prof. dr. N.M. (Nico M.) Wulffraat

prof. dr. N.M. (Nico M.) Wulffraat

Professor Emeritus
prof. dr. N.M. (Nico M.) Wulffraat
  • Immuno/Rheumatology ERN



Nico Wulffraat is professor of pediatric Rheumatology at the department of pediatrics, University Medical Center, Utrecht, The Netherlands. He obtained his MD and PhD (1987) at the Free University Hospital Amsterdam. He trained as a paediatrician from 1988 untill 1993 in Utrecht. He was fellow pediatric immunology and rheumatology from 1993 to 1995 in the WKZ. Since 1995 he worked as a consultant in pediatric immunology-rheumatology. Since 2010 he is the head of this subunit. From 1997-2004 he was also coordinator of the pediatric allogeneic and autologous stem cell transplantations for immune deficiencies, metabolic disorders and autoimmune diseases. He is PI of several investigator initiated trials of immunisations in children with rheumatic diseases including MMR, HPV and Men C, prevention of MTX side effects, and application of Mesenchymal Stem cells in refractory GvHD and JIA. He is coordinator of a FP7 consortium for pharmacovigilance of biologics used in JIA (PHARMACHILD). Also he leads the EHHC project SHARE that aims at documenting standards of care and treatment recommendations for pediatric rheumatic diseases throughout Europe.

Since 2008 he became supervisor of the postgraduate clinical fellowship pediatric rheumatology and since 2009 head of pediatric immunology and rheumatology. In 2014, he was appointed as head of pediatric Rheumatology, Immunology, hematology and infectious diseases.

He has co-authored 220 Pubmed cited papers in international journals on pediatric rheumatology and immunology and 12 chapters in books.

Side Activities


Gezondheidsraad advies CVS

ZonMW commissie programma translationeel onderzoek en adulte stamcellen, adviesgroep medische producten (2009-2016)

Evaluatie beoordeling NFU expertise centra

Council PRES (2004-2010)

Council PRINTO National representative for NL (2001-2014)

ERN RITA HCP Member Representative (2017) and since 2019 ERN RITA coordinator

Reviewer for all major rheumatology Journals, Blood, Lancet, NEJM


Member of EBMT working party for autoimmune diseases (Chair R Saccardi, Florence Italy)

Member of the ZONWM programme committee Translational Adult Stem cell research

Member of Advisory working group consisting of external experts for RIVM (Corona related) (2021- )

Member of the European Medicines Agency (EMA) expert group for pediatric rheumatology

Member of the ZONMW programme committee Priority medicines for children

Member of the advisory council Ter Meulen Fonds

Member of the Drug Safety Monitoring board of the adalumimab trial for uveitis (NHS, England)

Member of the board for the Dutch pediatric rheumatology society, for education and research (2001-2010)

Member of the board for Utrecht pediatric postgraduate courses (1999-2010)

Member of the Scientific Advisory Council of the Dutch League for Rheumatology (Nationaal Reumafonds, 2006-2009)

Member of the Utrecht study group for the development of the electronic patient file into clinical paractise (2005-2009)

Member of the EBMT working party for inborn errors and immunodeficiencies (1996-2008)

Potential Conflicts of Interest

Dr. Wulffraat has regular interaction with pharmaceutical and other industrial partners. These activities were continued until 2018 . Since then he is the chair of the European rare Diseases Network (RITA) and receives grants from the EU to sustain this network. As per may 2022 he will receive a part time salary for this. ERN RITA has supported international clinical practice guidelines. UMCU has received incidental funding (up to €10,000 as multi sponsoring per event as  support for research and educational activities deployed by the Pediatric Rheumatology European Society. This is a non-for profit organization. He has received support from the Dutch medical Insurance company het Zilveren Kruis for a study on the use of an App (as a medical device) specifically for patients with chronic arthritis

Fellowship and Awards

FP7 Grant Pharmachild


Div. ZON MW Grants



AbbVie (bijdrage Reuma2Go)

Roche (bijdrage Reuma2Go)

ERN coordinator RITA

ZonMW grant Chronic Fatique QFS and JIA

Research Output (644)

Juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening:analysis of the international Pharmachild registry

van Straalen Joeri W, Baas Laurie, Giancane Gabriella, Grebenkina Lyudmila, Brunner Jurgen, Vega-Cornejo Gabriel, Chasnyk Vyacheslav G, Harel Liora, Appenzeller Simone, Gervais Elisabeth, de Roock Sytze, Wulffraat Nico M, Ruperto Nicolino, Swart Joost F, 21 Feb 2023, In: Pediatric rheumatology online journal. 21 9 p.

