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prof. dr. D.W. (Prof.dr. D.W. (Dylan)) de Lange

prof. dr. D.W. (Prof.dr. D.W. (Dylan)) de Lange

Full Professor
prof. dr. D.W. (Prof.dr. D.W. (Dylan)) de Lange
  • Intensive Care Medicine
  • NVIC bedrijfsvoering

Research Programs

Biography

Biography

Dylan de Lange started his medical education at the University of Utrecht in 1992. After graduating he started as a resident in Internal Medicine in a teaching hospital in Amersfoort but he finished his residency in the University Medical Center in Utrecht (UMC Utrecht). Afterwards he did a fellowship in Infectious Diseases and subsequently a fellowship in Intensive Care Medicine. In 2007 he joined the medical staff of the Intensive Care Unit and the Dutch Poisons Information Center (DPIC) in the University Medical Center Utrecht, where he has been working ever since. 

Since 2017 he is full professor in Clinical Toxicology and the chair of the Dutch Poisons Information Center (www.vergiftigingen.info). As a clinical toxicologist (European Registered Toxicologist, ERT) he advises on medical treatment of intoxicated patients. The Dutch Poisons Information Center is contacted for medical advice over 150,000 times per year by other medical professionals.

He is a board member of the National Intensive Care Evaluation (NICE) Foundation, which benchmarks the all Dutch ICUs. Part of his current research is derived from this large national registry: (long term) outcome after intensive care treatment. Not only mortality is important but also the health related quality of life (HRQoL). Can we predict good/bad outcome?

From 2017 until 2020 he was the chair of the scientific section on "Health Safety Research and Outcome" (HSRO) of the European Society of Intensive Care Medicine (ESICM). Here he got involved in the (long-term) outcomes of older ICU patients. Not only survival is of importance but also the functional status and the quality of life of survivors. See www.vipstudy.org for more information.

His research interests obviously situate at the intersection of Clinical Toxicology and Intensive Care Medicine and focusses on "predicting outcome" in:

  1. critically ill intoxicated patient
  2. critically ill patients, especially in regard to the pharmacokinetics and toxicokinetics of antimicrobials and immunosuppressants 
  3. critically ill patients with the use of biomarkers

In 2019 a large European research project started looking at the (long-term) outcomes of intoxicated patients on various ICUs in the World. Can we predict outcome based on variables that ate present at admission to the hospital? This INTOXICATE study is gaining momentum and a lot of patients from all over the world have already been included in this study. For more up-to-date details, see www.toxicstudy.org 

Side Activities

Lid van de Commissie van Toezicht van de Postdoctorale Educatie Toxicologie (PET) van de Nederlandse Vereninging van Toxicologie - vanaf 2022?

Lid van de Safety commissie van de RATE-studie - sinds 2021

Lid van de werkgroep voor medicamenteuze behandeling van COVID-19 van de Stichting Werkgroep Antibiotica Beleid (SWAB) - sinds 2020 

Lid van het Expertiseteam Behandeling COVID-19 van de Federatie Medisch Specialisten (FMS) - sinds 2020 

Lid namens ESICM van de European Association of Hospital Pharmacists (EAHP) Special Interest Group (SIG) for the Investigation of Medication Errors in Intensive Care Units - sinds 2020 

Lid van de Data Safety Monitoring Board (DSMB) van de COVID-RESCAP-study - sinds 2020

Organisatie en docent van de de Multidisciplinaire Toxicologie cursus vanuit het Gemeensschappelijk Intoxicatie Forum (GIF) samenwerkingsverband - sinds 2019

Congrescommissie van de Nederlandse Vereniging van Intensive Care (NVIC) - sinds 2018 

Overleg niet-geregistreerde geneesmiddelen voor antidota en calamiteitenvoorraad i.sm. RIVM/IGJ/NVIC/CBG - sinds 2017

Podcast over intensive care gerelateerde onderwerpen samen met Bob Krijnen - sinds 2017 

VIP study group van de Health Research Services and Outcome (HSRO) section van de European Society of Intensive Care Medicine (ESICM) - sinds 2015

Vice-voorzitter van de Taskforce Infectieuze Bedreigingen van de Nederlandse Vereniging voor Intensive Care (NVIC) - sinds 2009

Secretaris van Stichting Nederlandse Intensive Care Evaluatie (NICE) - sinds 2006

Research Output (270)

Characteristics and outcome of COVID-19 patients admitted to the ICU:a nationwide cohort study on the comparison between the first and the consecutive upsurges of the second wave of the COVID-19 pandemic in the Netherlands

Dongelmans Dave A, Termorshuizen Fabian, Brinkman Sylvia, Bakhshi-Raiez Ferishta, Arbous M Sesmu, de Lange Dylan W, van Bussel Bas C T, de Keizer Nicolette F, Dec 2022, In: Annals of Intensive Care. 12

Comparison of outcome and characteristics between 6343 COVID-19 patients and 2256 other community-acquired viral pneumonia patients admitted to Dutch ICUs

Brinkman S, Termorshuizen F, Dongelmans D A, Bakhshi-Raiez F, Arbous M S, de Lange D W, de Keizer N F, Apr 2022, In: Journal of Critical Care. 68 , p. 76-82 7 p.

