prof. dr. W. (Wiepke) Cahn

prof. dr. W. (Wiepke) Cahn

Full Professor
prof. dr. W. (Wiepke) Cahn
  • Psychiatry

Research Programs




Prof. Wiepke Cahn has been a research psychiatrist at the University Medical Center Utrecht since 1996. In 2003 she obtained her PhD titled ‘brain morphology during the early course of schizophrenia’. She has set up various (multicenter) research projects, including GROUP. She has been chief psychiatrist for the schizophrenia program at the UMCUtrecht and project manager for the Utrecht Youth Cohort. Currently she is heading the ‘body & life’ clinic at the department of psychiatry. In 2016 she was appointed professor of psychiatry. Her research interest is the physical (ill-)health in psychiatric disorders and lifestyle psychiatry.

Wiepke Cahn has (co)authored more than 300 papers and book chapters and has been chief editor of ‘handboek schizofrenie spectrum stoornissen’ and author of 'focus op familie'. Her non-research-based activities consist of treating patients and their families with psychotic and affective disorders.

Research Line

Physical health in psychiatric disorders and lifestyle psychiatry.

Most recent key publications

  1. Liemburg EJ, Bruins J, van Beveren N, Islam MA, Alizadeh BZ; GROUP investigators. Cannabis and a lower BMI in psychosis: What is the role of AKT1? Schizophr Res. 2016 Oct;176(2-3):95-9.
  2. de Nijs J, Pet MA; GROUP Investigators.. Metabolic syndrome in schizophrenia patients associated with poor premorbid school performance in early adolescence. Acta Psychiatr Scand. 2016 Apr;133(4):289-97.
  3. Scheewe TW, Backx FJ, Takken T, Jörg F, van Strater AC, Kroes AG, Kahn RS, Cahn W. Exercise therapy improves mental and physical health in schizophrenia: a randomised controlled trial. Acta Psychiatr Scand. 2013 Jun;127(6):464-73.
  4. Welie H, Derks EM, Verweij KH, de Valk HW, Kahn RS, Cahn W. The prevalence of diabetes mellitus is increased in relatives of patients with a non-affective psychotic disorder. Schizophr Res. 2013 Feb;143(2-3):354-7.
  5. Cahn W, Ramlal D, Bruggeman R, de Haan L, Scheepers FE, van Soest MM, Assies J, Slooff CJ. [Prevention and treatment of somatic complications arising from the use of antipsychotics]. Tijdschr Psychiatr. 2008;50(9):579-91.


Side Activities

GGz Breburg Supervisory Board

Full Professor, Altrecht Science

Fellowship and Awards

  • Move2 project - 
  • Tactic project -
  • Lifestyle - A multi-modal lifestyle intervention program in routine clinical care for children with mental disorders.
  • Focus
  • Melia project -  
  • Psychosis Prognosis Predictor 
  • Genetic Risk and Outcome of Psychosis (GROUP project) Collaboration between AMC, UMCG en Universiteit van Maastricht and various psychiatric institutions in the Netherlands
  • Topfit project – i.s.m. met sportgeneeskunde
  • GRUMPY or Depressed – i.s.m. de sociale faculteit UU
  • Adding in- and outpatient parmacotherapeutic treatment information – i.s.m. de faculteit farmaceutische wetenschappen
  • International panel study on the appropriate pharmacological management of early schizophrenia – RAND/UCLA study

Research Output (324)

Genetic variants associated with longitudinal changes in brain structure across the lifespan

Brouwer Rachel M, Klein Marieke, Grasby Katrina L, Schnack Hugo G, Jahanshad Neda, Teeuw Jalmar, Thomopoulos Sophia I, Sprooten Emma, Franz Carol E, Gogtay Nitin, Kremen William S, Panizzon Matthew S, Olde Loohuis Loes M, Whelan Christopher D, Aghajani Moji, Alloza Clara, Alnæs Dag, Artiges Eric, Ayesa-Arriola Rosa, Barker Gareth J, Bastin Mark E, Blok Elisabet, Bøen Erlend, Breukelaar Isabella A, Bright Joanna K, Buimer Elizabeth E L, Bülow Robin, Cannon Dara M, Ciufolini Simone, Crossley Nicolas A, Damatac Christienne G, Dazzan Paola, de Mol Casper L, de Zwarte Sonja M C, Desrivières Sylvane, Díaz-Caneja Covadonga M, Janssen Joost, Koevoets Martijn G J C, Mandl René C W, Setiaman Nikita, van Haren Neeltje E M, Westeneng Henk-Jan, van Eijk Kristel R, Cahn Wiepke, Hillegers Manon, Kahn Rene S, Ophoff Roel A, van den Berg Leonard H, Veldink Jan H, Hulshoff Pol Hilleke E, Apr 2022, In: Nature Neuroscience. 25 , p. 421-432 12 p.

