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prof. dr. R. (Richard) van Hillegersberg

prof. dr. R. (Richard) van Hillegersberg

Full Professor
prof. dr. R. (Richard) van Hillegersberg
  • Department of Surgical Oncology

Research Programs

Strategic Program Cancer

Biography

Biography

Richard van Hillegersberg attended medical school in Rotterdam, the Netherlands. In 1993 he received his PhD with honor at the Department of Surgery, Erasmus MC in Rotterdam. From 1994-2000, he was trained in General Surgery in Rotterdam. From 2001-2002 he was fellow of Surgical Oncology in the Academic Medical Center and Antoni van Leeuwenhoek Netherlands Cancer Center Amsterdam. Since 2003 he is appointed as staff surgeon at the University Medical Center Utrecht. From 2009 he is a full professor of gastrointestinal oncology. Research is focused on Upper GI minimally invasive and robotic surgery, surgical imaging and genetic profiling. He has authored over 15 chapters in textbooks concerning robotic forgut surgery and over 500 articles in international peer-reviewed journals. From 2018 he is chairman of the Educational committee of the European Society for Diseases for the Esophagus (ESDE) and member of the education committee of ISDE, he is associate editor of Diseases of the Esophagus and Digestive Surgery, founder and chairman of the Upper GI International Robotic Association (UGIRA).

Side Activities

Member board and educational committee Europen Society Diseases of the Esophagus (ESDE)

Member Council European Digestive Surgery

Member Scientific Committee United European Gastroenterology (UEG)

Member Committee Dutch Guidelines oesophageal cancer

Member board Dutch UpperGI Cancer Audit (DUCA)

Associate editor Digestive Surgery

Associate editor Diseases of the Esophagus

Proctor Upper GI robotic Surgery Intuitive Surgical (paid)

Fellowship and Awards

2014-present. Principle investigator. Cost effectiveness of laparoscopic gastrectomy  as an alternative to open gastrectomy for gastric cancer (LOGICA trial). ClinTrial.gov: NCT02248519. ZonMw (837002502) Eu 400.000

2014-present. Principle investigator. Esophagectomy for Patients With Esophageal Cancer and Cervical Lymph Node Metastases (NODE trial). ClinTrial.gov: NCT02426879

2017-present. Intuitive Clinical Research Grant for the project “The International Registry for Robot-assisteted Minimally Invasive Esophagectomy” (RAMIE). Unrestricted Grant $ 50.000

2017-present. International Database collaboration Robotic esophagectomy, Intuitive Surgical, Unrestricted Grant. Eu 50.000

 2017-present. Coordinating Investigator of International Centers. Surgery for adenocarcinoma of the gastroesophageal junction (GEJ) type II: transthoracic esophagectomy vs. transhiatal extended gastrectomy (CARDIA trial). Analyzing in a multicenter international setting the optimal surgical strategy for tumors at the oesophago-gastric junction. This trial is now recruiting in collaboration with The University of Koln. Deutsches Register Klinischer Studien. DRKS-number: 00016923. Federal Ministry for Education and Research. Bundesministerium für Bildung und Forschung (BMBF) (grant number 01KG1816). Eu 1.940.000

2018-present. G.J.Meijer. Preoperative Image-guided Identification of Response to Neoadjuvant Chemoradiotherapy in Esophageal Cancer (PRIDE). ClinTrial.gov: NCT03474341. KWF (10291) Eu 890.260

2020-present Principal investigator. Paravertabral catheter versus epidural anagesia in minimally invasive esophageal resection : a RCT (PEPMEN trail). ZonMw (852002004) Eu 392.650

Research Output (463)

Detecting Interval Distant Metastases With 18F-FDG PET/CT After Neoadjuvant Chemoradiotherapy for Locally Advanced Esophageal Cancer

Kroese Tiuri E, Ruurda Jelle P, Bakker Anne S, Jairam Jasvir, Mook Stella, van der Horst Sylvia, Meijer Gert J, Haj Mohammad Nadia, van Rossum Peter S N, van Hillegersberg Richard 5 Apr 2022, In: Clinical Nuclear Medicine. 47 , p. 496-502 7 p.

