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dr. S.W. (Sander) van der Laan

dr. S.W. (Sander) van der Laan

Assistant Professor

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Research Output (69)

The Applications of Single-Cell RNA Sequencing in Atherosclerotic Disease

Slenders Lotte, Tessels Daniëlle E, van der Laan Sander W, Pasterkamp Gerard, Mokry Michal 8 Feb 2022, In: Frontiers in cardiovascular medicine. 9 , p. 826103

Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis

Slenders Lotte, Landsmeer Lennart P L, Cui Kai, Depuydt Marie A C, Verwer Maarten, Mekke Joost, Timmerman Nathalie, van den Dungen Noortje A M, Kuiper Johan, de Winther Menno P J, Prange Koen H M, Ma Wei Feng, Miller Clint L, Aherrahrou Redouane, Civelek Mete, de Borst Gert J, de Kleijn Dominique P V, Asselbergs Folkert W, den Ruijter Hester M, Boltjes Arjan, Pasterkamp Gerard, van der Laan Sander W, Mokry Michal Jan 2022, In: European heart journal open. 2

The power of genetic diversity in genome-wide association studies of lipids

Graham Sarah E, Clarke Shoa L, Wu Kuan-Han H, Kanoni Stavroula, Zajac Greg J M, Ramdas Shweta, Surakka Ida, Ntalla Ioanna, Vedantam Sailaja, Winkler Thomas W, Locke Adam E, Marouli Eirini, Hwang Mi Yeong, Han Sohee, Narita Akira, Choudhury Ananyo, Bentley Amy R, Ekoru Kenneth, Verma Anurag, Trivedi Bhavi, Martin Hilary C, Hunt Karen A, Hui Qin, Klarin Derek, Zhu Xiang, Thorleifsson Gudmar, Helgadottir Anna, Gudbjartsson Daniel F, Holm Hilma, Olafsson Isleifur, Akiyama Masato, Sakaue Saori, Terao Chikashi, Kanai Masahiro, Zhou Wei, Brumpton Ben M, Rasheed Humaira, Ruotsalainen Sanni E, Havulinna Aki S, van der Laan Sander W, van Setten Jessica, de Kleijn Dominique, de Borst Gert J, Asselbergs Folkert W, Kraaijeveld Adriaan O, Beulens Joline W J, Pasterkamp Gerard, Hoefer Imo E, van der Harst Pim, Holmes Michael V, 9 Dec 2021, In: Nature. 600 , p. 675-679 5 p.

Enhanced single-cell RNA-seq workflow reveals coronary artery disease cellular cross-talk and candidate drug targets

Ma Wei Feng, Hodonsky Chani J, Turner Adam W, Wong Doris, Song Yipei, Mosquera Jose Verdezoto, Ligay Alexandra V, Slenders Lotte, Gancayco Christina, Pan Huize, Barrientos Nelson B, Mai David, Alencar Gabriel F, Owsiany Katherine, Owens Gary K, Reilly Muredach P, Li Mingyao, Pasterkamp Gerard, Mokry Michal, van der Laan Sander W, Khomtchouk Bohdan B, Miller Clint L 26 Nov 2021, In: Atherosclerosis. 340 , p. 12-22 11 p.

Exploring the causal inference of shear stress associated DNA methylation in carotid plaque on cardiovascular risk

Methorst Ruben, Pasterkamp Gerard, van der Laan Sander W May 2021, In: Atherosclerosis. 325 , p. 30-37 8 p.

Common Variants Associated With OSMR Expression Contribute to Carotid Plaque Vulnerability, but Not to Cardiovascular Disease in Humans

van Keulen Danielle, van Koeverden Ian D, Boltjes Arjan, Princen Hans M G, van Gool Alain J, de Borst Gert J, Asselbergs Folkert W, Tempel Dennie, Pasterkamp Gerard, van der Laan Sander W 20 Apr 2021, In: Frontiers in cardiovascular medicine. 8 , p. 1-10

Monocyte-chemoattractant protein-1 levels in human atherosclerotic lesions associate with plaque vulnerability

Georgakis Marios K., van der Laan Sander W., Asare Yaw, Mekke Joost M., Haitjema Saskia, Schoneveld Arjan H., de Jager Saskia C.A., Nurmohamed Nick S., Kroon Jeffrey, Stroes Erik S.G., de Kleijn Dominique P.V., de Borst Gert J., Maegdefessel Lars, Soehnlein Oliver, Pasterkamp Gerard, Dichgans Martin 8 Apr 2021, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 41 , p. 2038-2048 11 p.

Common genetic variation in mc4r does not affect atherosclerotic plaque phenotypes and cardiovascular disease outcomes

Blauw Lisanne L., Noordam Raymond, van der Laan Sander W., Trompet Stella, Kooijman Sander, van Heemst Diana, Jukema Johan Wouter, van Setten Jessica, de Borst Gert J., Tybjærg-Hansen Anne, Pasterkamp Gerard, Berbée Jimmy F.P., Rensen Patrick C.N. 1 Mar 2021, In: Journal of Clinical medicine. 10 , p. 1-12 12 p.

Sex-dependent gene regulation of human atherosclerotic plaques by DNA methylation and transcriptome integration points to smooth muscle cell involvement in women

Hartman R., Siemelink M., Haitjema S., Dekkers K. F., Slenders L., Boltjes A., Mokry M., Timmerman N., De Borst G. J., Heijmans B. T., Asselbergs F. W., Pasterkamp G., Van der Laan S. W., Den Ruijter H. M. 29 Jan 2021,

The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease

Demandt J A F, Dubois L J, van Kuijk K, Zaťovičová M, Jin H, Parkkila S, van der Laan S W, Jelenska L, Mees B M E, Reutelingsperger C P M, Cleutjens K B J M, van der Kallen C J H, Schalkwijk C G, van Greevenbroek M M J, Biessen E A L, Pasterkamp G, Pastoreková S, Stehouwer C D A, Sluimer J C 11 Jan 2021, In: Scientific Reports. 11 14 p.

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