prof. dr. M.J.M. (Marc ) Bonten

prof. dr. M.J.M. (Marc ) Bonten

Full Professor
prof. dr. M.J.M. (Marc ) Bonten
  • Julius Center, dept. Epidemiology & Health Economics
  • Julius Center Research Program Infectious Diseases

Research Programs

Infection & Immunity



Marc Bonten earned his MD (1991) and PhD (“the role of colonization of the upper intestinal tract in the pathogenesis of ventilator-associated pneumonia, 1994) at the Maastricht University Medical School, the Netherlands. He registered as internist in 2000, as infectious disease specialist in 2002 and as clinical microbiologist in 2008, all at the University Medical Center Utrecht, the Netherlands. From 2008 till March 2021 he was head of the Department of Medical Microbiology. Since 2003 he is head of the research group of Infectious Disease Epidemiology of the Julius Center of Health Sciences and Primary Care and professor of molecular epidemiology of infectious diseases. He has been a principal investigator in many large scale epidemiologic studies and investigator-initiated randomized trials of prevention and treatment of infectious diseases. His experience covers the full range of epidemiologic study designs including clinical trials, cohorts, case-control studies and mathematical modelling to study antibiotic resistance and infection prevention. Specific research interests include the epidemiology of antibiotic-resistant bacteria such as VRE, MRSA and MDR Enterobacteriaceae, selective decontamination in intensive care unit patients, prevention of ventilator-associated pneumonia, treatment of community-acquired pneumonia, and prevention and treatment of community-acquired pneumonia, including COVID-19.

He is scientific Director of the research theme "Tackling Antimicrobial Resistance" of the Netherlands Centre for One Health (NCOH; (2016-)

He is chairman of the strategic research program Infection & Immunity at the UMC Utrecht. (2017-)

Coordinator of the H2020-funded project ECRAID-Base (March 2021-) and Chief Executive Officer of the ECRAID foundation (Jan 2022-)

Member of the Koninklijke Nederlandse Academie voor Wetenschappen en Kunsten (Royal Academy of Sciences and Art) (April 2021-)

Side Activities

Advisory boards, DSMBs and steering committees 

Chair of international study steering committee EMBRACE study, Janssen Vaccines; payments to UMC Utrecht) (2017-);

Independent Data Monitoring Committee of the PSK008 and PSK009 studies on pneumococcal vaccination, Sanofi Pasteur (payments to UMC Utrecht) (2019-)

Advisory Board clinical development for bactriophage therapy (international), Pherecytes (payments to Ecraid) (2022-)

Advisory Board pneumococcal vaccination (international), Merck Sharp & Dohme BV (payments to UMC Utrecht) (2020-)

Consultancy for Janssen Research & Devlopment for Ecraid assisting Janssen in finding study sites for E.mbrace study in European countries (all payments to Ecraid)

Board member "stichting ter bevordering van onderzoek en onderwijs op het gebied van intensive care geneeskunde en infectieziekten". Unpaid. No recent activities. 

Activities ended

Advisory Boards (all payments to UMC Utrecht: Covid-19 treatment (national), AstraZeneca (2021); Pneumococcal vaccination (international), Pfizer (2021); Clinical development ensovibep for treatment COVID-19 (international), Novartis (2022); RS Virus (national) GSK (April 2023); Ensitrelvir (international) Shionogi (April 2023). 

Speaker fees

Takeda (Nov 2019) (payments to M. Bonten)


Expert panels

Netherlands Veterinary Medicines Institute (SDa) (2019-) (payments to UMC Utrecht).

Cluster Infectieziektenbestrijding from ZorgOnderzoek Nederland (2019-) (attendance fees to UMC Utrecht). 

Scientific Advisory Board of GARDP (Global Antibiotic Research & Development Platform (2020-) (no payments).

Advisory Panel Innovative Treatments COVID-19 of the Ministry of Health, Welfare and Sport (2020-) (attendance fees to UMC Utrecht).

