dr. J. (Jorg) van Loosdregt

dr. J. (Jorg) van Loosdregt

Associate Professor
dr. J. (Jorg) van Loosdregt
  • Center for Translational Immunology (CTI) Research
  • Immuno/Rheumatology Research 3 (Loosdregt)



Jorg van Loosdregt (1981) obtained his PhD at the Molecular Immunology laboratory, University Medical Center Utrecht, The Netherlands. Here, he studied the regulation of the transcription factor FOXP3, which is crucial for both the differentiation and function of Regulatory T cells, and therefore for maintaining immune homeostasis. After completing his PhD program in 2011 (cum laude) Jorg moved to the Department of Translational Research, at the Sanford-Burnham Medical Institute in San Diego, USA, on a fellowship from the Dutch Arthritis Foundation.  Here he investigated the role of autophagy in orchestrating effector T cell responses, with a focus on rheumatoid arthritis. Since December 2013 van Loosdregt is working in the laboratory for translational immunology (LTI) and Center for Molecular Medicine (CMM) where he is supported by a VENI fellowship.  Here he uses a translational approach to study the molecular pathways that are deregulated in autoimmune diseases with the aim of identifying novel therapeutic strategies to treat these diseases.

Fellowship and Awards

2016:                                 Wilhelmina Childrens hospital, fellowship €150.000

2015:                                 Dutch Arthritis Foundation, fellowship €160.000

2014:                                 NWO VENI, fellowship €250.000

2014:                                 Wilhelmina Childrens hospital, fellowship €150.000

2013:                                 NWO Graduate Program, fellowship €200.000

(together with J. Peeters and P. Coffer)

2012:                                 Eureka translational medicine programme, scholarship €2.500

2012:                                 Girard de Mielet van Coehoorn Foundation, prize €2.000

2012:                                 Dutch Arthritis Foundation, fellowship €134.000

2011:                                 Thesis defence honored Cum Laude 

2010:                                 Dutch Society of Immunology, travel grant €500

2009:                                 UMC Utrecht, prize €500

Research Output (45)

N<sup>6</sup>-Methyladenosine Directly Regulates CD40L Expression in CD4<sup>+</sup> T Lymphocytes

van Vroonhoven Ellen C.N., Picavet Lucas W., Scholman Rianne C., van den Dungen Noortje A.M., Mokry Michal, Evers Anouk, Lebbink Robert J., Calis Jorg J.A., Vastert Sebastiaan J., van Loosdregt Jorg Jul 2023, In: Biology. 12 11 p.

Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation

Mocholi Enric, Russo Laura, Gopal Keshav, Ramstead Andrew G, Hochrein Sophia M, Vos Harmjan R, Geeven Geert, Adegoke Adeolu O, Hoekstra Anna, van Es Robert M, Pittol Jose Ramos, Vastert Sebastian, Rutter Jared, Radstake Timothy, van Loosdregt Jorg, Berkers Celia, Mokry Michal, Anderson Colin C, O'Connell Ryan M, Vaeth Martin, Ussher John, Burgering Boudewijn M T, Coffer Paul J 1 Jun 2023, In: Cell Reports. 42 , p. 1-24

The clinical and experimental treatment of Juvenile Idiopathic Arthritis

Nijhuis L, Swart J F, Prakken B J, V Loosdregt J, Vastert S J 19 Apr 2023, In: Clinical and Experimental Immunology. 213 , p. 276-287 12 p.

Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition

Peeters Janneke G C, Boltjes Arjan, Scholman Rianne C, Vervoort Stephin J, Coffer Paul J, Mokry Michal, Vastert Sebastiaan J, van Wijk Femke, van Loosdregt Jorg 10 Jan 2023, In: Rheumatology (Oxford, England). 62 , p. 2887-2897 11 p.

Conventional dendritic cells type 1 are strongly enriched, quiescent and relatively tolerogenic in local inflammatory arthritis

Boltjes Arjan, Samat Anoushka Ashok Kumar, Plantinga Maud, Mokry Michal, Castelijns Bas, Swart Joost F., Vastert Sebastiaan J., Creyghton Menno, Nierkens Stefan, van Loosdregt Jorg, van Wijk Femke 4 Jan 2023, In: Frontiers in Immunology. 13

NRF2/Itaconate Axis Regulates Metabolism and Inflammatory Properties of T Cells in Children with JIA

Rajendiran Anandhi, Subramanyam Sudheendra Hebbar, Klemm Patricia, Jankowski Vera, van Loosdregt Jorg, Vastert Bas, Vollbach Kristina, Wagner Norbert, Tenbrock Klaus, Ohl Kim 8 Dec 2022, In: Antioxidants (Basel, Switzerland). 11

Human regulatory T cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint

Lutter Lisanne, van der Wal M Marlot, Brand Eelco C, Maschmeyer Patrick, Vastert Sebastiaan, Mashreghi Mir-Farzin, van Loosdregt Jorg, van Wijk Femke 2022, In: Clinical & translational immunology. 11

Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation

Mijnheer Gerdien, Lutter Lisanne, Mokry Michal, van der Wal Marlot, Scholman Rianne, Fleskens Veerle, Pandit Aridaman, Tao Weiyang, Wekking Mark, Vervoort Stephin, Roberts Ceri, Petrelli Alessandra, Peeters Janneke G C, Knijff Marthe, de Roock Sytze, Vastert Sebastiaan, Taams Leonie S, van Loosdregt Jorg, van Wijk Femke Dec 2021, In: Nature Communications. 12 , p. 1-16

ZFP36 family members regulate the pro-inflammatory features of psoriatic dermal fibroblasts

Angiolilli Chiara, Leijten Emmerik F A, Bekker Cornelis P J, Eeftink Ella, Giovannone Barbara, Nordkamp Michel Olde, van der Wal Marlot, Thijs Judith L, Vastert Sebastiaan J, van Wijk Femke, Radstake Timothy R D J, van Loosdregt Jorg 30 Jul 2021, In: Journal of Investigative Dermatology. 142 , p. 402-413 12 p.

Dutch patients, caregivers and healthcare professionals generate first nationwide research agenda for juvenile idiopathic arthritis

Verwoerd Anouk, Armbrust Wineke, Cowan Katherine, van den Berg Lotte, de Boer Joke, Bookelman Sanne, Britstra Marjan, Cappon Jeannette, Certan Maria, Dedding Christine, van den Haspel Karin, Muller Petra Hissink, Jongsma Karin, Lelieveld Otto, van Loosdregt Jorg, Olsder Wendy, Rocha Johanna, Schatorjé Ellen, Schouten Natasja, Swart Joost F., Vastert Sebastiaan, Walter Margot, Schoemaker Casper G. 7 Apr 2021, In: Pediatric Rheumatology. 19 , p. 1-10

All research output

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