Back

Group Booes, Optimizing immune recognition

Group Booes, Optimizing immune recognition

Group Boes Infection & Immunity
Image of a research detail

My lab explores mechanisms that drive immune recognition in human disease. It is becoming increasingly clear that many diseases have an inflammatory component to them that may be treatable by immune response modification. Cancer is one such disease, that touches on many aspects of immune recognition. Our approach to finding mechanisms in human disease is to study common traits in diseases of limited complexity (primary immunodeficiencies presenting with autoinflammation) and conditions of increasing complexity (rheumatoid disorders, cancer). From 2003-2008, my laboratory was located at Harvard Medical School/Brigham and Women’s Hospital in Boston, USA. Since 2008, we are located at UMC-Utrecht.

Research interests / topics uitklapper, klik om te openen

  • Immunology
  • Antigen presentation
  • Immune recognition
  • Human disease
  • Pediatric

About the group leader(s) uitklapper, klik om te openen

Marianne Boes is chair of the Young Academy of the UMC Utrecht and board member of the Center for Unusual Collaborations (CUCo; working group of the Young Academies of the Strategic Alliance between TU-Eindhoven, Wageningen, Utrecht University and UMC-Utrecht). Boes is Faculty of Medicine-biomedical sciences member of the Education Committee of the Graduate School of Life Sciences (EC-LS), and serves as coordinator of the course 'Advanced Immunology' for PhD students, and the MSc course Logical Argumentation in Science: Publishing, Proposals and Pitching (co-coordinating with Dr. Eric Kalkhoven). Outside activities include her role as editor for several immunology and immunotherapy journals, membership of ZonMw evaluation committees and of data safety monitoring boards for clinical studies. She thoroughly enjoys to meet and learn from researchers, patients and societal partners in different fields. She works actively to improve the involvement of patients and their perspectives in translational research.

Related websites

Boes lab

Group members

Photo group Boes

Associated clinical researchers

  • Henk Schipper
  • Lilly Verhagen
  • Joris van Montfrans
  • Roger Schutgers
  • Friederike Meyer-Wentrup 

PhD Students

  • Sarah Schep
  • Francesca Ververs
  • Bas Smits
  • Mischa Koenen
  • Juliette Pouw
  • Nila Servaas
  • Patrick Greve
  • Angela Markovska 
  • Niels van Heusden

Education / Courses uitklapper, klik om te openen

Educational Comittee Life Sciences

Since 2017, Marianne Boes is a staff member of the Educational Comittee Life Sciences that assesses and ensures the quality of education of the master's programmes within the Graduate School of Life Sciences.

Key publications

Impaired proteolysis by SPPL2a causes CD74 fragment accumulation that can be recognized by anti-CD74 autoantibodies in human ankylosing spondylitis.

van Kempen TS, Leijten EFA, Lindenbergh MFS, Nordkamp MO, Driessen C, Lebbink RJ, Baerlecken N, Witte T, Radstake TRDJ, Boes M. Eur J Immunol. 2020 Mar 21. 10.1002. PMID: 32198923

Bystander T-Cells Support Clonal T-Cell Activation by Controlling the Release of Dendritic Cell-Derived Immune-Stimulatory Extracellular Vesicles.

Lindenbergh MFS, Koerhuis DGJ, Borg EGF, van 't Veld EM, Driedonks TAP, Wubbolts R, Stoorvogel W, Boes, M. Front Immunol. 2019 Mar 12; 10:448. IF: 4.716; PMID: 30915085

Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma.

Spel L, Nieuwenhuis J, Haarsma R, Stickel E, Bleijerveld OB, Altelaar M, Boelens JJ, Brummelkamp TR, Nierkens S, Boes M. Cancer Res. 2018 Dec 1; 78(23):6621-6631. IF: 8.378; PMID: 30213788

Defects in mitochondrial clearance predispose human monocytes to interleukin-1beta hypersecretion.

van der Burgh R, Nijhuis L, Pervolaraki K, Compeer EB, Jongeneel LH, van Gijn M, Coffer PJ, Murphy MP, Mastroberardino PG, Frenkel J, Boes M. J Biol Chem. 2014. PMID: 24356959 PMCID: PMC3931060 DOI: 10.1074

Natural killer T cells in adipose tissue prevent insulin resistance.