Outbreak Management Team for COVID-19 (2020-) (attendance fees to UMC Utrecht)


Research activities: contract research

UMC Utrecht coordinates in the Netherlands the HERALD study; A Phase 2b/3, Randomized, Observer-Blinded, Placebo-Controlled, Multicenter Clinical Study Evaluating the Efficacy and Safety of Investigational SARS-CoV-2 mRNA Vaccine CVnCoV in Adults 18 Years of Age and Older een fase2/3 studie. Study sponsor: CureVac. Bonten is principal investigator for the Netherlands. (2020-) (no personal payments)

UMC Utrecht executes the EMPATHY study; a randomized double-blind placebo-controlled multicenter study of ensovibep (MP0420) in ambulatory adult patients with symptomatic COVID-19. Study sponsor: Novartis & Molecular partners. Bonten is principal investigator for UMC Utrecht. (2021-) (no personal payments)

UMC Utrecht is a study site in the VAC31518COV2001 study; a phase 2 randomized double-blind placebo-controlled multicenter study of the COVID-19 vaccine from Janssen Vaccines. Study sponsor: Janssen Vaccines. Bonten is principal investigator for UMC Utrecht. (2020-) (no personal payments)

UMC Utrecht is a study site in the E.mbrace study; a phase 3 randomized double-blind placebo-controlled study of a 12-valent E. coli vaccine from Janssen Vaccines. Bonten is principal investigator for UMC Utrecht. (2022-) (no personal payments)

UMC Utrecht cordinates the PNEUMO study: an international observational study to quantify sero-type specific incidence of pneumococcal infections. Study sponsor: Merck. Bonten is principal investigator. (2018-) (no personal payments)

UMC Utrecht collaborates with Limmatech on exploring possibilities to study vaccination for Klebsiella infections. (2021-) (no personal payments)

Ecraid executes the open-label phase 2/3 clinical study to investigate safety and immunogenicity of a single VLA2100 booster vaccination in adult volunteers, after receipt of nationally rolled out mRNA COVID-19 vaccines and/or natural SARS-CoV2 infection. Study sponsor: Valneva Austria GmbH. Bonten is principal investigator. (2022-) (no personal payments)

Ecraid assists Spherecytes in the execution of PhagoDAIR I: A pilot, multicenter, randomized, non-comparative, double-blind study of phage therapy in patients with hip or knee prosthetic joint infection due to Staphylococcus aureus treated with DAIR and antibiotic therapy. (no personal payments)

UMC Utrecht executed the CAPiTA study and 3 related observational studies with PCV13 (2007-2014). Bonten performed until 2016 - on request of Pfizer - presentations on the results of these studies. Payments to UMC Utrecht. (no personal payments)

Ecraid executes the phase 3 randomized double-blind plaebo-ccontrolled study to ealuatve the efficacy and safety of bemnifosbuvir in high-risk outpatients with COVID-19. (no personal payments)

Research activities: public private partnerships (PPP) funded through the Innovative Medicine Initiative (IMI)

Bonten is, on behalf of UMC Utrecht, coordinator of COMBACTE-NET, COMBACTE-CARE, COMBACTE-MAGNET en COMBACTE-CDI) with the aim to improve efficiency of clinical evaluation of new antimicrobial treatments. Collaboration in this PPP is with AstraZeneca, Pfizer, GSK, Basilea, AiCuris, DaVolterra, Janssen, Sanofi, BioMerieux and MSD ( (2013-) COMBACTE CDI ended in 2021. (no personal payments)

Bonten is, on behalf of UMC Utrecht, co-coordinator of the PPP VITAL in which the effects of aging on vaccine response is investigated. Collaboration in this PPP is with Pfizer, GSK, Janssen, Sanofi, BioMerieux en MSD ( (2017-) (no personal payments)

Bonten is, on behalf of UMC Utrecht, scientific coordinator of the PPP PrIMAVera (Predicting the Impact of Monoclonal Antibodies & Vaccines on Antimicrobial Resistance) in which the potential effects of monoclonal antibodies and vaccines on the epidemiology of antimicrobial resistance will be investigated. Collaboration in this PPP is with GSK and Janssen. (2021-) (no personal payments)

UMC Utrecht is partner in VALUE-Dx in which the effects of diagnostics in the treatment of respiratory tract infections is investigated. Collaboration in this PPP is with BioMerieux, Abbot, Janssen, BioRad en BD ( Bonten co-leads the ADEQUATE study in which collaboration is with BioMerieux. (2019-) (no personal payments)


Fellowship and Awards

He is a VICI laureate (2006) from the Dutch Science Association, Principal Investigator of the CAPiTA study, coordinator of the EU-funded project R-GNOSIS, scientific coordinator of the IMI-funded consortiums COMBACTE-NET, COMBACTE-CARE and COMBACTE-MAGNET. He is member of the International Trial Steering Committee of the REMAP-CAP study, and coordinator of ECRAID-Base.  

