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dr. H.M. van Santen

Associate Professor - medical

  • Endocrinology patient care

dr. H.M. van Santen

Biography

Dr. HM van Santen moved her career in 2013 to Utrecht to support the Máxima initiative and to coordinate the endocrine care for children with cancer in the Princess Máxima Center. 

She has co-authored 59 publications on the endocrine effects of childhood cancer treatment, of which 32 as first or last author.

She is an associate professor and PI in the research program of Child Health, WKZ, UMCU and co-PI in the Máxima Center for Pediatric Oncology.

Her research program focuses on the endocrine and metabolic effects of children with craniopharyngioma, the acute and late effects of childhood cancer treatment on the endocrine system, and on pediatric thyroid cancer. The overall aim of her work is to preserve an intact endocrine system in children with neoplasms enabling normal growth and development into adulthood.

She is chair of the MC4 group Craniopharyngioma in the Máxima Center for Pediatric Oncology, chair of the Late Effects of Childhood Cancer International Guideline Harmonization Groups (IGHG) for thyroid and hypothalamic-pituitary disorders, and member of the IGHG working groups for male and female gonadal toxicity and preservation of fertility and metabolic syndrome. She is chair of the Dutch and the European Guideline for Thyroid cancer in children and the coordinator of the NFU/ ENDO-ERN expertise center Thyroid Tumors in Utrecht. She is member of the SIOP craniopharyngioma working group and the SIOP low grade glioma working group, the national consortium for Late effects of treatment for childhood thyroid carcinoma, the consortium of the Dexadagen-2 study, the Dutch Growth Hormone Advisory board and has a consultative function for the “Cyberpoli” for thyroid diseases and craniopharyngioma.

Side Activities

  • 2020             co-PI Prinses Maxima Center for Pediatric Oncology Utrecht

    2019             BKO qualification UMCU

    2019             Chair of the European Task Force for Recommendations of Treatment of Thyroid nodules and Carcinoma in Childhood

    2016 – now  Deputy educator ( plaatsvervangend opleider) of the clinical fellow pediatric endocrinology in the Wilhelmina Children’s Hospital, UMCU

    2018 - now   member of working group supportive care Princess Maxima Center

    2017 - now   member of fertility working group Princess Maxima Center

    2016 - now   Co-chair of the IGHG for surveillance of hypothalamic-pituitary disorders in Childhood Cancer Survivors

    2016 - now   Participant/ member of the working group of the IGHG working group for  preservation of fertility in male childhood cancer survivors (in progress)

    2016 – now  Participant / working group lead of the IGHG working group for preservation of fertility in female childhood cancer survivors (in progress)

    2016 - now   Participant/ member of the working group of the IGHG recommendation for surveillance of the metabolic syndrome in childhood cancer survivors (in progress)

    2016 - now   Co-chair of the Dutch Guideline for Treatment of Thyroid nodules and cancer in children (in progress)

    2016 - now   Participant of  the SIOP supportive care group

    2016 - now   Participant of the SIOP low grade glioma working group

    2016 - now   Participant of the national consortium for Late effects of treatment for childhood thyroid carcinoma ( PI T Links, UMCG)

    2016 - now   Participant of the consortium of the Dexadagen-2 study

    2015 - now   Participant of the Dutch Growth Hormone Advisory board (SEK)

    2015 - now   Consultative function for the “Cyberpoli” for thyroid diseases and craniopharyngioma(www.cyberpoli.nl)

     2015 – now    Participant of the SKION LATER Recommendations for screening Childhood Cancer Survivors https://www.skion.nl/workspace/uploads/vertaling-richtlijn-LATER-versie-final-okt-2014_2.pdf

     

Fellowship and Awards

  • 2019                KIKA project: THYRO-Dynamics Study (Prospective study on thyroid function during treatment with chemotherapy in 600 children)

    2019                Princess Maxima Grant; research grant for 4-year PhD student: “Building an organoid model for craniopharyngioma”

    2009-2011      Fellowship kinderendocrinologie in het Emma Kinderziekenhuis AMC

Research Output (90)

