dr. L.W. (Linda W.) van Laake

dr. L.W. (Linda W.) van Laake

Associate Professor
dr. L.W. (Linda W.) van Laake
  • Division of Heart & Lungs



Linda W. Van Laake, MD, PhD obtained her medical degree at Maastricht University and her PhD (title: Cardiac Recovery by Stem and Progenitor Cells) at Utrecht University, after which she continued her scientific career as a postdoctoral researcher at the Gladstone Institutes, University of California, San Francisco (USA). In 2011 she became Assistant Professor at the Department of Cardiology of the University Medical Center Utrecht and the Hubrecht Institute Utrecht, the Netherlands. In addition, she works as a clinical cardiologist specialized in heart failure.

Dr. Van Laake’s team explores novel approaches to regenerate the heart using stem- and progenitor cells. Many cardiovascular diseases, such as heart failure and myocardial infarction, are associated with loss of functional cardiomyocytes (heart muscle cells). A focus on the understanding of fundamental cardiac developmental – and repair processes will promote the recapitulation of cardiac differentiation in vitro. Currently, the team is investigating the influence of circadian or “day-night” rhythms on cardiac development and regeneration.

Combing a variety of novel approaches together with a greater understanding of how heart development and repair work, Dr. Van Laake and her team strive to create better personalized heart failure therapies.


Side Activities

  • Member of the Translational Committee of the Heart Failure Association, European Society of Cardiology
  • Selected participant of the Postgraduate Course in Heart Failure of the Heart Failure Association, European Society of Cardiology
  • Member of the Young ICIN (Interuniversity Cardiology Institute of the Netherlands) committee
  • Selected participant of the Jacob Jongbloed Talent Society Program, Circulatory Health, UMC Utrecht
  • Participant of “The Young Academy on Wheels”; an outreach program by the Young Academy of the KNAW to bring high school students in contact with science and scientists
  • Selected participant of UMC Utrecht female leadership program Steyn Parvé
  • Member of the Young Health Council, an advisory body to the government and parliament on the current level of knowledge with respect to public health issues and health (services) research
  • Nucleus Member of the Working Group on Cellular Biology of the Heart, European Society of Cardiology
  • Editorial Board member of Stem Cell Reviews and Reports, the Netherlands Heart Journal, and the Journal of Geriatric Cardiology
  • Regular reviewer for Stem Cells, Journal of Molecular and Cellular Cardiology, Stem Cell Reports, Differentiation, Stem Cell Research, European Journal of Heart Failure
  • Reviewer for NWO-ZonMw, Netherlands Heart Foundation, FWO (Flanders Research Foundation), KWF (Netherlands Cancer Foundation), National Research Foundation Luxembourg

 Conflict of interest: none

Fellowship and Awards


  • UMCU Clinical Research Talent Fellowship, 2014-2016
  • Jacob Jongbloed Talent Society grant for multidisciplinary team effort “Heart Failure with Preserved Ejection Fraction in Metabolic Syndrome”, 2014
  • Novartis personal grant for participation in the Postgraduate Course in Heart Failure of the European Society of Cardiology, 2014-2015
  • Netherlands Heart Foundation Dekker personal grant “Arts in Opleiding tot Specialist” 2013-2016
  • European Society of Cardiology First Contact Initiative Grant 2013
  • Veni ZonMw grant 2011-2014, a personal grant that is part of the Innovational Research Incentives Scheme of NWO (Netherlands Organization for Scientific Research)
  • Keystone Scholarship (Pathological and Physiological Regulation of Cardiac Hypertrophy), 2008
  • ICIN (Interuniversity Cardiology Institute of the Netherlands) Fellowship 2007 for post-doctoral training in the Gladstone Institute of Cardiovascular Disease, San Francisco.
  • Netherlands Heart Foundation grant for working visit to the US “Functional integration of transplanted human embryonic stem-cell derived cardiomyocytes”, 2006
  • Van Walree Fund grant, Royal Netherlands Academy of Arts and Sciences; 2004


  • Heineken Young Scientist Award for Medicine, of the KNAW (Royal Netherlands Academy of Arts and Sciences), 2012
  • Young Investigator Award, European Society of Cardiology Congress, Stockholm, 2010
  • Einthoven Dissertatieprijs 2009 (award for the best PhD thesis in Cardiology of 2008)
  • European Society of Cardiology Basic Cardiovascular Science Travel Award, 2008

Research Output (107)

PITX2 induction leads to impaired cardiomyocyte function in arrhythmogenic cardiomyopathy

van Kampen Sebastiaan J, Han Su Ji, van Ham Willem B, Kyriakopoulou Eirini, Stouthart Elizabeth W, Goversen Birgit, Monshouwer-Kloots Jantine, Perini Ilaria, de Ruiter Hesther, van der Kraak Petra, Vink Aryan, van Laake Linda W, Groeneweg Judith A, de Boer Teun P, Tsui Hoyee, Boogerd Cornelis J, van Veen Toon A B, van Rooij Eva 13 Feb 2023, In: Stem Cell Reports. 18 , p. 749-764 16 p.

