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prof. dr. J.C. (Hans) Clevers

Full Professor

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Research Output (566)

Establishment of Pancreatic Organoids from Normal Tissue and Tumors

Driehuis Else, Gracanin Ana, Vries Robert Gerhardus Jacob, Clevers Hans, Boj Sylvia Fernández 18 dec 2020, In: STAR protocols. 1 , p. 100192

Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Verstegen Monique M A, Roos Floris J M, Burka Ksenia, Gehart Helmuth, Jager Myrthe, de Wolf Maaike, Bijvelds Marcel J C, de Jonge Hugo R, Ardisasmita Arif I, van Huizen Nick A, Roest Henk P, de Jonge Jeroen, Koch Michael, Pampaloni Francesco, Fuchs Sabine A, Schene Imre F, Luider Theo M, van der Doef Hubert P J, Bodewes Frank A J A, de Kleine Ruben H J, Spee Bart, Kremers Gert-Jan, Clevers Hans, IJzermans Jan N M, Cuppen Edwin, van der Laan Luc J W 14 dec 2020, In: Scientific Reports. 10 , p. 1-16 16 p.

Single-cell derived tumor organoids display diversity in HLA class I peptide presentation

Demmers Laura C, Kretzschmar Kai, Van Hoeck Arne, Bar-Epraïm Yotam E, van den Toorn Henk W P, Koomen Mandy, van Son Gijs, van Gorp Joost, Pronk Apollo, Smakman Niels, Cuppen Edwin, Clevers Hans, Heck Albert J R, Wu Wei 1 dec 2020, In: Nature Communications. 11 , p. 1-10

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/beta-catenin pathway activation

Cho Yong-Hee, Ro Eun Ji, Yoon Jeong-Su, Mizutani Tomohiro, Kang Dong-Woo, Park Jong-Chan, Il Kim Tae, Clevers Hans, Choi Kang-Yell 1 dec 2020, In: Nature Communications. 11

Human-Derived Model Systems in Gynecological Cancer Research

Lõhmussaar Kadi, Boretto Matteo, Clevers Hans dec 2020, In: Trends in Cancer. 6 , p. 1031-1043 13 p.

Hepatocyte growth factor/MET and CD44 in colorectal cancer:partners in tumorigenesis and therapy resistance

Joosten Sander P.J., Spaargaren Marcel, Clevers Hans, Pals Steven T. dec 2020, In: Biochimica et Biophysica Acta - Reviews on Cancer. 1874 , p. 188437

Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles

Yan Helen H N, Siu Hoi Cheong, Ho Siu Lun, Yue Sarah S K, Gao Yang, Tsui Wai Yin, Chan Dessy, Chan April S, Wong Jason W H, Man Alice H Y, Lee Bernard C H, Chan Annie S Y, Chan Anthony K W, Hui Ho Sang, Cheung Arthur K L, Law Wai Lun, Lo Oswens S H, Yuen Siu Tsan, Clevers Hans, Leung Suet Yi dec 2020, In: Gut. 69 , p. 2165-2179 15 p.

Author Correction:Fasting-mimicking diet and hormone therapy induce breast cancer regression

Caffa Irene, Spagnolo Vanessa, Vernieri Claudio, Valdemarin Francesca, Becherini Pamela, Wei Min, Brandhorst Sebastian, Zucal Chiara, Driehuis Else, Ferrando Lorenzo, Piacente Francesco, Tagliafico Alberto, Cilli Michele, Mastracci Luca, Vellone Valerio G, Piazza Silvano, Cremonini Anna Laura, Gradaschi Raffaella, Mantero Carolina, Passalacqua Mario, Ballestrero Alberto, Zoppoli Gabriele, Cea Michele, Arrighi Annalisa, Odetti Patrizio, Monacelli Fiammetta, Salvadori Giulia, Cortellino Salvatore, Clevers Hans, De Braud Filippo, Sukkar Samir G, Provenzani Alessandro, Longo Valter D, Nencioni Alessio dec 2020, In: Nature. 588 , p. E33

Translation and Replication Dynamics of Single RNA Viruses

Boersma Sanne, Rabouw Huib H, Bruurs Lucas J M, Pavlovič Tonja, van Vliet Arno L W, Beumer Joep, Clevers Hans, van Kuppeveld Frank J M, Tanenbaum Marvin E 6 nov 2020, In: Cell. 183 , p. 1930-1945 e1-13

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

Miao Yi, Ha Andrew, de Lau Wim, Yuki Kanako, Santos António J M, You Changjiang, Geurts Maarten H, Puschhof Jens, Pleguezuelos-Manzano Cayetano, Peng Weng Chuan, Senlice Ramazan, Piani Carol, Buikema Jan W, Gbenedio Oghenekevwe M, Vallon Mario, Yuan Jenny, de Haan Sanne, Hemrika Wieger, Rösch Kathrin, Dang Luke T, Baker David, Ott Melanie, Depeille Philippe, Wu Sean M, Drost Jarno, Nusse Roeland, Roose Jeroen P, Piehler Jacob, Boj Sylvia F, Janda Claudia Y, Clevers Hans, Kuo Calvin J, Garcia K Christopher 5 nov 2020, In: Cell stem cell. 27 , p. 840-851.e6