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prof. dr. L.J. Bont

prof. dr. L.J. Bont

Full Professor
prof. dr. L.J. Bont
  • Laboratory for Translational Immunology (LTI)
  • Infectious Diseases Research 2

Biography

Biography

Louis Bont is a Paediatrician Infectiologist at the Wilhelmina Children’s Hospital in the University Medical Center Utrecht, The Netherlands. He leads the Utrecht RSV Research Group. He is the coordinator of the Interest Group on Respiratory Infections of the European Society of Pediatric Infectious Diseases (ESPID) Research Committee. Dr. Bont is the founder and chairman of ReSViNET, an international RSV Research consortium. He has a strong interest in education of young talented researchers and founded the successful Training of Upcoming Leaders in Pediatric Science (TULIPS) career training program in the Netherlands. Dr. Bont served as advisor of the World Health Organization (WHO), the European Center of Disease Control (ECDC) and the Europarliament.

Louis Bont did his medical training at the Academic Medical Center in Amsterdam (1989-1996). He performed his PhD under the supervision of professor Jan Kimpen and professor Cobi Heijnen at the Wilhelmina Children’s Hospital (1997-2000). He was a post-doc at the Garofalo lab in Galveston, Texas (2000-2001). After returning to Utrecht, he followed the pediatric residency program followed by a pediatric infectious diseases and immunology fellowship. He have led the RSV Research Group since 2003 and became full professor in 2015.

The vision of his research is to combine clinical and basic research to decrease the global burden of RSV infection. The mission of his research group is to improve knowledge of RSV epidemiology, and to develop safe and effective therapeutic and preventive interventions.

In his work collaborate with patients is of highest importance. His work is supported by the RSV Patient Advisory Board (PAB) since 2012. The PAB has reviewed every grant application by the RSV Research Group. PAB members have been interviewed for newspapers and national television on RSV-related subjects.

Louis Bont actively participates as a teacher in the SUMMA program. In addition, he founded the TULIPS program in 2008 to train colleagues and young clinician-scientists.

Potential Conflicts of Interest

Dr. Bont has regular interaction with pharmaceutical and other industrial partners. He has not received personal fees or other personal benefits. UMCU has received major funding (>€100,000 per industrial partner) for investigator initiated studies from AbbVie, MedImmune, AstraZeneca, Sanofi, Janssen, Pfizer and MeMed Diagnostics. UMCU has received major funding for the RSV GOLD study from the Bill and Melinda Gates Foundation. UMCU has received major funding as part of the public private partnership IMI-funded RESCEU and PROMISE projects with partners GSK, Novavax, Janssen, AstraZeneca, Pfizer and Sanofi. UMCU has received major funding by Julius Clinical for participating in clinical studies sponsored by MedImmune and Pfizer. UMCU received minor funding (€1,000-10,000 per industrial partner) for consultation and invited lectures by AbbVie, MedImmune, Ablynx, Bavaria Nordic, MabXience, GSK, Novavax, Pfizer, Janssen. Dr. Bont is the founding chairman of the ReSViNET Foundation.

Since April 1st 2020, Louis has been given a new position as medical scientific division manager of the Children's Division of the Wilhelmina Children's Hospital in Utrecht.

Side Activities

Coordinator of the Interest Group on Respiratory Infections of the European Society of Pediatric Infectious Diseases (ESPID) Research Committee

Chairman of ReSViNET, an international RSV Research Network.

Advisor of the Europarliament

Advisor of the World Health Organization for RSV-related programs

Fellowship and Awards

Full Professor (“Stimuleringshoogleraarschap”), expected in May 2015

International Congress of Pediatric Pulmunology (CIPP) Award for Contribution to Understanding Childhood Respiratory Disease and Global Medical Education (2013)

Dirkzwager-Assink Fonds Award by Catharijne Stichting for research on RSV bronchiolitis (2010)

Ter Meulen Fonds lecture: It is not all asthma that wheezes. 27e Congres Nederlandse Vereniging voor Kindergeneeskunde, Veldhoven (2005)

ESPID Fellowship Award 2001 Immunopathogenetic mechanisms of RSV infection in the mouse model (2001)

Royal Dutch Academy of Science (Ter Meulen Fonds Stipendium). Immunopathogenetic mechanisms of RSV infection in the mouse model (2000)

Research Output (235)

Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus

Lin Gu Lung, Drysdale Simon B., Snape Matthew D., O’Connor Daniel, Brown Anthony, MacIntyre-Cockett George, Mellado-Gomez Esther, de Cesare Mariateresa, Bonsall David, Ansari M. Azim, Öner Deniz, Aerssens Jeroen, Butler Christopher, Bont Louis, Openshaw Peter, Martinón-Torres Federico, Nair Harish, Bowden Rory, Campbell Harry, Cunningham Steve, Bogaert Debby, Beutels Philippe, Wildenbeest Joanne, Clutterbuck Elizabeth, McGinley Joseph, Thwaites Ryan, Wiseman Dexter, Gómez-Carballa Alberto, Rodriguez-Tenreiro Carmen, Rivero-Calle Irene, Dacosta-Urbieta Ana, Heikkinen Terho, Meijer Adam, Fischer Thea Kølsen, van den Berge Maarten, Giaquinto Carlo, Abram Michael, Dormitzer Philip, Stoszek Sonia, Gallichan Scott, Rosen Brian, Molero Eva, Machin Nuria, Spadetto Martina, Golubchik Tanya, Pollard Andrew J., dec 2021, In: Nature Communications. 12 , p. 1-11 11 p.

