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prof. dr. ir. E.P.J.G. (Edwin) Cuppen

prof. dr. ir. E.P.J.G. (Edwin) Cuppen

Full Professor
prof. dr. ir. E.P.J.G. (Edwin) Cuppen
  • Group Cuppen, section Genetics

Biography

Biography

Edwin Cuppen is initiator and scientific director of the Hartwig Medical Foundation (part-time since 2015 and full time since 2021), a not-for-profit organisation that aims to improve cancer care by systematic whole genome sequencing analysis of tumors and that also maintains one of the world’s largest databases of cancer whole genome sequencing data enriched with clinical patient data. After his undergraduate and PhD training at Wageningen University and Radboud University Nijmegen as a molecular geneticist, he held research and group leader positions at the Netherlands Cancer Institute, the Hubrecht Institute and the UMC Utrecht. His expertise is in cancer genomics and functional genetics.

Side Activities

Academic advisory activities

Scientific Advisory Board InteRNA Technologies BV (miRNA-based therapeutics) (personal remuneration)

Advisory Board Clinical Whole Genome Sequencing Illumina (remuneration transfered to employer)

Employment at other organisation

Full time Scientific Director Hartwig Medical Foundation

Minimal appointment at UMC Utrecht

Fellowship and Awards

European Young Investigator Award 2005

NWO Vici grant 2013

Research Output (358)

Distinct Genomic Profiles Are Associated with Treatment Response and Survival in Ovarian Cancer

de Witte Chris J, Kutzera Joachim, van Hoeck Arne, Nguyen Luan, Boere Ingrid A, Jalving Mathilde, Ottevanger Petronella B, van Schaik-van de Mheen Christa, Stevense Marion, Kloosterman Wigard P, Zweemer Ronald P, Cuppen Edwin, Witteveen Petronella O 2 Mar 2022, In: Cancers. 14 , p. 1-18

Precancerous liver diseases do not cause increased mutagenesis in liver stem cells

Nguyen Luan, Jager Myrthe, Lieshout Ruby, de Ruiter Petra E, Locati Mauro D, Besselink Nicolle, van der Roest Bastiaan, Janssen Roel, Boymans Sander, de Jonge Jeroen, IJzermans Jan N M, Doukas Michail, Verstegen Monique M A, van Boxtel Ruben, van der Laan Luc J W, Cuppen Edwin, Kuijk Ewart 18 Nov 2021, In: Communications biology. 4

The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets

van Riet Job, van de Werken Harmen J G, Cuppen Edwin, Eskens Ferry A L M, Tesselaar Margot, van Veenendaal Linde M, Klümpen Heinz-Josef, Dercksen Marcus W, Valk Gerlof D, Lolkema Martijn P, Sleijfer Stefan, Mostert Bianca 29 Jul 2021, In: Nature Communications. 12 , p. 1-14

Early technology assessment of using whole genome sequencing in personalized oncology

Simons Martijn, van de Ven Michiel, Coupé Veerle, Joore Manuela, IJzerman Maarten, Koffijberg Erik, Frederix Geert, Uyl-De Groot Carin, Cuppen Edwin, van Harten Wim, Retèl Valesca 3 Jun 2021, In: Expert Review of Pharmacoeconomics and Outcomes Research. 21 , p. 343-351 9 p.

VIRUSBreakend:Viral Integration Recognition Using Single Breakends

Cameron Daniel L, Jacobs Nina, Roepman Paul, Priestley Peter, Cuppen Edwin, Papenfuss Anthony T 11 May 2021, In: Bioinformatics (Oxford, England). 37 , p. 3115-3119

Clinical Validation of Whole Genome Sequencing for Cancer Diagnostics

Roepman Paul, de Bruijn Ewart, van Lieshout Stef, Schoenmaker Lieke, Boelens Mirjam C., Dubbink Hendrikus J., Geurts-Giele Willemina R.R., Groenendijk Floris H., Huibers Manon M.H., Kranendonk Mariëtte E.G., Roemer Margaretha G.M., Samsom Kris G., Steehouwer Marloes, de Leng Wendy W.J., Hoischen Alexander, Ylstra Bauke, Monkhorst Kim, van der Hoeven Jacobus J.M., Cuppen Edwin 5 May 2021, In: Journal of Molecular Diagnostics. 23 , p. 816-833 18 p.

Prospective experimental treatment of colorectal cancer patients based on organoid drug responses

Ooft S. N., Weeber F., Schipper L., Dijkstra K. K., McLean C. M., Kaing S., van de Haar J., Prevoo W., van Werkhoven E., Snaebjornsson P., Hoes L. R., Chalabi M., van der Velden D., van Leerdam M., Boot H., Grootscholten C., Huitema A. D.R., Bloemendal H. J., Cuppen E., Voest E. E. 19 Apr 2021, In: ESMO open. 6 , p. 100103 1 p.

Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features

Mendelaar Pauline A J, Smid Marcel, van Riet Job, Angus Lindsay, Labots Mariette, Steeghs Neeltje, Hendriks Mathijs P, Cirkel Geert A, van Rooijen Johan M, Ten Tije Albert J, Lolkema Martijn P, Cuppen Edwin, Sleijfer Stefan, Martens John W M, Wilting Saskia M 25 Jan 2021, In: Nature Communications. 12 11 p.

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

Bollen Yannik, Stelloo Ellen, van Leenen Petra, van den Bos Myrna, Ponsioen Bas, Lu Bingxin, van Roosmalen Markus J., Bolhaqueiro Ana C.F., Kimberley Christopher, Mossner Maximilian, Cross William C.H., Besselink Nicolle J.M., van der Roest Bastiaan, Boymans Sander, Oost Koen C., de Vries Sippe G., Rehmann Holger, Cuppen Edwin, Lens Susanne M.A., Kops Geert J.P.L., Kloosterman Wigard P., Terstappen Leon W.M.M., Barnes Chris P., Sottoriva Andrea, Graham Trevor A., Snippert Hugo J.G. 2021, In: Nature Genetics. 53 , p. 1187-1195 9 p.

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Verstegen Monique M A, Roos Floris J M, Burka Ksenia, Gehart Helmuth, Jager Myrthe, de Wolf Maaike, Bijvelds Marcel J C, de Jonge Hugo R, Ardisasmita Arif I, van Huizen Nick A, Roest Henk P, de Jonge Jeroen, Koch Michael, Pampaloni Francesco, Fuchs Sabine A, Schene Imre F, Luider Theo M, van der Doef Hubert P J, Bodewes Frank A J A, de Kleine Ruben H J, Spee Bart, Kremers Gert-Jan, Clevers Hans, IJzermans Jan N M, Cuppen Edwin, van der Laan Luc J W 14 Dec 2020, In: Scientific Reports. 10 , p. 1-16 16 p.

All research output

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