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prof. dr. P.A.F.M. (Pieter A.) Doevendans

prof. dr. P.A.F.M. (Pieter A.) Doevendans

Full Professor
prof. dr. P.A.F.M. (Pieter A.) Doevendans
  • Division of Heart & Lungs

Biography

Biography

Pieter A. Doevendans became a cardiologist in Maastricht (trained by H. Wellens) after his medical training at the Leiden University. In 1993-1994 he had the opportunity to work with Ken Chien at the University of California San Diego, where the work on embryonic stem cells started. The work was completed in Maastricht and provided the basis for a thesis on the function of the promoter of the atrial Myosin Light Chain gene. Upon return in The Netherlands he worked with Christine Mummery and Hans Clevers on both human Embryonic as well as human Cardiac stem cells. In the meantime he remained active as an interventional cardiologist initially in Maastricht, but from 2002 on in Utrecht at the UMC Utrecht. Here he was appointed full professor in Translational Cardiology in 2004 and head of the department in 2005. The focus of the department of cardiology is on Cardiac Failure, Stem Cells and Genetics. He was funded by various national and international foundations. Thus far (2017) he published more than 700 peer reviewed papers and 11 books

Side Activities

                                   

  • Member of the Scientific Board, Netherlands Heart Institute                                                                                         
  • Chairman Steering committee Heart and Vascular Center  
  • Advisor AMT Utrecht
  • Advisor and shareholder HeartEye                                                                          

Fellowship and Awards

 

Honors

  • Fellow of the European Society of Cardiology, 2000
  • Honorary Professor Yantai Yuhuangding Hospital, China, 2007
  • Visiting Professor Harvard University, USA, 2007-2009
  • Romanian Academy of Medical Sciences (Honorary Foreign Fellow), 2009
  • Visiting Professor Rose Weiss Lahey Hospital & Medical Center, USA, 2014

 

Research grants obtained 

  • NATO Collaborative Research Grant. 1996-1997. Travel grant for collaboration with Robert S. Kass, University of Columbia, New York USA. "Expression of min K channels in heart".
  • The Netherlands Heart Foundation: 1997-1999. "The characterization of the regulatory sequence of the atrial myosin light chain 2 gene".

  • NIH: "The role of the min K gene". Grant with R.S. Kass.

  • The Netherlands Heart Foundation: “Hypertrophic cardiomyopathy: early non-invasive identification of altered myocardial mechanics and coronary flow” (nr. 99.203) with A.C. van Rossum, VU Amsterdam.

  • The Netherlands Heart Foundation: “Characterization of the effects of estrogen on cardiac function under pathophysiologic conditions” (nr. 99.114)

  • The Netherlands Heart Foundation: “Elucidation of pathogenic genetic pathways in the hypertrophic and failing heart by micro-array-technology” (nr. 99.122) with H. Smeets, University Maastricht.

  • Jan Dekkerstichting en dr. Ludgardine Bouwmanstichting: “Adenovirale gentherapie voor boezemfibrilleren” (nr. 99-04)

  • The Netherlands Heart Foundation: “Inhibition of myocardial hypertrophy and dilatation by viral mediated blockade of intracellular signaling pathways” (nr. 2000.160)

  • ICIN: Molecular genetic basis of cardiovascular disease (2000)

  • ICIN: Human genetics and cardiovascular developement (2000)

  • NHS: Dekker program: Vanessa van Empel (2001-2004)

  • STW: Stem cell based cardiomyocyte differentiation and classification in 3 D cultures (2003)

  • BSIK: Weefsel op maat (2003)

  • Bekales Research Grant – Cardiology 2004, candidature.

  • Bekales Research Grant (2005)

  • NHS: Translational medicine: stem cell applications (2006)

  • ICIN: Stem cells from patients with genetic cardiac disease (2007)

  • BMM: SMARTCARE: cardiac repair with microtissues (2008)

  • NIRM: Stem cells as disease models (2009)

  • ZonMw: TAS (Translationeel Adult Stamcelonderzoek) Cardiomyocyte progenitor cells for clinical application in cardiac repair (2011-2015)
    Phase A1 preclinical PL €300.000 (total project  €2.0M)

  • CVON: HUSTCARE: HUman STem cells for CArdiac Repair (2012-2017)
    (Total project 0,5M)

  • CAS-NW Program: Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathie (Total project 450K)

  • Leducq (Total project 6 M€) (2018)

  • RegMed: Cardiovascular Moonshot (4 M€) (2018)

Research Output (975)

Multielectrode Contact Measurement Can Improve Long-Term Outcome of Pulmonary Vein Isolation Using Circular Single-Pulse Electroporation Ablation

Groen Marijn H.A., Van Driel Vincent J.H.M., Neven Kars, Van Wessel Harry, De Bakker Jacques M.T., Doevendans Pieter A.F., Wittkampf Fred H.M., Loh Peter, Van Es René 1 Aug 2022, In: Circulation: Arrhythmia and Electrophysiology. 15 , p. 510-518 9 p.

