prof. dr. J.J. (Jim) van Os

Full Professor

  • Division Neuroscience

prof. dr. J.J. (Jim) van Os



Research Programs


I have a background in Epidemiology (London School of Hygiene and Tropical Medicine) and Psychiatry (Institute of Psychiatry, King’s College London). My research has focused on elucidating the nature of mental variation in relation to context, and identifying the interactions between environment and genetic liability driving this variation. Over the course of my career, I have developed a passion for making psychiatry more relevant for its users in terms of diagnostic practice, the use of scientific findings to create clinical impact, health service organization, teaching and co-creation with users. I think there is an urgent need to balance the discourse and the scientific focus of the psychiatric profession on the one hand, and the needs and wishes of patients and their relatives on the other. In my work as Neuroscience Division leader at MUMC and now UMCU, I have attempted to forge collaboration between the clinical neurosciences in order to create patient value, for example in the area of neuromodulation. After several decades of directing activities in health care and research, I think effective leadership is about facilitating others, creating a community and fostering the network – in the shared belief that our work serves to inspire students and impact the lives of patients.


Basic Teaching Qualification, BROK certified

Ten most important scientific publications

  • Van Os, J., Hanssen, M., Bijl, R.V. & Vollebergh, W. (2001) Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Archives of General Psychiatry, 58, 663-668.

  • Van Os, J., Hanssen, M., Bak, M., et al (2003) Do urbanicity and familial liability coparticipate in causing psychosis? American Journal of Psychiatry, 160, 477-482.
  • Van Os, J., Altamura, A.C., Bobes, J. et al (2004) Evaluation of the Two-Way Communication Checklist as a clinical intervention. Results of a multinational, randomised controlled trial. British Journal of Psychiatry, 184, 79-83.
  • van Os, J. & Kapur, S. (2009) Schizophrenia. Lancet, 374, 635-645.
  • van Os, J., Kenis, G. & Rutten, B.P. (2010) The environment and schizophrenia. Nature, 468, 203-212.
  • van Os, J. & Reininghaus, U. (2016) Psychosis as a transdiagnostic and extended phenotype in the general population. World Psychiatry, 15, 118-124.
  • Van Os J, Marsman A, Van Dam D, Simons CJ, GROUP Investigators (2017). Evidence That the Impact of Childhood Trauma on IQ Is Substantial in Controls, Moderate in Siblings, and Absent in Patients With Psychotic Disorder. Schizophrenia Bulletin, 43(2), 316-324.
  • Van Os J, Van Der Steen Y, Islam MA, Guloksuz S, Rutten BP, Simons CJ, GROUP Investigators (2017). Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine, 47(14), 2421-2437.
  • Van Os, J. & Güloksuz, S. (2017). A critique of the popular “ultra-high risk” and “transition” paradigm in psychiatry. World Psychiatry,16, 200-206
  • Van Os, J., Verhagen, S., Marsman, et al. (2017) The Experience Sampling Method as an mHealth Tool to Support Self-monitoring, Self-Insight and Personalised Health Care in Clinical Practice. Depression and Anxiety, 34(6), 481-493.

Side Activities

  • Chairman of the Psychosenet Foundation

    Member of the DeNieuweGGZ foundation

    Member Editorial boards: Psychilogical Medicine, Schizophrenia Research, Schizophrenia Bulletin, Early intervention in Psychiatry, Acta Psychiatrica Scandinavica, Journal of Mental Health, Plos One

    Member of the GGZ-VS Supervisory Board (GGZ nurse specialist training)

Fellowship and Awards

  • Ramaer Medal Outstanding Research, Dutch Psychiatric Association, 1997

    Association of European Psychiatrists research price 2003 (20.000 euro)

    Member, KNAW (2011).

    Fellow, King’s College London (2016).

    Thompson-Reuter WoS list of ‘most influential scientific minds’ and ‘highly cited researchers’

Research Output (334)

Sex differences in cognitive functioning of patients at-risk for psychosis and healthy controls:Results from the European Gene-Environment Interactions study

Menghini-Müller Stephanie, Studerus Erich, Ittig Sarah, Valmaggia Lucia R., Kempton Matthew J., van der Gaag Mark, de Haan Lieuwe, Nelson Barnaby, Bressan Rodrigo A., Barrantes-Vidal Neus, Jantac Célia, Nordentoft Merete, Ruhrmann Stephan, Sachs Garbiele, Rutten Bart P., van Os Jim, Riecher-Rössler Anita, 13 mrt 2020, In: European Psychiatry. 63 , p. e25

To continue or not to continue?:Antipsychotic medication maintenance versus dose-reduction/discontinuation in first episode psychosis: HAMLETT, a pragmatic multicenter single-blind randomized controlled trial

