prof. dr. R.S. (René) Kahn

prof. dr. R.S. (René) Kahn

Full Professor
prof. dr. R.S. (René) Kahn
  • Psychiatry

Research Programs




Dr René Kahn is Professor and until 2017, was Chair of the Department of Psychiatry and Head of the Division of Neurosciences at the University Medical Center, Utrecht, The Netherlands. In 1995 he received a Fulbright Scholarship for study at Yale and subsequently did a Fellowship in Biological Psychiatry at the Montefiore Hospital and Albert Einstein College of Medicine in New York. He then moved to the Mount Sinai School of Medicine where he conducted schizophrenia research and became Unit Chief of one of the research units.

Dr Kahn has received many grants for his research into the origins and treatment of schizophrenia. His current research interests include neuroimaging in schizophrenia and the genetic dissection of complex traits in specific psychiatric disorders. He has published over 500 research papers and book chapters. He is on the editorial boards of Schizophrenia research, Schizophrenia Bulletin, Early Interventions in Psychiatry and European Neuropsychopharmacology. He was both Treasurer and Vice-President of the European College for Neuropsychopharmacology and currently is President-Elect of the Schizophrenia International Research Society. He sat on the Neuroscience andd Mental Health Board of the Medical Research Council of the UK and was on the scientific advisory group for CNS of the European Medicines Agency. He leads a large EU-funded study, OPTiMiSE, on developing a treatment algorithm in first episode schizophrenia. He is honorary lifetime professor at Jilin University in Changchun, P.R. China and a member of the Royal Netherlands Academy of Arts and Sciences.

As of January 2017, he is appointed head of the Department of Psychiatry at Icahn School of Medicine at Mount Sinai in New York. His main tasks at UMC Utrecht are now: coaching his PhD students and coordinating research projects.

Most recent key publications

1: Kahn RS, Fleischhacker WW, Boter H, Davidson M, Vergouwe Y, Keet IP, Gheorghe MD, Rybakowski JK, Galderisi S, Libiger J, Hummer M, Dollfus S, López-Ibor JJ, Hranov LG, Gaebel W, Peuskens J, Lindefors N, Riecher-Rössler A, Grobbee DE, EUFEST study group. E
2: van der Schot AC, Vonk R, Brans RG, van Haren NE, Koolschijn PC, Nuboer V, Schnack HG, van Baal GC, Boomsma DI, Nolen WA, Hulshoff Pol HE, Kahn RS. Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder. Arch Gen Psychiatry. 2009 Feb,66(2):142-51
3: van der Schot AC, Vonk R, Brouwer RM, van Baal GC, Brans RG, van Haren NE, Schnack HG, Boomsma DI, Nolen WA, Pol HE, Kahn RS. Genetic and environmental influences on focal brain density in bipolar disorder. Brain. 2010 Sep 12
4: van Haren NE, Schnack HG, Cahn W, van den Heuvel MP, Lepage C, Collins L, Evans AC, Hulshoff Pol HE, Kahn RS Changes in cortical thickness during the course of illness in schizophrenia Arch Gen Psychiatry. 2011 Sep,68(9):871-80
5: van Haren NE, Rijsdijk F, Schnack HG, Picchioni MM, Toulopoulou T, Weisbrod M, Sauer ,H, van Erp TG, Cannon TD, Huttunen MO, Boomsma DI, Hulshoff Pol HE, Murray RM, Kahn RS. The genetic and environmental determinants of the association between brain abnormalities and schizophrenia: the schizophrenia twins and relatives consortium. Biol Psychiatry. 2012 May 15,71(10):915-21

Side Activities

Chair of the Division of Psychiatry at the Icahn School of Medicine of Mount Sinai (ISMMS) in New York, Icahn School of Medicine at Mount Sinai (ISMMS) since January 1st 2017.


Fellowship and Awards

1985 Fulbright Scholarship
1989 Ramaer Medaille
2009 Member Royal Netherlands Academy for Arts and Sciences

Research Output (1118)

Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

Schijven Dick, Postema Merel C., Fukunaga Masaki, Matsumoto Junya, Miura Kenichiro, de Zwarte Sonja M.C., van Haren Neeltje E.M., Cahn Wiepke, Hulshoff Pol Hilleke E., Kahn René S., Ayesa-Arriola Rosa, Ortiz-García de la Foz Víctor, Tordesillas-Gutierrez Diana, Vázquez-Bourgon Javier, Crespo-Facorro Benedicto, Alnæs Dag, Dahl Andreas, Westlye Lars T., Agartz Ingrid, Andreassen Ole A., Jönsson Erik G., Kochunov Peter, Bruggemann Jason M., Catts Stanley V., Michie Patricia T., Mowry Bryan J., Quidé Yann, Rasser Paul E., Schall Ulrich, Scott Rodney J., Carr Vaughan J., Green Melissa J., Henskens Frans A., Loughland Carmel M., Pantelis Christos, Weickert Cynthia Shannon, Weickert Thomas W., de Haan Lieuwe, Brosch Katharina, Pfarr Julia Katharina, Ringwald Kai G., Stein Frederike, Jansen Andreas, Kircher Tilo T.J., Nenadić Igor, Krämer Bernd, Gruber Oliver, Satterthwaite Theodore D., Bustillo Juan, Janssen Joost, 4 Apr 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120

Generalizability of the Results of Efficacy Trials in First-Episode Schizophrenia:Comparing Outcome and Study Discontinuation of Groups of Participants in the Optimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE) Trial

Nasib Lyliana G, Winter-van Rossum Inge, Zuithoff Nicolaas P A, Boudewijns Zimbo S R M, Leucht Stefan, Kahn René S 29 Mar 2023, In: The Journal of clinical psychiatry. 84 10 p.

