prof. dr. ir. H.M. (Hester M.) den Ruijter

prof. dr. ir. H.M. (Hester M.) den Ruijter

Full Professor
prof. dr. ir. H.M. (Hester M.) den Ruijter
  • Department of Cardiology

Research Programs

Circulatory Health



Welcome to my page. Let me introduce myself, I am Hester den Ruijter, Professor of Cardiovascular disease in women. My aim is to translate knowledge from experimental research to the patient. In women, the diagnosis of heart disease is a problem. Most available diagnostics for heart disease have been tested in men and directly translated to women. Nowadays we are increasingly becoming aware that male-derived tests do not always detect heart disease in women. There are interesting sex differences in the pathophysiology of heart disease that may explain why diagnostic tests developed in men fail to detect heart disease in women. Therefore, my goal is to obtain novel biomarkers that facilitate the diagnosis of heart disease in women. If you have any questions regarding my research, you are welcome to contact me.

Side Activities

  • Vice Chairwoman of the Young Academy of the Royal Netherlands Academy of Sciences 
  • Specialty Chief editor of Frontiers in Cardiovascular Medicine (Sex and gender section)
  • Board member of funding agency “Vrienden UMC Utrecht”. 

Fellowship and Awards

Agnites Vrolikprijs award for research impact UU (2019)

AHA Scott Grundy Award for Excellence in Metabolism Research (2010)

Research Output (209)

Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis

Slenders Lotte, Landsmeer Lennart P L, Cui Kai, Depuydt Marie A C, Verwer Maarten, Mekke Joost, Timmerman Nathalie, van den Dungen Noortje A M, Kuiper Johan, de Winther Menno P J, Prange Koen H M, Ma Wei Feng, Miller Clint L, Aherrahrou Redouane, Civelek Mete, de Borst Gert J, de Kleijn Dominique P V, Asselbergs Folkert W, den Ruijter Hester M, Boltjes Arjan, Pasterkamp Gerard, van der Laan Sander W, Mokry Michal Jan 2022, In: European heart journal open. 2

Electrocardiographic Features of Left Ventricular Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction:A Systematic Review

Van Ommen Anne-Mar, Kessler Elise Laura, Valstar Gideon, Onland-Moret N Charlotte, Cramer Maarten Jan, Rutten Frans, Coronel Ruben, Den Ruijter Hester 17 Dec 2021, In: Frontiers in cardiovascular medicine. 8 , p. 1-11

The changing landscape of the vulnerable plaque:a call for fine-tuning of preclinical models

Buono Michele F, Slenders Lotte, Wesseling Marian, Hartman Robin J G, Monaco Claudia, den Ruijter Hester M, Pasterkamp Gerard, Mokry Michal Dec 2021, In: Vascular Pharmacology. 141 , p. 1-10

Evaluation of non-invasive imaging parameters in coronary microvascular disease:a systematic review

Groepenhoff F, Klaassen R G M, Valstar G B, Bots S H, Onland-Moret N C, Den Ruijter H M, Leiner T, Eikendal A L M Dec 2021, In: BMC medical imaging. 21 , p. 1-23

Correction to:Evaluation of non-invasive imaging parameters in coronary microvascular disease: a systematic review

Groepenhof F, Klaassen R G M, Valstar G B, Bots S H, Onland-Moret N C, Ruijter H M Den, Leiner T, Eikendal A L M 20 Oct 2021, In: BMC medical imaging. 21 , p. 1-2

Sex-dependent gene co-expression in the human body

Hartman Robin J G, Mokry Michal, Pasterkamp Gerard, den Ruijter Hester M 21 Sep 2021, In: Scientific Reports. 11

2021 ESC Guidelines on cardiovascular disease prevention in clinical practice: Developed by the Task Force for cardiovascular disease prevention in clinical practice with representatives of the European Society of Cardiology and 12 medical societies With the special contribution of the European Association of Preventive Cardiology (EAPC)

Visseren Frank L.J., MacH François, Smulders Yvo M., Carballo David, Koskinas Konstantinos C., Bäck Maria, Benetos Athanase, Biffi Alessandro, Boavida José Manuel, Capodanno Davide, Cosyns Bernard, Crawford Carolyn, Davos Constantinos H., Desormais Ileana, DI Angelantonio Emanuele, Franco Oscar H., Halvorsen Sigrun, Hobbs F. D.Richard, Hollander Monika, Jankowska Ewa A., Michal Matthias, Sacco Simona, Sattar Naveed, Tokgozoglu Lale, Tonstad Serena, Tsioufis Konstantinos P., Van DIs Ineke, Van Gelder Isabelle C., Wanner Christoph, Williams Bryan, De Backer Guy, Regitz-Zagrosek Vera, Aamodt Anne Hege, Abdelhamid Magdy, Aboyans Victor, Albus Christian, Asteggiano Riccardo, Bäck Magnus, Borger Michael A., Brotons Carlos, Ielutkienė Jelena, Cifkova Renata, Cikes Maja, Cosentino Francesco, Dagres Nikolaos, De Backer Tine, Den Ruijter Hester, Kotecha DIpak, Verschuren W. M.Monique, Hollander Monika, 7 Sep 2021, In: European heart journal. 42 , p. 3227-3337 111 p.

Plasma Testosterone Levels and Atherosclerotic Plaque Gene Expression in Men With Advanced Atherosclerosis

Groepenhoff Floor, Diez Benavente Ernest, Boltjes Arjan, Timmerman Nathalie, Waissi Farahnaz, Hartman Robin J G, Onland-Moret N C, Pasterkamp Gerard, Den Ruijter Hester 14 Jun 2021, In: Frontiers in cardiovascular medicine. 8 , p. 1-10

Routine clinical care data from thirteen cardiac outpatient clinics:design of the Cardiology Centers of the Netherlands (CCN) database

Bots Sophie H, Siegersma Klaske R, Onland-Moret N Charlotte, Asselbergs Folkert W, Somsen G Aernout, Tulevski Igor I, den Ruijter Hester M, Hofstra Leonard 10 Jun 2021, In: BMC Cardiovascular Disorders. 21 , p. 1-9

Persistent Symptoms and Health Needs of Women and Men With Non-Obstructed Coronary Arteries in the Years Following Coronary Angiography

Groepenhoff Floor, Eikendal Anouk L M, Rittersma Z H Saskia, Gijsberts Crystel M, Asselbergs Folkert W, Hoefer Imo E, Pasterkamp Gerard, Rutten Frans H, Onland-Moret N Charlotte, Den Ruijter Hester M 3 May 2021, In: Frontiers in cardiovascular medicine. 8 , p. 1-8

All research output

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