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prof. dr. K.P.J. (Kees) Braun

prof. dr. K.P.J. (Kees) Braun

Full Professor
prof. dr. K.P.J. (Kees) Braun
  • Neurologen

Research Programs

Brain

Biography

Biography

Kees Braun obtained his Medical Degree at Utrecht University in January 1992. He specialized in Neurology (registered in 2000) and Paediatric Neurology (registered in 2002) in the UMC Utrecht. In 2000 he obtained his PhD degree on a thesis entitled “Magnetic Resonance Spectroscopy in Hydrocephalus. He was appointed as staff neurologist in 2000 and paediatric neurologist in 2002. Since 2011 he is head of Paediatric Neurology/Neurosurgery.  In May 2012 he was appointed as a full professor of Paediatric Neurology.

His clinical and scientific areas of expertise are: refractory paediatric epilepsy, epilepsy surgery,  imaging in epilepsy, and childhood arteriopathic stroke, in particular moyamoya treatment.

He coordinates epilepsy research in the  UMCU Brain center. The epilepsy research projects he is personally involved in  focus on the effects of focal epilepsy on the brain in animal models and patients (structural and functional integrity and network analysis); seizure- and cognitive outcome after paediatric epilepsy surgery; postoperative antiepileptic drug withdrawal; ESES treatment; stress and epilepsy; and epileptic focus detection in surgical candidates.

Kees Braun currently is president of the Dutch Society of Paediatric Neurology and of the organizing committee of the 2016 world congress of child neurology (ICNC) in Amsterdam. He is member of the European Task Force for Epilepsy Surgery in Children (U-Task), the European Network for Epilepsy Research (ENER), and work-package leader of the EU-funded E-PILEPSY project.

Research line

Refractory epilepsy

Most recent key publications

1: Boshuisen K, Arzimanoglou A, Cross JH, Uiterwaal CS, Polster T, van Nieuwenhuizen O, Braun KP; for the TimeToStop study Group. Timing of antiepileptic drug withdrawal and long-term seizure outcome after paediatric epilepsy surgery (TimeToStop): a retrospective observational study. Lancet Neurol 2012:11:784-791
2: Van Campen JS, Jansen FE, Pet MA, Otte WM, Hillegers MH, Joels M, Braun KP. Relation between stress-precipitated seizures and the stress response in childhood epilepsy. Brain 2015;138:2234-2248
3: Lamberink HJ, Boshuisen K, van Rijen PC, Gosselaar PH, Braun KP. Changing profiles of pediatric epilepsy surgery candidates over time: a nationwide single-center experience from 1990 to 2011. Epilepsia 215;56:717-725
4: Boshuisen K, van Schooneveld MM, Uiterwaal CS, Cross JH, Harrison S, Polster T, Daehn M, Djimjadi S, Yalnizoglu D, Turanli G, Sassen R, Hoppe C, Kuczaty S, Barba C, Kahane P, Schubert-Bast S, Reuner G, Bast T, Strobl K, Mayer H, de Saint-Martin A, Seegmuller C, Laurent A, Arzimanoglou A, Braun KP, for the TimeToStop cognitive outcome study group. Intelligence quotient improves after antiepileptic drug withdrawal following pediatric epilepsy surgery. Ann Neurol 2015;78:104-114
5: Braun KPJ, Bulder MMM, Chabrier S, Kirkham FJ, Uiterwaal CSP, Tardieu M, Sebire G. Longitudinal vascular imaging in 79 children with ischemic stroke and unilateral intracranial arteriopathy. Brain 2009;132:544-557

Side Activities

As mentioned in the Biography.

Fellowship and Awards

1: Recipient of the first “Patrick Hanlo Award”, March 17 2009
2: Personal investment grant for epilepsy research by the Dutch National Epilepsy Fund
3: Recipient of the “Gerlach Cerfontaine Fellowship” of the Catharijne Foundation, UMCU, 1998-2000, for the PhD project “Magnetic Resonance Spectroscopy in Hydrocephalus”
4: Recipient of several research grants from e.g. the Dutch Epilepsy Fund, Johanna Children’s Fund, and Wilhelmina Research Fund.

Research Output (269)

Antiseizure Medication Withdrawal Practice Patterns:A Survey among Members of the American Academy of Neurology and EpiCARE

Terman Samuel W., Slinger Geertruida, Rheaume Carol E., Haque Anisa S., Smith Shawna N., Van Griethuysen Renate, Van Asch Charlotte J.J., Otte Willem M., Burke James F., Braun Kees P.J. 13 Feb 2023, In: Neurology: Clinical Practice. 13

Clinical Outcome, Cognition, and Cerebrovascular Reactivity after Surgical Treatment for Moyamoya Vasculopathy:A Dutch Prospective, Single-Center Cohort Study

Deckers Pieter Thomas, Kronenburg Annick, van den Berg Esther, van Schooneveld Monique M., Vonken Evert Jan P.A., Otte Willem M., van Berckel Bart N.M., Yaqub Maqsood, Klijn Catharina J.M., van der Zwan Albert, Braun Kees P.J. 2 Dec 2022, In: Journal of Clinical medicine. 11 , p. 1-23

Yield and risk associated with prolonged presurgical video-EEG monitoring:a systematic review

van Griethuysen Renate, van Asch Charlotte J.J., Otte Wim M., Sander Josemir W., Braun Kees P.J. 1 Dec 2022, In: Epileptic disorders : international epilepsy journal with videotape. 24 , p. 1033-1045 13 p.

Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy:A systematic review and individual participant data meta-analysis

Stevelink Remi, Al-Toma Dania, Jansen Floor E., Lamberink Herm J., Asadi-Pooya Ali A., Farazdaghi Mohsen, Cação Gonçalo, Jayalakshmi Sita, Patil Anuja, Özkara Çiğdem, Aydın Şenay, Gesche Joanna, Beier Christoph P., Stephen Linda J., Brodie Martin J., Unnithan Gopeekrishnan, Radhakrishnan Ashalatha, Höfler Julia, Trinka Eugen, Krause Roland, Irelli Emanuele Cerulli, Di Bonaventura Carlo, Szaflarski Jerzy P., Hernández-Vanegas Laura E., Moya-Alfaro Monica L., Zhang Yingying, Zhou Dong, Pietrafusa Nicola, Specchio Nicola, Japaridze Giorgi, Beniczky Sándor, Janmohamed Mubeen, Kwan Patrick, Syvertsen Marte, Selmer Kaja K., Vorderwülbecke Bernd J., Holtkamp Martin, Viswanathan Lakshminarayanapuram G., Sinha Sanjib, Baykan Betül, Altindag Ebru, von Podewils Felix, Schulz Juliane, Seneviratne Udaya, Viloria-Alebesque Alejandro, Karakis Ioannis, D'Souza Wendyl J., Koeleman Bobby P.C., Otte Willem M., Braun Kees P.J., Nov 2022, In: EClinicalMedicine. 53

Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery in the Netherlands (the HFO trial):a randomised, single-blind, adaptive non-inferiority trial

Zweiphenning Willemiek, Klooster Maryse A.van t., van Klink Nicole E.C., Leijten Frans S.S., Ferrier Cyrille H., Gebbink Tineke, Huiskamp Geertjan, van Zandvoort Martine J.E., van Schooneveld Monique M.J., Bourez M., Goemans Sophie, Straumann Sven, van Rijen Peter C., Gosselaar Peter H., van Eijsden Pieter, Otte Willem M., van Diessen Eric, Braun Kees P.J., Zijlmans Maeike, Bloemen-Carlier Eltje M., Cibulková Veronika, de Munnink Renee, van der Salm Sandra, Eijkemans Martinus J.C., Ophorst-van Eck Janine M., Velders Anouk, van Asch Charlotte J.J., Zwemmer Jack, van Regteren-van Griethuysen Renate, Smeding Henriette, van der Berg Lydia, de Bresser Jeroen, de Kort Gérard A.P., Dankbaar Jan Willem, Nov 2022, In: The Lancet. Neurology. 21 , p. 982-993 12 p.

Cumulative effects of antiseizure medication on intelligence in children with focal epilepsy

Stevering Carmen H., Lamberink Herm J., Woodfield Julie, van Schooneveld Monique, Otte Willem M., Chin Richard F.M., Bastin Mark E., Geleijns Karin, Braun Kees P.J. 1 Oct 2022, In: Epileptic disorders : international epilepsy journal with videotape. 24 , p. 877-888 12 p.

Incidence of and predictors for antiseizure medication gaps in Medicare beneficiaries with epilepsy:a retrospective cohort study

Terman Samuel W., Niznik Joshua D., Slinger Geertruida, Otte Willem M., Braun Kees P.J., Aubert Carole E., Kerr Wesley T., Boyd Cynthia M., Burke James F. 1 Sep 2022, In: BMC Neurology. 22 , p. 1-14

Tailored epilepsy surgery with high frequency oscillations versus spikes in intra-operative electrocorticography: Results of the RCT HFO trial

Klooster M. Van ' T., Zweiphenning W., Van Klink N., Leijten F., Ferrier C., Gebbink T., Huiskamp G., Van Zandvoort M., Van Schooneveld M., Bourez M., Goemans S., Straumann S., Van Rijen P., Gosselaar P., Van Eijsden P., Otte W., Van Diessen E., Braun K., Zijlmans M. Sep 2022, In: Epilepsia. 63 , p. 19-20

Accurate differentiation between physiological and pathological ripples recorded with scalp-EEG

Mooij Anne H, Huiskamp Geertjan J M, Aarts Emmeke, Ferrier Cyrille H, Braun Kees P J, Zijlmans Maeike 30 Aug 2022, In: Clinical Neurophysiology. 143 , p. 172-181 10 p.

Neurostimulation in people with drug-resistant epilepsy:Systematic review and meta-analysis from the ILAE Surgical Therapies Commission

Touma Lahoud, Dansereau Bénédicte, Chan Alvin Y., Jetté Nathalie, Kwon Churl Su, Braun Kees P.J., Friedman Daniel, Jehi Lara, Rolston John D., Vadera Sumeet, Wong-Kisiel Lily C., Englot Dario J., Keezer Mark R. Jun 2022, In: Epilepsia. 63 , p. 1314-1329 16 p.

All research output

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