prof. dr. R.M. (Raymond) Schiffelers

prof. dr. R.M. (Raymond) Schiffelers

Full Professor
prof. dr. R.M. (Raymond) Schiffelers
  • Central Diagnostic Laboratory



Raymond Schiffelers studied Bio-Pharmaceutical Sciences at Leiden University (1990-1995). After an industrial traineeship at SmithKline Beecham Pharmaceuticals (UK) he did his PhD in medical microbiology at Erasmus University Rotterdam on liposomal targeting of antimicrobial agents (1996-2001). Subsequently he became post-doc at Utrecht University working on liposomes targeting tumor vasculature. In 2002-2003, at Intradigm Co (USA) he expanded his tumor vasculature-targeting work with polymers for delivery of siRNA. After his return to Utrecht University he became assistant and then associate professor. He co-invented OncoCort® a nanomedicine formulation of corticosteroids that will enter clinical trials in 2015.  In 2011, he moved to the Laboratory for Clinical Chemistry & Hematology of the University Medical Center Utrecht to work on nanomedicines, both for diagnosis and therapy. In particularly, he focuses on extracellular vesicles in the circulation as inspiration for new drug delivery systems and diagnostic readouts. He is founding member of the International Society for Extracellular Vesicles (ISEV) founding member and member organizing committee for the ISEV2014-annual meeting, Associate Editor of the Journal Extracellular Vesicles and editor of the International Journal of Pharmaceutics and the Journal of Controlled Release. He is Founder of EXCYTEX-an extracellular vesicle-based company and member of the Scientific Advisory Board for a number of start-up companies.


Side Activities

Without remuneration

President European Technology Platform Nanomedicine

Associate Editor Journal of Extracellular Vesicles & Drug Delivery and Translational Research

Founder/Share holder (<5%)/Scientific Advisor Excytex bv

Member Scientific Advisory Board Anjarium BioSciences

Member Scientific Advisory Board SentryX bv 



Remuneration for department

Editor International Journal Pharmaceutics

Editor Journal Controlled Release


Part-time employment

Nanocell Therapeutics BV

Fellowship and Awards

Vidi 2007 ‘Targeting inflammation to fight cancer’

Galenus Research Award 2009

ERC Consolidator grant 2010 260627 ‘Microvesicle-inspired drug delivery systems’

ERC Proof of Concept grant 2012 29744 ‘TargetMV’

Research Output (175)

TOP-EVs:Technology of Protein delivery through Extracellular Vesicles is a versatile platform for intracellular protein delivery

Ilahibaks Nazma F., Ardisasmita Arif I., Xie Songpu, Gunnarsson Anders, Brealey Joseph, Vader Pieter, de Jong Olivier G., de Jager Saskia, Dekker Niek, Peacock Ben, Schiffelers Raymond M., Sluijter Joost P.G., Lei Zhiyong Mar 2023, In: Journal of Controlled Release. 355 , p. 579-592 14 p.

mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells

Bevers Sanne, Kooijmans Sander A A, Van de Velde Elien, Evers Martijn J W, Seghers Sofie, Gitz-Francois Jerney J J M, van Kronenburg Nicky C H, Fens Marcel H A M, Mastrobattista Enrico, Hassler Lucie, Sork Helena, Lehto Taavi, Ahmed Kariem E, El Andaloussi Samir, Fiedler Katja, Breckpot Karine, Maes Michael, Van Hoorick Diane, Bastogne Thierry, Schiffelers Raymond M, De Koker Stefaan 11 Jul 2022, In: Molecular Therapy. 30 , p. 3078-3094 17 p.

Extracellular vesicles enclosed-miR-421 suppresses air pollution (PM 2.5 )-induced cardiac dysfunction via ACE2 signalling.

Wang Hongyun, Wang Tianhui, Rui Wei, Xie Jinxin, Xie Yuling, Zhang Xiao, Guan Longfei, Li Guoping, Lei Zhiyong, Schiffelers Raymond M, Sluijter Joost P G, Xiao Junjie May 2022, In: Journal of Extracellular Vesicles. 11 , p. 1-20

Utilizing in vitro drug release assays to predict in vivo drug retention in micelles

Varela-Moreira Aida, van Leur Heleen, Krijgsman Danielle, Ecker Veronika, Braun Martina, Buchner Maike, Fens Marcel H A M, Hennink Wim E, Schiffelers Raymond M 25 Apr 2022, In: International Journal of Pharmaceutics. 618

A robust post-insertion method for the preparation of targeted siRNA LNPs

Swart L E, Koekman C A, Seinen C W, Issa H, Rasouli M, Schiffelers R M, Heidenreich O 11 Apr 2022, In: International Journal of Pharmaceutics. 620 , p. 1-11

VhH anti-thrombomodulin clone 1 inhibits TAFI activation and enhances fibrinolysis in human whole blood under flow

van Moorsel Marc V A, Poolen Geke, Koekman Cornelis A, Verhoef Sandra, de Maat Steven, Barendrecht Arjan, van Kleef Nadine D, Meijers Joost C M, Schiffelers Raymond, Maas Coen, Urbanus Rolf T 16 Feb 2022, In: Journal of thrombosis and haemostasis : JTH. 20 , p. 1213-1222 10 p.

Delivery of modified mRNA to damaged myocardium by systemic administration of lipid nanoparticles

Evers Martijn J W, Du Wenjuan, Yang Qiangbing, Kooijmans Sander A A, Vink Arjan, van Steenbergen Mies, Vader Pieter, de Jager Saskia C A, Fuchs Sabine A, Mastrobattista Enrico, Sluijter Joost P G, Lei Zhiyong, Schiffelers Raymond 22 Jan 2022, In: Journal of controlled release : official journal of the Controlled Release Society. 343 , p. 207-216 10 p.

Anti-PEG antibodies compromise the integrity of PEGylated lipid-based nanoparticles via complement

Senti Mariona Estape, de Jongh Caroline A., Dijkxhoorn Kim, Verhoef Johan J. F., Szebeni Janos, Storm Gert, Hack C. Erik, Schiffelers Raymond M., Fens Marcel H., Boross Peter 7 Dec 2021, In: Journal of controlled release : official journal of the Controlled Release Society. 341 , p. 475-486 12 p.

Themed issue:Extracellular vesicles in drug delivery and bioengineering

Fuhrmann Gregor, Lehr Claus-Michael, Schiffelers Raymond 1 Dec 2021, In: Advanced Drug Delivery Reviews. 181

Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity

van Haren Matthijs J, Gao Yongzhi, Buijs Ned, Campagna Roberto, Sartini Davide, Emanuelli Monica, Mateuszuk Lukasz, Kij Agnieszka, Chlopicki Stefan, Escudé Martinez de Castilla Pol, Schiffelers Raymond, Martin Nathaniel I 14 Sep 2021, In: Biomolecules. 11

All research output

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