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dr. J.J. Luykx

dr. J.J. Luykx

Assistant Professor - medical
  • Psychiatry

Research Programs

Brain

Biography

Biography

Jurjen Luykx obtained his medical degree at Utrecht University in 2005. He was a visiting scholar and was trained in neurogenetics at the University of California, Los Angeles (UCLA) in 2006/2007. In 2012 he finished his residency in psychiatry and has since held several clinical consultant positions at psychiatric hospitals in Arnhem and the Utrecht area. In March 2013 he obtained his PhD in neuropsychiatric genetics at Utrecht University. Starting February 1st, 2019 he heads the residency program at GGNet Mental Healthy in Apeldoorn, where he also sees outpatients suffering from a range of psychiatric disorders.

Education and positions in academia

Current: University Medical Center Utrecht Utrecht, The Netherlands
Human Neurogenetics Unit, Head of Program in Psychiatric Genetics 
2007 – 2013 University Medical Center Utrecht Utrecht
Ph.D. program (“Determinants of Neurotransmitters in Cerebrospinal Fluid and Plasma”)
2006 – 2007 University of California (UCLA) Los Angeles, USA
Program in Neurogenetics
1999 – 2005 Utrecht University Utrecht
Doctor of Medicine

Research line

We welcome master students with an interest in psychiatric genetics coming from different backgrounds. A lot of the work we do concerns biostatistics; some of the work also involves wet lab activities.With our lab of postdocs, PhD students, lab technicians, bioinformaticians we focus on the following projects:

• Targeted DNA and RNA sequencing in schizophrenia and bipolar disorder
• Genetic overlap studies: ALS-schizophrenia, OCD-schizophrenia, metabolic traits-schizophrenia, and EEG-epilepsy
• Other genetic studies in psychiatric patients: PTSD-related phenotypes; Pathway analysis studies in schizophrenia; Genetics of clozapine use (www.clozinstudy.com); Genetics of antipsychotic-induced weight gain; Genetics of ECT responsiveness; EEG genomics.
• I am also country coordinator for the Prednisolone trial (placebo-controlled randomized trial studying the effects of prednisolone addition to antipsychotics), EULAST (European randomized controlled trial studying treatment effects of oral vs depot antipsychotics and pharmacogenetics in schizophrenia) and RAPSODI (trial into add-on of raloxifene vs. placebo in the treatment of schizophrenia).

Professional associations

• Psychiatric Genomics Consortium (PGC) - Eating Disorders working group & Obsessive-Compulsive Disorder and Tourette Syndrome working group & Post-Traumatic Stress Disorder working group & Substance Use Disorders steering committee & MDD working group & ENIGMA-EEG working group & ENIGMA-cortex working group

Highlighted publications

• B.D. Lin, A. Alkema, …. & J.J. Luykx. Assessing causal links between metabolic traits, inflammation and schizophrenia: a univariable and multivariable bidirectional Mendelian Randomization study (International Journal of Epidemiology, in press): using both univariate and multivariate MR we find evidence that dyslipidemia has a role in schizophrenia independent of medication status.

•J.J. Luykx, R. van der Spek, …., Annelien Bredenoord & Ger Palmboom. Unconsented genetic testing in psychiatry: an (almost) no go? (Lancet Psychiatry, 2019). 

• D. Schijven, J.H. Veldink & J.J. Luykx. Genetic cross-disorder analysis in psychiatry: from methodology to clinical utility (British Journal of Psychiatry, 2019): in this paper we discuss the ramifications and clinical implications of genetic cross-disorder research for patients and psychiatrists.

• R. McLaughlin, D. Schijven,….. & O. Hardiman / J.H. Veldink / J.J. Luykx (shared supervision). Genetic correlation between amyotrophic lateral sclerosis and schizophrenia (Nature Communications, 2017): under my supervision the first evidence of genetic overlap between schizophrenia and ALS was discovered.

• M. Lancee, C.M.C. Lemmens, … & J.J. Luykx. Outcome reporting bias in trials investigating antipsychotic drugs (Translational Psychiatry, 2017): here, we demonstrated the nature and degree of outcome reporting bias in antipsychotics trials.

• J.J. Luykx, S.C. Bakker, et al. Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma (Molecular Psychiatry, 2015): we outline the first genetic evidence of the involvement of schizophrenia risk genes in determining neurotransmitter coagonist levels in CSF.

