dr. J.H.W. (Jeanette) Leusen

dr. J.H.W. (Jeanette) Leusen

Associate Professor
dr. J.H.W. (Jeanette) Leusen
  • Center for Translational Immunology (CTI) Research



Dr. Jeanette Leusen, received her PhD in 1995 at the University of Amsterdam, The Netherlands. She became associate professor and head of the immunotherapy group of the University Medical Center in Utrecht in 2006, and head of the UMAB facility in 2012. She has co-authored more than 120 publications in peer-reviewed journals and is inventor on 10 patent applications. Her group of 24 FTE works on the mechanism of action of therapeutic antibodies, with a special interest in IgA as a novel class of antibody for the treatment of both malignant as infectious disease.


See her research group webpage here >

Side Activities

Dr Leusen is the scientific founder of TigaTx in 2018, a spin-off company on engineered IgA as therapeutic antibody in oncology.

Dr Leusen is senior editor of several Immunology/cancer journals and was organizer of the FASEB meeting on Immunoreceptors of 2014 and 2016, and was vice chair of the Gordon Research Conference on Antibody Biology and Engineering in 2018, and main chair in 2022,

Fellowship and Awards

Dr Leusen holds several grants from Health Holland, KWF, Villa Joep! and industry.

Research Output (131)

Effective, Long-Term, Neutrophil Depletion Using a Murinized Anti-Ly-6G 1A8 Antibody

Olofsen Patricia A, Stip Marjolein C, Jansen J H Marco, Chan Chilam, Nederend Maaike, Tieland Ralph G, Tsioumpekou Maria, Leusen Jeanette H W Nov 2022, In: Cells. 11

IgG Subclass-Dependent Pulmonary Antigen Retention during Acute IgG-Dependent in Mice

Todorova Biliana, Godon Ophélie, Conde Eva, Gillis Caitlin M., Iannascoli Bruno, Richard-Le Goff Odile, Fiole Daniel, Roumenina Lubka T., Leusen Jeanette H.W., Murphy Andrew J., Macdonald Lynn E., Reber Laurent L., Jönsson Friederike, Bruhns Pierre 1 Oct 2022, In: Journal of immunology (Baltimore, Md. : 1950). 209 , p. 1243-1251 9 p.

Corrigendum: Targeting myeloid checkpoint molecules in combination with antibody therapy: A novel anti-cancer strategy with IgA antibodies?

Chan Chilam, Lustig Marta, Baumann Niklas, Valerius Thomas, van Tetering Geert, Leusen Jeanette H.W. 13 Sep 2022, In: Frontiers in Immunology. 13 , p. 1-2

Myeloid checkpoint blockade improves killing of T-acute lymphoblastic leukemia cells by an IgA2 variant of daratumumab

Baumann Niklas, Arndt Christian, Petersen Judith, Lustig Marta, Rösner Thies, Klausz Katja, Kellner Christian, Bultmann Miriam, Bastian Lorenz, Vogiatzi Fotini, Leusen Jeanette H W, Burger Renate, Schewe Denis M, Peipp Matthias, Valerius Thomas 16 Aug 2022, In: Frontiers in Immunology. 13

Targeting Myeloid Checkpoint Molecules in Combination With Antibody Therapy:A Novel Anti-Cancer Strategy With IgA Antibodies?

Chan Chilam, Lustig Marta, Baumann Niklas, Valerius Thomas, van Tetering Geert, Leusen Jeanette H W 5 Jul 2022, In: Frontiers in Immunology. 13 , p. 1-21

Fc gamma receptor is not required for in vivo processing of radio- and drug-conjugates of the dead tumor cell-targeting monoclonal antibody, APOMAB (R)

Staudacher Alexander H, Liapis Vasilios, Wittwer Nicole L, Tieu William, Lam Hiu Chun, Leusen Jeanette, Brown Michael P 11 May 2022, In: Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie. 151 , p. 1-10

Analysing the protection from respiratory tract infections and allergic diseases early in life by human milk components:the PRIMA birth cohort

van Stigt Arthur H., Oude Rengerink Katrien, Bloemenkamp Kitty W.M., de Waal Wouter, Prevaes Sabine M.P.J., Le Thuy My, van Wijk Femke, Nederend Maaike, Hellinga Anneke H., Lammers Christianne S., den Hartog Gerco, van Herwijnen Martijn J.C., Garssen Johan, Knippels Léon M.J., Verhagen Lilly M., de Theije Caroline G.M., Lopez-Rincon Alejandro, Leusen Jeanette H.W., Van't Land Belinda, Bont Louis, 14 Feb 2022, In: BMC Infectious Diseases. 22

Anti-C2 Antibody ARGX-117 Inhibits Complement in a Disease Model for Multifocal Motor Neuropathy

Budding Kevin, Johansen Lill Eva, Van de Walle Inge, Dijkxhoorn Kim, de Zeeuw Elisabeth, Bloemenkamp Lauri M., Bos Jeroen W., Jansen Marc D., Curial Chantall A.D., Silence Karen, de Haard Hans, Blanchetot Christophe, Van de Ven Liesbeth, Leusen Jeanette H.W., Pasterkamp R. Jeroen, van den Berg Leonard H., Hack C. Erik, Boross Peter, van der Pol W. Ludo 1 Jan 2022, In: Neurology® neuroimmunology & neuroinflammation. 9 , p. 1-11

Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

Wachsmann Tassilo L A, Wouters Anne K, Remst Dennis F G, Hagedoorn Renate S, Meeuwsen Miranda H, van Diest Eline, Leusen Jeanette, Kuball Jürgen, Falkenburg J H Frederik, Heemskerk Mirjam H M 2022, In: OncoImmunology. 11

Targeting the high affinity receptor, FcγRI, in autoimmune disease, neuropathy, and cancer

Holtrop Tosca, Budding Kevin, Brandsma Arianne M, Leusen Jeanette H W 2022, In: Immunotherapy Advances. 2

All research output

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