prof. dr. L.J. (Jaap) Kappelle

prof. dr. L.J. (Jaap) Kappelle

Full Professor
prof. dr. L.J. (Jaap) Kappelle
  • Neurologen

Research Programs



Jaap Kappelle was registered as a clinical neurologist in 1988. He obtained his PhD degree in Utrecht (1990) with Jan van Gijn. He carried out postdoctoral research at the University of Iowa, Iowa City, USA (1991) and the John P. Robarts Research Institute, London (Ontario) Canada (1998). He was appointed assistant professor at the University Utrecht in 1988, associate professor in 1994 and full professor in 2000.  He is former head of the department of cerebrovascular diseases of the University Medical Centre (UMC) Utrecht (2011-2020). As of 2020 he has been appointed medicale safety officer of the UMCU.

His research is embedded in the research lines 'Circulatory Health' and 'Brain' of the UMCU in close collaboration with the departments of neurosurgery, radiology, vascular medicine, vascular surgery, rehabilitation, clinical epidemiology, primary health care and neuropsychology. His current line of research concerns stroke, in particular the diagnosis, treatment and prognosis of patients with TIA or ischaemic stroke. As part of his research activities he is member of steering committees of reserrch programs embedded in 'Cardio-Vasculair Onderzoek Nederland' and serves as expert adjucation panelmeber of several clinical trials.

He is founding president of the Dutch Neurovascular Society. He is a member of the education committee if the Dutch Neurological Society and Dutch delegate for stroke of the European Association of Neurology. Besides his regular education duties in the UMC Utrecht, he is member of the board of supervisors of the Medical student Societÿ 'MSFU SAMS)

Jaap Kappelle is member elect of the European Stroke Council, the World Stroke Organisation and premium professional silver heart memeber  of the American Heart Associatiuon. He holds also memberships of the Dutch Society of Neurology, the Dutch Vascular Society, the European Association of Neurology, the Royal Dutch Association of Medicine and the Dutch Society of Medical Litigation Assessments.

He serves as neutral expert for different courts, insurance companies and health care organisations. 

Research line

Cerebrovascular diseases


Side Activities

As mentioned in the Biography.

Research Output (893)

Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes

Sharif Shahnam, Van der Graaf Y, Cramer M J, Kapelle L J, de Borst G J, Visseren Frank L J, Westerink Jan, 9 Nov 2021, In: Cardiovascular Diabetology. 20 , p. 1-8

Risk, Clinical Course, and Outcome of Ischemic Stroke in Patients Hospitalized With COVID-19:A Multicenter Cohort Study

Sluis Wouter M, Linschoten Marijke, Buijs Julie E, Biesbroek J Matthijs, den Hertog Heleen M, Ribbers Tessa, Nieuwkamp Dennis J, van Houwelingen Reinier C, Dias Andreas, van Uden Ingeborg W M, Kerklaan Joost P, Bienfait H Paul, Vermeer Sarah E, de Jong Sonja W, Ali Mariam, Wermer Marieke J H, de Graaf Marieke T, Brouwers Paul J A M, Asselbergs Folkert W, Kappelle L Jaap, van der Worp H Bart, Algra Annemijn M, 4 Nov 2021, In: Stroke. 52 , p. 3978-3986 9 p.

Sex Differences in Risk Profile, Stroke Cause and Outcome in Ischemic Stroke Patients With and Without Migraine

Linstra Katie M., van Os Hendrikus J.A., Ruigrok Ynte M., Nederkoorn Paul J., van Dijk Ewoud J., Kappelle L. Jaap, Koudstaal Peter J., Visser Marieke C., Ferrari Michel D., MaassenVanDenBrink Antoinette, Terwindt Gisela M., Wermer Marieke J.H., 3 Nov 2021, In: Frontiers in Neuroscience. 15 , p. 1-7 7 p.