Fellowship and Awards

Amount

Year

Topic

Funded by

€200,000 (personal grant)

2014

Next-generation targeted sequencing

Brain division, UMCU

€149,000 (main applicant)

2015

Emergency psychiatry guidelines

SKMS

€309,000 (main applicant)

2017

Imaging genomics

ALS foundation

€260,000 (co-applicant)

2018

Genetic Counseling Consortium

COST

Research Output (112)

Psychiatric organisations should unite voices in condemning the invasion of Ukraine

Luykx Jurjen J. Apr 2022, In: The Lancet Psychiatry. 9 , p. e20

Editorial:Cross-disorder Genetics in Neuropsychiatry

Van Assche Evelien, Schulte Eva C., Andreassen Ole A., Smeland Olav B., Luykx Jurjen J. 9 Feb 2022, In: Frontiers in Neuroscience. 16 , p. 1-3

Stratified psychiatry:Tomorrow's precision psychiatry?

Arns Martijn, van Dijk Hanneke, Luykx Jurjen J., van Wingen Guido, Olbrich Sebastian Feb 2022, In: European Neuropsychopharmacology. 55 , p. 14-19 6 p.

Representation and Outcomes of Individuals with Schizophrenia Seen in Everyday Practice Who Are Ineligible for Randomized Clinical Trials

Taipale Heidi, Schneider-Thoma Johannes, Pinzón-Espinosa Justo, Radua Joaquim, Efthimiou Orestis, Vinkers Christiaan H., Mittendorfer-Rutz Ellenor, Cardoner Narcís, Pintor Luis, Tanskanen Antti, Tomlinson Anneka, Fusar-Poli Paolo, Cipriani Andrea, Vieta Eduard, Leucht Stefan, Tiihonen Jari, Luykx Jurjen J. 2022, In: JAMA Psychiatry. 79 , p. 210-218 9 p.

Cerebrospinal fluid abnormalities in first- and multi-episode schizophrenia-spectrum disorders:impact of clinical and demographical variables

Oviedo-Salcedo Tatiana, Wagner Elias, Campana Mattia, Gagsteiger Anna, Strube Wolfgang, Eichhorn Peter, Louiset Marie Luise, Luykx Jurjen, de Witte Lot D., Kahn René S., Benros Michael E., Falkai Peter, Hasan Alkomiet Dec 2021, In: Translational Psychiatry. 11 , p. 1-8 8 p.

Impact of the first COVID-19 outbreak on mental health service utilisation at a Dutch mental health centre:Retrospective observational study

Chow Man Wei, Noorthoorn Eric O., Wierdsma André I., Van Der Horst Marte, De Boer Nini, Guloksuz Sinan, Luykx Jurjen J. 17 Nov 2021, In: BJPsych open. 7 , p. 1-7

The genetic basis of major depression

Kendall K. M., Van Assche E., Andlauer T. F.M., Choi K. W., Luykx J. J., Schulte E. C., Lu Y. 8 Oct 2021, In: Psychological medicine. 51 , p. 2217-2230 14 p.

Diphtheria And Tetanus Vaccination History Is Associated With Lower Odds of COVID-19 Hospitalization

Monereo-Sánchez Jennifer, Luykx Jurjen J., Pinzón-Espinosa Justo, Richard Geneviève, Motazedi Ehsan, Westlye Lars T., Andreassen Ole A., van der Meer Dennis 7 Oct 2021, In: Frontiers in Immunology. 12

Large-scale collaboration in ENIGMA-EEG:A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity

Smit Dirk J.A., Andreassen Ole A., Boomsma Dorret I., Burwell Scott J., Chorlian David B., de Geus Eco J.C., Elvsåshagen Torbjørn, Gordon Reyna L., Harper Jeremy, Hegerl Ulrich, Hensch Tilman, Iacono William G., Jawinski Philippe, Jönsson Erik G., Luykx Jurjen J., Magne Cyrille L., Malone Stephen M., Medland Sarah E., Meyers Jacquelyn L., Moberget Torgeir, Porjesz Bernice, Sander Christian, Sisodiya Sanjay M., Thompson Paul M., van Beijsterveldt Catharina E.M., van Dellen Edwin, Via Marc, Wright Margaret J. Aug 2021, In: Brain and Behavior. 11

Antipsychotic discontinuation:mind the patient and the real-world evidence

Luykx Jurjen J., Tiihonen Jari Jul 2021, In: The Lancet Psychiatry. 8 , p. 555-557 3 p.

All research output

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