Follistatin-like 1 promotes proliferation of matured human hypoxic iPSC-cardiomyocytes and is secreted by cardiac fibroblasts

Peters Marijn C., Di Martino Sofia, Boelens Thomas, Qin Jiabin, van Mil Alain, Doevendans Pieter A., Chamuleau Steven A.J., Sluijter Joost P.G., Neef Klaus 9 Jun 2022, In: Molecular Therapy - Methods and Clinical Development. 25 , p. 3-16 14 p.

Life-threatening ventricular arrhythmia prediction in patients with dilated cardiomyopathy using explainable electrocardiogram-based deep neural networks

Zabihi Sammani Arjan, van de Leur Rutger R, Henkens Michiel T H M, Meine Mathias, Loh Peter, Hassink Rutger J, Oberski Daniel L, Heymans Stephane R B, Doevendans Pieter A, Asselbergs Folkert W, te Riele Anneline S J M, van Es René 1 Jun 2022, In: Europace. 24 , p. 1645-1654 10 p.

Electrocardiogram-based mortality prediction in patients with COVID-19 using machine learning

van de Leur R. R., Bleijendaal H., Taha K., Mast T., Gho J. M.I.H., Linschoten M., van Rees B., Henkens M. T.H.M., Heymans S., Sturkenboom N., Tio R. A., Offerhaus J. A., Bor W. L., Maarse M., Haerkens-Arends H. E., Kolk M. Z.H., van der Lingen A. C.J., Selder J. J., Wierda E. E., van Bergen P. F.M.M., Winter M. M., Zwinderman A. H., Doevendans P. A., van der Harst P., Pinto Y. M., Asselbergs F. W., van Es R., Tjong F. V.Y., Jun 2022, In: Netherlands Heart Journal. 30 , p. 312-318 7 p.

Circadian Dependence of the Acute Immune Response to Myocardial Infarction

Kilgallen Aoife B, van den Akker Frederieke, Feyen Dries A M, Crnko Sandra, Snijders Blok Christian J B, Gremmels Hendrik, du Pré Bastiaan C, Reijers Robin, Doevendans Pieter A, de Jager Saskia C A, Sluijter Joost P G, Sampaio-Pinto Vasco, van Laake Linda W 25 May 2022, In: Frontiers in Pharmacology. 13 , p. 1-13

Safety and feasibility study of non-invasive robot-assisted high-intensity focused ultrasound therapy for the treatment of atherosclerotic plaques in the femoral artery:protocol for a pilot study

Simons Michelle V., Groen Marijn H.A., de Borst Gert J., Leiner Tim, Doevendans Pieter A.F., Ebbini Emad, Slieker Fons J.B., van Es René, Hazenberg Constantijn E.V.B. 2 May 2022, In: BMJ Open. 12 , p. 1-10

Modifiable risk factors in adults with and without prior cardiovascular disease:findings from the Indonesian National Basic Health Research

Arsyad Dian Sidik, Westerink Jan, Cramer Maarten J., Ansar Jumriani, Wahiduddin , Visseren Frank L.J., Doevendans Pieter A., Ansariadi 5 Apr 2022, In: BMC Public Health. 22 , p. 1-11

Generation of human induced pluripotent stem cell (iPSC) lines derived from five patients carrying the pathogenic phospholamban-R14del (PLN-R14del) variant and three non-carrier family members

Mittal Nishka, Dave Jaydev, Harakalova Magdalena, van Tintelen J. Peter, Asselbergs Folkert W., Doevendans Pieter A., Costa Kevin D., Turnbull Irene C., Stillitano Francesca Apr 2022, In: Stem Cell Research. 60 , p. 1-5

Preclinical Comparison of Distal Off-Pump Anastomotic Remodeling:Hand-Sewn Versus ELANA Heart Bypass

Stecher David, Hoogewerf Marieke, van Putte Bart P., Osman Shadan, Doevendans Pieter A., Tulleken Cornelis, van Herwerden Lex, Pasterkamp Gerard, Buijsrogge Marc P. 18 Mar 2022, In: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery. 17 , p. 111-118 8 p.

Characteristics and time course of acute and chronic myocardial lesion formation after electroporation ablation in the porcine model

Neven Kars, van Driel Vincent J.H.M., Vink Aryan, du Pré Bastiaan C., van Wessel Harry, Füting Anna, Doevendans Pieter A., Wittkampf Fred H.M., van Es René Mar 2022, In: Journal of Cardiovascular Electrophysiology. 33 , p. 360-367 8 p.

All research output

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