Definition of oligometastatic esophagogastric cancer and impact of local oligometastasis-directed treatment:A systematic review and meta-analysis

Kroese Tiuri E, van Laarhoven Hanneke W M, Nilsson Magnus, Lordick Florian, Guckenberger Matthias, Ruurda Jelle P, D'Ugo Domenico, Haustermans Karin, van Cutsem Eric, van Hillegersberg Richard, van Rossum Peter S N 24 Mar 2022, In: European Journal of Cancer. 166 , p. 254-269 16 p.

Definitions and treatment of oligometastatic oesophagogastric cancer according to multidisciplinary tumour boards in Europe

Kroese Tiuri E., van Hillegersberg Richard, Schoppmann Sebastian, Deseyne Pieter R.A.J., Nafteux Philippe, Obermannova Radka, Nordsmark Marianne, Pfeiffer Per, Hawkings Maria A., Smyth Elizabeth, Markar Sheraz, Hanna George B., Cheong Edward, Chaudry Asif, Elme Anneli, Adenis Antoine, Piessen Guillaume, Gani Cihan, Bruns Christiane J., Moehler Markus, Liakakos Theodore, Reynolds John, Morganti Alessio, Rosati Riccardo, Castoro Carlo, D'Ugo Domenico, Roviello Franco, Bencivenga Maria, de Manzoni Giovanni, Jeene Paul, van Sandick Johanna W., Muijs Christel, Slingerland Marije, Nieuwenhuijzen Grard, Wijnhoven Bas, Beerepoot Laurens V., Kolodziejczyk Piotr, Polkowski Wojciech P., Alsina Maria, Pera Manuel, Kanonnikoff Tania F., Nilsson Magnus, Guckenberger Matthias, Monig Stefan, Wagner Dorethea, Wyrwicz Lucjan, Berbee Maaike, van Rossum Peter S.N., Mazza Elena, Lips Irene, 5 Feb 2022, In: European Journal of Cancer. 164 , p. 18-29 12 p.

ASO Visual Abstract:Patient-Related Prognostic Factors for Anastomotic Leakage, Major Complications, and Short-Term Mortality Following Esophagectomy for Cancer: A Systematic Review and Meta-Analyses

van Kooten Robert T., Voeten Daan M., Steyerberg Ewout W., Hartgrink Henk H., van Berge Henegouwen Mark I., van Hillegersberg Richard, Tollenaar Rob A.E.M., Wouters Michel W.J.M. 1 Dec 2021, In: Annals of surgical oncology. 28 , p. 740-741 2 p.

Radiofrequency ablation and chemotherapy versus chemotherapy alone for locally advanced pancreatic cancer (PELICAN):study protocol for a randomized controlled trial

Walma M. S., Rombouts S. J., Brada L. J.H., Borel Rinkes I. H., Bosscha K., Bruijnen R. C., Busch O. R., Creemers G. J., Daams F., van Dam R. M., van Delden O. M., Festen S., Ghorbani P., de Groot D. J., de Groot J. W.B., Haj Mohammad N., van Hillegersberg R., de Hingh I. H., D’Hondt M., Kerver E. D., van Leeuwen M. S., Liem M. S., van Lienden K. P., Los M., de Meijer V. E., Meijerink M. R., Mekenkamp L. J., Nio C. Y., Oulad Abdennabi I., Pando E., Patijn G. A., Polée M. B., Pruijt J. F., Roeyen G., Ropela J. A., Stommel M. W.J., de Vos-Geelen J., de Vries J. J., van der Waal E. M., Wessels F. J., Wilmink J. W., van Santvoort H. C., Besselink M. G., Molenaar I. Q., Dec 2021, In: Trials. 22 , p. 1-12

