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dr. H.T. (Eric) Spierings

dr. H.T. (Eric) Spierings

Associate Professor
dr. H.T. (Eric) Spierings
  • Central Diagnostic Laboratory

Biography

Biography

Dr. Spierings received his PhD degree as immunologist at the Leiden University Medical Center, The Netherlands and was subsequently recognized as SMBWO Immunologist by the Dutch Society for Immunology. His postdoctoral training was performed on minor H antigens in organ- and stem-cell transplantation in the laboratory of Prof. Dr. Els Goulmy, Leiden, The Netherlands. In 2008, he was appointed as lab director of the HLA laboratory of the University Medical Centre Utrecht, The Netherlands. In that position, he combines diagnostic histocompatibility testing with research. His current scientific interest focusses on the role of indirect recognition of mismatched HLA in transplantation and on post-transplant immunomonitoring via Next Generation Sequencing of T- and B-cell receptors and immunoglobulins.

Side Activities

  • Associate editor: Frontiers in Immunology ( Section Alloimmunity and Transplantation)
  • Editorial Board: HLA
  • Editorial board: Cellular Immunology
  • Co-chair for the 18th International HLA & Immunogenetics Workshop (ihiw18.org)
  • Co-chair for the 35th Conference of the European Federation for Immunogenetics
  • Chair of the Bio-informatics Committee of the European Federation for Immunogenetics
  • Head of the Matchis Expertise Center, Leiden, The Netherlands

Fellowship and Awards

  • 1997: KNAW van Walree Grant
  • 2002: Best Abstract Award – 13th International Histocompatibility Workshop Conference 
  • 2004: Special Fellow – Leukemia and Lymphoma Society 
  • 2007: Best Abstract Award – European Federation for Immunogenetics Conference
  • 2009: Best Abstract Award – European Federation for Immunogenetics Conference
  • 2013: Ureka Mega Challenge Award for Innovation – UMC Utrecht
  • 2016: Novartis Award for best scientific publication – Dutch Transplantation Society
  • 2017: Medical Immunology Science Award – Dutch Society for Immunology

Research Output (116)

Snowflake epitope matching correlates with child-specific antibodies during pregnancy and donor-specific antibodies after kidney transplantation

Niemann Matthias, Strehler Yara, Lachmann Nils, Halleck Fabian, Budde Klemens, Hönger Gideon, Schaub Stefan, Matern Benedict M, Spierings Eric 28 Oct 2022, In: Frontiers in Immunology. 13

The number of donor HLA-derived T cell epitopes available for indirect antigen presentation determines the risk for vascular rejection after kidney transplantation

Betjes Michiel G.H., Peereboom Emma T.M., Otten Henny G., Spierings Eric 30 Aug 2022, In: Frontiers in Immunology. 13

Snowflake:A deep learning-based human leukocyte antigen matching algorithm considering allele-specific surface accessibility

Niemann Matthias, Matern Benedict M, Spierings Eric 29 Jul 2022, In: Frontiers in Immunology. 13

The Value of Single-cell Technologies in Solid Organ Transplantation Studies

Peereboom Emma T M, Matern Benedict M, Spierings Eric, Geneugelijk Kirsten 25 Jul 2022, In: Transplantation. 106 , p. 2325-2337 13 p.

Assessment of human leukocyte antigen matching algorithm PIRCHE-II on liver transplantation outcomes

Kok Gautam, Verstegen Monique Ma, Houwen Roderick Hj, Nieuwenhuis Edward Es, Metselaar Herold J, Polak Wojciech G, van der Laan Luc Jw, Spierings Eric, den Hoed Caroline M, Fuchs Sabine A 25 Apr 2022, In: Liver Transplantation. 28 , p. 1356-1366 11 p.

HLA-DQ Heterodimers in Hematopoietic-Cell Transplantation

Petersdorf Effie W, Bengtsson Mats, Horowitz Mary M, McKallor Caroline, Spellman Stephen R, Spierings Eric, Gooley Theodore A, Stevenson Philip A 10 Mar 2022, In: Blood. 139 , p. 3009-3017 9 p.

The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation

Carapito Raphael, Aouadi Ismail, Verniquet Martin, Untrau Meiggie, Pichot Angélique, Beaudrey Thomas, Bassand Xavier, Meyer Sébastien, Faucher Loic, Posson Juliane, Morlon Aurore, Kotova Irina, Delbos Florent, Walencik Alexandre, Aarnink Alice, Kennel Anne, Suberbielle Caroline, Taupin Jean-Luc, Matern Benedict M, Spierings Eric, Congy-Jolivet Nicolas, Essaydi Arnaud, Perrin Peggy, Blancher Antoine, Charron Dominique, Cereb Nezih, Maumy-Bertrand Myriam, Bertrand Frédéric, Garrigue Valérie, Pernin Vincent, Weekers Laurent, Naesens Maarten, Kamar Nassim, Legendre Christophe, Glotz Denis, Caillard Sophie, Ladrière Marc, Giral Magali, Anglicheau Dany, Süsal Caner, Bahram Seiamak 2022, In: Nature Medicine. 28 , p. 989-998 10 p.

Protective HLA Alleles Recruit Biased and Largely Similar Antigen-Specific T Cell Repertoires across Different Outcomes in HIV Infection

Koning Dan, Quakkelaar Esther D, Schellens Ingrid M M, Spierings Eric, van Baarle Debbie 8 Dec 2021, In: Journal of Immunology. 208 , p. 3-15 13 p.

T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

Peereboom Emma T M, Matern Benedict M, Tomosugi Toshihide, Niemann Matthias, Drylewicz Julia, Joosten Irma, Allebes Wil A, van der Meer Arnold, Hilbrands Luuk B, Baas Marije C, van Reekum Franka E, Verhaar Marianne C, Kamburova Elena G, Seelen Marc A J, Sanders Jan Stephan, Hepkema Bouke G, Lambeck Annechien J, Bungener Laura B, Roozendaal Caroline, Tilanus Marcel G J, Voorter Christien E, Wieten Lotte, van Duijnhoven Elly M, Gelens Mariëlle A C J, Christiaans Maarten H L, van Ittersum Frans J, Nurmohamed Azam, Lardy Neubury M, Swelsen Wendy, van der Pant Karlijn A, van der Weerd Neelke C, Ten Berge Ineke J M, Bemelman Fréderike J, de Vries Aiko P J, de Fijter Johan W, Betjes Michiel G H, Roelen Dave L, Claas Frans H, Otten Henny G, Heidt Sebastiaan, van Zuilen Arjan D, Kobayashi Takaaki, Geneugelijk Kirsten, Spierings Eric 18 Nov 2021, In: Frontiers in Immunology. 12 , p. 1-13

KIR3DS1 directs NK cell-mediated protection against human adenovirus infections

Jung Johannes M, Ching Wilhelm, Baumdick Martin E, Hofmann-Sieber Helga, Bosse Jens B, Koyro Tobias, Möller Kimberly J, Wegner Lucy, Niehrs Annika, Russu Kristina, Ohms Mareike, Zhang Wenli, Ehrhardt Anja, Duisters Kevin, Spierings Eric, Hölzemer Angelique, Körner Christian, Jansen Suze A, Peine Sven, Königs Ingo, Lütgehetmann Marc, Perez Daniel, Reinshagen Konrad, Lindemans Caroline A, Altfeld Marcus, Belderbos Mirjam, Dobner Thomas, Bunders Madeleine J 17 Sep 2021, In: Science Immunology. 6 , p. 1-13 14 p.

All research output

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