prof. dr. P.W.B. (Patrick W.B.) Derksen
prof. dr. P.W.B. (Patrick W.B.) Derksen
- Department of Pathology
Research Programs
Biography
Biography
Patrick Derksen (1970) obtained his PhD at the department of Pathology, Academic Medical Center, Amsterdam, The Netherlands. Following his graduation in 2003, he moved to the Netherlands Cancer Institute to study the consequences inactivation of cell-cell adhesion in breast cancer development and progression. Here he developed two mouse models for human invasive lobular carcinoma (ILC), by conditional and mammary-specific knockout of E-cadherin and p53. In 2005 he was awarded an independent researcher grant from the Dutch organization for scientific research (NWO-VENI) in 2005. In 2007, he joined the Medical Oncology department as an independent researcher and head of the UMCU Mouse Cancer Clinic. He received a NWO-VIDI award in 2008. In 2010 his position was tenured as an Associate Professor at the Department of Pathology.
His group is aiming at combining expertise on adhesion molecules, cell signaling and clinically relevant mouse models to study the downstream effectors of the adherens junction complex that propel breast cancer development and progression.
Research in the Derksen laboratory is currently sponsored by grants from NWO, KWF, H2020, STW and Breast Cancer Now.
Side Activities
Chair European Lobular Breast Cancer Consortium (ELBCC)
Chair COST Action #19138 LOBSTERPOT
Scientific Advisory Board Member of the Lobular Breast Cancer Alliance (LBCA)
co-investigator POSEIDON-2-Lobular Clinical intervention trial
Fellowship and Awards
NWO-VENI 916.56.135. (2006)
AICR 07-585. (2007)
Pink Ribbon Award (2008)
NWO-VIDI 016.096.318. (2009)
KWF-UU 2011-5230 (2011)
Stichting Vrienden UMC Utrecht (2011)
KWF UU 2013-5801 (2013)
KWF-UU 2014-7201 (2015)
Research Output (49)
Ter Steege Eline J, Boer Mandy, Timmer Nikki C, Ammerlaan Carola Me, Song Ji-Ying, Derksen Patrick Wb, Hilkens John, Bakker Elvira Rm Nov 2022, In: Journal of Pathology. 258 , p. 289-299 11 p.
van der Velden Lieke M, Maas Peter, van Amersfoort Miranda, Timmermans-Sprang Elpetra P M, Mensinga Anneloes, van der Vaart Elisabeth, Malergue Fabrice, Viëtor Henk, Derksen Patrick W B, Klumperman Judith, van Agthoven Andreas, Egan David A, Mol Jan A, Strous Ger J 28 Jul 2022, In: Frontiers in Endocrinology. 13
Rätze Max A K, Koorman Thijs, Sijnesael Thijmen, Bassey-Archibong Blessing, van de Ven Robert, Enserink Lotte, Visser Daan, Jaksani Sridevi, Viciano Ignacio, Bakker Elvira R M, Richard François, Tutt Andrew, O'Leary Lynda, Fitzpatrick Amanda, Roca-Cusachs Pere, van Diest Paul J, Desmedt Christine, Daniel Juliet M, Isacke Clare M, Derksen Patrick W B 24 May 2022, In: Oncogene. 41 , p. 3507-3509 3 p.
Van Baelen K, Geukens T, Maetens M, Tjan-Heijnen V, Lord C J, Linn S, Bidard F-C, Richard F, Yang W W, Steele R E, Pettitt S J, Van Ongeval C, De Schepper M, Isnaldi E, Nevelsteen I, Smeets A, Punie K, Voorwerk L, Wildiers H, Floris G, Vincent-Salomon A, Derksen P W B, Neven P, Senkus E, Sawyer E, Kok M, Desmedt C 20 May 2022, In: Annals of oncology : official journal of the European Society for Medical Oncology. 33 , p. 769-785 17 p.
Rätze Max A K, Koorman Thijs, Sijnesael Thijmen, Bassey-Archibong Blessing, van de Ven Robert, Enserink Lotte, Visser Daan, Jaksani Sridevi, Viciano Ignacio, Bakker Elvira R M, Richard François, Tutt Andrew, O'Leary Lynda, Fitzpatrick Amanda, Roca-Cusachs Pere, van Diest Paul J, Desmedt Christine, Daniel Juliet M, Isacke Clare M, Derksen Patrick W B 20 May 2022, In: Oncogene. 41 , p. 2932-2944 13 p.
Tavares Sandra, Liv Nalan, Pasolli Milena, Opdam Mark, Rätze Max A K, Saornil Manuel, Sluimer Lilian M, Hengeveld Rutger C C, van Es Robert, van Werkhoven Erik, Vos Harmjan, Rehmann Holger, Burgering Boudewijn M T, Oosterkamp Hendrika M, Lens Susanne M A, Klumperman Judith, Linn Sabine C, Derksen Patrick W B 5 Apr 2022, In: Cell Reports. 39 , p. 1-24
Koorman Thijs, Jansen Karin A, Khalil Antoine, Haughton Peter D, Visser Daan, Rätze Max A K, Haakma Wisse E, Sakalauskaitè Gabrielè, van Diest Paul J, de Rooij Johan, Derksen Patrick W B 15 Mar 2022, In: Oncogene. 41 , p. 2458-2469 12 p.
De Schepper Maxim, Vincent-Salomon Anne, Christgen Matthias, Van Baelen Karen, Richard François, Tsuda Hitoshi, Kurozumi Sasagu, Brito Maria Jose, Cserni Gabor, Schnitt Stuart, Larsimont Denis, Kulka Janina, Fernandez Pedro Luis, Rodríguez-Martínez Paula, Olivar Ana Aula, Melendez Cristina, Van Bockstal Mieke, Kovacs Aniko, Varga Zsuzsanna, Wesseling Jelle, Bhargava Rohit, Boström Pia, Franchet Camille, Zambuko Blessing, Matute Gustavo, Mueller Sophie, Berghian Anca, Rakha Emad, van Diest Paul J., Oesterreich Steffi, Derksen Patrick W.B., Floris Giuseppe, Desmedt Christine 2022, In: Modern Pathology. 35 , p. 1812-1820 9 p.
Sflomos George, Schipper Koen, Koorman Thijs, Fitzpatrick Amanda, Oesterreich Steffi, Lee Adrian V, Jonkers Jos, Brunton Valerie G, Christgen Matthias, Isacke Clare, Derksen Patrick W B, Brisken Cathrin 1 Nov 2021, In: Cancers. 13
Christgen Matthias, Cserni Gábor, Floris Giuseppe, Marchio Caterina, Djerroudi Lounes, Kreipe Hans, Derksen Patrick W.B., Vincent-Salomon Anne 1 Aug 2021, In: Cancers. 13 , p. 1-34 34 p.