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prof. dr. H.B. van der Worp

prof. dr. H.B. van der Worp

Full Professor
prof. dr. H.B. van der Worp
  • Neurologen

Research Programs

Biography

Biography

Bart van der Worp is a neurologist with a special interest in cerebrovascular diseases at the University Medical Center in Utrecht, the Netherlands. He has been (co-)Chief Investigator of the randomised stroke trials HAMLET, PAIS, COOLIST, VAST, APACHE-AF, and MR ASAP and is Chief Investigator of PRECIOUS. He is a member of the Dutch CONTRAST consortium which aims to identify and test new treatments for patients with acute ischaemic stroke or intracerebral haemorrhage. He is former President of the European Stroke Organisation.

Side Activities

2008 –          fellow of the European Stroke Organisation (ESO)

2011 – 2022 member of the Board of Directors of ESO

2011 – 2016 member of the Committee for Professional Interests (BBC) of the NVN

2013 – 2015 member of the Committee for Clinical trials of ESO

2013 – 2017 member of the Guideline Committee of ESO

2014 – 2016 vice-president ESO

2014 – 2021 member of the writing committee of the Dutch Stroke Guideline

2016 – 2018 president-elect ESO

2018 – 2020 president ESO

2019 – 2021 member of Committee on emergency prehospital care (45-minutennorm) of the Gezondheidsraad

2019 - 2020 consultant, Bayer

2020 – 2022 past president ESO

2020 – 2021 Chair module writing group ESO guideline on space-occupying oedema

2022 -          consultant, TargED

2022 -          national coordinator randomised trial, Bayer

 

Member of Data and Safety Monitoring Boards of randomised trials

2005 – 2007 Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis

2009 – 2011 Intrathecal methylprednisolone for intractable postherpetic neuralgia: STIP study. (Steroids for Intractable Postherpetic Neuralgia)

2009 – 2011 A randomised sequential trial of Lithium In amyotrophic lateral sclerosis

2015 – 2021 TELSTAR: Treatment of electroencephalographic status epilepticus after cardiopulmonary resuscitation - a randomized controlled trial (Chair)

2018 – 2019 PHALS: A placebo-controlled double blind randomized trial to investigate the efficacy and safety of the combination of Penicillin G / Hydrocortisone treatment in ALS patients (Chair)

2018 –          RESSTORE: Regenerative Stem Cell Therapy for Stroke in Europe

2019 –          GRECO: Ghrelin treatment of comatose patients after cardiac arrest: A phase 2 clinical trial to estimate safety and efficacy of ghrelin to promote cerebral (Chair)

Research Output (216)

Time Since Stroke Onset, Quantitative Collateral Score, and Functional Outcome After Endovascular Treatment for Acute Ischemic Stroke

Uniken Venema Simone M, Wolff Lennard, van den Berg Sophie A, Reinink Hendrik, Luijten Sven P R, Lingsma Hester F, Marquering Henk A, Boers Anna M M, Bot Joost, Hammer Sebastiaan, Nederkoorn Paul J, Roos Yvo B W E M, Majoie Charles B L M, Dankbaar Jan Willem, van der Lugt Aad, van der Worp H Bart, 11 Oct 2022, In: Neurology. 99 , p. e1609-e1618

Cerebral Collateral Circulation in the Era of Reperfusion Therapies for Acute Ischemic Stroke

Uniken Venema Simone M, Dankbaar Jan Willem, van der Lugt Aad, Dippel Diederik W J, van der Worp H Bart Oct 2022, In: Stroke. 53 , p. 3222-3234 13 p.

Prevalence, risk factors, and long-term outcomes of cerebral ischemia in hospitalized COVID-19 patients - study rationale and protocol of the CORONIS study:A multicentre prospective cohort study

van Lith Theresa J, Sluis Wouter M, Wijers Naomi T, Meijer Frederick Ja, Kamphuis-van Ulzen Karin, de Bresser Jeroen, Dankbaar Jan Willem, van den Heuvel Frederik Ma, Antoni M Louisa, Mulders-Manders Catharina M, de Mast Quirijn, van de Veerdonk Frank L, Klok Frederikus A, Tuladhar Anil M, Cannegieter Suzanne C, Wermer Marieke Jh, van der Worp H Bart, Huisman Menno V, de Leeuw Frank-Erik Jun 2022, In: European Stroke Journal. 7 , p. 180-187 8 p.

