prof. dr. G. (Gerard) Pasterkamp

prof. dr. G. (Gerard) Pasterkamp

Full Professor
prof. dr. G. (Gerard) Pasterkamp
  • Central Diagnostic Laboratory

Research Programs

Circulatory Health



Gerard Pasterkamp, MD, is professor Experimental Cardiology and quarter maker of the Circulatory Health Research Center, UMC Utrecht. His research interests are in the field of cardiovascular biology and more specifically innovation in biomarkers. His research interests are in the field of cardiovascular biology and innovation in biomarkers and drug targets. The research group houses the largest atherosclerotic plaque biobank worldwide: Athero Express including >4000 patients. This biobank has generated new insights into determinants of plaque destabilisation. The laboratory also invests in the excavation of genetic determinants of atherosclerotic plaque characteristics. He coordinates national and EU based consortia with the aim to unravel biomarkers and mechanisms of atherosclerotic disease. His translational profile is noted in the private public consortia he is involved in. He is supervising three public private grants that have been rewarded with the aim to develop novel biomarkers and imaging technology to detect cardiac ischemia and endothelial dysfunction. In 2018 he obtained a LeDucq grant together with Prof G Owens (Virginia University) on the role of smooth muscle cell plasticity in the atherosclerotic plaque. 

Side Activities

Editorial scientific board ATVB, Cardiovascular research, Atherosclerosis, Eur J Cardiovascular Pharmacology

Board member of Dutch Atherosclerosis Society

Review board LS7 EU-ERC advanced grants and Finnish Academy of Sciences


Research Output (645)

The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis.

Karamanavi Elisavet, McVey David G, van der Laan Sander W, Stanczyk Paulina J, Morris Gavin E, Wang Yifan, Yang Wei, Chan Kenneth, Poston Robin N, Luo Jun, Zhou Xinmiao, Gong Peng, Jones Peter D, Cao Junjun, Kostogrys Renata B, Webb Tom R, Pasterkamp Gerard, Yu Haojie, Xiao Qingzhong, Greer Peter A, Stringer Emma J, Samani Nilesh J, Ye Shu 2 Dec 2022, In: Circulation research. 131 , p. 1004-1017 14 p.

Detection and localization of early- and late-stage cancers using platelet RNA

In 't Veld Sjors G J G et al. 30 Aug 2022, In: Cancer Cell. 40 , p. 999-1009.e6

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Ramdas Shweta, Judd Jonathan, Graham Sarah E, Kanoni Stavroula, Wang Yuxuan, Surakka Ida, Wenz Brandon, Clarke Shoa L, Chesi Alessandra, Wells Andrew, Bhatti Konain Fatima, Vedantam Sailaja, Winkler Thomas W, Locke Adam E, Marouli Eirini, Zajac Greg J M, Wu Kuan-Han H, Ntalla Ioanna, Hui Qin, Klarin Derek, Hilliard Austin T, Wang Zeyuan, Xue Chao, Thorleifsson Gudmar, Helgadottir Anna, Gudbjartsson Daniel F, Holm Hilma, Olafsson Isleifur, Hwang Mi Yeong, Han Sohee, Akiyama Masato, Sakaue Saori, Terao Chikashi, Kanai Masahiro, Zhou Wei, Brumpton Ben M, Rasheed Humaira, Havulinna Aki S, Hemerich Daiane, van der Laan Sander W, van Setten Jessica, de Kleijn Dominique, de Borst Gert J, Asselbergs Folkert W, Kraaijeveld Adriaan O, Beulens Joline W J, Pasterkamp Gerard, Hoefer Imo E, van der Harst Pim, Holmes Michael V, 4 Aug 2022, In: American Journal of Human Genetics. 109 , p. 1366-1387 22 p.

The Role of the Vulnerable Carotid Plaque in Embolic Stroke of Unknown Source

Willey Joshua Z, Pasterkamp Gerard 7 Jun 2022, In: Journal of the American College of Cardiology. 79 , p. 2200-2202 3 p.

Increased frequency of proangiogenic tunica intima endothelial kinase 2 (Tie2) expressing monocytes in individuals with type 2 diabetes mellitus

Reijrink M, van Ark J, Lexis C P H, Visser L M, Lodewijk M E, van der Horst I C C, Zeebregts C J, van Goor H, de Jager S C A, Pasterkamp G, Wolffenbuttel B H R, Hillebrands J L 12 May 2022, In: Cardiovascular Diabetology. 21 , p. 1-16

Protective role of chaperone-mediated autophagy against atherosclerosis

Madrigal-Matute Julio, de Bruijn Jenny, van Kuijk Kim, Riascos-Bernal Dario F, Diaz Antonio, Tasset Inmaculada, Martín-Segura Adrián, Gijbels Marion J J, Sander Bianca, Kaushik Susmita, Biessen Erik A L, Tiano Simoni, Bourdenx Mathieu, Krause Gregory J, McCracken Ian, Baker Andrew H, Jin Han, Sibinga Nicholas E S, Bravo-Cordero Jose Javier, Macian Fernando, Singh Rajat, Rensen Patrick C N, Berbée Jimmy F P, Pasterkamp Gerard, Sluimer Judith C, Cuervo Ana Maria 5 Apr 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119 , p. 1-12

Ceramides and phospholipids in plasma extracellular vesicles are associated with high risk of major cardiovascular events after carotid endarterectomy

Timmerman Nathalie, Waissi Farahnaz, Dekker Mirthe, de Borst Gert J., van Bennekom Joelle, de Winter Robbert J., Hilvo Mika, Jylhä Antti, Pasterkamp Gerard, de Kleijn Dominique P.V., Laaksonen Reijo 1 Apr 2022, In: Scientific Reports. 12 , p. 1-13

Preclinical Comparison of Distal Off-Pump Anastomotic Remodeling:Hand-Sewn Versus ELANA Heart Bypass

Stecher David, Hoogewerf Marieke, van Putte Bart P., Osman Shadan, Doevendans Pieter A., Tulleken Cornelis, van Herwerden Lex, Pasterkamp Gerard, Buijsrogge Marc P. 18 Mar 2022, In: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery. 17 , p. 111-118 8 p.

Flow Cytometry Based Platelet Reactivity Testing to Predict the Occurrence of Per-operative Solid Microemboli During Carotid Endarterectomy

Brand Aarent R T, Leunissen Tesse C, van Vriesland Daniel, Pasterkamp Gerard, Roest Mark, Korporaal Suzanne J A, Urbanus Rolf T, de Borst Gert J 10 Mar 2022, In: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 63 , p. 800-806 7 p.

All research output

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