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dr. F.S.S. (Frans) Leijten

dr. F.S.S. (Frans) Leijten

Associate Professor - medical
dr. F.S.S. (Frans) Leijten
  • Neurologen

Research Programs

Brain

Biography

Biography

Dr. Frans S.S. Leijten (1960) studied medicine at Utrecht University and obtained his MD in 1986. He became a neurologist and clinical neurophysiologist in 1994. In 1996 he defended his PhD thesis on critical illness polyneuropathy at Leiden University. He worked as an epileptologist at epilepsy center SEIN, then called Meer en Bosch, in Heemstede, from 1994-1996. Since then, he has been working at the University Medical Center Utrecht, where he is now head of the EEG department and the monitoring unit for invasive EEG recordings. He is also chairman of the National Dutch Epilepsy Surgery Taskforce. He is a member of the European Childhood Epilepsy Surgery Group U-TASK and of the European Network for Epilepsy Research ENER. He is a member of the Consilium Neurologicum, responsible for the education of neurology residents in the Netherlands. He has received various educational awards and is a well-known speaker at congresses.

Research line

His research focuses on intractable focal epilepsy and epilepsy surgery. His team explored the clinical use of new advanced neuroimaging methods, clinical decision-making in focal epilepsy, quality-of-life and coping issues in intractable epilepsy, and new treatments. He is engaged in a national collaboration which led to the develop a device to detect seizures during the night (Nightwatch). Recent research focuses on networks in the intracranial EEG measured on the cortex. Together with the department of Applied Mathematics of Twente University, he is engaged in developing a neural mass computer model that can represent the epileptic cortex of individual patients. For a demonstration tool, look at

https://wwwhome.ewi.utwente.nl/~meijerhge/resector_en.html .

Using epileptic network knowledge, he has started a clinical trial of closed loop cortical stimulation in patients with intractable epilepsy in the primary sensorimotor cortex. Dr Leijten has over 150 publications in peer-review journals and is the editor of a Dutch textbook on clinical epilepsy. 

Most recent key publications

1: Demuru M, Kalitzin S, Zweiphenning W, Van Blooijs D, Van ’t Klooster M,  Van Eijsden P, Leijten F, Zijlmans M, on behalf of the RESPECT group. The value of intra-operative electrographic biomarkers for tailoring during epilepsy surgery: from  group-level to patient-level analysis. Sci Rep 2020;10:14654.

2: Hebbink J, Huiskamp G, Van Gils SA, Leijten FSS, Meijer HGE. Pathological responses to single pulse electrical stimuli in epilepsy: the role of feedforward inhibition. Eur J Neurosci 2020;51:1122-36.

3: Arends JBAM, Thijs RD, Gutter T, Ungureanu C, Cluitmans P, Van Dijk J, Van Andel J, Tan F, De Weerd A, Vledder B, Hofstra W, Lazeron R,  Van Thiel G, Roes KCB, Leijten F, and the Dutch Tele-Epilepsy Consortium. Multimodal nocturnal seizure detection in a residential care setting: a long-term prospective trial. Neurology 2018;91:e2010-9.

4: Van Blooijs D, Leijten FSS, Van Rijen PC, Meijer HGE, Huiskamp GJM. Evoked directional network characteristics of epileptogenic tissue derived from Single Pulse Electrical Stimulation. Hum Brain Mapp 2018;39:4611-22.

5: Hebbink J, Meijer H, Huiskamp GJ, Van Gils S, Leijten FS. Phenomenological network models: lessons for epilepsy surgery. Epilepsia 2017;58:e147-51.

Education

2020 SKO (Senior Teaching Qualification)

Side Activities

(1) I am chair of the TeleEpilepsy consortium that has developed a medical device to detect nocturnal motor seizures, NightWatch, together with a commercial partner, LivAssured. There are no direct financial ties, but a percentage of future profit from the sales of NightWatch will be made available to the consortium for further research in epilepsy.

(2)  I am a consultant of and hold shares in ProLira, a start-up company that developed DeltaScan, a device to detect delirium making use of EEG technology.