Cerebrospinal fluid volume improves prediction of malignant edema after endovascular treatment of stroke

Kauw Frans, Bernsen Marie Louise, Dankbaar Jan Willem, de Jong Hugo, Kappelle Jaap, Velthuis Birgitta K, Van der Worp H B, van der Lugt Aad, Roos Y B, Yo Lonneke, van Walderveen Marianne Aa, Hofmeijer Jeannette, Bennink Edwin 4 Apr 2022, In: International Journal of Stroke. p. 187-192

Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED):an open-label, multicentre, randomised controlled trial

van der Steen Wouter, van de Graaf Rob A, Chalos Vicky, Lingsma Hester F, van Doormaal Pieter Jan, Coutinho Jonathan M, Emmer Bart J, de Ridder Inger, van Zwam Wim, van der Worp H Bart, van der Schaaf Irene, Gons Rob A R, Yo Lonneke S F, Boiten Jelis, van den Wijngaard Ido, Hofmeijer Jeannette, Martens Jasper, Schonewille Wouter, Vos Jan Albert, Tuladhar Anil Man, de Laat Karlijn F, van Hasselt Boudewijn, Remmers Michel, Vos Douwe, Rozeman Anouk, Elgersma Otto, Uyttenboogaart Maarten, UMC Amsterdam, van Tuijl Julia, Boukrab Issam, van den Berg René, Beenen Ludo F M, Roosendaal Stefan D, Postma Alida Annechien, Krietemeijer Menno, Lycklama Geert, Meijer Frederick J A, Hammer Sebastiaan, van der Hoorn Anouk, Yoo Albert J, Gerrits Dick, Truijman Martine T B, Zinkstok Sanne, Koudstaal Peter J, Manschot Sanne, Kerkhoff Henk, Nieboer Daan, Berkhemer Olvert, Wolff Lennard, van der Sluijs P Matthijs, 12 Mar 2022, In: Lancet (London, England). 399 , p. 1059-1069 11 p.

Malignant infarction after endovascular treatment:Incidence and prediction

Bernsen Marie Louise E, Kauw Frans, Martens Jasper M, van der Lugt Aad, Yo Lonneke Sf, van Walderveen Marianne Aa, Roos Yvo Bwem, van der Worp H Bart, Dankbaar Jan W, Hofmeijer Jeannette Feb 2022, In: International Journal of Stroke. 17 , p. 198-206 9 p.

Impact of the lockdown on acute stroke treatments during the first surge of the COVID-19 outbreak in the Netherlands

Benali Faysal, Stolze Lotte J, Rozeman Anouk D, Dinkelaar Wouter, Coutinho Jonathan M, Emmer Bart J, Gons Rob A R, Yo Lonneke F S, van Tuijl Julia H, Boukrab Issam, van Dam-Nolen Dianne H K, van den Wijngaard Ido R, Lycklama À Nijeholt Geert J, de Laat Karlijn F, van Dijk Lukas C, den Hertog Heleen M, Flach H Zwenneke, Wermer Marieke J H, van Walderveen Marianne A A, Brouwers Paul J A M, Bulut Tomas, Vermeer Sarah E, Bernsen Marie Louise E, Uyttenboogaart Maarten, Bokkers Reinoud P H, Boogaarts Jeroen D, de Leeuw Frank-Erik, van der Worp H Bart, van der Schaaf Irene C, Schonewille Wouter J, Vos Jan A, Remmers Michel J M, Imani Farshad, Dippel Diederik W J, van Zwam Wim H, Nederkoorn Paul J, van Oostenbrugge Robert J 11 Jan 2022, In: BMC Neurology. 22

VWF-targeted thrombolysis to overcome rh-tPA resistance in experimental murine ischemic stroke models

van Moorsel Marc V.A., de Maat Steven, Vercruysse Kristof, van Leeuwen Esther M., Jacqmarcq Charlène, Bonnard Thomas, Vivien Denis, van der Worp H. Bart, Dijkhuizen Rick M., Maas Coen 2022, In: Blood. 140 , p. 2844-2848 5 p.

Risk, Clinical Course, and Outcome of Ischemic Stroke in Patients Hospitalized With COVID-19:A Multicenter Cohort Study

Sluis Wouter M, Linschoten Marijke, Buijs Julie E, Biesbroek J Matthijs, den Hertog Heleen M, Ribbers Tessa, Nieuwkamp Dennis J, van Houwelingen Reinier C, Dias Andreas, van Uden Ingeborg W M, Kerklaan Joost P, Bienfait H Paul, Vermeer Sarah E, de Jong Sonja W, Ali Mariam, Wermer Marieke J H, de Graaf Marieke T, Brouwers Paul J A M, Asselbergs Folkert W, Kappelle L Jaap, van der Worp H Bart, Algra Annemijn M, 4 Nov 2021, In: Stroke. 52 , p. 3978-3986 9 p.

Apixaban versus no anticoagulation after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation in the Netherlands (APACHE-AF):a randomised, open-label, phase 2 trial

Schreuder Floris H B M, van Nieuwenhuizen Koen M, Hofmeijer Jeannette, Vermeer Sarah E, Kerkhoff Henk, Zock Elles, Luijckx Gert-Jan, Messchendorp Gert P, van Tuijl Julia, Bienfait H Paul, Booij Suzanne J, van den Wijngaard Ido R, Remmers Michel J M, Schreuder Antonia H C M L, Dippel Diederik W, Staals Julie, Brouwers Paul J A M, Wermer Marieke J H, Coutinho Jonathan M, Kwa Vincent I H, van Gelder Isabelle C, Schutgens Roger E G, Zweedijk Berber, Algra Ale, van Dalen Jan Willem, Jaap Kappelle L, Rinkel Gabriel J E, van der Worp H Bart, Klijn Catharina J M, Nov 2021, In: The Lancet. Neurology. 20 , p. 907-916 10 p.

All research output

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