Health-related quality of life in older patients surviving ICU treatment for COVID-19::results from an international observational study of patients older than 70 years

Soliman Ivo W, Leaver Susannah, Flaatten Hans, Fjølner Jesper, Wernly Bernhard, Bruno Raphael R, Artigas Antonio, Bollen Pinto Bernardo, Schefold Joerg C, Beil Michael, Sviri Sigal, van Heerden Peter Vernon, Szczeklik Wojciech, Elhadi Muhammed, Joannidis Michael, Oeyen Sandra, Zafeiridis Tilemachos, Wollborn Jakob, Banzo Maria Jose Arche, Fuest Kristina, Marsh Brian, Andersen Finn H, Moreno Rui, Boumendil Ariane, Guidet Bertrand, Jung Christian, De Lange Dylan W, 2 Feb 2022, In: Age and ageing. 51 , p. 1-10 10 p.

Alarming increase in poisonings from recreational nitrous oxide use after a change in EU-legislation, inquiries to the Dutch Poisons Information Center

van Riel Antoinette, Hunault C C, van den Hengel-Koot I S, Nugteren-van Lonkhuyzen Annette, de Lange D W, Hondebrink L Feb 2022, In: The International journal on drug policy. 100

The importance of revealing data on limitation of life sustaining therapy in critical ill elderly Covid-19 patients

Flaatten Hans, Guidet Bertrand, de Lange Dylan W, Beil Michael, Leaver Susannah K, Fjølner Jesper, van Heerden Peter Vernon, Sigal Sviri, Szczeklik Wojciech, Jung Christian Feb 2022, In: Journal of Critical Care. 67 , p. 147-148 2 p.

Response to:MR-proADM has a good ability to predict mortality in critically ill patients with SARS-CoV-2 pneumonia: Beware of some potential confounders!

van Oers Jos A H, de Grooth Harm-Jan, de Lange Dylan W, Girbes Armand R J Feb 2022, In: Journal of Critical Care. 67 , p. 214-215 2 p.

Can we reliably automate clinical prognostic modelling?:A retrospective cohort study for ICU triage prediction of in-hospital mortality of COVID-19 patients in the Netherlands

Vagliano I, Brinkman S, Abu-Hanna A, Arbous M S, Dongelmans D A, Elbers P W G, de Lange D W, van der Schaar M, de Keizer N F, Schut M C, 22 Jan 2022, In: International Journal of Medical Informatics. 160 , p. 1-12 12 p.

Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 - Insights from the PRoVENT-COVID study

Roozeman Jan-Paul, Mazzinari Guido, Serpa Neto Ary, Hollmann Markus W, Paulus Frederique, Schultz Marcus J, Pisani Luigi, , Cremer Olaf, de Lange Prof.dr. D.W. (Dylan) 3 Dec 2021, In: Journal of Critical Care. 68 , p. 31-37 7 p.

Management and outcomes in critically ill nonagenarian versus octogenarian patients

Bruno Raphael Romano, Wernly Bernhard, Kelm Malte, Boumendil Ariane, Morandi Alessandro, Andersen Finn H., Artigas Antonio, Finazzi Stefano, Cecconi Maurizio, Christensen Steffen, Faraldi Loredana, Lichtenauer Michael, Muessig Johanna M., Marsh Brian, Moreno Rui, Oeyen Sandra, Öhman Christina Agvald, Pinto Bernardo Bollen, Soliman Ivo W., Szczeklik Wojciech, Valentin Andreas, Watson Ximena, Leaver Susannah, Boulanger Carole, Walther Sten, Schefold Joerg C., Joannidis Michael, Nalapko Yuriy, Elhadi Muhammed, Fjølner Jesper, Zafeiridis Tilemachos, De Lange Dylan W., Guidet Bertrand, Flaatten Hans, Jung Christian, Dec 2021, In: BMC Geriatrics [E]. 21 , p. 1-14

Publisher Correction:Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis

Wernly Bernhard, Bruno Raphael Romano, Kelm Malte, Boumendil Ariane, Morandi Alessandro, Andersen Finn H, Artigas Antonio, Finazzi Stefano, Cecconi Maurizio, Christensen Steffen, Faraldi Loredana, Lichtenauer Michael, Muessig Johanna M, Marsh Brian, Moreno Rui, Oeyen Sandra, Öhman Christina Agvald, Pinto Bernado Bollen, Soliman Ivo W, Szczeklik Wojciech, Niederseer David, Valentin Andreas, Watson Ximena, Leaver Susannah, Boulanger Carole, Walther Sten, Schefold Joerg C, Joannidis Michael, Nalapko Yuriy, Elhadi Muhammed, Fjølner Jesper, Zafeiridis Tilemachos, De Lange Dylan W, Guidet Bertrand, Flaatten Hans, Jung Christian Dec 2021, In: Scientific Reports. 11 1 p.

All research output

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