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dr. J. (Jorg) van Loosdregt

dr. J. (Jorg) van Loosdregt

Associate Professor
dr. J. (Jorg) van Loosdregt
  • Center for Translational Immunology (CTI) Research
  • Immuno/reuma onderzoek 3 (Loosdregt)

Biography

Biography

Jorg van Loosdregt (1981) obtained his PhD at the Molecular Immunology laboratory, University Medical Center Utrecht, The Netherlands. Here, he studied the regulation of the transcription factor FOXP3, which is crucial for both the differentiation and function of Regulatory T cells, and therefore for maintaining immune homeostasis. After completing his PhD program in 2011 (cum laude) Jorg moved to the Department of Translational Research, at the Sanford-Burnham Medical Institute in San Diego, USA, on a fellowship from the Dutch Arthritis Foundation.  Here he investigated the role of autophagy in orchestrating effector T cell responses, with a focus on rheumatoid arthritis. Since December 2013 van Loosdregt is working in the laboratory for translational immunology (LTI) and Center for Molecular Medicine (CMM) where he is supported by a VENI fellowship.  Here he uses a translational approach to study the molecular pathways that are deregulated in autoimmune diseases with the aim of identifying novel therapeutic strategies to treat these diseases.

Fellowship and Awards

2016:                                 Wilhelmina Childrens hospital, fellowship €150.000

2015:                                 Dutch Arthritis Foundation, fellowship €160.000

2014:                                 NWO VENI, fellowship €250.000

2014:                                 Wilhelmina Childrens hospital, fellowship €150.000

2013:                                 NWO Graduate Program, fellowship €200.000

(together with J. Peeters and P. Coffer)

2012:                                 Eureka translational medicine programme, scholarship €2.500

2012:                                 Girard de Mielet van Coehoorn Foundation, prize €2.000

2012:                                 Dutch Arthritis Foundation, fellowship €134.000

2011:                                 Thesis defence honored Cum Laude 

2010:                                 Dutch Society of Immunology, travel grant €500

2009:                                 UMC Utrecht, prize €500

Research Output (36)

Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation

Mijnheer Gerdien, Lutter Lisanne, Mokry Michal, van der Wal Marlot, Scholman Rianne, Fleskens Veerle, Pandit Aridaman, Tao Weiyang, Wekking Mark, Vervoort Stephin, Roberts Ceri, Petrelli Alessandra, Peeters Janneke G C, Knijff Marthe, de Roock Sytze, Vastert Sebastiaan, Taams Leonie S, van Loosdregt Jorg, van Wijk Femke Dec 2021, In: Nature Communications. 12 , p. 1-16

ZFP36 family members regulate the pro-inflammatory features of psoriatic dermal fibroblasts

Angiolilli Chiara, Leijten Emmerik F A, Bekker Cornelis P J, Eeftink Ella, Giovannone Barbara, Nordkamp Michel Olde, van der Wal Marlot, Thijs Judith L, Vastert Sebastiaan J, van Wijk Femke, Radstake Timothy R D J, van Loosdregt Jorg 30 Jul 2021, In: Journal of Investigative Dermatology. 142 , p. 402-413 12 p.

Dutch patients, caregivers and healthcare professionals generate first nationwide research agenda for juvenile idiopathic arthritis

Verwoerd Anouk, Armbrust Wineke, Cowan Katherine, van den Berg Lotte, de Boer Joke, Bookelman Sanne, Britstra Marjan, Cappon Jeannette, Certan Maria, Dedding Christine, van den Haspel Karin, Muller Petra Hissink, Jongsma Karin, Lelieveld Otto, van Loosdregt Jorg, Olsder Wendy, Rocha Johanna, Schatorjé Ellen, Schouten Natasja, Swart Joost F., Vastert Sebastiaan, Walter Margot, Schoemaker Casper G. 7 Apr 2021, In: Pediatric Rheumatology. 19

Tissue-Resident Memory T Cells in Chronic Inflammation-Local Cells with Systemic Effects?

