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prof. dr. D.W.J. Klomp

Full Professor

  • 7T Group

prof. dr. D.W.J. Klomp

Biography

Research interests

In my research team, we are investigating novel methods to enable imaging of metabolism and physiology of diseases and treatments non-invasively to aid clinical decision making. Using ultra-high magnetic fields, we demonstrated feasibility of imaging metabolism with magnetic resonance in the human body at clinically relevant spatial resolutions. Observing physiology and metabolism will provide a more direct and therefore faster and accurate means to characterize diseases and responses to treatments when compared to conventional morphologic imaging as known from cell studies. In fact, we have recently proven that metabolic images can predict efficacy of neoadjuvant chemotherapy in breast cancer much better and faster than any morphologic imaging technique could. The results have motivated public-private partnerships in translating the technology for clinical studies involving metabolic MRI throughout the body.

Compared to a few morpholic imaging contrasts conventionally available in radiology, potentially hundred of different metabolite levels could soon be imaged. Our innovation therefore brings radiology into the world of biochemistry and visa versa, creating a new bridge between research groups in identifying what non-invasively detectable metabolites would be useful for aiding clinic. In parallel, acceleration techniques in imaging are being investigated to maximize metabolic and physiologic information within a single scan session for each patient. These incorporate high density receiver array and even novel ways in gradient coil designs that speed up (metabolic) MRI with an anticiptated acceleration of an order of magnitude.

The very first prototype worldwide of metabolic MRI dedicated for clinical use will become available at the UMCU and clinical projects are being compiled for the focus areas of cancer, heart/vasculature, regenerative medicine, child, infections, brain. Teams from Dutch UMCU’s will use our system, while plans have been compiled to take the scientific lead of the next 8 systems positioned worldwide (3 already confirmed) prior to FDA approval.

Side Activities

  • Non executive board member, Tesla, August 2019 - August 2050

Research Output (150)

Lipid-suppressed and tissue-fraction corrected metabolic distributions in human central brain structures using 2D H-1 magnetic resonance spectroscopic imaging at 7 T

Bhogal Alex A, Broeders Tommy A A, Morsinkhof Lisan, Edens Mirte, Nassirpour Sahar, Chang Paul, Klomp Dennis W J, Vinkers Christiaan H, Wijnen Jannie P 20 nov 2020, In: Brain and Behavior. 10 , p. e01852

Introduction of the snake antenna array:Geometry optimization of a sinusoidal dipole antenna for 10.5T body imaging with lower peak SAR

Steensma Bart, van de Moortele Pierre-Francois, Ertürk Arcan, Grant Andrea, Adriany Gregor, Luijten Peter, Klomp Dennis, van den Berg Nico, Metzger Gregory, Raaijmakers Alexander nov 2020, In: Magnetic Resonance in Medicine. 84 , p. 2885-2896 12 p.

Correcting time-intensity curves in dynamic contrast-enhanced breast MRI for inhomogeneous excitation fields at 7T

van Rijssel Michael J., Pluim Josien P.W., Chan Hui Shan M., van den Wildenberg Lieke, Schmitz Alexander M.Th, Luijten Peter R., Gilhuijs Kenneth G.A., Klomp Dennis W.J. 1 aug 2020, In: Magnetic Resonance in Medicine. 84 , p. 1000-1010 11 p.

Metabolite cycled liver 1 H MRS on a 7 T parallel transmit system

Xavier Aline, Arteaga de Castro Catalina, Andia Marcelo E, Luijten Peter R, Klomp Dennis W, Fillmer Ariane, Prompers Jeanine J aug 2020, In: NMR in Biomedicine. 33 14 p.

Introduction of Ultra-High-Field MR Imaging in Infants:Preparations and Feasibility

Annink K V, van der Aa N E, Dudink J, Alderliesten T, Groenendaal F, Lequin M, Jansen F E, Rhebergen K S, Luijten P, Hendrikse J, Hoogduin H J M, Huijing E R, Versteeg E, Visser F, Raaijmakers A J E, Wiegers E C, Klomp D W J, Wijnen J P, Benders M J N L 30 jul 2020, In: American Journal of Neuroradiology. 41 , p. 1532-1537 6 p.

T2* mapping in an equine articular groove model:Visualizing changes in collagen orientation

Brinkhof Sander, Te Moller Nikae, Froeling Martijn, Brommer Harold, van Weeren René, Ito Keita, Klomp Dennis 3 jun 2020, In: Journal of Orthopaedic Research. 38 , p. 2383-2389 7 p.

Pushing functional MRI spatial and temporal resolution further:High-density receive arrays combined with shot-selective 2D CAIPIRINHA for 3D echo-planar imaging at 7 T

Hendriks Arjan D, D'Agata Federico, Raimondo Luisa, Schakel Tim, Geerts Liesbeth, Luijten Peter R, Klomp Dennis W J, Petridou Natalia 3 mrt 2020, In: NMR in Biomedicine. 33 13 p.

Whole brain 31P MRSI at 7T with a dual‐tuned receive array

Rowland Benjamin C, Driver Ian D, Tachrount Mohamed, Klomp Dennis W J, Rivera Debra, Forner Ria, Pham Anh, Italiaander Michel, Wise Richard G feb 2020, In: Magnetic Resonance in Medicine. 83 , p. 765-775 11 p.

Inherently decoupled H-1 antennas and P-31 loops for metabolic imaging of liver metastasis at 7 T

Rivera Debra, Kalleveen Irene, de Castro Catalina Arteaga, van Laarhoven Hanneke, Klomp Dennis, van der Kemp Wybe, Stoker Jaap, Nederveen Aart 10 jan 2020, In: NMR in Biomedicine. 33 10 p.

On the magnetic field dependence of deuterium metabolic imaging

de Graaf Robin A., Hendriks Arjan D., Klomp Dennis W.J., Kumaragamage Chathura, Welting Dimitri, Arteaga de Castro Catalina S., Brown Peter B., McIntyre Scott, Nixon Terence W., Prompers Jeanine J., De Feyter Henk M. 26 dec 2019, In: NMR in Biomedicine. 33 9 p.

All Research Output (150)