Apixaban versus no anticoagulation after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation in the Netherlands (APACHE-AF):a randomised, open-label, phase 2 trial

Schreuder Floris H B M, van Nieuwenhuizen Koen M, Hofmeijer Jeannette, Vermeer Sarah E, Kerkhoff Henk, Zock Elles, Luijckx Gert-Jan, Messchendorp Gert P, van Tuijl Julia, Bienfait H Paul, Booij Suzanne J, van den Wijngaard Ido R, Remmers Michel J M, Schreuder Antonia H C M L, Dippel Diederik W, Staals Julie, Brouwers Paul J A M, Wermer Marieke J H, Coutinho Jonathan M, Kwa Vincent I H, van Gelder Isabelle C, Schutgens Roger E G, Zweedijk Berber, Algra Ale, van Dalen Jan Willem, Jaap Kappelle L, Rinkel Gabriel J E, van der Worp H Bart, Klijn Catharina J M, Nov 2021, In: The Lancet. Neurology. 20 , p. 907-916 10 p.

Sex and Cardiovascular Function in Relation to Vascular Brain Injury in Patients with Cognitive Complaints

Kuipers Sanne, Biessels Geert Jan, Greving Jacoba P, Amier Raquel P, de Bresser Jeroen, Bron Esther E, van der Flier Wiesje M, van der Geest Rob J, Hooghiemstra Astrid M, van Oostenbrugge Robert J, van Osch Matthias J P, Kappelle L Jaap, Exalto Lieza G, 26 Oct 2021, In: Journal of Alzheimer's Disease. 84 , p. 261-271 11 p.

Second asymptomatic carotid surgery trial (ACST-2):a randomised comparison of carotid artery stenting versus carotid endarterectomy

Halliday Alison, Bulbulia Richard, Bonati Leo H., Chester Johanna, Cradduck-Bamford Andrea, Peto Richard, Pan Hongchao, Potter John, Henning Eckstein Hans, Farrell Barbara, Flather Marcus, Mansfield Averil, Mihaylova Boby, Rahimi Kazim, Simpson David, Thomas Dafydd, Sandercock Peter, Gray Richard, Molyneux Andrew, Shearman Cliff P., Rothwell Peter, Belli Anna, Herrington Will, Judge Parminder, Leopold Peter, Mafham Marion, Gough Michael, Cao Piergiorgio, MacDonald Sumaira, Bari Vasha, Berry Clive, Bradshaw S., Brudlo Wojciech, Clarke Alison, Cox Robin, Fathers Susan, Gaba Kamran, Gray Mo, Hayter Elizabeth, Holliday Constance, Kurien Rijo, Lay Michael, Poorthuis Michiel, Schmidt Andrej, de Borst Gert J., Moll Frans L., Toorop Raechel, van der Worp Bart H., Vonken Evert J., Kappelle Jaap L., 18 Sep 2021, In: The Lancet. 398 , p. 1065-1073 9 p.

External applicability of SGLT2 inhibitor cardiovascular outcome trials to patients with type 2 diabetes and cardiovascular disease

Smidt Lisanne C.A., Visseren Frank L.J., de Ranitz-Greven Wendela L., Nathoe Hendrik M., Kappelle L. Jaap, de Borst Gert J., de Valk Harold W., Westerink Jan, 8 Sep 2021, In: Cardiovascular Diabetology. 20

Clinical Response to Procedural Stroke Following Carotid Endarterectomy:A Delphi Consensus Study

Meershoek Armelle J A, de Waard Djurre D, Trappenburg Jaap, Zeebregts Clark J, Bulbulia Richard, Kappelle Jaap L J, de Borst Gert J, Sep 2021, In: European Journal of Vascular and Endovascular Surgery. 62 , p. 350-357 8 p.

Association of Ischemic Imaging Phenotype With Progression of Brain Atrophy and Cerebrovascular Lesions on MRI:The SMART-MR Study

Rissanen Ina, Lucci Carlo, Ghaznawi Rashid, Hendrikse Jeroen, Kappelle L. Jaap, Geerlings Mirjam I., , van der Kaaij NP, Asselbergs Folkert 21 Jul 2021, In: Neurology. 97 , p. e1063-e1074

Apparent treatment resistant hypertension and the risk of recurrent cardiovascular events and mortality in patients with established vascular disease

Groenland Eline H, Bots Michiel L, Asselbergs Folkert W, de Borst Gert J, Kappelle L Jaap, Visseren Frank L J, Spiering Wilko, 1 Jul 2021, In: International Journal of Cardiology. 334 , p. 135-141 7 p.

All research output

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