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prof. dr. M.G.E.H. (Marnix) Lam

prof. dr. M.G.E.H. (Marnix) Lam

Full Professor
prof. dr. M.G.E.H. (Marnix) Lam
  • Researchgr. Nucleaire Geneeskunde

Research Programs

Strategic Program Cancer

Biography

Biography

Marnix Lam (1975) studied Pharmaceutical sciences (passed with distinction) and Medicine at Utrecht University. He became a resident in Nuclear Medicine, respectively Radiology and finalized his PhD thesis (2009) on radionuclide therapy in prostate cancer patients with metastatic bone pain. This was followed by a two-year postdoctoral fellowship at Stanford University School of Medicine, USA. In 2016 he was appointed Professor of Nuclear Medicine.
Translational research in molecular medicine has been the scope of his scientific work, with a focus on oncology. Bringing new radiopharmaceuticals to clinical practice. This specifically resulted in the introduction of new oncological treatment modalities in the Netherlands, such as bone seeking radiopharmaceuticals for the palliation of metastatic bone pain (Sm-153-EDTMP, Re-188-HEDP) and radioembolization for treatment of hepatic malignancies (Y-90 and Ho-166 microspheres). Current research is focussed on dosimetry of therapeutic radiopharmaceuticals, image-guided treatment technology, alfa- and beta-emitting isotopes for therapeutic purposes, intra-arterial and intra-tumor treatment approaches, and radio-immunotherapy.

Side Activities

Public Private Partnerships

Consultancy / (scientific) advisory board meetings and research support from Terumo / Quirem Medical B.V.

Consultancy / (scientific) advisory board meetings and research support from Boston Scientific

Research support from Novartis

The department of Radiology and Nuclear Medicine of the UMC Utrecht receives royalties and milestone payments from Terumo / Quirem Medical B.V.

Educational activities

Board Member of the National Education Committee on Nuclear Medicine

National Coordinator on Education of Gastrointestinal Nuclear Medicine and Musculoskeletal Nuclear Medicine

Memberships of professional societies

Member of the Dutch society of Nuclear Medicine: ‘De Nederlandse Vereniging voor Nucleaire Geneeskunde (NVNG)’.

Member of the Royal Dutch society for promotion of the medical profession: ‘De Koninklijke Nederlandse Maatschappij ter bevordering van de Geneeskunst (KNMG)’.

Member of ‘the European Association of Nuclear Medicine (EANM)’.

Member of the Dutch society of Radiology: ‘De Nederlandse Vereniging voor Radiologie (NVvR)’.

 

Fellowship and Awards

2021 - Research grant from ‘Zorginstituut, Veelbelovende zorg’: SIRT with 166Ho-microspheres in elderly and fragile patients with previously untreated unresectable liver-only metastases of colorectal cancer, CAIRO7 study of the Dutch Colorectal Cancer Group (DCCG)

2021 - Research grant from Quirem: clinical research on the safety and efficacy of holmium-166 (166Ho)-microspheres radioembolization in patients with hepatic malignancies. 

2021 - Research grant from Terumo: Individualized dosimetry for holmium-166 (166Ho)-radioembolization in patients with unresectable hepatocellular carcinoma; a multi-center, interventional, non-randomized, non-comparative, open label, early phase II study: iHEPAR. 

2021 - Research grant from Terumo: The RALLY study: Dose finding study for unilobar radiation lobectomy using holmium-166 (166H0)-microspheres to improve resectability in patients with HCC .

2020 - Research grant from Boston Scientific: Hepatic glass yttrium-90 (90Y)-microspheres radioembolization.

2020 - Awarded CVIR Editors’ Medal for 2020: Radioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases: International Multicenter Study on Efficacy and Toxicity. Braat, A.J.A.T., Kappadath, S.C., Ahmadzadehfar, H. et al. Cardiovasc Intervent Radiol (2019) 42(3).

2020 - Awarded Editors’ Choice Paper and top 10% downloaded papers in Medical Physics: Kunnen B et al. Feasibility of imaging 90Y microspheres at diagnositc activity levels for hepatic radioembolization treatment planning. Med Phys.

2019 - Alavi-Mandell award for best publication in Journal of Nuclear Medicine: Efficacy of Radioembolization with 166Ho-Microspheres in Salvage Patients with Liver Metastases: A Phase 2 Study. J Nucl Med. 2018 Apr;59(4):582-588.

2018 - Research grant from the Dutch Cancer Society (KWF): Diagnostic accuracy of Gallium-68 PSMA PET/CT in primary staging of prostate cancer

2018 - Research grant from NWO Industrial Doctorates program: Advanced dosimetry for personalized radioembolization treatment (ADOPT)

2018 - Research grant from BTG / Boston Scientific: LUMI DEBIRI and TheraSphere for treatment of metastatic colorectal cancer (DEBIRY)

2018 - Research grant from Health Holland program: Intra-arterial lutetium-177-dotatate for treatment of patients with neuroendocrine tumor liver metastases

2017 - Alavi-Mandell award for best publication in Journal of Nuclear Medicine: Insights into the dose-response relationship of radioembolization with resin yttrium-90 microspheres: a prospective cohort study in patients with colorectal cancer liver metastases. J Nucl Med. 2016 Jul;57(7):1014-9.

2016 - Research grant from the Dutch Cancer Society (KWF): Holmium-166 microspheres for radioembolization in HCC patients: new generation microspheres for individualized treatment

2016 Alavi-Mandell award for best publication in Journal of Nuclear Medicine: Safety of a Scout Dose Preceding Hepatic Radioembolization with 166Ho Microspheres. J Nucl Med. 2015 Jun;56(6):817-23.

2016 - Alavi-Mandell award for best publication in Journal of Nuclear Medicine: Impact of Personal Characteristics and Technical Factors on Quantification of Sodium 18F-Fluoride Uptake in Human Arteries: Prospective Evaluation of Healthy Subjects. J Nucl Med. 2015 Oct;56(10):1534-40.

2016 - Appointed as full professor of Nuclear Medicine at the University of Utrecht, The Netherlands

2014 - Research grant from Alpe d’Huzes / Dutch Cancer Society (KWF): Holmium micro-brachytherapy: an innovative intratumoral treatment modality in head and neck cancer

2014 - Appointed as honorary professor at the medical school of the People’s Liberation Army General Hospital and Military University, Beijing, China

2014 - CIRSE Award of Excellence and Innovation in Interventional Radiology

2010 - Research grant from the Dutch Cancer Society (KWF): translational research in oncology

Research Output (223)

166Holmium–99mTechnetium dual‑isotope imaging: scatter compensation and automatic healthy‑liver segmentation for 166Holmium radioembolization dosimetry

Stella M, Braat Arthur, Lam Marnix, de Jong Hugo, van Rooij Rob 21 Apr 2022, In: EJNMMI Physics. 9 , p. 1-17

Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm

de Vor Lisanne, van Dijk Bruce, van Kessel Kok, Kavanaugh Jeffrey S., de Haas Carla, Aerts Piet C., Viveen Marco C., Boel Edwin C., Fluit Ad C., Kwiecinski Jakub M., Krijger Gerard C., Ramakers Ruud M., Beekman Freek J., Dadachova Ekaterina, Lam Marnix G. E. H., Vogely H. Charles, van der Wal Bart C. H., van Strijp Jos A. G., Horswill Alexander R., Weinans Harrie, Rooijakkers Suzan H. M. 6 Jan 2022, In: eLife. 11

Gallium-68-somatostatin receptor PET/CT parameters as potential prognosticators for clinical time to progression after peptide receptor radionuclide therapy: a cohort study

Ebbers Sander C., Heimgartner Muriel, Barentsz Maarten W., van Leeuwaarde Rachel S., van Treijen Mark J. C., Lam Marnix M. E. G., Braat Arthur J. A. T. 9 Dec 2021, In: European Journal of Hybrid Imaging. 5 , p. 1-11

Beyond the MAA-Y90 Paradigm: The Evolution of Radioembolization Dosimetry Approaches and Scout Particles

Keane Grace, Lam Marnix, de Jong Hugo Dec 2021, In: Seminars in Interventional Radiology. 38 , p. 542-553 12 p.

The Impact of Diferent 99mTc Activities on Dual Isotope Imaging for 166Holmium Scout Radioembolization Procedure

Stella M, Braat Arthur, Lam Marnix, de Jong Hugo, van Rooij Rob Sep 2021, p. S226

Intra-arterial administration boosts 177Lu-HA-DOTATATE accumulation in salvage meningioma patients

Vonken Evert-Jan P A, Bruijnen Rutger C G, Snijders Tom J, Seute Tatjana, Lam Marnix G E H, de Keizer Bart, Braat Arthur Johannes Anthonius Theodorus 22 Jul 2021, In: Journal of Nuclear Medicine. 63 , p. 406-409 4 p.

Competition ('Steal' Phenomenon) between [68Ga]Ga-PSMA-11 Uptake in Prostate Tumor Tissue Versus Healthy Tissue

van der Sar Esmée C A, de Keizer Bart, Lam Marnix G E H, Braat Arthur J A T 11 May 2021, In: Pharmaceutics. 13 , p. 1-11 11 p.

Holmium-166 Radioembolization in NET Patients

Stella M, Braat Arthur, Lam Marnix May 2021, p. 241-250

Nuclear Medicine Imaging in Neuroblastoma:Current Status and New Developments

Samim Atia, Tytgat Godelieve A M, Bleeker Gitta, Wenker Sylvia T M, Chatalic Kristell L S, Poot Alex J, Tolboom Nelleke, van Noesel Max M, Lam Marnix G E H, de Keizer Bart 4 Apr 2021, In: Journal of Personalized Medicine. 11 , p. 1-22

All research output

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