prof. dr. L.S. (Linda) de Vries

prof. dr. L.S. (Linda) de Vries

Professor Emeritus
prof. dr. L.S. (Linda) de Vries
  • Birth Center Neonatology - Medical



Linda de Vries obtained her PhD degree in Utrecht (1987) with Leo van de Brande. The degree was based on data collected during a 4 year research period at the Hammersmith Postgraduate school in London where she worked with Lilly and Victor Dubowitz in the field of Neonatal Neurology. Between 1987 and 1989 she did her Pediatric Neurology fellowship in Leuven with Paul Casaer. Since 1989, she has worked in the department of Neonatology in Utrecht, where she is a professor in Neonatal Neurology since 2001.

Her research focuses on prediction of neurodevelopmental outcome in high risk preterm and full-term newborns, using neurophysiology and neuro-imaging methods.  These at risk children are also seen by her in the follow-up clinic until early childhood. She has a special interest in neonatal stroke and brain plasticity.  Her work has been published in >300 publications.


Research line

Neonatal Neurology

Most recent key publications

1: van de Aa NE, Benders MJNL, Vincken KL,Groenendaal F, de Vries LS, The course of apparent diffusion coefficient values following perinatal arterial ischemic stroke. PlosOne 2013;8(2):e56784
2: Haastert IC, Groenendaal F, Uiterwaal CSPM, Termote JUM, van der Heide-Jalving M, Eijsermans MJC, Gorter JW, Helders PJM, Jongmans MJ, de Vries LS. Decreasing incidence and severity of cerebral palsy in prematurely born children. J Pediatr 2011; 159:8
3: Van Rooij, LGM, Toet, MC , van Huffelen AC, Groenendaal F, Laan W, Zezic A, de Haan T, van Straaten ILM, Vrancken S, van Wezel G, van der Sluijs J, ter Horst H, Gavilanes D, Laroche S, Naulaers G, de Vries LS. Effect of treatment of subclinical neonatal seizures detected with continuous amplitude-integrated electroencephalographic monitoring: a randomised controlled Trial. Pediatrics. 2010;125:e358-66
4: de Vries LS, Koopman C, Groenendaal F, van Schooneveld M, Verheijen F, Verbeek E, WitkampTh D, van der Worp HB, Mancini GMS. COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage. Annals Neurol 2009; 65:12-18
5: Pressler RM, Boylan GB, Marlow N, Blennow M, Chiron C, Cross JH, de Vries LS, Hallberg B, Hellström-Westas L, Jullien V, Livingstone V, Mangum B, Murphy B, Murray D, Pons G, Rennie J, Swarte R, Toet MC, Vanhatalo S, Zohar S, for the NEonatal seizure treatment with Medication Off -patent (NEMO)consortium Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. Lancet Neurology 2015 Mar 9. pii: S1474-4422(14)70303-5

Fellowship and Awards

1: Honorary award of the German speaking society of Neuropediatrics (GNP) 2015
2: ZonMW, co-applicant, Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain (2011)
3: EU-FP7, co-applicant, NEMO1: An open label exploratory dose finding and pharmacokinetic clinical trial of bumetanide for the treatment of NEonatal seizure using Medication Off-patent. (2010)
4: Harwood Nash memorial lecture, Toronto, 2012
5: McCance Lecture (British Neonatal Society), 2004
6: Bruce Berg Visiting Professor Lecture (UCSF San Francisco), 2004

Research Output (687)

Normative mammillary body volumes:From the neonatal period to young adult

Vann Seralynne D, Zachiu Cornel, Meys Karlijn M E, Ambrosino Sara, Durston Sarah, de Vries Linda S, Groenendaal Floris, Lequin Maarten H Dec 2022, In: Neuroimage. Reports. 2 , p. 1-7

Variability in the diagnostic and management practices of post-hemorrhagic ventricular dilatation in very preterm infants across Canadian centers and comparison with European practices

Afifi J, Leijser L M, de Vries L S, Shah P S, Mitra S, Brouwer M J, Walling S, McNeely P D 30 Nov 2022, In: Journal of neonatal-perinatal medicine. 15 , p. 721-729 9 p.