Olanzapine/Samidorphan in Young Adults With Schizophrenia, Schizophreniform Disorder, or Bipolar I Disorder Who Are Early in Their Illness:Results of the Randomized, Controlled ENLIGHTEN-Early Study

Kahn René S, Kane John M, Correll Christoph U, Arevalo Christina, Simmons Adam, Graham Christine, Yagoda Sergey, Hu Beibei, McDonnell David 22 Mar 2023, In: The Journal of clinical psychiatry. 84

Efficacy of oral versus long-acting antipsychotic treatment in patients with early-phase schizophrenia in Europe and Israel:a large-scale, open-label, randomised trial (EULAST)

Winter-van Rossum Inge, Weiser Mark, Galderisi Silvana, Leucht Stefan, Bitter Istvan, Glenthøj Birte, Hasan Alkomiet, Luykx Jurjen, Kupchik Marina, Psota Georg, Rocca Paola, Stefanis Nikos, Teitelbaum Alexander, Bar Haim Mor, Leucht Claudia, Kemmler Georg, Schurr Timo, Davidson Michael, Kahn René S., Fleischhacker W. Wolfgang, 1 Mar 2023, In: The lancet. Psychiatry. 10 , p. 197-208 12 p.

Clinical features of individuals with schizotypal personality disorder with and without suicidal ideation

Sher Leo, Challman Katelyn N, Smith Emma C, New Antonia S, Perez-Rodriguez M Mercedes, McClure Margaret M, Goodman Marianne, Kahn René S, Hazlett Erin A 23 Feb 2023, In: Psychiatry Research. 322 , p. 115132

Inflammatory monocyte gene signature predicts beneficial within group effect of simvastatin in patients with schizophrenia spectrum disorders in a secondary analysis of a randomized controlled trial

Aichholzer Mareike, Gangadin Shiral S., Sommer Iris E.C., Wijkhuis Annemarie, de Witte Lot D., Kahn René S., Bahn Sabine, Drexhage Hemmo A., Schiweck Carmen Dec 2022, In: Brain, Behavior, and Immunity - Health. 26 , p. 100551

Diagnostic model development for schizophrenia based on peripheral blood mononuclear cell subtype-specific expression of metabolic markers

Zaki Jihan K, Lago Santiago G, Rustogi Nitin, Gangadin Shiral S, Benacek Jiri, van Rees Geertje F, Haenisch Frieder, Broek Jantine A, Suarez-Pinilla Paula, Ruland Tillmann, Auyeung Bonnie, Mikova Olya, Kabacs Nikolett, Arolt Volker, Baron-Cohen Simon, Crespo-Facorro Benedicto, Drexhage Hemmo A, de Witte Lot D, Kahn René S, Sommer Iris E, Bahn Sabine, Tomasik Jakub 30 Oct 2022, In: Translational Psychiatry. 12

Publisher Correction: Brain charts for the human lifespan:Brain charts for the human lifespan (Nature, (2022), 604, 7906, (525-533), 10.1038/s41586-022-04554-y)

Bethlehem R A I, Seidlitz J, White S R, Vogel J W, Anderson K M, Adamson C, Adler S, Alexopoulos G S, Anagnostou E, Areces-Gonzalez A, Astle D E, Auyeung B, Ayub M, Bae J, Ball G, Baron-Cohen S, Beare R, Bedford S A, Benegal V, Beyer F, Blangero J, Blesa Cábez M, Boardman J P, Borzage M, Bosch-Bayard J F, Bourke N, Calhoun V D, Chakravarty M M, Chen C, Chertavian C, Chetelat G, Chong Y S, Cole J H, Corvin A, Costantino M, Courchesne E, Crivello F, Cropley V L, Crosbie J, Crossley N, Delarue M, Delorme R, Desrivieres S, Devenyi G A, Di Biase M A, Huang H, Kahn R S, Lee S, Li J, Wang Y S, 23 Sep 2022, In: Nature. 610 , p. E6

Cognitive dysfunction in schizophrenia:An expert group paper on the current state of the art

Harvey Philip D., Bosia Marta, Cavallaro Roberto, Howes Oliver D., Kahn René S., Leucht Stefan, Müller Daniel R., Penadés Rafael, Vita Antonio Sep 2022, In: Schizophrenia Research: Cognition. 29 , p. 1-13 13 p.

Evidence of discontinuity between psychosis-risk and non-clinical samples in the neuroanatomical correlates of social function

Haas Shalaila S, Doucet Gaelle E, Antoniades Mathilde, Modabbernia Amirhossein, Corcoran Cheryl M, Kahn René S, Kambeitz Joseph, Kambeitz-Ilankovic Lana, Borgwardt Stefan, Brambilla Paolo, Upthegrove Rachel, Wood Stephen J, Salokangas Raimo K R, Hietala Jarmo, Meisenzahl Eva, Koutsouleris Nikolaos, Frangou Sophia Sep 2022, In: Schizophrenia Research: Cognition. 29 , p. 100252

All research output

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