In 2015 he received the ESCMID 2015 Award for Excellence in Clinical Microbiology and Infectious Diseases.

In 2017 he received a honorary fellowship of the Royal College of Physicians of Ireland, and was awarded the ESCMID fellowship.

In 2021 he was elected member of the Koninklijke Nederlandse Academi voor Wetenschappen.

Research Output (819)

Safe shortening of antibiotic treatment duration for complicated Staphylococcus aureus bacteraemia (SAFE trial):protocol for a randomised, controlled, open-label, non-inferiority trial comparing 4 and 6 weeks of antibiotic treatment.

Buis Dtp, van Werkhoven C H, van Agtmael M A, Bax H I, Berrevoets M, de Boer Mgj, Bonten Mjm, Bosmans J E, Branger J, Douiyeb S, Gelinck Lbs, Jong E, Lammers Ajj, Van der Meer Jtm, Oosterheert J J, Sieswerda E, Soetekouw R, Stalenhoef J E, Van der Vaart T W, Bij de Vaate E A, Verkaik N J, Van Vonderen Mga, De Vries P J, Prins J M, Sigaloff Kce, 21 Apr 2023, In: BMJ Open. 13 , p. 1-9

BCG Vaccination of Health Care Workers Does Not Reduce SARS-CoV-2 Infections nor Infection Severity or Duration:a Randomized Placebo-Controlled Trial

Claus Juana, Ten Doesschate Thijs, Gumbs Cheyenne, van Werkhoven Cornelis H, van der Vaart Thomas W, Janssen Axel B, Smits Gaby, van Binnendijk Rob, van der Klis Fiona, van Baarle Debbie, Paganelli Fernanda L, Leavis Helen, Verhagen Lilly M, Joosten Simone A, Bonten Marc J M, Netea Mihai G, van de Wijgert Janneke H H M, 28 Mar 2023, In: mBio. 14 16 p.

Comparative effectiveness of β-lactams for empirical treatment of methicillin-susceptible Staphylococcus aureus bacteraemia:a prospective cohort study

Buis D T P, van der Vaart T W, Prins J M, van der Meer J T M, Bonten M J M, Sieswerda E, van Werkhoven C H, Sigaloff K C E, Herpers B L, Jansen R R, Rozemeijer W, Soetekouw R, van Twillert G, Veenstra J 10 Mar 2023, In: The Journal of antimicrobial chemotherapy. 78 , p. 1175-1181 7 p.

Enhancing Public Health Communication Regarding Vaccine Trials:Design and Development of the Pan-European VACCELERATE Toolkit

Argyropoulos Christos D, Leckler Janina, Salmanton-García Jon, Constantinou Marinos, Alexandrou Alexandra, Themistocleous Sophia, Noula Evgenia, Shiamakkides George, Nearchou Andria, Stewart Fiona A, Albus Kerstin, Koniordou Markela, Kopsidas Ioannis, Spivak Orly, Hellemans Margot, Hendrickx Greet, Davis Ruth Joanna, Azzini Anna Maria, Simon Paula Valle, Carcas Antonio Javier, Askling Helena Hervius, Vene Sirkka, Prellezo Jana Baranda, Álvarez-Barco Elena, Macken Alan J, Di Marzo Romina, Luís Catarina, Olesen Ole F, Frias Iniesta Jesus A, Barta Imre, Tóth Krisztina, Akova Murat, Bonten Marc M J, Cohen-Kandli Miriam, Cox Rebecca Jane, Součková Lenka, Husa Petr, Jancoriene Ligita, Launay Odile, Lundgren Jens, Mallon Patrick, Armeftis Charis, Marques Laura, Naucler Pontus, Ochando Jordi, Tacconelli Evelina, van Damme Pierre, Zaoutis Theoklis, Hofstraat Sanne, Bruijning-Verhagen Patricia, Zeitlinger Markus, Cornely Oliver A, Pana Zoi Dorothea 28 Feb 2023, In: JMIR public health and surveillance. 9 , p. 1-8

