dr. J.M.L. (Jeanine) Roodhart

dr. J.M.L. (Jeanine) Roodhart

Associate Professor - medical
dr. J.M.L. (Jeanine) Roodhart
  • Department of Medical Oncology

Research Programs

Strategic Program Cancer

Side Activities

DSMB membership

  1. PelVex-II trial - multicenter trial for recurrent rectal cancer evaluating the additive value of induction chemotherapy before chemoradiation.
  1. RADAR-PANC – TwiC comparing standardized versus non-standardized follow-up after resection of pancreatic adenocarcinoma.

Advisory boards:

Pierre Fabre, Merck, Bayer, Servier, BMS, AMGEN

Public-private  research collaborations:

HUB organoid technology

Cleara Biotech

BMS pharmaceutical company

Pierre Fabre pharmaceutical company

Servier pharmaceutical company          

GSK pharmaceytical company

Xilis MOS technology

Other academic activities

  • 2018 - .. Steering committee UPORT
  • 2020 - ..ONCODE clinical advisory board
  • 2020 – .. Editor patient information regarding colorectal cancer on ‘’
  • 2021-.. Member of the TC Bio (ethical committee for the UMC Utrecht biobank)
  • 2021 Reviewer at Medicom Medical Publishers for ASCO GI 2021 Medicom Conference Report.
  • 2021-2022 Editor at Medicom Medical Publishers for Medical Education: developing e-learnings regarding colorectal cancer for medical oncologist.
  • 2022 editor patient information video’s for patië
  • 2023 Framingham selectie colorectal cancer

Invited lectures

  • 2023-2 jaarsymposium oncologie (continuum), landelijke nascholing NVMO, annual training course for medical oncologist: update on colorectal cancer
  • 2022-9 MEDTALKS round table discussion regarding updated CRC guideline (main guest)
  • 2022-9 Expert meeting mCRC /ESMO, Innovaties & moleculaire diagnostiek
  • 2022-6 Swedish post-ASCO meeting to discuss CRC update from ASCO 2022 (invited by Karolinska institute for national event).
  • 2022-5 NVMO targeted therapies, organoid technology for every patient!
  • 2021-10 Biocartis user meeting Amsterdam, Netherlands/Scandinavia. Biomarkers in colorectal cancer treatment.
  • 2021-9 ESMO 2021 MEDTALKS colorectal cancer summary of ESMO
  • 2021-9 Summerschool for young medical oncologist, panel discussion session.
  • 2020-11 Annual meeting of the Nederlandse Vereniging voor Oncologie (NVMO, dutch society of medical oncologists), satellite symposium: clinical implications of biomarkers.
  • 2020-10 post-ESMO meeting of the NVMO (dutch society of medical oncologists): ESMO updates on colorectal cancer (Amsterdam)
  • 2020-9 Pre-ESMO colorectal cancer expert meeting: biomarkers and targeted therapy
  • 2019-4 Post-AACR meeting: translational gastro-intestinal updates. (Amsterdam)
  • 2019-3 14e jaarsymposium oncologie (continuum), landelijke nascholing NVMO, annual training course for medical oncologist: update on colorectal cancer

Research Output (53)

FOxTROT2:innovative trial design to evaluate the role of neoadjuvant chemotherapy for treating locally advanced colon cancer in older adults or those with frailty

Platt J R, Todd O M, Hall P, Craig Z, Quyn A, Seymour M, Braun M, Roodhart J, Punt C, Christou N, Taieb J, Karoui M, Brown J, Cairns D A, Morton D, Gilbert A, Seligmann J F Feb 2023, In: ESMO open. 8 , p. 1-9

Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice

Küçükköse Emre, Heesters Balthasar A, Villaudy Julien, Verheem André, Cercel Madalina, van Hal Susan, Boj Sylvia F, Borel Rinkes Inne H M, Punt Cornelis J A, Roodhart Jeanine M L, Laoukili Jamila, Koopman Miriam, Spits Hergen, Kranenburg Onno Dec 2022, In: Journal for ImmunoTherapy of Cancer. 10

Pre-Diagnostic Circulating Resistin Concentrations Are Not Associated with Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study

Pham Thu-Thi, Nimptsch Katharina, Aleksandrova Krasimira, Jenab Mazda, Reichmann Robin, Wu Kana, Tjønneland Anne, Kyrø Cecilie, Schulze Matthias B, Kaaks Rudolf, Katzke Verena, Palli Domenico, Pasanisi Fabrizio, Ricceri Fulvio, Tumino Rosario, Krogh Vittorio, Roodhart Jeanine, Castilla Jesús, Sánchez Maria-Jose, Colorado-Yohar Sandra Milena, Harbs Justin, Rutegård Martin, Papier Keren, Aglago Elom K, Dimou Niki, Mayen-Chacon Ana-Lucia, Weiderpass Elisabete, Pischon Tobias 9 Nov 2022, In: Cancers. 14

