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prof. dr. M.C. (Marianne C.) Verhaar

prof. dr. M.C. (Marianne C.) Verhaar

Full Professor
prof. dr. M.C. (Marianne C.) Verhaar

Biography

Biography

The research of Marianne Verhaar focuses on renal and vascular regeneration and involves translational studies from basic cell studies to animal experiments and clinical trials. Het general aim is to improve care for the patient with chronic kidney disease by developing new strategies to enhance protective mechanisms against microvascular dysfunction, atherosclerotic disease and chronic kidney disease, to enhance vascular and renal regeneration and to improve renal replacement therapies. Specific interests of her group are: mechanisms underlying increased cardiovascular risk in chronic kidney disease, the relation between chronic kidney disease, microvascular dysfunction and heart failure, kidney organoids and their potential role in disease modeling and (materials-driven) kidney regeneration, vascular regeneration, development of a wearable artificial kidney.

Side Activities

Board activities

  • Wetenschappelijke Raad Nierstichting (2019- )
  • Scientific Advisory Board European Renal Association (ERA) (2019- )
  • ERA Continuing Medical Education Committee (chair) (2019- )
  • Scientific Committee ERA Scientific Congress (2019- )
  • Agence National de la Recherche (ANR), Selection Committee of University Hospital institutes (IHU) (chair) (2017- )
  • Expert panel – The scientific challenge “Lab-Grown Organ Replacement “German Federal Ministry of Education and Research (BMBF) (2019- )
  • Strategic Advisory Board Regenerative Medicine Crossing Borders (RegMedXB) (2020- )
  • Kidney Moonshot leader RegMedXB (2020- )
  • Nationaal Actieprogramma: Tafel 1 Regeneratieve Geneeskunde + Stamcel Therapie (2020- )
  • Advisory Board werkgroep Living Technologies Eindhoven-Wageningen-UU-UMC Utrecht (EWUU) Alliantie (2021- )

Memberships

  • Nederlandse Internisten Vereniging
  • Nederlandse Federatie voor Nefrologie
  • Dutch Cardio Vascular Alliance
  • Regenerative Medicine Crossing Borders
  • European Renal Association
  • ERA- EUropean REnal and CArdiovascular Medicine (EURECA-m) Working Group
  • American Society of Nephrology
  • American Heart Association

Fellowship and Awards

Dirkzwager-Assink Award

NWO Vidi & ASPASIA grant (2008)

NWO Veni grant (2002)

Jaarprijs Vasculaire Biologie, Nederlandse Vereniging voor Cardiologie (1998)

Research Output (331)

Chronic kidney disease and atrial fibrillation:A dangerous combination

Ocak Gurbey, Khairoun Meriem, Khairoun Othman, Bos Willem Jan W, Fu Edouard L, Cramer Maarten J, Westerink Jan, Verhaar Marianne C, Visseren Frank L, Apr 2022, In: PLoS ONE. 17 , p. 1-13

Substrate Stiffness Determines the Establishment of Apical-Basal Polarization in Renal Epithelial Cells but Not in Tubuloid-Derived Cells

Hagelaars Maria J, Yousef Yengej Fjodor A, Verhaar Marianne C, Rookmaaker Maarten B, Loerakker Sandra, Bouten Carlijn V C 2022, In: Frontiers in bioengineering and biotechnology. 10 , p. 1-10

GFR estimation is complicated by a high incidence of non-steady-state serum creatinine concentrations at the emergency department

Niemantsverdriet M. S.A., Pieters T. T., Hoefer I. E., Verhaar M. C., Joles J. A., van Solinge W. W., Tiel Groenestege W. M., Haitjema S., Rookmaaker M. B. Dec 2021, In: PLoS ONE. 16

Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Pei J, Schuldt M, Nagyova E, Gu Z, El Bouhaddani S, Yiangou L, Jansen M, Calis J J A, Dorsch L M, Blok C Snijders, van den Dungen N A M, Lansu N, Boukens B J, Efimov I R, Michels M, Verhaar M C, de Weger R, Vink A, van Steenbeek F G, Baas A F, Davis R P, Uh H W, Kuster D W D, Cheng C, Mokry M, van der Velden J, Asselbergs F W, Harakalova M Dec 2021, In: Clinical Epigenetics. 13 , p. 1-20

Controlling cellular plasticity to improve in vitro models for kidney regeneration

Pou Casellas Carla, Rookmaaker Maarten B., Verhaar Marianne C. Dec 2021, In: Current Opinion in Biomedical Engineering. 20 , p. 1-9

Stem cells, organoids, and organ-on-a-chip models for personalized in vitro drug testing

van Berlo Damiën, Nguyen Vivian V.T., Gkouzioti Vasiliki, Leineweber Kirsten, Verhaar Marianne C., van Balkom Bas W.M. Dec 2021, In: Current Opinion in Toxicology. 28 , p. 7-14 8 p.

T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

Peereboom Emma T M, Matern Benedict M, Tomosugi Toshihide, Niemann Matthias, Drylewicz Julia, Joosten Irma, Allebes Wil A, van der Meer Arnold, Hilbrands Luuk B, Baas Marije C, van Reekum Franka E, Verhaar Marianne C, Kamburova Elena G, Seelen Marc A J, Sanders Jan Stephan, Hepkema Bouke G, Lambeck Annechien J, Bungener Laura B, Roozendaal Caroline, Tilanus Marcel G J, Voorter Christien E, Wieten Lotte, van Duijnhoven Elly M, Gelens Mariëlle A C J, Christiaans Maarten H L, van Ittersum Frans J, Nurmohamed Azam, Lardy Neubury M, Swelsen Wendy, van der Pant Karlijn A, van der Weerd Neelke C, Ten Berge Ineke J M, Bemelman Fréderike J, de Vries Aiko P J, de Fijter Johan W, Betjes Michiel G H, Roelen Dave L, Claas Frans H, Otten Henny G, Heidt Sebastiaan, van Zuilen Arjan D, Kobayashi Takaaki, Geneugelijk Kirsten, Spierings Eric 18 Nov 2021, In: Frontiers in Immunology. 12 , p. 1-13

Protein-Bound Uremic Toxins Induce Reactive Oxygen Species-Dependent and Inflammasome-Mediated IL-1β Production in Kidney Proximal Tubule Cells

Mihajlovic Milos, Krebber Merle M, Yang Yi, Ahmed Sabbir, Lozovanu Valeria, Andreeva Daria, Verhaar Marianne C, Masereeuw Rosalinde 26 Sep 2021, In: Biomedicines. 9 , p. 1-24

Renal Biology Driven Macro- and Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies

Vermue IJsbrand M, Begum Runa, Castilho Miguel, Rookmaaker Maarten B, Masereeuw Rosalinde, Bouten Carlijn V C, Verhaar Marianne C, Cheng Caroline 7 Sep 2021, In: ACS Biomaterials Science and Engineering. 7 , p. 4679-4693 15 p.

Regulation of Solute Carriers OCT2 and OAT1/3 in the Kidney:A Phylogenetic, Ontogenetic and Cell Dynamic Perspective

Pou Casellas Carla, Jansen Katja, Rookmaaker Maarten B, Clevers Hans, Verhaar Marianne C, Masereeuw Rosalinde 6 Sep 2021, In: Physiological Reviews. 102 , p. 993-1024 32 p.

All research output

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