Modeling gross motor developmental curves of extremely and very preterm infants using the AIMS home-video method

Suir I, Boonzaaijer M, Oudgenoeg-Paz O, Westers P, de Vries L S, van der Net J, Nuysink J, Jongmans M J 19 Nov 2022, In: Early Human Development. 175 , p. 1-10

Risk Factors for Perioperative Brain Lesions in Infants With Congenital Heart Disease:A European Collaboration

Bonthrone Alexandra F, Stegeman Raymond, Feldmann Maria, Claessens Nathalie H P, Nijman Maaike, Jansen Nicolaas J G, Nijman Joppe, Groenendaal Floris, de Vries Linda S, Benders Manon J N L, Haas Felix, Bekker Mirielle N, Logeswaran Thushiha, Reich Bettina, Kottke Raimund, Hagmann Cornelia, Latal Beatrice, Dave Hitendu, Simpson John, Pushparajah Kuberan, Austin Conal, Kelly Christopher J, Arulkumaran Sophie, Rutherford Mary A, Counsell Serena J, Knirsch Walter, Breur Johannes M P J 27 Oct 2022, In: Stroke. 53 , p. 3652-3661 10 p.

Early Determinants of Adverse Motor Outcomes in Preschool Children with a Critical Congenital Heart Defect

Sprong Maaike C A, Huijgen Barbara C H, de Vries Linda S, Talacua Hanna, van Loon Kim, Eijsermans Rian M J C, Nijman Joppe, Breur Johannes M P J, van Brussel Marco, Slieker Martijn G 16 Sep 2022, In: Journal of Clinical medicine. 11

Neurological Surveillance in Moderate-Late Preterm Infants—Results from a Dutch–Canadian Survey

Krüse-Ruijter Martine F., Boswinkel Vivian, Consoli Anna, Nijholt Ingrid M., Boomsma Martijn F., de Vries Linda S., van Wezel-Meijler Gerda, Leijser Lara M. 8 Jun 2022, In: Children (Basel, Switzerland). 9 , p. 1-11

The Mammillary Bodies:A Review of Causes of Injury in Infants and Children

Meys K. M.E., de Vries L. S., Groenendaal F., Vann S. D., Lequin M. H. 1 Jun 2022, In: American Journal of Neuroradiology. 43 , p. 802-812 11 p.

Development and Validation of a Prediction Model for Perinatal Arterial Ischemic Stroke in Term Neonates

Srivastava Ratika, Dunbar Mary, Shevell Michael, Oskoui Maryam, Basu Anna, Rivkin Michael John, Shany Eilon, de Vries Linda S, Dewey Deborah, Letourneau Nicole, Hill Michael D, Kirton Adam 1 Jun 2022, In: JAMA network open. 5 , p. 1-13

Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN):a first-in-human, open-label intervention study

Baak Lisanne M., Wagenaar Nienke, van der Aa Niek E., Groenendaal Floris, Dudink Jeroen, Tataranno Maria Luisa, Mahamuud Ubah, Verhage Cornelia H., Eijsermans Rian M.J.C., Smit Liesbeth S., Jellema Reint K., de Haan Timo R., ter Horst Hendrik J., de Boode Willem P., Steggerda Sylke J., Prins Henk Jan, de Haar Colin G., de Vries Linda S., van Bel Frank, Heijnen Cobi J., Nijboer Cora H., Benders Manon J.N.L. Jun 2022, In: The Lancet. Neurology. 21 , p. 528-536 9 p.

Ventricular volume in infants born very preterm:Relationship with Brain Maturation and Neurodevelopment at Age 4.5 Years

Sheng Min, Guo Ting, Mabbott Connor, Chau Vann, Synnes Anne, de Vries Linda S, Grunau Ruth E, Miller Steven P 10 May 2022, In: The Journal of Pediatrics. 248 , p. 51-58.e2

All research output

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