External Validation of the Colon Life Nomogram for Predicting 12-Week Mortality in Dutch Metastatic Colorectal Cancer Patients Treated with Trifluridine/Tipiracil in Daily Practice

Hamers Patricia A.H., Wensink G. Emerens, van Smeden Maarten, Vink Geraldine R., Smabers Lidwien P., Lunenberg Renee A., Laclé Miangela M., Koopman Miriam, May Anne M., Roodhart Jeanine M.L. 18 Oct 2022, In: Cancers. 14

Correlation of Immunological and Histopathological Features with Gene Expression-Based Classifiers in Colon Cancer Patients

van de Weerd Simone, Smit Marloes A, Roelands Jessica, Mesker Wilma E, Bedognetti Davide, Kuppen Peter J K, Putter Hein, Tollenaar Rob A E M, Roodhart Jeanine M L, Hendrickx Wouter, Medema Jan Paul, van Krieken J Han J M 2 Oct 2022, In: International journal of molecular sciences. 23 , p. 1-16

Consensus molecular subtype 4 (CMS4)-targeted therapy in primary colon cancer:A proof-of-concept study

Peters Niek A., Constantinides Alexander, Ubink Inge, van Kuik Joyce, Bloemendal Haiko J., van Dodewaard Joyce M., Brink Menno A., Schwartz Thijs P., Lolkema Martijn P.J.K., Lacle Miangela M., Moons Leon M., Geesing Joost, van Grevenstein Wilhelmina M.U., Roodhart Jeanine M.L., Koopman Miriam, Elias Sjoerd G., Borel Rinkes Inne H.M., Kranenburg Onno 6 Sep 2022, In: Frontiers in oncology. 12

Neoadjuvant FOLFOXIRI prior to chemoradiotherapy for high-risk (“ugly”) locally advanced rectal cancer:study protocol of a single-arm, multicentre, open-label, phase II trial (MEND-IT)

van den Berg K., Schaap D. P., Voogt E. L.K., Buffart T. E., Verheul H. M.W., de Groot J. W.B., Verhoef C., Melenhorst J., Roodhart J. M.L., de Wilt J. H.W., van Westreenen H. L., Aalbers A. G.J., van ‘t Veer M., Marijnen C. A.M., Vincent J., Simkens L. H.J., Peters N. A.J.B., Berbée M., Werter I. M., Snaebjornsson P., Peulen H. M.U., van Lijnschoten I. G., Roef M. J., Nieuwenhuijzen G. A.P., Bloemen J. G., Willems J. M.W.E., Creemers G. J.M., Nederend J., Rutten H. J.T., Burger J. W.A. 6 Sep 2022, In: BMC Cancer. 22

External Validation of Two Established Clinical Risk Scores Predicting Outcome after Local Treatment of Colorectal Liver Metastases in a Nationwide Cohort

Bolhuis Karen, Wensink G. Emerens, Elferink Marloes A.G., Bond Marinde J.G., Dijksterhuis Willemieke P.M., Fijneman Remond J.A., Kranenburg Onno W., Borel Rinkes Inne H.M., Koopman Miriam, Swijnenburg Rutger Jan, Vink Geraldine R., Hagendoorn Jeroen, Punt Cornelis J.A., Elias Sjoerd G., Roodhart Jeanine M.L. 10 May 2022, In: Cancers. 14 , p. 1-17

Impact of Dose-Escalated Chemoradiation on Quality of Life in Patients With Locally Advanced Rectal Cancer:2-Year Follow-Up of the Randomized RECTAL-BOOST Trial

Verweij Maaike E., Hoendervangers Sieske, Couwenberg Alice M., Burbach J. P.Maarten, Berbee Maaike, Buijsen Jeroen, Roodhart Jeanine, Reerink Onne, Pronk Apollo, Consten Esther C.J., Smits Anke B., Heikens Joost T., van Grevenstein W. Helma M.U., Intven Martijn P.W., Verkooijen H. Lenny M. 1 Mar 2022, In: International Journal of Radiation Oncology Biology Physics. 112 , p. 694-703 10 p.

External validation of the MSKCC nomogram to estimate five-year overall survival after surgery for stage I–III colon cancer in a Dutch population

Bond Marinde J.G., Hamers Patricia A.H., Vink Geraldine R., van Grevenstein Wilhelmina M.U., Laclé Miangela M., van Smeden Maarten, Koopman Miriam, Roodhart Jeanine M.L., Punt Cornelis J.A., May Anne M. 2022, In: Acta Oncologica. 61 , p. 560-565 6 p.

All research output

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