dr. M. (Marco) Boks
dr. M. (Marco) Boks
- Psychiatry
Research Programs
Biography
Biography
Genetic, epigenetic and epidemiological studies of Gene- Environment interplay
The main theme of my research is how our genetic background shapes the influence of the environmental risk for bipolar disorder and schizophrenia.
The idea that psychiatric disorders develop as a result of the interaction between genes and environment is generally supported. However methodological challenges of such studies have limited large scale genome wide efforts. Therefore studies that focus on the interaction between environmental risk and genetic background remain timely and necessary.
However such genetic studies do not take into account a more subtle but highly relevant molecular mechanisms of interactions between environment and genes that recently is identified as a key mechanism of adaptation. These mechanisms, referred to as epigenetics, are extensive and complex and to date not fully understood. Central to our understanding is that epigenetic mechanisms influences transcription of DNA by modifying access to the DNA sequences. What makes this line of research extra interesting is the potential for pharmaceutical manipulation.
To focus these studies we have chosen cannabis and trauma as a main environmental exposure.
Specialties: Psychiatry, epigenetics, genetics, bio-informatics
Fellowship and Awards
1: NARSAD Young Investigator Award 2010
2: Semel Institute of Neuroscience, 2009 Phenomics Travel Award
Research Output (251)
Van der A Julia, De Jager Jesca E., van Dellen Edwin, Mandl René C.W., Somers Metten, Boks Marco P.M., Sommer Iris E.C., Nuninga Jasper O. 15 Mar 2023, In: Journal of Affective Disorders. 325 , p. 321-328 8 p.
Bassil Katherine, Krontira Anthi C., Leroy Thomas, Escoto Alana I.H., Snijders Clara, Pernia Cameron D., Pasterkamp R. Jeroen, de Nijs Laurence, van den Hove Daniel, Kenis Gunter, Boks Marco P., Vadodaria Krishna, Daskalakis Nikolaos P., Binder Elisabeth B., Rutten Bart P.F. Mar 2023, In: Neurobiology of stress. 23 20 p.
Marchi Mattia, Elkrief Laurent, Alkema Anne, van Gastel Willemijn, Schubart Chris D, van Eijk Kristel R, Luykx Jurjen J, Branje Susan, Mastrotheodoros Stefanos, Galeazzi Gian M, van Os Jim, Cecil Charlotte A, Conrod Patricia J, Boks Marco P Dec 2022, In: Translational Psychiatry. 12 , p. 1-10
Schwarz Tommer, Boltz Toni, Hou Kangcheng, Bot Merel, Duan Chenda, Loohuis Loes Olde, Boks Marco P, Kahn René S, Ophoff Roel A, Pasaniuc Bogdan 14 Jul 2022, In: HGG advances. 3 , p. 1-12
Higgins-Chen Albert T., Thrush Kyra L., Wang Yunzhang, Minteer Christopher J., Kuo Pei Lun, Wang Meng, Niimi Peter, Sturm Gabriel, Lin Jue, Moore Ann Zenobia, Bandinelli Stefania, Vinkers Christiaan H., Vermetten Eric, Rutten Bart P.F., Geuze Elbert, Okhuijsen-Pfeifer Cynthia, van der Horst Marte Z., Schreiter Stefanie, Gutwinski Stefan, Luykx Jurjen J., Picard Martin, Ferrucci Luigi, Crimmins Eileen M., Boks Marco P., Hägg Sara, Hu-Seliger Tina T., Levine Morgan E. Jul 2022, In: Nature Aging. 2 , p. 644-661 18 p.
Berdenis van Berlekom Amber, Kübler Raphael, Hoogeboom Jeske W, Vonk Daniëlle, Sluijs Jacqueline A, Pasterkamp R Jeroen, Middeldorp Jinte, Kraneveld Aletta D, Garssen Johan, Kahn René S, Hol Elly M, de Witte Lot D, Boks Marco P 2 May 2022, In: Nutrients. 14 , p. 1-19
Gumbs Stephanie B.H., Berdenis van Berlekom Amber, Kübler Raphael, Schipper Pauline J., Gharu Lavina, Boks Marco P., Ormel Paul R., Wensing Annemarie M.J., de Witte Lot D., Nijhuis Monique 16 Apr 2022, In: Viruses. 14 , p. 1-20
Palmer Duncan S, Howrigan Daniel P, Chapman Sinéad B, Adolfsson Rolf, Bass Nick, Blackwood Douglas, Boks Marco P M, Chen Chia-Yen, Churchhouse Claire, Corvin Aiden P, Craddock Nicholas, Curtis David, Di Florio Arianna, Dickerson Faith, Freimer Nelson B, Goes Fernando S, Jia Xiaoming, Jones Ian, Jones Lisa, Jonsson Lina, Kahn Rene S, Landén Mikael, Locke Adam E, McIntosh Andrew M, McQuillin Andrew, Morris Derek W, O'Donovan Michael C, Ophoff Roel A, Owen Michael J, Pedersen Nancy L, Posthuma Danielle, Reif Andreas, Risch Neil, Schaefer Catherine, Scott Laura, Singh Tarjinder, Smoller Jordan W, Solomonson Matthew, Clair David St, Stahl Eli A, Vreeker Annabel, Walters James T R, Wang Weiqing, Watts Nicholas A, Yolken Robert, Zandi Peter P, Neale Benjamin M 11 Apr 2022, In: Nature Genetics. 54 , p. 541-547 7 p.
Feklicheva Inna, Boks Marco P., de Kloet E. Ron, Chipeeva Nadezda, Maslennikova Ekaterina, Pashkov Anton, Korobova Svetlana, Komelkova Mariia, Kuznetsova Yulia, Platkovski Pavel, Mamonova Marina, Sidorenko Olga, Vasilenko Tatyana, Tseilikman Olga, Tseilikman Vadim Apr 2022, In: Journal of Psychiatric Research. 148 , p. 258-263 6 p.
de Witte Lot D., Wang Zhaoyu, Snijders Gijsje L.J.L., Mendelev Natalia, Liu Qingkun, Sneeboer Marjolein A.M., Boks Marco P.M., Ge Yongchao, Haghighi Fatemeh 15 Mar 2022, In: Biological Psychiatry. 91 , p. 572-581 10 p.