Molecular characterization of Barrett's esophagus at single-cell resolution

Busslinger Georg A, de Barbanson Buys, Oka Rurika, Weusten Bas L A, de Maat Michiel, van Hillegersberg Richard, Brosens Lodewijk A A, van Boxtel Ruben, van Oudenaarden Alexander, Clevers Hans 23 Nov 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118 , p. 1-12

Robot-assisted and conventional minimally invasive esophagectomy are associated with better postoperative results compared to hybrid and open transthoracic esophagectomy

van der Sluis Pieter C, Babic Bejamin, Uzun Eren, Tagkalos E, Berlth Felix, Hadzijusufovic Edin, Lang Hauke, Gockel Ines, van Hillegersberg Richard, Grimminger Peter P 19 Nov 2021, In: European Journal of Surgical Oncology. 48 , p. 776-782 7 p.

ASO Visual Abstract: The Value of Paratracheal Lymphadenectomy in Esophagectomy for Adenocarcinoma of the Esophagus or Gastroesophageal Junction: a Systematic Review of the Literature

Gantxegi Amaia, Kingma B. Feike, Ruurda Jelle P., Nieuwenhuijzen Grard A. P., Luyer Misha D. P., van Hillegersberg Richard 30 Oct 2021, In: Annals of Surgical Oncology. 29 , p. 1357-1357 1 p.

<sup>18</sup>F-Fludeoxyglucose-Positron Emission Tomography/Computed Tomography and Laparoscopy for Staging of Locally Advanced Gastric Cancer:A Multicenter Prospective Dutch Cohort Study (PLASTIC)

Gertsen Emma C., Brenkman Hylke J.F., Van Hillegersberg Richard, Van Sandick Johanna W., Van Berge Henegouwen Mark I., Gisbertz Suzanne S., Luyer Misha D.P., Nieuwenhuijzen Grard A.P., Van Lanschot Jan J.B., Lagarde Sjoerd M., Wijnhoven Bas P.L., De Steur Wobbe O., Hartgrink Henk H., Stoot Jan H.M.B., Hulsewe Karel W.E., Spillenaar Bilgen Ernst J., Van Det Marc J., Kouwenhoven Ewout A., Van Der Peet Donald L., Daams Freek, Van Grieken Nicole C.T., Heisterkamp Joos, Van Etten Boudewijn, Van Den Berg Jan Willem, Pierie Jean Pierre, Eker Hasan H., Thijssen Annemieke Y., Belt Eric J.T., Van Duijvendijk Peter, Wassenaar Eelco, Van Laarhoven Hanneke W.M., Wevers Kevin P., Hol Lieke, Wessels Frank J., Haj Mohammad Nadia, Van Der Meulen Miriam P., Frederix Geert W.J., Vegt Erik, Siersema Peter D., Ruurda Jelle P. 27 Oct 2021, In: JAMA Surgery. 156 , p. E1-E9

Lymphovascular invasion quantification could improve risk prediction of lymph node metastases in patients with submucosal (T1b) esophageal adenocarcinoma

van de Ven Steffi E M, Suzuki Lucia, Gotink Annieke W, Ten Kate Fiebo J C, Nieboer Daan, Weusten Bas L A M, Brosens Lodewijk A A, van Hillegersberg Richard, Alvarez Herrero Lorenza, Seldenrijk Cees A, Alkhalaf Alaa, Moll Freek C P, Curvers Wouter, van Lijnschoten Ineke G, Tang Thjon J, van der Valk Hans, Nagengast Wouter B, Kats-Ugurlu Gursah, Plukker John T M, Houben Martin H M G, van der Laan Jaap S, Pouw Roos E, Bergman Jacques J G H M, Meijer Sybren L, van Berge Henegouwen Mark I, Wijnhoven Bas P L, de Jonge Pieter J F, Doukas Michael, Bruno Marco J, Biermann Katharina, Koch Arjun D 5 Oct 2021, In: United European Gastroenterology Journal. 9 , p. 1066-1073 8 p.

All research output

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