Effectiveness and implementation of a multidisciplinary lifestyle focused approach in the treatment of inpatients with mental illness (MULTI +):a stepped wedge study protocol

den Bleijker N M, van Schothorst M M E, Hendriksen I J M, Cahn W, de Vries N K, van Harten P N, Deenik J 31 Mar 2022, In: BMC Psychiatry. 22 , p. 230

Validation and recalibration of OxMIV in predicting violent behaviour in patients with schizophrenia spectrum disorders

Lamsma Jelle, Yu Rongqin, Fazel Seena, van Amelsvoort Therese, Bartels-Velthuis Agna, Cahn Wiepke, de Haan Lieuwe, Schirmbeck Frederike, Simons Claudia, 10 Jan 2022, In: Scientific Reports. 12 , p. 1-7

Stemmings- en angststoornissen als risicofactor voor cardiovasculaire ziekten

Quadackers Davy M.C., Cath Danielle C., Liemburg Edith J., Houtman Ingrid E.M., Oud Marian J.T., Berger Marjolein Y., Cahn Wiepke, Mulder Hans 28 Oct 2021, In: Nederlands Tijdschrift voor Geneeskunde. 165

The impact of childhood sexual trauma on intimacy and sexuality needs among people with non-affective psychosis

de Jager Jose, Topper Maurice, Nugter Annet, van Os Jim, van Amelsvoort Therese, Bartels-Velthuis Agna A., Bruggeman Richard, Cahn Wiepke, de Haan Lieuwe, Schirmbeck Frederike, Simons Claudia J.P., Oct 2021, In: Schizophrenia Research. 236 , p. 97-103 7 p.

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Mullins Niamh, Kang JooEun, Campos Adrian I, Coleman Jonathan R I, Edwards Alexis C, Galfalvy Hanga, Levey Daniel F, Lori Adriana, Shabalin Andrey, Starnawska Anna, Su Mei-Hsin, Watson Hunna J, Adams Mark, Awasthi Swapnil, Gandal Michael, Hafferty Jonathan D, Hishimoto Akitoyo, Kim Minsoo, Okazaki Satoshi, Otsuka Ikuo, Ripke Stephan, Ware Erin B, Bergen Andrew W, Berrettini Wade H, Bohus Martin, Brandt Harry, Chang Xiao, Chen Wei J, Chen Hsi-Chung, Crawford Steven, Crow Scott, DiBlasi Emily, Duriez Philibert, Fernández-Aranda Fernando, Fichter Manfred M, Gallinger Steven, Glatt Stephen J, Gorwood Philip, Guo Yiran, Hakonarson Hakon, Halmi Katherine A, Hwu Hai-Gwo, Jain Sonia, Jamain Stéphane, Jiménez-Murcia Susana, Johnson Craig, Boks Marco P, Cahn Wiepke, Kahn René S, Ophoff Roel A, 9 Sep 2021, In: Biological Psychiatry. 91 , p. 313-327 15 p.

The effect of psychiatric comorbidities on treatment decisions for - and survival after radiotherapy

Boersma H., Peters M., Cahn W., Verhoeff J. J. Aug 2021, In: Radiotherapy and Oncology. 161 , p. S1231-S1233

Individualized prediction of three- and six-year outcomes of psychosis in a longitudinal multicenter study:a machine learning approach

de Nijs Jessica, Burger Thijs J, Janssen Ronald J, Kia Seyed Mostafa, van Opstal Daniël P J, de Koning Mariken B, de Haan Lieuwe, Cahn Wiepke, Schnack Hugo G, 2 Jul 2021, In: npj Schizophrenia. 7 11 p.

Sex Differences in Lifespan Trajectories and Variability of Human Sulcal and Gyral Morphology

Díaz-Caneja Covadonga M, Alloza Clara, Gordaliza Pedro M, Fernández-Pena Alberto, de Hoyos Lucía, Santonja Javier, Buimer Elizabeth E L, van Haren Neeltje E M, Cahn Wiepke, Arango Celso, Kahn René S, Hulshoff Pol Hilleke E, Schnack Hugo G, Janssen Joost 26 Jun 2021, In: Cerebral Cortex. 31 , p. 5107-5120 14 p.

Relationship between social cognition, general cognition, and risk for suicide in individuals with a psychotic disorder

Dickhoff Justine, Opmeer Esther Marije, Heering Henriette Dorotheé, Bruggeman Richard, van Amelsvoort Therese, Bartels-Velthuis Agna A., Cahn Wiepke, de Haan Lieuwe, Schirmbeck Frederike, Simons Claudia J.P., van Os Jim, Aleman André, van Tol Marie José 14 May 2021, In: Schizophrenia Research. 231 , p. 227-236 10 p.

All research output

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