prof. dr. W.L. (Wouter) de Laat

prof. dr. W.L. (Wouter) de Laat

Full Professor
prof. dr. W.L. (Wouter) de Laat
  • Group Burgering, section Molecular Cancer Research
  • Department of Genetics
  • Department of Genetics

Research Programs



Wouter de Laat studied biology at the Utrecht University. During his PhD (1998) at the Erasmus University Rotterdam (Prof. Jan Hoeijmakers) he investigated the molecular mechanism of nucleotide excision repair. He identified one of the nucleases and characterized the interplay between repair factors at the site of the lesion. As a postdoc, he joined the group of Prof. Frank Grosveld to work on beta-globin gene activation. In 2000 he received a career grant (VIDI) to work on long-range gene activation. His group used 3C technology, and later developed 4C technology, to demonstrate chromatin loops between genes and enhancers and to uncover long-range DNA contacts within and between chromosomes.
In 2008 he received an ERC Young Investigator Grant. In September 2008 de Laat moved his group to the Hubrecht Institute, where he continued his work on genome structure and function. In January 2009 he was appointed professor in Biomedical Genomics at the University Medical Center Utrecht. He received a prestigious VICI career grant in 2012.

Side Activities

  • Mentor UAF, Universitair Asielfonds    
  • Founder of Cergentis. Cergentis was acquired by Solvias in 2022. Wouter de Laat no longer has financial interest/role in Cergentis.
  • Scientific Advisory Board Max Planck Institute for Molecular Genetics Berlin

Fellowship and Awards

VIDI (2000)

VICI (2012)

ERC Starting Grant (2008)

EMBO Member

Research Output (91)

Formalin-Fixed, Paraffin-Embedded-Targeted Locus Capture:A Next-Generation Sequencing Technology for Accurate DNA-Based Gene Fusion Detection in Bone and Soft Tissue Tumors

Stelloo Ellen, Meijers Ruud W J, Swennenhuis Joost F, Allahyar Amin, Hajo Karima, Cangiano Mario, de Leng Wendy W J, van Helvert Sjoerd, Van der Meulen Joni, Creytens David, van Kempen Léon C, Cleton-Jansen Anne-Marie, Bovee Judith V M G, de Laat Wouter, Splinter Erik, Feitsma Harma 28 Jul 2023, In: Journal of Molecular Diagnostics. 25 , p. 758-770 13 p.

Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia

Smits Willem K, Vermeulen Carlo, Hagelaar Rico, Kimura Shunsuke, Vroegindeweij Eric M, Buijs-Gladdines Jessica G C A M, van de Geer Ellen, Verstegen Marjon J A M, Splinter Erik, van Reijmersdal Simon V, Buijs Arjan, Galjart Niels, van Eyndhoven Winfried, van Min Max, Kuiper Roland, Kemmeren Patrick, Mullighan Charles G, de Laat Wouter, Meijerink Jules P P 13 Apr 2023, In: Cell Reports. 42 25 p.

Current challenges in understanding the role of enhancers in disease

Zaugg Judith Barbara, Sahlén Pelin, Andersson Robin, Alberich-Jorda Meritxell, de Laat Wouter, Deplancke Bart, Ferrer Jorge, Mandrup Susanne, Natoli Gioacchino, Plewczynski Dariusz, Rada-Iglesias Alvaro, Spicuglia Salvatore Dec 2022, In: Nature Structural and Molecular Biology. 29 , p. 1148-1158 11 p.

Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes

Rinzema Niels J., Sofiadis Konstantinos, Tjalsma Sjoerd J.D., Verstegen Marjon J.A.M., Oz Yuva, Valdes-Quezada Christian, Felder Anna Karina, Filipovska Teodora, van der Elst Stefan, de Andrade dos Ramos Zaria, Han Ruiqi, Krijger Peter H.L., de Laat Wouter Jun 2022, In: Nature Structural and Molecular Biology. 29 , p. 563-574 12 p.

Role of the cellular factor CTCF in the regulation of bovine leukemia virus latency and three-dimensional chromatin organization

Bellefroid Maxime, Rodari Anthony, Galais Mathilde, Krijger Peter H.L., Tjalsma Sjoerd J.D., Nestola Lorena, Plant Estelle, Vos Erica S.M., Cristinelli Sara, Van Driessche Benoit, Vanhulle Caroline, Ait-Ammar Amina, Burny Arsène, Ciuffi Angela, De Laat Wouter, Van Lint Carine 8 Apr 2022, In: Nucleic acids research. 50 , p. 3190-3202 13 p.

A public–private partnership model for COVID-19 diagnostics

Krijger Peter H.L., Hoek Tim A., Boersma Sanne, Donders Lieke I.P.M., Broeders Maaike M.C., Pieterse Mark, Toonen Pim W., Logister Ive, Verhagen Bram M.P., Verstegen Marjon J.A.M., van Ravesteyn Thomas W., Roymans Rene J.T.M., Mattiroli Francesca, Vandesompele Jo, Nijhuis Monique, Meijer Stefan, van Weert Anton, Dekker Edwin, Dom Fred J., Ruijtenbeek Rob, van der Velden Lieven B.J., van de Bovenkamp Jeroen H.B., Bosch Martijn, de Laat Wouter, Tanenbaum Marvin E. Oct 2021, In: Nature Biotechnology. 39 , p. 1182-1184 3 p.

Interplay between CTCF boundaries and a super enhancer controls cohesin extrusion trajectories and gene expression

Vos Erica S.M., Valdes-Quezada Christian, Huang Yike, Allahyar Amin, Verstegen Marjon J.A.M., Felder Anna Karina, van der Vegt Floor, Uijttewaal Esther C.H., Krijger Peter H.L., de Laat Wouter 5 Aug 2021, In: Molecular Cell. 81 , p. 3082-3095.e6

Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing

Allahyar Amin, Pieterse Mark, Swennenhuis Joost, Los-de Vries G. Tjitske, Yilmaz Mehmet, Leguit Roos, Meijers Ruud W.J., van der Geize Robert, Vermaat Joost, Cleven Arjen, van Wezel Tom, Diepstra Arjan, van Kempen Léon C., Hijmering Nathalie J., Stathi Phylicia, Sharma Milan, Melquiond Adrien S.J., de Vree Paula J.P., Verstegen Marjon J.A.M., Krijger Peter H.L., Hajo Karima, Simonis Marieke, Rakszewska Agata, van Min Max, de Jong Daphne, Ylstra Bauke, Feitsma Harma, Splinter Erik, de Laat Wouter 7 Jun 2021, In: Nature Communications. 12 , p. 1-15

Novel orthogonal methods to uncover the complexity and diversity of nuclear architecture

Tjalsma Sjoerd Jd, de Laat Wouter Apr 2021, In: Current Opinion in Genetics & Development. 67 , p. 10-17 8 p.

How chromosome topologies get their shape:views from proximity ligation and microscopy methods

Huang Yike, Neijts Roel, de Laat Wouter Nov 2020, In: FEBS letters. 594 , p. 3439-3449 11 p.

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical uses cookies

This website uses cookies This website displays videos from, among others, YouTube. Such parties place cookies (third-party cookies). If you do not want these cookies, you can indicate that here. We also place cookies ourselves to improve our site.

Read more about the cookie policy

Agree No, rather not