Transcriptome of airway neutrophils reveals an interferon response in life-threatening respiratory syncytial virus infection

Besteman Sjanna B., Callaghan Amie, Langedijk Annefleur C., Hennus Marije P., Meyaard Linde, Mokry Michal, Bont Louis J., Calis Jorg J.A. nov 2020, In: Clinical Immunology. 220 , p. 1-10

Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017-2018 INFORM-RSV Study

Tabor David E, Fernandes Fiona, Langedijk Annefleur C, Wilkins Deidre, Lebbink Robert Jan, Tovchigrechko Andrey, Ruzin Alexey, Kragten-Tabatabaie Leyla, Jin Hong, Esser Mark T, Bont Louis J, Abram Michael E, 21 okt 2020, In: Journal of Clinical Microbiology. 59 , p. 1-13

Defining asthma in children:how well do parents, doctors and spirometry agree?

Korsten Koos, Naaktgeboren Christiana A, Bont Louis J, van der Ent Cornelis K, de Hoog Marieke L A okt 2020, In: ERJ Open Research. 6 , p. 1-10

Live-attenuated Respiratory Syncytial Virus Vaccines:Time for the Next Step

Billard Marie-Noëlle, Bont Louis J 28 sep 2020, In: American Journal of Respiratory and Critical Care Medicine. 203 , p. 538-539 2 p.

Comparison of illumina versus nanopore 16s rRNA gene sequencing of the human nasal microbiota

Heikema Astrid P., Horst-Kreft Deborah, Boers Stefan A., Jansen Rick, Hiltemann Saskia D., de Koning Willem, Kraaij Robert, de Ridder Maria A.J., van Houten Chantal B., Bont Louis J., Stubbs Andrew P., Hays John P. 21 sep 2020, In: Genes. 11 , p. 1-17 17 p.

Respiratory Syncytial Virus Consortium in Europe (RESCEU) Birth Cohort Study:Defining the Burden of Infant Respiratory Syncytial Virus Disease in Europe

Wildenbeest Joanne G, Zuurbier Roy P, Korsten Koos, van Houten Marlies A, Billard Marie N, Derksen-Lazet Nicole, Snape Matthew D, Drysdale Simon B, Robinson Hannah, Pollard Andrew J, Heikkinen Terho, Cunningham Steve, Leach Amanda, Martinón-Torres Federico, Rodríguez-Tenreiro Sánchez Carmen, Gómez-Carballa Alberto, Bont Louis J, 14 aug 2020, In: The Journal of infectious diseases. 222 , p. S606-S612

Presumed Risk Factors and Biomarkers for Severe Respiratory Syncytial Virus Disease and Related Sequelae:Protocol for an Observational Multicenter, Case-Control Study From the Respiratory Syncytial Virus Consortium in Europe (RESCEU)

Jefferies Kimberley, Drysdale Simon B, Robinson Hannah, Clutterbuck Elizabeth Ann, Blackwell Luke, McGinley Joseph, Lin Gu-Lung, Galal Ushma, Nair Harish, Aerssens Jeroen, Öner Deniz, Langedijk Annefleur, Bont Louis, Wildenbeest Joanne G, Martinon-Torres Federico, Rodríguez-Tenreiro Sánchez Carmen, Nadel Simon, Openshaw Peter, Thwaites Ryan, Widjojoatmodjo Myra, Zhang Linong, Nguyen Thi Lien-Anh, Giaquinto Carlo, Giordano Giuseppe, Baraldi Eugenio, Pollard Andrew J, 14 aug 2020, In: The Journal of infectious diseases. 222 , p. S658-S665

Bovine IgG Prevents Experimental Infection With RSV and Facilitates Human T Cell Responses to RSV

Nederend Maaike, van Stigt Arthur H., Jansen J. H.Marco, Jacobino Shamir R., Brugman Sylvia, de Haan Cornelis A.M., Bont Louis J., van Neerven R. J.Joost, Leusen Jeanette H.W. 6 aug 2020, In: Frontiers in Immunology. 11 , p. 1-9

Assessing the strength of evidence for a causal effect of respiratory syncytial virus lower respiratory tract infections on subsequent wheezing illness:a systematic review and meta-analysis

Brunwasser Steven M, Snyder Brittney M, Driscoll Amanda J, Fell Deshayne B, Savitz David A, Feikin Daniel R, Skidmore Becky, Bhat Niranjan, Bont Louis J, Dupont William D, Wu Pingsheng, Gebretsadik Tebeb, Holt Patrick G, Zar Heather J, Ortiz Justin R, Hartert Tina V aug 2020, In: The Lancet Respiratory Medicine. 8 , p. 795-806 12 p.

All research output

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