Samat Anoushka Ashok Kumar, van der Geest Jolijn, Vastert Sebastiaan J, van Loosdregt Jorg, van Wijk Femke 16 Feb 2021, In: Cells. 10 18 p.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Klionsky Daniel J, Abdel-Aziz Amal Kamal, Abdelfatah Sara, Abdellatif Mahmoud, Abdoli Asghar, Abel Steffen, Abeliovich Hagai, Abildgaard Marie H, Abudu Yakubu Princely, Acevedo-Arozena Abraham, Adamopoulos Iannis E, Adeli Khosrow, Adolph Timon E, Adornetto Annagrazia, Aflaki Elma, Agam Galila, Agarwal Anupam, Aggarwal Bharat B, Agnello Maria, Agostinis Patrizia, Agrewala Javed N, Agrotis Alexander, Aguilar Patricia V, Ahmad S Tariq, Ahmed Zubair M, Ahumada-Castro Ulises, Aits Sonja, Aizawa Shu, Akkoc Yunus, Akoumianaki Tonia, Akpinar Hafize Aysin, Al-Abd Ahmed M, Al-Akra Lina, Al-Gharaibeh Abeer, Alaoui-Jamali Moulay A, Alberti Simon, Alcocer-Gómez Elísabet, Alessandri Cristiano, Ali Muhammad, Alim Al-Bari M Abdul, Aliwaini Saeb, Alizadeh Javad, Almacellas Eugènia, Almasan Alexandru, Alonso Alicia, Lorenowicz Magdalena J, Manzoni Claudia, Reggiori Fulvio, van Loosdregt Jorg, Wang Yan, Jan 2021, In: Autophagy. 17 , p. 1-382 382 p.

COMPARTMENTALIZATION, PERSISTENCE AND CONSERVED SHARED MOTIFS OF DOMINANT (REGULATORY) T CELL CLONES IN AUTOIMMUNE INFLAMMATION

Mijnheer G., Servaas N., Lutter L., Leong J. Y., Spierings E., Chen P., Petrelli A., Vastert S., de Boer R., Albani S., van Loosdregt J., Pandit A., van Wijk F. 2021, In: Clinical and Experimental Rheumatology. 39 , p. 1153-1154

Treatment to Target Using Recombinant Interleukin-1 Receptor Antagonist as First-Line Monotherapy in New-Onset Systemic Juvenile Idiopathic Arthritis:Results From a Five-Year Follow-Up Study

ter Haar Nienke M., van Dijkhuizen E. H.Pieter, Swart Joost F., van Royen-Kerkhof Annet, el Idrissi Ayman, Leek Arjen P., de Jager Wilco, de Groot Mark C.H., Haitjema Saskia, Holzinger Dirk, Foell Dirk, van Loosdregt Jorg, Wulffraat Nico M., de Roock Sytze, Vastert Sebastiaan J. 8 Mar 2019, In: Arthritis & Rheumatology. 71 , p. 1163-1173 11 p.

Restoring T cell tolerance, exploring the potential of histone deacetylase inhibitors for the treatment of juvenile idiopathic arthritis

Nijhuis Lotte, Peeters Janneke G.C., Vastert Sebastiaan J., Van Loosdregt Jorg 7 Feb 2019, In: Frontiers in Immunology. 10

Molecular mechanisms of autophagic memory in pathogenic T cells in human arthritis

Kumar Pavanish, Yao Leong Jing, Saidin Suzan, Paleja Bhairav, van Loosdregt Jorg, Chua Camillus, Arkachaisri Thaschawee, Consolaro Alessandro, Gattorno Marco, Martini Alberto, Pischel Ken D., Williams Gary W., Lotz Martin, Albani Salvatore 1 Nov 2018, In: Journal of Autoimmunity. 94 , p. 90-98 9 p.

The role of WNT signaling in mature T cells:T cell factor is coming home

Van Loosdregt Jorg, Coffer Paul J. 15 Oct 2018, In: Journal of Immunology. 201 , p. 2193-2200 8 p.

All research output

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