Group Booes, Optimizing immune recognition
Group Booes, Optimizing immune recognition
My lab explores mechanisms that drive immune recognition in human disease. It is becoming increasingly clear that many diseases have an inflammatory component to them that may be treatable by immune response modification. Cancer is one such disease, that touches on many aspects of immune recognition. Our approach to finding mechanisms in human disease is to study common traits in diseases of limited complexity (primary immunodeficiencies presenting with autoinflammation) and conditions of increasing complexity (rheumatoid disorders, cancer). From 2003-2008, my laboratory was located at Harvard Medical School/Brigham and Women’s Hospital in Boston, USA. Since 2008, we are located at UMC-Utrecht.
Research interests / topics uitklapper, klik om te openen
- Immunology
- Antigen presentation
- Immune recognition
- Human disease
- Pediatric
About the group leader(s) uitklapper, klik om te openen
Marianne Boes is chair of the Young Academy of the UMC Utrecht and board member of the Center for Unusual Collaborations (CUCo; working group of the Young Academies of the Strategic Alliance between TU-Eindhoven, Wageningen, Utrecht University and UMC-Utrecht). Boes is Faculty of Medicine-biomedical sciences member of the Education Committee of the Graduate School of Life Sciences (EC-LS), and serves as coordinator of the course 'Advanced Immunology' for PhD students, and the MSc course Logical Argumentation in Science: Publishing, Proposals and Pitching (co-coordinating with Dr. Eric Kalkhoven). Outside activities include her role as editor for several immunology and immunotherapy journals, membership of ZonMw evaluation committees and of data safety monitoring boards for clinical studies. She thoroughly enjoys to meet and learn from researchers, patients and societal partners in different fields. She works actively to improve the involvement of patients and their perspectives in translational research.
Related websites
Group members
Associated clinical researchers
- Henk Schipper
- Lilly Verhagen
- Joris van Montfrans
- Roger Schutgers
- Friederike Meyer-Wentrup
PhD Students
- Sarah Schep
- Francesca Ververs
- Bas Smits
- Mischa Koenen
- Juliette Pouw
- Nila Servaas
- Patrick Greve
- Angela Markovska
- Niels van Heusden
Education / Courses uitklapper, klik om te openen
Educational Comittee Life Sciences
Since 2017, Marianne Boes is a staff member of the Educational Comittee Life Sciences that assesses and ensures the quality of education of the master's programmes within the Graduate School of Life Sciences.
Key publications
van Kempen TS, Leijten EFA, Lindenbergh MFS, Nordkamp MO, Driessen C, Lebbink RJ, Baerlecken N, Witte T, Radstake TRDJ, Boes M. Eur J Immunol. 2020 Mar 21. 10.1002. PMID: 32198923
Lindenbergh MFS, Koerhuis DGJ, Borg EGF, van 't Veld EM, Driedonks TAP, Wubbolts R, Stoorvogel W, Boes, M. Front Immunol. 2019 Mar 12; 10:448. IF: 4.716; PMID: 30915085
Spel L, Nieuwenhuis J, Haarsma R, Stickel E, Bleijerveld OB, Altelaar M, Boelens JJ, Brummelkamp TR, Nierkens S, Boes M. Cancer Res. 2018 Dec 1; 78(23):6621-6631. IF: 8.378; PMID: 30213788
van der Burgh R, Nijhuis L, Pervolaraki K, Compeer EB, Jongeneel LH, van Gijn M, Coffer PJ, Murphy MP, Mastroberardino PG, Frenkel J, Boes M. J Biol Chem. 2014. PMID: 24356959 PMCID: PMC3931060 DOI: 10.1074