Schipper HS, Rakhshandehroo M, van de Graaf SF, Venken K, Koppen A, Stienstra R, Prop S, Meerding J, Hamers N, Besra G, Boon L, Nieuwenhuis EE, Elewaut D, Prakken B, Kersten S, Boes M, Kalkhoven E. J. Clin. Invest. 2012. PMID: 22863618 PMCID: PMC3428087 DOI: 10.1172/JCI62739

Show more publications

Achievements

Funding & Grants

Lymph&Co

2019, 385.000 Euro

Nutricia Research

2020, 47.500 Euro

Actuate Therapeutics

2020, 100.000 dollar


Awards/Achievements/Prizes

2020: Marianne Boes nominated as Regional Editor for Europe  for Immunotherapy Advances (a journal of the British Society for Immunology)

2019: Marianne Boes nominated as Facilitation Team member of the Alliance Wageningen University – Eindhoven University – Utrecht University and UMC Utrecht

2019 IUIS travel grant to visit the Beijing International Congress of Immunology, 2.000 Euro

2019: Marianne Boes nominated as chair of the Young Academy of the UMC Utrecht

 2019- Marianne Boes nominated as member of ZonMw program and grant evaluation committees

Show more Awards/Achievements/Prizes

Alumni / PhD theses

Arie Jan Stoppelenburg

2014 | Mechanisms involved with immune hyperresponsiveness in newborns infected with respiratory diseases

Supervisor: prof. dr. Berent Prakken
Co-supervisor: dr. Marianne Boes

Read more

Fenna Sille

2010 | Functional requirements for CD-1 - Invariant Natural Killer T (INKT) Cells

Supervisor: prof. dr. Berent Prakken
Co-supervisor: dr. Marianne Boes

Read more

Annick van de Ven

2011 | Common Variable Immunedeficiency - To solve the variable of the equation

Supervisor: prof. dr. Lieke Sanders
Co-supervisors: dr. Joris van Montfrans and dr. Marianne Boes

Read more

Robert van der Burgh

2015 | Mechanisms thant Kindle Disease in Periodic Hereditary Diseases

Supervisor: prof. dr. Berent Prakken
Co-supervisor: dr. Marianne Boes

Read more

Ewoud Compeer

2015 | Cell-Biological Mechanisms Regulating Antigen Presentation - Signaling Towards Adaptive immunity

Supervisor: prof. dr. Lieke Sanders
Co-supervisor: dr. Marianne Boes

Read more

Thijs Flinsenberg

2014 | Optimizing DC Cross-Presentation - Orchestrating the Immune Response

Supervisor: prof. dr. Edward Nieuwenhuis
Co-supervisors: dr. Marianne Boes and dr. Jaap Jan Boelens

Read more

Willemijn Janssen

2017 | Connecting Clinical and Molecular Disease Features in Common Variable Immune Deficiency Disorder

Supervisor: prof. dr. Lieke Sanders
Co-supervisors: dr. Joris van Montfrans and dr. Marianne Boes

Read more

Lotte Spel

2018 | Classing Up to Get Noticed - MHC Class I Antigen Display in Dendritic Cells and Neuroblastoma

Supervisor: prof. dr. Berent Prakken
Co-supervisors: dr. Marianne Boes, dr. Stefan Nierkens and dr. Jaap Jan Boelens

Read more

Lisa Ott de Bruin

2018 | Cut and Paste - Using CRISPR/Cas9 to Model RAG1

Supervisor: prof. dr. Nico Wulffraat
Co-supervisors: dr. Luigi Notarangelo and dr. Marianne Boes

Read more

Marthe Lindenbergh

2019 | Triggers for the release of extracellular vesicles from dendritic cells

Supervisor: prof. dr. Willem Stoorvogel
Co-supervisor: dr. Marianne Boes

Read more

Sandra Cardoso

2019 | Exploring the role of CXCL4 in modulating immune responses triggered by monocyte-derived dendritic cells

Supervisor: prof. dr. Timothy Radstake
Co-supervisors: dr. Marianne Boes and dr. Aridaman Pandit

Read more
Show more Alumni / PhD theses

Collaborations uitklapper, klik om te openen

van Creveldkliniek

Prof Dr Roger Schutgens, Dr. Kathelijn Fischer

Princes Maxima Centrum voor Kinderoncologie

Dr. Friederike Meyer-Wentrup

UU Veterinary Department

Prof. Dr. Willem Stoorvogel

Molecular Cancer Research

Dr. Eric Kalkhoven

Boston Children's Hospital

Prof. Dr. Hidde Ploegh

In the media uitklapper, klik om te openen

Contact information

Marianne Boes

E

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht

Contact

Emergency?

Directions

Appointments

Practical

umcutrecht.nl maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet