prof. dr. O.W. Kranenburg

prof. dr. O.W. Kranenburg

Full Professor
prof. dr. O.W. Kranenburg
  • Lab Translational Oncology



Onno Kranenburg received his PhD in 1995 from Leiden University (Prof Lex van der Eb). He then studied RAS and RHO small GTPase signaling in cancer in the Netherlands Cancer Institute (Prof Wouter Moolenaar). In 2000 he became senior Post-Doc in the Dept of Medical Oncology in the UMC Utrecht (Prof Emile Voest) where he started his translational studies on the mechanism of action of anti-angiogenic drugs. In 2003 he became Assistant Professor and PI at the Dept. of Surgery (Prof Inne Borel Rinkes) and started to work on the mechanisms of colon cancer metastasis, initially focusing on the role of the K-RAS oncogene.  In 2006 he became Associate Professor, head of the Surgery Lab and staff member at the Dept. of Surgery. In 2012 he became coordinator of the PhD research school Clinical and Translational Oncology. In 2015 he was appointed Professor of Surgical and Translational Tumor Biology at the Cancer Center UMC Utrecht where he continues to design and test novel strategies for the prevention and treatment of colon cancer metastasis. 

Side Activities

2013-present: Coordinator of the PhD program Clinical and Translational Oncology


2005-present Head Laboratory Translational Oncology


2018-present: chair working group translational research Dutch Colorectal Cancer Group (DCCG)


2018-present: Chair U-PORT

Fellowship and Awards

1. KWF2015-8088. Targeting mesenchymal-tyope colon cancer by aggravating oxidative damage. €573.500. 
2. Scope: Modulation of chemotherapy efficacy and toxicity by nutrition in metastatic colorectal cancer. €586.000.
3. ZonMw 2014: PDGF-receptor-targeted therapy for the treatment of poor prognosis mesenchymal-type colon cancer: A window trial. €108.000
4. Gieskes-Strijbis Fonds 2014: The relationship between primary colorectal tumors and their liver metastases: Biological subgroups and therapy response. €290.000
5. Vrienden UMC Utrecht 2013. Title: Targeting colon tumors at their root: Elimination of Cancer Stem Cells. €217.000   
6. KWF UU2011-5226 Title: LIMK1 control of CD95 function in colorectal cancer. €553.300   
7. KWF UU2011-5135. Suppression of LIMK1 by oncogenic KRAS and RAF1: A critical survival pathway in colorectal cancer? €560.000
8. KWF UU2009-4417. The contribution of CD95 signalling to recurrence of colorectal liver metastases following radiofrequency ablation. €592.100   

Research Output (127)

Tissue clearing and immunostaining to visualize the spatial organization of vasculature and tumor cells in mouse liver

Frenkel Nicola, Poghosyan Susanna, van Wijnbergen Jan Willem, van den Bent Lotte, Wijler Liza, Verheem André, Borel Rinkes Inne, Kranenburg Onno, Hagendoorn Jeroen 2023, In: Frontiers in oncology. 13 10 p.

Molecular characterization of colorectal cancer related peritoneal metastatic disease

Lenos Kristiaan J., Bach Sander, Ferreira Moreno Leandro, ten Hoorn Sanne, Sluiter Nina R., Bootsma Sanne, Vieira Braga Felipe A., Nijman Lisanne E., van den Bosch Tom, Miedema Daniel M., van Dijk Erik, Ylstra Bauke, Kulicke Ruth, Davis Fred P., Stransky Nicolas, Smolen Gromoslaw A., Coebergh van den Braak Robert R.J., IJzermans Jan N.M., Martens John W.M., Hallam Sally, Beggs Andrew D., Kops Geert J.P.L., Lansu Nico, Bastiaenen Vivian P., Klaver Charlotte E.L., Lecca Maria C., El Makrini Khalid, Elbers Clara C., Dings Mark P.G., van Noesel Carel J.M., Kranenburg Onno, Medema Jan Paul, Koster Jan, Koens Lianne, Punt Cornelis J.A., Tanis Pieter J., de Hingh Ignace H., Bijlsma Maarten F., Tuynman Jurriaan B., Vermeulen Louis Dec 2022, In: Nature Communications. 13

Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice

Küçükköse Emre, Heesters Balthasar A, Villaudy Julien, Verheem André, Cercel Madalina, van Hal Susan, Boj Sylvia F, Borel Rinkes Inne H M, Punt Cornelis J A, Roodhart Jeanine M L, Laoukili Jamila, Koopman Miriam, Spits Hergen, Kranenburg Onno Dec 2022, In: Journal for ImmunoTherapy of Cancer. 10

BRAF<sup>V600E</sup> in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis

Laoukili Jamila, van Schelven Susanne, Küçükköse Emre, Verheem André, Goey Kaitlyn, Koopman Miriam, Borel Rinkes Inne, Kranenburg Onno 29 Nov 2022, In: Cell Reports. 41 , p. 1-22

Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue

Kuijk Ewart, Kranenburg Onno, Cuppen Edwin, Van Hoeck Arne 7 Oct 2022, In: Nature Communications. 13 , p. 1-10

Consensus molecular subtype 4 (CMS4)-targeted therapy in primary colon cancer:A proof-of-concept study

Peters Niek A., Constantinides Alexander, Ubink Inge, van Kuik Joyce, Bloemendal Haiko J., van Dodewaard Joyce M., Brink Menno A., Schwartz Thijs P., Lolkema Martijn P.J.K., Lacle Miangela M., Moons Leon M., Geesing Joost, van Grevenstein Wilhelmina M.U., Roodhart Jeanine M.L., Koopman Miriam, Elias Sjoerd G., Borel Rinkes Inne H.M., Kranenburg Onno 6 Sep 2022, In: Frontiers in oncology. 12

Detection of Experimental Colorectal Peritoneal Metastases by a Novel PDGFRβ-Targeting Nanobody

Strating Esther, Elias Sjoerd, van Scharrenburg Guus, Luoto Kaisa, Verheem André, Borel Rinkes Inne, Steen Herman, Kranenburg Onno Sep 2022, In: Cancers. 14

KIT promotes tumor stroma formation and counteracts tumor-suppressive TGFβ signaling in colorectal cancer

Küçükköse Emre, Peters Niek A, Ubink Inge, van Keulen Veere A M, Daghighian Roxanna, Verheem André, Laoukili Jamila, Kranenburg Onno 16 Jul 2022, In: Cell death & disease. 13 , p. 1-10

Fibroblast activation protein identifies Consensus Molecular Subtype 4 in colorectal cancer and allows its detection by 68Ga-FAPI-PET imaging

Strating Esther, Wassenaar Emma, Verhagen Mathijs, Rauwerdink Paulien, van Schelven Susanne, de Hingh Ignace, Rinkes Inne Borel, Boerma Djamila, Witkamp Arjen, Lacle Miangela, Fodde Riccardo, Volckmann Richard, Koster Jan, Stedingk Kris, Giesel Frederik, de Roos Remmert, Poot Alex, Bol Guus, Lam Marnix, Elias Sjoerd, Kranenburg Onno 1 Jul 2022, In: British Journal of Cancer. 127 , p. 145-155 11 p.

Dynamic Visualization of TGF-β/SMAD3 Transcriptional Responses in Single Living Cells

Marvin Dieuwke L, You Li, Bornes Laura, van Dinther Maarten, Peters Niek, Dang Hao, Hakuno Sarah K, Hornsveld Marten, Kranenburg Onno, van Rheenen Jacco, Rohling Jos H T, Chien Miao-Ping, Ten Dijke Peter, Ritsma Laila 19 May 2022, In: Cancers. 14

All research output

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