prof. dr. L.J. (Jaap) Kappelle

prof. dr. L.J. (Jaap) Kappelle

Full Professor
prof. dr. L.J. (Jaap) Kappelle
  • Neurologen

Research Programs



Jaap Kappelle was registered as a clinical neurologist in 1988. He obtained his PhD degree in Utrecht (1990) with Jan van Gijn. He carried out postdoctoral research at the University of Iowa, Iowa City, USA (1991) and the John P. Robarts Research Institute, London (Ontario) Canada (1998). He was appointed assistant professor at the University Utrecht in 1988, associate professor in 1994 and full professor in 2000.  He is former head of the department of cerebrovascular diseases of the University Medical Centre (UMC) Utrecht (2011-2020). As of 2020 he has been appointed medicale safety officer of the UMCU.

His research is embedded in the research lines 'Circulatory Health' and 'Brain' of the UMCU in close collaboration with the departments of neurosurgery, radiology, vascular medicine, vascular surgery, rehabilitation, clinical epidemiology, primary health care and neuropsychology. His current line of research concerns stroke, in particular the diagnosis, treatment and prognosis of patients with TIA or ischaemic stroke. As part of his research activities he is member of steering committees of reserrch programs embedded in 'Cardio-Vasculair Onderzoek Nederland' and serves as expert adjucation panelmeber of several clinical trials.

He is founding president of the Dutch Neurovascular Society. He is a member of the education committee if the Dutch Neurological Society and Dutch delegate for stroke of the European Association of Neurology. Besides his regular education duties in the UMC Utrecht, he is member of the board of supervisors of the Medical student Societÿ 'MSFU SAMS)

Jaap Kappelle is member elect of the European Stroke Council, the World Stroke Organisation and premium professional silver heart memeber  of the American Heart Associatiuon. He holds also memberships of the Dutch Society of Neurology, the Dutch Vascular Society, the European Association of Neurology, the Royal Dutch Association of Medicine and the Dutch Society of Medical Litigation Assessments.

He serves as neutral expert for different courts, insurance companies and health care organisations. 

Research line

Cerebrovascular diseases


Side Activities

As mentioned in the Biography.

Research Output (912)

Detection of Cardioembolic Sources With Nongated Cardiac Computed Tomography Angiography in Acute Stroke:Results From the ENCLOSE Study

Kauw Frans, Velthuis Birgitta K, Takx Richard A P, Guglielmo Marco, Cramer Maarten J, van Ommen Fasco, Bos Anneloes, Bennink Edwin, Marquering Henk A., Kappelle L Jaap, de Jong Hugo W A M, Dankbaar Jan W 13 Feb 2023, In: Stroke. 54 , p. 821-830 10 p.

Drivers of healthcare costs in patients with ischaemic stroke:a hospital-based retrospective cohort study

Mensing Liselore A., Kappelle L. Jaap, Koffijberg Hendrik, Ruigrok Ynte M. 3 Jan 2023, In: BMJ Open. 13

A research agenda for selective screening for asymptomatic carotid artery stenosis

Poorthuis Michiel H F, Kappelle L Jaap, de Borst Gert J 1 Jan 2023, In: International Journal of Cardiology. 370 , p. 421-422 2 p.

Neighbourhood walkability in relation to cognitive functioning in patients with disorders along the heart-brain axis

Timmermans Erik J, Leeuwis Anna E, Bots Michiel L, van Alphen Juliette L, Biessels Geert Jan, Brunner-La Rocca Hans-Peter, Kappelle L Jaap, van Rossum Albert C, van Osch Matthias J P, Vaartjes Ilonca, 14 Dec 2022, In: Health & place. 79 , p. 1-10

Risk evaluation of cognitive impairment in patients with heart failure:A call for action

Kuipers Sanne, Greving Jacoba P, Brunner-La Rocca Hans-Peter, Gottesman Rebecca F, van Oostenbrugge Robert J, Williams Nicole L, Jan Biessels Geert, Jaap Kappelle L, Dec 2022, In: IJC Heart and Vasculature. 43

Detection of Early Ischemic Changes with Virtual Noncontrast Dual-Energy CT in Acute Ischemic Stroke:A Noninferiority Analysis

Kauw F., Ding V. Y., Dankbaar J. W., Ommen F. van, Zhu G., Boothroyd D. B., Wolman D. N., Molvin L., de Jong H. W.A.M., Kappelle L. J., Velthuis B. K., Heit J. J., Wintermark M. 11 Aug 2022, In: American Journal of Neuroradiology. 43 , p. 1259-1264 6 p.

Antitrombotica ter preventie van cardiovasculaire complicaties:De voor- en nadelen van ‘dual pathway inhibition’

Nugteren Michael J., de Borst Gert J., van den Broek Wout W.A., Ten Berg Jur M., Kappelle L. Jaap, Ünlü Çağdaş 22 Jun 2022, In: Nederlands Tijdschrift voor Geneeskunde. 166 , p. 1-8

Lifestyle changes and kidney function:A 10-year follow-up study in patients with manifest cardiovascular disease

Østergaard Helena Bleken, Demirhan Imre, Westerink Jan, Verhaar Marianne C, Asselbergs Folkert W, de Borst Gert J, Kappelle L Jaap, Visseren Frank L J, van der Leeuw Joep, 17 May 2022, In: European Journal of Clinical Investigation. 52

Cerebrospinal fluid volume improves prediction of malignant edema after endovascular treatment of stroke

Kauw Frans, Bernsen Marie Louise, Dankbaar Jan Willem, de Jong Hugo, Kappelle Jaap, Velthuis Birgitta K, Van der Worp H B, van der Lugt Aad, Roos Y B, Yo Lonneke, van Walderveen Marianne Aa, Hofmeijer Jeannette, Bennink Edwin 4 Apr 2022, In: International Journal of Stroke. 18 , p. 187-192 6 p.

Screen-detected abnormal ankle brachial index:A risk indicator for future cardiovascular morbidity and mortality in patients with manifest cardiovascular disease

Jagt Vivianne L., Hazenberg Constantijn E.V.B., Kapelle Jaap, Cramer Maarten J., Visseren Frank L.J., Westerink Jan 10 Mar 2022, In: PLoS ONE. 17 , p. 1-17

All research output

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