prof. dr. F. (Femke) van Wijk

prof. dr. F. (Femke) van Wijk

Full Professor
prof. dr. F. (Femke) van Wijk
  • Laboratory for Translational Immunology (LTI)



Dr. van Wijk obtained her PhD on mechanisms of oral tolerance and allergic sensitization to peanut at the Utrecht University in 2006. After her first postdoctoral training in human immunology in the lab of Prof. B. Prakken at the UMCU she obtained a KNAW fellowship for a 2-year postdoc in the lab of Prof. H. Cheroutre in the La Jolla Institute for Immunology in La Jolla (USA) to work on tissue T cell adaptation . After being awarded a VENI personal fellowship, she moved to the UMCU to start her own research group. For her research on how antigen presenting cells sabotage T cell regulation in local inflammation van Wijk was awarded a prestigious ZonMw VIDI career development grant (2014), and in 2021 she received a ZonMw VICI grant for her work on naïve T cell imprinting and immune development. Her research program aims to elucidate tissue T cell responses in health and inflammation and to translate these insights into tools for (pre-clinical) disease monitoring and therapeutic targeting in chronic inflammatory diseases.  She takes a disease- and age-overarching approach to decipher common and specific pathogenic processes underlying different inflammatory conditions and one of her specific interests is early imprinting of disease. Diseases her group is working on include atopic dermatitis, inflammatory bowel disease, juvenile idiopathic arthritis, juvenile dermatomyositis and immune toxicity following immune therapy in cancer.

 Dr. van Wijk is the author of 85 publications in leading peer-reviewed journals and has extensive experience with national and international scientific advisory committees (NWO off-road program, samenwerkende gezondheidsfondsen PPS Immunology consortia, Sanofi type 2 innovation grant, EU Horizon 2020 REA-FET-OPEN and COFUND). She is participating in several international networks including T_CELL_CONNECT_EUROPE, Eureka Institute for Translational Medicine, and Understanding Childhood Arthritis Worldwide Network that are aimed at (international) exchanges and training of young scientists, knowledge sharing, and enhancing reproducibility of human data. In 2017 Dr. van Wijk received the PhD supervisor of the year award by the Utrecht University Graduate School of Life Sciences.

Dr. van Wijk is a member of the Utrecht Life Sciences (ULS) Program Board for the domain One Health, and scientific director FOCIS (federation of clinical immunology societies) center of excellence.

Side Activities

Scientific director FOCIS (federation of clinical immunology societies) center of excellence UMC Utrecht. (honorary)

Member Utrecht Life Sciences Program Board, domain One Health (honorary)

Member scientific advisory committee "Samenwerkende Gezondheidsfondsen PPS Immunologie Consortia" (honorary)

Consultant/speaker Takeda, Johnson&Johnson, Sanofi/Regeneron, VC lspvc (paid)


Fellowship and Awards

ZonMw VICI (2021)

PhD Supervisor (co-promotor) of the year 2017, Graduate School of Life Sciences

Stimulerings Associate Professorship UMCU (2015)

ZonMw VIDI (2014)

ZonMw Veni (2010)

KNAW fellowship Ter Meulen Fund (2007)



Research Output (87)

Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis

Bakker D S, van der Wal M M, Heeb L E M, Giovannone B, Asamoah M, Delemarre E M, Drylewicz J, Nierkens S, Boyman O, de Bruin-Weller M S, Thijs J L, Wijk F van 18 feb 2021, In: Journal of Investigative Dermatology. 141 , p. 1943-1953.e13

Tissue-Resident Memory T Cells in Chronic Inflammation-Local Cells with Systemic Effects?

Samat Anoushka Ashok Kumar, van der Geest Jolijn, Vastert Sebastiaan J, van Loosdregt Jorg, van Wijk Femke 16 feb 2021, In: Cells. 10 18 p.

Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4+ and CD8+ T-cell clusters in systemic sclerosis

Servaas N H, Zaaraoui-Boutahar F, Wichers C G K, Ottria A, Chouri E, Affandi A J, Silva-Cardoso S, van der Kroef M, Carvalheiro T, van Wijk F, Radstake T R D J, Andeweg A C, Pandit A feb 2021, In: Journal of Autoimmunity. 117 14 p.