Begemann Marieke J.H., Thompson Ilse A., Veling Wim, Gangadin Shiral S., Geraets Chris N.W., Van 'T Hag Erna, Müller-Kuperus Sanne J., Oomen Priscilla P., Voppel Alban E., Van Der Gaag Mark, Kikkert Martijn J., Van Os Jim, Smit H. Filip E., Knegtering Rikus H., Wiersma Sybren, Stouten Luyken H., Gijsman Harm J., Wunderink Lex, Staring Anton B.P., Veerman Selene R.T., Mahabir Amrita G.S., Kurkamp Jörg, Pijnenborg Gerdina H.M., Veen Natalie D., Marcelis Machteld, Grootens Koen P., Faber Gunnar, Van Beveren Nico J., Been Agaath, Van Den Brink Truus, Bak Maarten, Van Amelsvoort Therese A.M.J., Ruissen Andrea, Blanke Christine, Groen Karin, De Haan Lieuwe, Sommer Iris E.C. 7 feb 2020, In: Trials. 21

The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI):Incidence and First-Episode Case-Control Programme

Gayer-Anderson Charlotte, Jongsma Hannah E., Di Forti Marta, Quattrone Diego, Velthorst Eva, de Haan Lieuwe, Selten Jean-Paul, Szoke Andrei, Llorca Pierre-Michel, Tortelli Andrea, Arango Celso, Bobes Julio, Bernardo Miguel, Sanjuan Julio, Santos Jose Luis, Arrojo Manuel, Parellada Mara, Tarricone Ilaria, Berardi Domenico, Ruggeri Mirella, Lasalvia Antonio, Ferraro Laura, La Cascia Caterina, La Barbera Daniele, Menezes Paulo Rossi, Del-Ben Cristina Marta, Rutten Bart P., van Os Jim, Jones Peter B., Murray Robin M., Kirkbride James B., Morgan Craig 23 jan 2020, In: Social Psychiatry and Psychiatric Epidemiology. 55 , p. 645-657 13 p.

Aggressive Behavior, Hostility, and Associated Care Needs in Patients With Psychotic Disorders:A 6-Year Follow-Up Study

Faay Margo D. M., van Os Jim, van Amelsvoort Therese, Bartels-Velthuis Agna A., Bruggeman Richard, Cahn Wiepke, de Haan Lieuwe, Schirmbeck Frederike, Simons Claudia J. P., 8 jan 2020, In: Frontiers in Psychiatry. 10 , p. 934

Tackling rising numbers of opioid prescriptions users

Groot Peter C., van Os Jim jan 2020, In: The Lancet Public Health. 5 , p. e16

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Lee Phil H., Anttila Verneri, Won Hyejung, Feng Yen-Chen A., Rosenthal Jacob, Zhu Zhaozhong, Tucker-Drob Elliot M., Nivard Michel G., Grotzinger Andrew D., Posthuma Danielle, Wang Meg M-J, Yu Dongmei, Stahl Eli A., Walters Ray-mond K., Anney Richard J. L., Duncan Laramie E., Ge Tian, Adolfsson Rolf, Banaschewski Tobias, Belangero Sintia, Cook Edwin H., Coppola Giovanni, Derks Eske M., Hoekstra Pieter J., Kaprio Jaakko, Keski-Rahkonen Anna, Kirov George, Kranzler Henry R., Luykx Jurjen J., Rohde Luis A., Zai Clement C., Agerbo Esben, Arranz M. J., Asherson Philip, Baekvad-Hansen Marie, Baldursson Gisli, Bellgrove Mark, Belliveau Richard A., Jr., Buitelaar Jan, Burton Christie L., Bybjerg-Grauholm Jonas, Casas Miguel, Cerrato Felecia, Chambert Kimberly, Churchhouse Claire, Gormand Bru, Ophoff Roel A., Adan Roger A. H., Kas Martien J. H., van Os Jim, 12 dec 2019, In: Cell. 179 , p. 1469-1482.e11

Postsurgical Compliance and Eating Behavior 5 Years after Surgery

Konings Gerdy, Drukker Marjan, Mulkens Sandra, Severeijns Ruud, Van Os Jim, Ponds Rudolf 5 dec 2019, In: Bariatric Surgical Practice and Patient Care. 15 , p. 148-154 7 p.

Reward anticipation in individuals with subclinical psychotic experience:A functional MRI approach

Michielse Stijn, Lange Iris, Bakker Jindra, Goossens Liesbet, Verhagen Simone, Papalini Silvia, Wichers Marieke, Lieverse Ritsaert, Schruers Koen, van Amelsvoort Therese, van Os Jim, Murray Graham K., Marcelis Machteld 1 dec 2019, In: European Neuropsychopharmacology. 29 , p. 1374-1385 12 p.

Cognitive Functioning in Psychotic Disorders Across the Lifespan and Illness-Stages

Velthorst Eva, Mollon Josephine, Reichenberg Abraham, Murray Robin, Myin-Germeys Inez, Bruggeman Richard, Glahn David, De Haan Lieuwe, Van Os Jim dec 2019, In: Neuropsychopharmacology. 44 , p. 166-167

TwinssCan - Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes:Risk and Protective Factors in a General Population Twin Sample

Pries Lotta-Katrin, Snijders Clara, Menne-Lothmann Claudia, Decoster Jeroen, van Winkel Ruud, Collip Dina, Delespaul Philippe, De Hert Marc, Derom Catherine, Thiery Evert, Jacobs Nele, Wichers Marieke, Guloksuz Sinan, van Os Jim, Rutten Bart P F dec 2019, In: Twin Research and Human Genetics. 22 , p. 460-466 7 p.

All Research Output (334)