Pediatric Tumor Immunology and HCT: Group Nierkens
Pediatric Tumor Immunology and HCT: Group Nierkens
Pediatric Immunology and HCT
About
Group Nierkens studies the functional dynamics of the immune system in pediatric cancer patients, in particular in children treated with immune therapy and/or hematopoietic cell transplantation (HCT). The group developed a comprehensive immune monitoring program and performs PK-PD analyses (chemo-, serotherapy and steroids) to make cell transplantation as safe and efficient as possible. Using cord blood as a cell therapy platform, Nierkens and his group generated an efficient protocol for TCR-transduction of cord blood cells for anti-tumor T-cell therapy. Their cord blood-derived dendritic cell vaccine has recently been approved for a phase-I/II in children with AML (U-DANCE trial).
Research programme uitklapper, klik om te openen
Infection and Immunity
Research interests uitklapper, klik om te openen
Hematopoietic Cell Transplantation (HCT)
Immune Therapy
Immune Monitoring
Dendritic cell vaccination
T- cell therapy
PK-PD
Contact uitklapper, klik om te openen
Stefan Nierkens
Medical Immunologist
Associate Professor Pediatric Tumorimmunology and HCT
Head Central Immune Monitoring Platform
Phone +31 (0)6 33048039
Location
Center for Translational Immunology
University Medical Center Utrecht
Heidelberglaan 100, 3584 CX Utrecht. Room F03.818
Related website
Group members uitklapper, klik om te openen
Group leader uitklapper, klik om te openen
Postdocs
Niek van Til
Maud Plantinga
Coco de Koning
Technicians
Denise van den Beemt
Ester Dunnebach
PhD students
Annelisa Cornel, PhD student
Vania LoPresti , PhD student
Celina Szanto, PhD student
Brigitte van den Broek, MD, PhD student
Shanice Beerepoot, MD, PhD student
Julia Mohlman, PhD student
Linde Dekker, PhD student
Join the group uitklapper, klik om te openen
Students interested in an internship from 6-9 months can contact
Key publications uitklapper, klik om te openen
- Cord-Blood-Stem-Cell-Derived Conventional Dendritic Cells Specifically Originate from CD115-Expressing Precursors. Plantinga M, de Haar CG, Dünnebach E, van den Beemt DAMH, Bloemenkamp KWM, Mokry M, Boelens JJ, Nierkens S. Cancers (Basel). 2019 Feb 5;11(2). pii: E181. doi: 10.3390/cancers1102018 View
- Spel L, Nieuwenhuis J, Haarsma R, Stickel E, Bleijerveld OB, Altelaar M, Boelens JJ, Brummelkamp TR, Nierkens S*, Boes M*. *shared. Nedd4 Binding Protein 1 (N4BP1) and TNFAIP3 Interacting Protein 1 (TNIP1) control MHC-1 display in neuroblastoma. Cancer Res. 2018 Sep 13. pii: canres.0545.2018. doi: 10.1158/0008-5472.CAN-18-0545. View
- de Koning C, Gabelich JA, Langenhorst J, Admiraal R, Kuball J, Boelens JJ, Nierkens S. Filgrastim enhances T-cell clearance by antithymocyte globulin exposure after unrelated cord blood transplantation. Blood Adv. 2018 Mar 13;2(5):565-574. doi: 10.1182/bloodadvances.2017015487. View
- Admiraal R, de Koning C, Lindemans CA, Bierings MB, Wensing AMJ, Versluys AB, Wolfs TFW, Nierkens S*, Boelens JJ*. *shared. Viral Reactivations and Associated Outcomes in Context of Immune Reconstitution after Paediatric Hematopoietic CellTransplantation: a Retrospective Cohort study of Consecutive Patients. J Allergy Clin Immunol. 2017 Apr 7. pii: S0091-6749(17)30571-7. View
- Admiraal R, Nierkens S, de Witte M, Petersen E, Fleurke G, Verrest L, Raymakers R, Knibbe C, Minnema M, van Kesteren C, Kuball,J, Boelens JJ. Association between anti-thymocyte globulin exposure and survival outcomes in adult unrelated haemopoietic cell transplantation: a retrospective, pharmacodynamic cohort analysis. Lancet Haematol. 2017 Apr;4(4):e183-e191. View
Collaborations uitklapper, klik om te openen
The Netherlands
Caroline Lindemans, MD/PhD, Princess Máxima Center for Pediatric Oncology, HCT unit, Utrecht
Alwin Huitema, Prof, Pharmacy, UMCU / NKI, Utrecht/Amsterdam
Femke van Wijk, PhD, CTI, UMCU, Utrecht
Linde Meyaard, Prof, CTI, UMCU, Utrecht
Jolanda de Vries, Prof. Radboud UMC, Nijmegen
Jurgen Kuball, MD/PhD, UMCU Hematology, Utrecht
Jan Molenaar, PhD, Princess Máxima Center for Pediatric Oncology, Utrecht
Dannis van Vuurden, Princess Máxima Center for Pediatric Oncology, Utrecht
Michel Zwaan, Prof, Princess Máxima Center for Pediatric Oncology, Utrecht
Ruben van Boxtel, PhD. Princess Máxima Center for Pediatric Oncology, Utrecht
UK
John Anderson, Prof. UCL, UK
Paul Veys, Prof. GOSH, UK
USA
Jaap Jan Boelens, MSKCC, NY, USA
EuroFlow consortium
Clinical trials uitklapper, klik om te openen
Dutch Ethical Committee approval Phase I/II study on Dendritic cell vaccines in AML
PARACHUTE trial on individualized dosing of ATG
Research implementation in patient care uitklapper, klik om te openen
Implementation of ATG dosing nomogram to achieve optimal exposure in the patient
Implementation of ATG therapeutic drug monitoring in high-risk HCT children
Video gallery uitklapper, klik om te openen
Advanced Diagnostics in Immunology Research
In deze folder bevindt zich extra informatie door middel van een video. Scan de bovenste QR-code met uw telefoon om deze video te bekijken. Of bekijk de video via:
Training the Immune System to Fight Neuroblastoma
In deze folder bevindt zich extra informatie door middel van een video. Scan de bovenste QR-code met uw telefoon om deze video te bekijken. Of bekijk de video via:
Utrecht – Dendritic Cells against Cancer (U-DANCE) project
In the media uitklapper, klik om te openen
2016 Dec 13: RTL live interview - anti kanker vaccin voor kinderen met acu
2016 Jan 14: "De kennis van nu" - ATC in autologous HCT
2014: Koningin Máxima op bezoek bij Villa Joep - Panel discussion in Stedelijk Museum Amsterdam for Queen Máxima of the Netherlands
UMC NEWS uitklapper, klik om te openen
2019 Apr 2: Stamceltransplantatie vergt behandeling op maat
- Read (in Dutch)