Healthy cotwins share gut microbiome signatures with their inflammatory bowel disease twins and unrelated patients

Brand Eelco C, Klaassen Marjolein A Y, Gacesa Ranko, Vila Arnau Vich, Ghosh Hiren, de Zoete Marcel R, Boomsma Dorret I, Hoentjen Frank, Horjus Talabur Horje Carmen S, van de Meeberg Paul C, Willemsen Gonneke, Fu Jingyuan, Wijmenga Cisca, van Wijk Femke, Zhernakova Alexandra, Oldenburg Bas, Weersma Rinse K, 18 jan 2021, In: Gastroenterology. 160 , p. 1970-1985 16 p.

Biomarker profiles of endothelial activation and dysfunction in rare systemic autoimmune diseases:implications for cardiovascular risk

Wienke Judith, Mertens Jorre S, Garcia Samuel, Lim Johan, Wijngaarde Camiel A, Yeo Joo Guan, Meyer Alain, van den Hoogen Lucas L, Tekstra Janneke, Hoogendijk Jessica E, Otten Henny G, Fritsch-Stork Ruth D E, de Jager Wilco, Seyger Marieke M B, Thurlings Rogier M, de Jong Elke M G J, van der Kooi Anneke J, van der Pol W Ludo, Arkachaisri Thaschawee, Radstake Timothy R D J, van Royen-Kerkhof Annet, van Wijk Femke, 18 aug 2020, In: Rheumatology (Oxford, England). 60 , p. 785-801 17 p.

Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs

Wienke Judith, Brouwers Laura, van der Burg Leone M, Mokry Michal, Scholman Rianne C, Nikkels Peter G J, van Rijn Bas B, van Wijk Femke 18 aug 2020, In: JCI Insight. 5 , p. 1-21

Endothelial and Inflammation Biomarker Profiles at Diagnosis Reflecting Clinical Heterogeneity and Serving as a Prognostic Tool for Treatment Response in Two Independent Cohorts of Patients With Juvenile Dermatomyositis

Wienke Judith, Pachman Lauren M, Morgan Gabrielle A, Yeo Joo Guan, Amoruso Maria C, Hans Victoria, Kamphuis Sylvia S M, Hoppenreijs Esther P A H, Armbrust Wineke, van den Berg J Merlijn, Hissink Muller Petra C E, Gelderman Kyra A, Arkachaisri Thaschawee, van Wijk Femke, van Royen-Kerkhof Annet 26 feb 2020, In: Arthritis & Rheumatology. 72 , p. 1214-1226 13 p.

Dupilumab is very effective in a large cohort of difficult-to-treat adult atopic dermatitis patients:First clinical and biomarker results from the BioDay registry

Ariëns Lieneke F M, van der Schaft Jorien, Bakker Daphne S, Balak Deepak, Romeijn Margreet L E, Kouwenhoven Tessa, Kamsteeg Marijke, Giovannone Barbara, Drylewicz Julia, van Amerongen Cynthia Catalina Aurora, Delemarre Evelien M, Knol Edward F, van Wijk Femke, Nierkens Stefan, Thijs Judith L, Schuttelaar Marie L A, de Bruin-Weller Marjolein S 1 jan 2020, In: Allergy. 75 , p. 116-126 11 p.

Colonic mucosal kinase activity, cytokine and chemokine profiles in inflammatory bowel disease

Brand E., Roosenboom B., Fernandez B. Malvar, Lutter L., van Koolwijk E., van Lochem E. G., Horje C. S. Horjus Talabur, Reedquist K. A., van Wijk F., Oldenburg B. jan 2020, In: Journal of Crohn's & Colitis. 14 , p. S139-S140

Confirmation of multiple endotypes in atopic dermatitis based on serum biomarkers

Bakker Daphne S, Nierkens Stefan, Knol Edward F, Giovannone Barbara, Delemarre Eveline M, van der Schaft Jorien, van Wijk Femke, de Bruin-Weller Marjolein S, Drylewicz Julia, Thijs Judith L 2020, In: The Journal of Allergy and Clinical Immunology. 147 , p. 189-198 10 p.

All research output

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