dr. C.A. (Caroline) Lindemans

dr. C.A. (Caroline) Lindemans

Assistant Professor - medical
dr. C.A. (Caroline) Lindemans
  • SCT patient care



Caroline Lindemans, MD, PhD is a pediatrician, BMT specialist  and pediatric immunologist in the UMC Utrecht. Appointed as a consultant in HCT she has a special  research interest in graft versus host disease, intestinal toxicity, it’s prevention and therapy.  After receiving a KWF fellowship grant she recently worked at Memorial Sloan Kettering Cancer Center in the Research groups of Marcel van den Brink  and Alan Hanash resulting in a first author Nature paper, published December 2015. She has ongoing collaborations with these groups and is currently expanding this line of research in the UMC Utrecht.  Caroline is an active member of various international working committees (e.g. EBMT, CIBMTR: chair of one of the CIBMTR working committees).

Side Activities

  • Co-chair CIBMTR working committee Infection and Immunity February 2014—Feb 2017
  • Medical Consultant Chimerix europe (Brincidofovir studies): 2015-heden

Fellowship and Awards

  • 2000 Wilhelmina Children's Hospital Student Research Prize
  • 2010 ASBMT Travel grant for young investigators $500
  • 2012 Abstract award winner international cord blood symposium
  • 2012 UMC Utrecht mobilization grant  €20.000 euro
  • 2013 Wilhelmina Children’s hospital Fund: Leading ladies  research stimulation grant €125.000 euro
  • 2013 Travel Stipendium Nijbakker Morra Foundation €9.600 euro
  • 2013 KWF (Dutch Cancer Society) Clinical fellowship Grant €250.000 euro. To study tissue regeneratation in GVHD.
  • 2014 ASH Abstract Achievement Award

Research Output (84)

KIR3DS1 directs NK cell-mediated protection against human adenovirus infections

Jung Johannes M, Ching Wilhelm, Baumdick Martin E, Hofmann-Sieber Helga, Bosse Jens B, Koyro Tobias, Möller Kimberly J, Wegner Lucy, Niehrs Annika, Russu Kristina, Ohms Mareike, Zhang Wenli, Ehrhardt Anja, Duisters Kevin, Spierings Eric, Hölzemer Angelique, Körner Christian, Jansen Suze A, Peine Sven, Königs Ingo, Lütgehetmann Marc, Perez Daniel, Reinshagen Konrad, Lindemans Caroline A, Altfeld Marcus, Belderbos Mirjam, Dobner Thomas, Bunders Madeleine J 17 sep 2021, In: Science Immunology. 6 , p. 1-13 14 p.

Long-term effect of hematopoietic cell transplantation on systemic inflammation in patients with mucopolysaccharidoses

van den Broek Brigitte T A, Lindemans Caroline A, Boelens Jaap Jan, Delemarre Eveline M, Drylewicz Julia, Verhoeven-Duif Nanda, van Hasselt Peter M, Nierkens Stefan 24 aug 2021, In: Blood Advances. 5 , p. 3092-3101 10 p.

CD4+ T-cell reconstitution predicts survival outcomes after acute graft-versus-host-disease:a dual-center validation

de Koning Coco, Prockop Susan, van Roessel Ichelle, Kernan Nancy, Klein Elizabeth, Langenhorst Jurgen, Szanto Celina, Belderbos Mirjam, Bierings Marc, Boulad Farid, Bresters Dorine, Cancio Maria, Curran Kevin, Kollen Wouter, O'Reilly Richard, Scaradavou Andromachi, Spitzer Barbara, Versluijs Birgitta, Huitema Alwin, Lindemans Caroline, Nierkens Stefan, Boelens Jaap Jan 11 feb 2021, In: Blood. 137 , p. 848-855 8 p.

Clinical Grade Production of Wilms' Tumor-1 Loaded Cord Blood-Derived Dendritic Cells to Prevent Relapse in Pediatric AML After Cord Blood Transplantation

Plantinga Maud, Lo Presti Vania, de Haar Colin G, Dünnebach Ester, Madrigal Alejandro, Lindemans Caroline A, Boelens Jaap Jan, Nierkens Stefan 25 sep 2020, In: Frontiers in Immunology. 11 , p. 1-13

Hematopoietic cell transplantation in chronic granulomatous disease: a study of 712 children and adults

Chiesa Robert, Wang Junfeng, Blok Henric-Jan, Hazelaar Sheree, Neven Benedicte, Moshous Despina, Schulz Ansgar, Hoenig Manfred, Hauck Fabian, Al Seraihy Amal, Gozdzik Jolanta, Ljungman Per, Lindemans Caroline A, Fernandes Juliana F, Kalwak Krzysztof, Strahm Brigitte, Schanz Urs, Sedlacek Petr, Sykora Karl-Walter, Aksoylar Serap, Locatelli Franco, Stepensky Polina, Wynn Robert, Lum Su Han, Zecca Marco, Porta Fulvio, Taskinen Mervi, Gibson Brenda, Matthes Susanne, Karakukcu Musa, Hauri-Hohl Mathias, Veys Paul, Gennery Andrew R, Lucchini Giovanna, Felber Matthias, Albert Michael H, Balashov Dmitry, Lankester Arjan, Güngör Tayfun, Slatter Mary A 3 sep 2020, In: Blood. 136 , p. 1201-1211 11 p.

Reconstitution of T Cell Subsets Following Allogeneic Hematopoietic Cell Transplantation

Dekker Linde, de Koning Coco, Lindemans Caroline, Nierkens Stefan 20 jul 2020, In: Cancers. 12 , p. 1-21 21 p.

Hurdles in treating Hurler disease:potential routes to achieve a "real" cure

van den Broek Brigitte T A, van Doorn Jaap, Hegeman Charlotte V, Nierkens Stefan, Lindemans Caroline A, Verhoeven-Duif Nanda, Boelens Jaap Jan, van Hasselt Peter M 23 jun 2020, In: Blood Advances. 4 , p. 2837-2849 13 p.

Metachromatic leukodystrophy and transplantation:remyelination, no cross-correction

Wolf Nicole I., Breur Marjolein, Plug Bonnie, Beerepoot Shanice, Westerveld Aimee S.R., van Rappard Diane F., de Vries Sharon I., Kole Maarten H.P., Vanderver Adeline, van der Knaap Marjo S., Lindemans Caroline A., van Hasselt Peter M., Boelens Jaap J., Matzner Ulrich, Gieselmann Volkmar, Bugiani Marianna 22 jan 2020, In: Annals of Clinical and Translational Neurology. 7 , p. 169-180 12 p.

Cross-cutting view of current challenges in paediatric solid organ and haematopoietic stem cell transplantation in Europe:The European Reference Network TransplantChild

Jara P., Baker A., Baumann U., Borobia A. M., Branchereu S., Candusso M., Carcas A. J., Chardot C., Cobas J., D'Antiga L., Ferreras C., Fitzpatrick E., Frauca E., Hernández-Oliveros F., Kaliciński P., Lindemans C., Lopes M. F., López-Granados E., De Magnée C., Mota C., Muñoz J. M., Ojeda J. J., Pérez-Martínez A., Perilongo G., Rascon J., Sciveres M., Stone R., Tarutis V., Toporski J., Torres J. M., Wennberg L. 15 jan 2020, In: Orphanet Journal of Rare Diseases. 15 , p. 1-9

Incidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury-Laboratory Confirmed Bloodstream Infections in the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplant

Dandoy Christopher E., Kim Soyoung, Chen Min, Ahn Kwang Woo, Ardura Monica I., Brown Valerie, Chhabra Saurabh, Diaz Miguel Angel, Dvorak Christopher, Farhadfar Nosha, Flagg Aron, Ganguly Siddartha, Hale Gregory A., Hashmi Shahrukh K., Hematti Peiman, Martino Rodrigo, Nishihori Taiga, Nusrat Roomi, Olsson Richard F., Rotz Seth J., Sung Anthony D., Perales Miguel Angel, Lindemans Caroline A., Komanduri Krishna V., Riches Marcie L. 3 jan 2020, In: JAMA network open. 3

All research output

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