Dynamic modeling of experience sampling methodology data reveals large heterogeneity in biopsychosocial factors associated with persistent fatigue in young people living with a chronic condition:Dynamic biopsychosocial associations with fatigue

Vroegindeweij Anouk, Levelt Lisa, Houtveen Jan, Van de Putte Elise M, Wulffraat Nico M, Swart Joost F, Nijhof Sanne L 13 Feb 2023, In: Journal of Psychosomatic Research. 167

Prevalence of familial autoimmune diseases in juvenile idiopathic arthritis:results from the international Pharmachild registry

van Straalen Joeri W., de Roock Sytze, Giancane Gabriella, Alexeeva Ekaterina, Koskova Elena, Mesa-del-Castillo Bermejo Pablo, Zulian Francesco, Civino Adele, Montin Davide, Wulffraat Nico M., Ruperto Nicolino, Swart Joost F., 18 Nov 2022, In: Pediatric rheumatology online journal. 20

Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis:a propensity score matched cohort study

van Straalen Joeri W., de Roock Sytze, Giancane Gabriella, Consolaro Alessandro, Rygg Marite, Nordal Ellen B., Rubio-Pérez Nadina, Jelusic Marija, De Inocencio Jaime, Vojinovic Jelena, Wulffraat Nico M., Bruijning-Verhagen Patricia C.J., Ruperto Nicolino, Swart Joost F., Pallotti Chiara, Scala Silvia, Angioloni Simona, Villa Luca, 14 Nov 2022, In: Pediatric rheumatology online journal. 20

Feasibility of quantitative sensory testing in juvenile idiopathic arthritis

Mensink Maarten O, Eijkelkamp Niels, Veldhuijzen Dieuwke S, Wulffraat Nico M 9 Aug 2022, In: Pediatric rheumatology online journal. 20 , p. 1-7

Factors associated with care- and health-related quality of life of caregivers of children with juvenile idiopathic arthritis

Grazziotin Luiza R., Currie Gillian, Twilt Marinka, IJzerman Maarten J., Kip Michelle M.A., Koffijberg Hendrik, Bonsel Gouke, Benseler Susanne M., Swart Joost F., Vastert Sebastiaan J., Wulffraat Nico M., Yeung Rae S.M., Armbrust Wineke, van den Berg J. Merlijn, Marshall Deborah A. 23 Jul 2022, In: Pediatric rheumatology online journal. 20 , p. 1-12

Preclinical Aortic Atherosclerosis in Adolescents With Chronic Disease

Ververs Francesca A, Eikendal Anouk L M, Kofink Daniel, Nuboer Roos, Westenberg Jos J M, Hovenkamp Gijs T, Kemps Jitske J A, Coenen Iris C J, Daems Joëlle J N, Claus Laura R, Ju Yillie, Wulffraat Nico M, van der Ent Cornelis K, Monaco Claudia, Boes Marianne, Leiner Tim, Grotenhuis Heynric B, Schipper Henk S 19 Jul 2022, In: Journal of the American Heart Association. 11 , p. 1-18

Pharmacological treatment patterns in patients with juvenile idiopathic arthritis in the Netherlands:a real-world data analysis

Kip Michelle M A, de Roock Sytze, Currie Gillian, Marshall Deborah A, Grazziotin Luiza R, Twilt Marinka, Yeung Rae S M, Benseler Susanne M, Vastert Sebastiaan J, Wulffraat Nico, Swart Joost F, IJzerman Maarten J 18 May 2022, In: Rheumatology (Oxford, England). 62 , p. SI170-SI180 11 p.

A diagnostic prediction model for separating juvenile idiopathic arthritis and chronic musculoskeletal pain syndrome

van Straalen Joeri W, van Stigt Thans Martine, Wulffraat Nico M, de Roock Sytze, Swart Joost F 20 Apr 2022, In: The Journal of Pediatrics. 251 , p. 164-171.e6

All research output

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