prof. dr. J. Hendrikse

prof. dr. J. Hendrikse

Research Staff Other
prof. dr. J. Hendrikse



The overall aim of prof. Hendrikse’s research is to understand the cause of ischemic stroke with a focus on the three P’s: Pipes (vessel and vessel walls), Perfusion (CBF and reserve capacity) and Parenchyma (brain tissue and tissue changes/infarcts). After his PhD in 2004 he has created a new research field with technical development and clinical applications of MR methods of cerebral perfusion (so called arterial spin labeling MRI) and intracranial vessel wall imaging. His original MR research is recognized by the international research field with European grants (FP7, Biocog; WP leader) and personal national excellence grants (ERC-StG, VIDI, VENI, Heart association, Technical Research Council), chairmanship of international (ISMRM) perfusion study group, steering committee member of Carotid Stenosis Triallists Collaboration (CSTC), invited lectures, reviews, white papers and book chapters. 22 of his publications are within international collaborations (including Johns Hopkins University and Vanderbilt University, USA). He has over 30 publications within the field of 7T MRI brain imaging method developments. In the radiology and neurovascular research arena ‘RADIOLOGY and ‘STROKE’ are leading journals: he has over 30 publications in these journals. He is the first radiologist awarded with a VIDI grant and an ERC-StG. The focus of his research group is to understand the relation between the ‘3Ps’: pipes (arterial vasculature), perfusion and parenchyma (brain tissue damage) by using innovative imaging methods. Early 2017 he was appointed Chairman of Radiology and Nuclear Medicine UMC Utrecht.


Research line

Brain MRI: Pipes, Perfusion, Parenchyma

Most recent key publications

1: Dieleman N, Van der Kolk AG. Hendrikse J. MR intracranial vessel wall imaging: current prospects and future directions. Circulation. 2014 Jul 8;130(2):192-201
2: De Vis JB, Petersen ET, Bhogal A, Hartkamp NS, Klijn CJ, Kappelle LJ, Hendrikse J. Calibrated MRI to evaluate cerebral hemodynamics in patients with an internal carotid artery occlusion. J Cereb Blood Flow Metab. 2015 Jun;35(6):1015-23
3: Van der Kolk AG, Zwanenburg JJ, Brundel M, Biessels GJ, Visser F, Luijten PR, Hendrikse J. Distribution and natural course of intracranial vessel wall lesions in patients with ischemic stroke or TIA at 7.0 Tesla MRI. Eur Radiol. 2015 Jun;25(6):1692-700
4: De Rotte AA, Truijman MT, van Dijk AC, Liem MI, Schreuder FH, van der Kolk AG, de Kruijk JR, Daemen MJ, van der Steen AF, de Borst GJ, Luijten PR, Nederkoorn PJ, Kooi ME, van der Lugt A, Hendrikse J. Plaque components in symptomatic moderately stenosed carotid arteries related to cerebral infarcts: the plaque at RISK study. Stroke. 2015 Feb;46(2):568-71
5: Hendrikse J, Van der Grond J, Lu H, Van Zijl PCM, Golay X. Flow territory mapping of the cerebral arteries with MRI. Stroke. 2004;35:882-887

Side Activities

Instituut Verbeeten Raad van Toezicht 2023- (payment to UMC Utrecht) 

ZonMW Veni-subsidiereviewer 2018, 2019, 2020, 2021, 2022

ASNR congres 2022: panel discussion


Fellowship and Awards

1: ERC-StG
2: VENI and VIDI
3: FP7-WP-Leader
4: Dutch Heart Association
5: STW/Technical Research Council

Research Output (100)

Seven-tesla magnetic resonance imaging of atherosclerotic plaque in the significantly stenosed carotid artery:A feasibility study

De Rotte Alexandra A J, Koning Wouter, Truijman Martine T B, Den Hartog Anne G., Bovens Sandra M., Vink Aryan, Sepehrkhouy Shahrzad, Zwanenburg Jaco J M, Klomp Dennis W J , Pasterkamp Gerard, Moll Frans L., Luijten Peter R, Hendrikse Jeroen , De Borst Gert Jan 1 Nov 2014, In: Investigative Radiology. 49 , p. 749-757 9 p.

7.0 T MRI detection of cerebral microinfarcts in patients with a symptomatic high-grade carotid artery stenosis

de Rotte A.A.J., Koning W., den Hartog A.G., Bovens S.M., Zwanenburg J.J.M., Klomp D.W.J., Pasterkamp G., Moll F.L., Luijten P.R., de Borst G.J., Hendrikse J. 30 Jul 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34 , p. 1715-1719 5 p.

Imaging intracranial vessel wall pathology with magnetic resonance imaging:current prospects and future directions

Dieleman Nikki, Van Der Kolk Anja G., Zwanenburg Jaco J M, Harteveld Anita A., Biessels Geert J., Luijten Peter R., Hendrikse Jeroen 8 Jul 2014, In: Circulation. 130 , p. 192-201 10 p.

Periprocedural hemodynamic depression is associated with a higher number of new ischemic brain lesions after stenting in the International Carotid Stenting Study-MRI Substudy

Altinbas A., Algra A., Bonati L.H., Brown M.M., Kappelle L.J., de Borst G.J., Hendrikse J., van der Tweel I., ICSS Inverstigators x, et al X, van der Worp H.B. Jan 2014, In: Stroke. 45 , p. 146-151 6 p.

Ipsilateral foetal-type posterior cerebral artery is associated with cognitive decline after carotid revascularisation

Altinbas A., Hendrikse J., Algra A., Van Zandvoort M.J.E., Brown M.M., Bonati L.H., de Borst G.J., Kappelle L.J., van der Worp H.B. 2014, In: BMC Neurology. 14 , p. 84-84 1 p.

Effects of carotid endarterectomy or stenting on arterial diameters in the circle of Willis

Bost R.B., Hendrikse J., Algra A., de Borst G.J., Kappelle L.J., Jongen L.M., Brown M.M., van der Worp H.B. 2014, In: Journal of Stroke and Cerebrovascular Diseases. 23 , p. 699-705 7 p.

Simultaneous quantitative assessment of cerebral physiology using respiratory-calibrated MRI and near-infrared spectroscopy in healthy adults

Alderliesten T., de Vis J.B., Lemmers P.M., van Bel F., Benders M.J.N.L., Hendrikse J., Petersen E.T. 2014, In: NeuroImage. 58 Pt1 , p. 255-263 9 p.

Impact of neonate haematocrit variability on the longitudinal relaxation time of blood: Implications for arterial spin labelling MRI

de Vis J.B., Hendrikse J., Groenendaal F., de Vries L.S., Kersbergen Karina, Benders M.J.N.L., Petersen E.T. 2014, In: Neuroimage: Clinical [E]. 4 , p. 517-525 9 p.

Non-invasive MRI measurements of venous oxygenation, oxygen extraction fraction and oxygen consumption in neonates

de Vis J.B., Petersen E.T., Alderliesten T., Groenendaal F., de Vries L.S., van Bel F., Benders M.J.N.L., Hendrikse J. 2014, In: NeuroImage. 95 , p. 185-192 8 p.

Cortical microinfarcts on 7T MRI in patients with spontaneous intracerebral hemorrhage

van Veluw S.J., Jolink W.M.T., Hendrikse J., Geerlings M.I., Luijten P.R., Biessels G.J., Klijn C.J.M. 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34 , p. 1104-1106 3 p.

All research output

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