The impact of circadian rhythm on Bacillus Calmette-Guérin vaccination effects on SARS-CoV-2 infections

Föhse Konstantin, Taks Esther J M, Moorlag Simone J C F M, Bonten Marc J M, van Crevel Reinout, Ten Oever Jaap, van Werkhoven Cornelis H, Netea Mihai G, van de Maat Josephine S, Hoogerwerf Jacobien J 16 Feb 2023, In: Frontiers in Immunology. 14

Epidemiology, Clinical Features, and Antimicrobial Resistance of Invasive Escherichia Coli Disease in Patients Admitted in Tertiary Care Hospitals

Doua Joachim, Geurtsen Jeroen, Rodriguez-Baño Jesus, Cornely Oliver A, Go Oscar, Gomila-Grange Aina, Kirby Andrew, Hermans Peter, Gori Andrea, Zuccaro Valentina, Gravenstein Stefan, Bonten Marc, Poolman Jan, Sarnecki Michal Feb 2023, In: Open forum infectious diseases. 10 11 p.

Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial

Higgins Alisa M, Berry Lindsay R, Lorenzi Elizabeth, Murthy Srinivas, McQuilten Zoe, Mouncey Paul R, Al-Beidh Farah, Annane Djillali, Arabi Yaseen M, Beane Abi, van Bentum-Puijk Wilma, Bhimani Zahra, Bonten Marc J M, Bradbury Charlotte A, Brunkhorst Frank M, Burrell Aiden, Buzgau Adrian, Buxton Meredith, Charles Walton N, Cove Matthew, Detry Michelle A, Estcourt Lise J, Fagbodun Elizabeth O, Fitzgerald Mark, Girard Timothy D, Goligher Ewan C, Goossens Herman, Haniffa Rashan, Hills Thomas, Horvat Christopher M, Huang David T, Ichihara Nao, Lamontagne Francois, Marshall John C, McAuley Daniel F, McGlothlin Anna, McGuinness Shay P, McVerry Bryan J, Neal Matthew D, Nichol Alistair D, Parke Rachael L, Parker Jane C, Parry-Billings Karen, Peters Sam E C, Reyes Luis F, Rowan Kathryn M, Saito Hiroki, Santos Marlene S, Saunders Christina T, Derde Lennie P G, Leavis HL, 16 Dec 2022, In: JAMA - The Journal of The American Medical Association. 329 , p. 39-51 13 p.

Selective Decontamination of the Digestive Tract:An Answer at Last?

Bonten Marc 15 Nov 2022, In: JAMA - The Journal of The American Medical Association. 328 , p. 2310-2311 2 p.

Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients:a randomised controlled trial

Chastre Jean, François Bruno, Bourgeois Marc, Komnos Apostolos, Ferrer Ricard, Rahav Galia, De Schryver Nicolas, Lepape Alain, Koksal Iftihar, Luyt Charles-Edouard, Sánchez-García Miguel, Torres Antoni, Eggimann Philippe, Koulenti Despoina, Holland Thomas L, Ali Omar, Shoemaker Kathryn, Ren Pin, Sauser Julien, Ruzin Alexey, Tabor David E, Akhgar Ahmad, Wu Yuling, Jiang Yu, DiGiandomenico Antonio, Colbert Susan, Vandamme Drieke, Coenjaerts Frank, Malhotra-Kumar Surbhi, Timbermont Leen, Oliver Antonio, Barraud Olivier, Bellamy Terramika, Bonten Marc, Goossens Herman, Reisner Colin, Esser Mark T, Jafri Hasan S, 15 Nov 2022, In: Critical care (London, England). 26

Air pollution from livestock farms and the oropharyngeal microbiome of COPD patients and controls

van Kersen Warner, Bossers Alex, de Steenhuijsen Piters Wouter A.A., de Rooij Myrna M.T., Bonten Marc, Fluit Ad C., Heederik Dick, Paganelli Fernanda L., Rogers Malbert, Viveen Marco, Bogaert Debby, Leavis Helen L., Smit Lidwien A.M. Nov 2022, In: Environment International. 169 , p. 1-9

All research output

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