Clinical impact of hypothalamic-pituitary disorders after conformal radiation therapy for pediatric low-grade glioma or ependymoma

van Iersel Laura, van Santen Hanneke M, Potter Brian, Li Zhenghong, Conklin Heather M, Zhang Hui, Chemaitilly Wassim, Merchant Thomas E 1 dec 2020, In: Pediatric Blood & Cancer. 67 , p. e28723

Reproductive Complications in Childhood Cancer Survivors

van Santen Hanneke M, van de Wetering Marianne D, Bos Annelies M E, Vd Heuvel-Eibrink Marry M, van der Pal Helena J, Wallace William Hamish dec 2020, In: The pediatric clinics of North America. 67 , p. 1187-1202 16 p.

Safety of GH after treatment for childhood cancer

van Santen Hanneke M dec 2020, In: European Journal of Endocrinology. 183 , p. C15-C18

Visual functions in children with craniopharyngioma at diagnosis:A systematic review

Nuijts Myrthe A, Veldhuis Nienke, Stegeman Inge, van Santen Hanneke M, Porro Giorgio L, Imhof Saskia M, Schouten-van Meeteren Antoinette Y N 1 okt 2020, In: PLoS ONE. 15 , p. e0240016

Endocrine Health in Childhood Cancer Survivors

van Santen Hanneke M, Chemaitilly Wassim, Meacham Lillian R, Tonorezos Emily S, Mostoufi-Moab Sogol okt 2020, In: The pediatric clinics of North America. 67 , p. 1171-1186 16 p.

New national recommendations for the treatment of pediatric differentiated thyroid carcinoma in the Netherlands

Lebbink C. A., Dekker B. L., Bocca G., Braat A. J.A.T., Derikx J. P.M., Dierselhuis M. P., de Keizer B., Kruijff S., Kwast A. B.G., van Nederveen F. H., Nieveen van Dijkum E. J.M., Nievelstein R. A.J., Peeters R. P., Terwisscha van Scheltinga C. E.J., Tissing W. J.E., van der Tuin K., Vriens M. R., Zsiros J., van Trotsenburg A. S.P., Links T. P., van Santen H. M. okt 2020, In: European Journal of Endocrinology. 183 , p. P11-P18

Clinical considerations for the treatment of secondary differentiated thyroid carcinoma in childhood cancer survivors

van Santen Hanneke M., Alexander Erik K., Rivkees Scott A., Frey Eva, Clement Sarah C., Dierselhuis Miranda P., Lebbink Chantal A., Links Thera P., Lorenz Kerstin, Peeters Robin P., Reiners Christoph, Vriens Menno R., Nathan Paul, Schneider Arthur B., Verburg Frederik 1 sep 2020, In: European Journal of Endocrinology. 183 , p. P1-P10

Experiences with Glucagon-Like Peptide-1 Receptor Agonist in Children with Acquired Hypothalamic Obesity

van Schaik Jiska, Begijn Dominique G A, van Iersel Laura, Vergeer Yvonne, Hoving Eelco W, Peeters Babette, van Santen Hanneke M 11 aug 2020, In: Obesity Facts. 13 , p. 361-370 10 p.

Presentation and outcome of subsequent thyroid cancer among childhood cancer survivors compared to sporadic thyroid cancer:a matched national study

Clement Sarah C, Lebbink Chantal A, Klein Hesselink Mariëlle S, Teepen Jop C, Links Thera P, Ronckers Cecile M, van Santen Hanneke M aug 2020, In: European Journal of Endocrinology. 183 , p. 169-180 12 p.

Risk factors for significant weight gain, overweight and obesity in childhood brain tumor survivors

van Schaïk Jiska, Van Roessel I. M.A.A., Schouten-van Meeteren Antoinette Y. N., van Iersel Laura, Clement S.C., Boot Annemieke M, Claahsen-van der Grinten Hedi L, Caron Huib N., Janssens G.O., van Vuurden Dannis G, Michiels Erna M., Granzen Bernd, Han KS, van Trotsenburg A. S. Paul, Vandertop W. Peter, Kremer Leontine C M, van Santen HM 24 feb 2020, 2 p.

All Research Output (90)