and pancreatic pathology

Visiting professor of pathology, University of Verona, Italy

Associate Editor Cancer Biology & Therapy


Fellowship and Awards

2018: University of Verona Internationalization Program Stipend

2014: MLDS Career Development Grant

2013: UICC Yamagiwa-Yoshida Memorial international study grant

2013: Nijbakker-Morra Stichting Stipend

Research Output (159)

Neoantigen Quantity and Quality in Relation to Pancreatic Cancer Survival

Levink Iris J M, Brosens Lodewijk A A, Rensen Sander S, Aberle Merel R, Olde Damink Steven S W, Cahen Djuna L, Buschow Sonja I, Fuhler Gwenny M, Peppelenbosch Maikel P, Bruno Marco J 9 Feb 2022, In: Frontiers in medicine. 8 , p. 1-7

Refining targeted therapeutic approaches in pancreatic cancer:from histology and molecular pathology to the clinic

Mattiolo Paola, Kryklyva Valentyna, Brosens Lodewijk A, Mafficini Andrea, Lawlor Rita T, Milella Michele, Scarpa Aldo, Corbo Vincenzo, Luchini Claudio 31 Dec 2021, In: Expert opinion on therapeutic targets. 26 , p. 1-4 4 p.

Significant variation in histopathological assessment of endoscopic resections for Barrett's neoplasia suggests need for consensus reporting:propositions for improvement

van der Wel M. J., Klaver E., Pouw R. E., Brosens L. A.A., Biermann K., Doukas M., Huysentruyt C., Karrenbeld A., Ten Kate F. J.W., Kats-Ugurlu G., van der Laan J., van Lijnschoten I., Moll F. C.P., Offerhaus G. J.A., Ooms A. H.A.G., Seldenrijk C. A., Visser M., Tijssen J. G., Meijer S. L., Bergman J. J.G.H.M. 24 Dec 2021, In: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. 34 , p. 1-10

Dataset for the reporting of carcinoma of the exocrine pancreas: recommendations from the International Collaboration on Cancer Reporting (ICCR)

Verbeke Caroline, Webster Fleur, Brosens Lodewijk, Campbell Fiona, Del Chiaro Marco, Esposito Irene, Feakins Roger M., Fukushima Noriyoshi, Gill Anthony J., Kakar Sanjay, Kench James G., Krasinskas Alyssa M., van Laethem Jean-Luc, Schaeffer David F., Washington Kay Dec 2021, In: Histopathology. 79 , p. 902-912 11 p.

Molecular characterization of Barrett's esophagus at single-cell resolution

Busslinger Georg A, de Barbanson Buys, Oka Rurika, Weusten Bas L A, de Maat Michiel, van Hillegersberg Richard, Brosens Lodewijk A A, van Boxtel Ruben, van Oudenaarden Alexander, Clevers Hans 23 Nov 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118 , p. 1-12

The spectrum of pathogenic germline variants in pancreatic cancer patients with multiple primary tumors.

Kryklyva Valentyna, Brosens Lodewijk A. A., Ligtenberg Marjolijn J. L., Nagtegaal Iris D. Nov 2021, In: Cancer Research. 81 , p. 9-9

Lymphovascular invasion quantification could improve risk prediction of lymph node metastases in patients with submucosal (T1b) esophageal adenocarcinoma

van de Ven Steffi E M, Suzuki Lucia, Gotink Annieke W, Ten Kate Fiebo J C, Nieboer Daan, Weusten Bas L A M, Brosens Lodewijk A A, van Hillegersberg Richard, Alvarez Herrero Lorenza, Seldenrijk Cees A, Alkhalaf Alaa, Moll Freek C P, Curvers Wouter, van Lijnschoten Ineke G, Tang Thjon J, van der Valk Hans, Nagengast Wouter B, Kats-Ugurlu Gursah, Plukker John T M, Houben Martin H M G, van der Laan Jaap S, Pouw Roos E, Bergman Jacques J G H M, Meijer Sybren L, van Berge Henegouwen Mark I, Wijnhoven Bas P L, de Jonge Pieter J F, Doukas Michael, Bruno Marco J, Biermann Katharina, Koch Arjun D 5 Oct 2021, In: United European Gastroenterology Journal. 9 , p. 1066-1073 8 p.

Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer

Cejas Paloma, Xie Yingtian, Font-Tello Alba, Lim Klothilda, Syamala Sudeepa, Qiu Xintao, Tewari Alok K, Shah Neel, Nguyen Holly M, Patel Radhika A, Brown Lisha, Coleman Ilsa, Hackeng Wenzel M, Brosens Lodewijk, Dreijerink Koen M A, Ellis Leigh, Alaiwi Sarah Abou, Seo Ji-Heui, Baca Sylvan, Beltran Himisha, Khani Francesca, Pomerantz Mark, Dall'Agnese Alessandra, Crowdis Jett, Van Allen Eliezer M, Bellmunt Joaquim, Morrisey Colm, Nelson Peter S, DeCaprio James, Farago Anna, Dyson Nicholas, Drapkin Benjamin, Liu X Shirley, Freedman Matthew, Haffner Michael C, Corey Eva, Brown Myles, Long Henry W 1 Oct 2021, In: Nature Communications. 12 , p. 1-11 11 p.

Genomic characterization of hepatoid tumors:context matters

Lawlor Rita T, Mafficini Andrea, Sciammarella Concetta, Cantù Cinzia, Rusev Borislav C, Piredda Maria L, Antonello Davide, Grimaldi Sonia, Bonizzato Giada, Sperandio Nicola, Marchegiani Giovanni, Malleo Giuseppe, Pea Antonio, Salvia Roberto, Mombello Aldo, Mazzoleni Guido, Nottegar Alessia, Hanspeter Esther, Riva Giulio, Tomezzoli Anna, Bencivenga Maria, de Manzoni Giovanni, Pedron Serena, Paolino Gaetano, Mattiolo Paola, Brosens Lodewijk A, Silvestris Nicola, Fassan Matteo, Cooke Susanna L, Beer Philip A, Milella Michele, Adsay Volkan N, Cheng Liang, Scarpa Aldo, Luchini Claudio 22 Sep 2021, In: Human Pathology. 118 , p. 30-41 12 p.

Tumor Mutational Burden as a Potential Biomarker for Immunotherapy in Pancreatic Cancer:Systematic Review and Still-Open Questions

Lawlor Rita T, Mattiolo Paola, Mafficini Andrea, Hong Seung-Mo, Piredda Maria L, Taormina Sergio V, Malleo Giuseppe, Marchegiani Giovanni, Pea Antonio, Salvia Roberto, Kryklyva Valentyna, Shin Jae Il, Brosens Lodewijk A, Milella Michele, Scarpa Aldo, Luchini Claudio 22 Jun 2021, In: Cancers. 13 , p. 1-15

All research output

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