Schipper HS, Rakhshandehroo M, van de Graaf SF, Venken K, Koppen A, Stienstra R, Prop S, Meerding J, Hamers N, Besra G, Boon L, Nieuwenhuis EE, Elewaut D, Prakken B, Kersten S, Boes M, Kalkhoven E. J. Clin. Invest. 2012. PMID: 22863618 PMCID: PMC3428087 DOI: 10.1172/JCI62739
Achievements
Funding & Grants
Lymph&Co
2019, 385.000 Euro
Nutricia Research
2020, 47.500 Euro
Actuate Therapeutics
2020, 100.000 dollar
Awards/Achievements/Prizes
2020: Marianne Boes nominated as Regional Editor for Europe for Immunotherapy Advances (a journal of the British Society for Immunology)
2019: Marianne Boes nominated as Facilitation Team member of the Alliance Wageningen University – Eindhoven University – Utrecht University and UMC Utrecht
2019 IUIS travel grant to visit the Beijing International Congress of Immunology, 2.000 Euro
2019: Marianne Boes nominated as chair of the Young Academy of the UMC Utrecht
2019- Marianne Boes nominated as member of ZonMw program and grant evaluation committees
Alumni / PhD theses
Arie Jan Stoppelenburg
2014 | Mechanisms involved with immune hyperresponsiveness in newborns infected with respiratory diseases
Supervisor: prof. dr. Berent Prakken
Co-supervisor: dr. Marianne Boes
Fenna Sille
2010 | Functional requirements for CD-1 - Invariant Natural Killer T (INKT) Cells
Supervisor: prof. dr. Berent Prakken
Co-supervisor: dr. Marianne Boes
Annick van de Ven
2011 | Common Variable Immunedeficiency - To solve the variable of the equation
Supervisor: prof. dr. Lieke Sanders
Co-supervisors: dr. Joris van Montfrans and dr. Marianne Boes
Robert van der Burgh
2015 | Mechanisms thant Kindle Disease in Periodic Hereditary Diseases
Supervisor: prof. dr. Berent Prakken
Co-supervisor: dr. Marianne Boes
Ewoud Compeer
2015 | Cell-Biological Mechanisms Regulating Antigen Presentation - Signaling Towards Adaptive immunity
Supervisor: prof. dr. Lieke Sanders
Co-supervisor: dr. Marianne Boes
Thijs Flinsenberg
2014 | Optimizing DC Cross-Presentation - Orchestrating the Immune Response
Supervisor: prof. dr. Edward Nieuwenhuis
Co-supervisors: dr. Marianne Boes and dr. Jaap Jan Boelens
Willemijn Janssen
2017 | Connecting Clinical and Molecular Disease Features in Common Variable Immune Deficiency Disorder
Supervisor: prof. dr. Lieke Sanders
Co-supervisors: dr. Joris van Montfrans and dr. Marianne Boes
Lotte Spel
2018 | Classing Up to Get Noticed - MHC Class I Antigen Display in Dendritic Cells and Neuroblastoma
Supervisor: prof. dr. Berent Prakken
Co-supervisors: dr. Marianne Boes, dr. Stefan Nierkens and dr. Jaap Jan Boelens
Lisa Ott de Bruin
2018 | Cut and Paste - Using CRISPR/Cas9 to Model RAG1
Supervisor: prof. dr. Nico Wulffraat
Co-supervisors: dr. Luigi Notarangelo and dr. Marianne Boes
Marthe Lindenbergh
2019 | Triggers for the release of extracellular vesicles from dendritic cells
Supervisor: prof. dr. Willem Stoorvogel
Co-supervisor: dr. Marianne Boes
Sandra Cardoso
2019 | Exploring the role of CXCL4 in modulating immune responses triggered by monocyte-derived dendritic cells
Supervisor: prof. dr. Timothy Radstake
Co-supervisors: dr. Marianne Boes and dr. Aridaman Pandit
Collaborations uitklapper, klik om te openen
van Creveldkliniek
Prof Dr Roger Schutgens, Dr. Kathelijn Fischer
Princes Maxima Centrum voor Kinderoncologie
Dr. Friederike Meyer-Wentrup
UU Veterinary Department
Prof. Dr. Willem Stoorvogel
Molecular Cancer Research
Dr. Eric Kalkhoven
Boston Children's Hospital
Prof. Dr. Hidde Ploegh