Left ventricular assist device implantation and clinical outcomes in the Netherlands

Damman Kevin, Caliskan Kadir, Birim Ozcan, Kuijpers Michiel, Otterspoor Luuk C, Yazdanbakhsh Aria, Palmen Meindert, Ramjankhan Faiz Z, Tops Lauren F, van Laake Linda W, 1 Feb 2023, In: Netherlands Heart Journal. 31 , p. 189-195 7 p.

Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival

van den Hoogen Patricia, Huibers Manon M.H., van den Dolder Floor W., de Weger Roel, Siera-de Koning Erica, Oerlemans Marish I.F., de Jonge Nicolaas, van Laake Linda W., Doevendans Pieter A., Sluijter Joost P.G., Vink Aryan, de Jager Saskia C.A. Jan 2023, In: Biology. 12

A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity

Lu Dongchao, Chatterjee Shambhabi, Xiao Ke, Riedel Isabelle, Huang Cheng-Kai, Costa Alessia, Cushman Sarah, Neufeldt Dimyana, Rode Laura, Schmidt Arne, Juchem Malte, Leonardy Julia, Büchler Gwen, Blume Jonas, Gern Olivia-Luise, Kalinke Ulrich, Wen Tan Wilson Lek, Foo Roger, Vink Aryan, van Laake Linda W, van der Meer Peter, Bär Christian, Thum Thomas 7 Nov 2022, In: European heart journal. 43 , p. 4496-4511 16 p.

Characteristics and outcomes of COVID-19 in heart transplantation recipients in the Netherlands

Muller S A, Manintveld O C, Szymanski M K, Damman K, van der Meer M G, Caliskan K, van Laake L W, Oerlemans M I F J 8 Sep 2022, In: Netherlands Heart Journal. 30 , p. 519-525 7 p.

Letter by Muller et al Regarding Article "Impact of COVID-19 on Patients Supported with a Left Ventricular Assist Device"

Muller Steven A, Van Der Meer Manon G, Szymanski Mariusz K, Van Laake Linda W, Oerlemans Marish I F J 1 Sep 2022, In: ASAIO journal. 68 , p. E156-E156

Data-driven monitoring in patients on left ventricular assist device support

Numan Lieke, Moazeni Mehran, Oerlemans Marish I F J, Aarts Emmeke, Van Der Kaaij Niels P, Asselbergs Folkert W, Van Laake Linda W Sep 2022, In: Expert Review of Medical Devices. 19 , p. 677-685 9 p.

Spatial multi-omic map of human myocardial infarction

Kuppe Christoph, Ramirez Flores Ricardo O, Li Zhijian, Hayat Sikander, Levinson Rebecca T, Liao Xian, Hannani Monica T, Tanevski Jovan, Wünnemann Florian, Nagai James S, Halder Maurice, Schumacher David, Menzel Sylvia, Schäfer Gideon, Hoeft Konrad, Cheng Mingbo, Ziegler Susanne, Zhang Xiaoting, Peisker Fabian, Kaesler Nadine, Saritas Turgay, Xu Yaoxian, Kassner Astrid, Gummert Jan, Morshuis Michiel, Amrute Junedh, Veltrop Rogier J A, Boor Peter, Klingel Karin, Van Laake Linda W, Vink Aryan, Hoogenboezem Remco M, Bindels Eric M J, Schurgers Leon, Sattler Susanne, Schapiro Denis, Schneider Rebekka K, Lavine Kory, Milting Hendrik, Costa Ivan G, Saez-Rodriguez Julio, Kramann Rafael 25 Aug 2022, In: Nature. 608 , p. 766–777 12 p.

Validity and success rate of noninvasive mean arterial blood pressure measurements in cf-LVAD patients: A technical review

Lankheet Steven, Pieterse Martijn M, Rijnhout Robin, Tuerlings Emma, Oppelaar Anne-Marie C, van Laake Linda W, Ramjankhan Faiz Z, Westerhof Berend E, Oerlemans Marish I F J 3 Aug 2022, In: Artificial Organs. 46 , p. 2361-2370 10 p.

Circadian rhythms in ischaemic heart disease:key aspects for preclinical and translational research: position paper of the ESC working group on cellular biology of the heart

Lecour Sandrine, Du PrCrossed D Sign© Bastiaan C., Bøtker Hans Erik, Brundel Bianca J.J.M., Daiber Andreas, Davidson Sean M., Ferdinandy Peter, Girao Henrique, Gollmann-Tepeköylü Can, Gyöngyösi Mariann, Hausenloy Derek J., Madonna Rosalinda, Marber Michael, Perrino Cinzia, Pesce Maurizio, Schulz Rainer, Sluijter Joost P.G., Steffens Sabine, Van Linthout Sophie, Young Martin E., Van Laake Linda W. 1 Aug 2022, In: Cardiovascular research. 118 , p. 2566-2581 16 p.

All research output

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