Fellowship and Awards

1: 2020 ZonMW parel for neural mass research

2: 2012 Editor's Choice of best publication in NeuroImage

3: 2012 Editor's Choice of best publication in Human Brain Mapping

4: 2009 SUMMA medical teacher of the year

5: 2004 VAANdrager national prize for best teacher in Neurology 

Research Output (213)

High-frequency oscillations recorded with surface EEG in neonates with seizures

Noorlag Lotte, van 't Klooster Maryse, van Huffelen Alexander, van Klink Nicole, Benders Manon, de Vries Linda, Leijten Frans, Jansen Floor E., Braun Kees, Zijlmans Maeike Nov 2021, In: Epilepsia. 62 , p. 114-115

High-resolution electric source imaging for presurgical evaluation of tuberous sclerosis complex patients

Mouthaan Brian E., Jansen Floor E., Colon Albert J., Huiskamp Geertjan M., van Eijsden Pieter, Leijten Frans S.S., Braun Kees P.J. 29 Oct 2021, In: Clinical Neurophysiology. 133 , p. 126-134 9 p.

Decoding four hand gestures with a single bipolar pair of electrocorticography electrodes

Verwoert Maxime, Vansteensel Mariska J., Freudenburg Zachary V., Aarnoutse Erik J., Leijten Frans S.S., Ramsey Nick F., Branco Mariana P. 4 Oct 2021, In: Journal of Neural Engineering. 18 , p. 1-10

High-frequency oscillations recorded with surface EEG in neonates with seizures

Noorlag Lotte, van 't Klooster Maryse A, van Huffelen Alexander C, van Klink Nicole E C, Benders Manon J N L, de Vries Linda S, Leijten Frans S S, Jansen Floor E, Braun Kees P J, Zijlmans Maeike 16 Apr 2021, In: Clinical Neurophysiology. 132 , p. 1452-1461 10 p.

Detailed somatotopy of tongue movement in the human sensorimotor cortex:A case study

Schippers Anouck, Vansteensel Mariska J, Freudenburg Zachary V, Leijten Frans S S, Ramsey Nick F 19 Jan 2021, In: Brain stimulation. 14 , p. 287-289 3 p.

Neervallen met schokken

Leijten F 2021, p. 23-32

Timing of syncope in ictal asystole as a guide when considering pacemaker implantation

van Westrhenen Anouk, Shmuely Sharon, Surges Rainer, Diehl Beate, Friedman Daniel, Leijten Frans S.S., van Hoey Smith Jorien, Benditt David G., van Dijk J. Gert, Thijs Roland D. 2021, In: Journal of Cardiovascular Electrophysiology. 32 , p. 3019-3026 8 p.

Corticosteroids versus clobazam in epileptic encephalopathy with ESES:a European multicentre randomised controlled clinical trial (RESCUE ESES*)

van den Munckhof Bart, Arzimanoglou Alexis, Perucca Emilio, van Teeseling Heleen C, Leijten Frans S S, Braun Kees P J, Jansen Floor E, 23 Nov 2020, In: Trials. 21 , p. 1-11

Validation of virtual resection on intraoperative interictal data acquired during epilepsy surgery

Demuru Matteo, Zweiphenning Willemiek, van Blooijs Dorien, Van Eijsden Pieter, Leijten Frans, Zijlmans Maeike, Kalitzin Stiliyan 21 Oct 2020, In: Journal of Neural Engineering. 17 , p. 1-10

The value of intra-operative electrographic biomarkers for tailoring during epilepsy surgery:from group-level to patient-level analysis

Demuru Matteo, Kalitzin Stiliyan, Zweiphenning Willemiek, van Blooijs Dorien, van’t Klooster Maryse, Van Eijsden Pieter, Leijten Frans, Zijlmans Maeike, Braun Kees, Ferrier Cyrille, Gebbink Tineke, Gosselaar Peter, Huiskamp Geertjan, van Klink Nicole, Ophorst Janine, van Rijen Peter, van der Salm Sandra, Winter Anouk Velders de, 4 Sep 2020, In: Scientific Reports. 10

All research output

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