prof. dr. ir. H.H. (Harrie) Weinans

Associate Professor

  • Department of Orthopaedics

prof. dr. ir. H.H. (Harrie) Weinans


Our stiff bones are held together by ligaments and tendons and carry the weight and transfer the large forces that are required for locomotion. Without these load bearing mechanical tissues we would look like a gelatin pudding. With aging or after trauma the delicate internal architecture of these connective tissues gets lost, which can result in e.g. cartilage damage and subsequent deterioration (osteoarthritis), loss of bone mass (osteoporosis) problematic healing of fractures or tendons. Bone and cartilage are load bearing structures and degeneration and regeneration in these tissues are continuously influenced by and adapted to the biomechanical demands. The major goal of my research is to investigate the degenerative processes in the skeletal structures and find methods to counterbalance this degeneration or even induce appropriate regeneration after the tissue is already diminished.


Research Output (162)

Treating infections with ionizing radiation:a historical perspective and emerging techniques

van Dijk B, Lemans J V C, Hoogendoorn R M, Dadachova E, de Klerk J M H, Vogely H C, Weinans H, Lam M G E H, van der Wal B C H 31 jul 2020, In: Antimicrobial Resistance and Infection Control. 9 , p. 121

Cohort profile:The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers

van Helvoort Eefje M., van Spil Willem E., Jansen Mylène P., Welsing Paco M.J., Kloppenburg Margreet, Loef Marieke, Blanco Francisco J., Haugen Ida K., Berenbaum Francis, Bacardit Jaume, Ladel Christoph H., Loughlin John, Bay-Jensen Anne C., Mobasheri Ali, Larkin Jonathan, Boere Janneke, Weinans Harrie H., Lalande Agnes, Marijnissen Anne C.A., Lafeber Floris P.J.G. 28 jul 2020, In: BMJ Open. 10 10 p.

Multi-classifier prediction of knee osteoarthritis progression from incomplete imbalanced longitudinal data

Widera Paweł, Welsing Paco M.J., Ladel Christoph, Loughlin John, Lafeber Floris P.F.J., Petit Dop Florence, Larkin Jonathan, Weinans Harrie, Mobasheri Ali, Bacardit Jaume 21 mei 2020, In: Scientific Reports. 10 15 p.

Radioimmunotherapy of methicillin-resistant Staphylococcus aureus in planktonic state and biofilms

van Dijk B, Allen K J H, Helal M, Vogely H C, Lam M G E H, de Klerk J M H, Weinans H, van der Wal B C H, Dadachova E 14 mei 2020, In: PLoS ONE. 15 10 p.

Deep learning-based MR-to-CT synthesis:The influence of varying gradient echo-based MR images as input channels

Florkow Mateusz C, Zijlstra Frank, Willemsen Koen, Maspero Matteo, van den Berg Cornelis A T, Kerkmeijer Linda G W, Castelein René M, Weinans Harrie, Viergever Max A, van Stralen Marijn, Seevinck Peter R apr 2020, In: Magnetic Resonance in Medicine. 83 , p. 1429-1441 13 p.

Predicting the mechanical hip–knee–ankle angle accurately from standard knee radiographs:a cross-validation experiment in 100 patients

Gielis Willem Paul, Rayegan Hassan, Arbabi Vahid, Ahmadi Brooghani Seyed Y., Lindner Claudia, Cootes Tim F., de Jong Pim A., Weinans H., Custers Roel J.H. 2020, In: Acta Orthopaedica. 91 , p. 732-737 6 p.

Effect of unfocused extracorporeal shockwave therapy on bone mineral content of twelve distal forearms of postmenopausal women:a clinical pilot study

Koolen Marianne K.E., Kruyt Moyo C., Öner Fetullah C., Schaden Wolfgang, Weinans Harrie, van der Jagt Olav P. 1 dec 2019, In: ARCHIVES OF OSTEOPOROSIS. 14 7 p.

An automated workflow based on hip shape improves personalized risk prediction for hip osteoarthritis in the CHECK study

Gielis W P, Weinans H, Welsing P M J, van Spil W E, Agricola R, Cootes T F, de Jong P A, Lindner C 8 okt 2019, In: Osteoarthritis and Cartilage. 28 , p. 62-70 9 p.

Contrast enhanced computed tomography for real-time quantification of glycosaminoglycans in cartilage tissue engineered constructs

Garcia João P, Longoni Alessia, Gawlitta Debby, J W P Rosenberg Antoine, Grinstaff Mark W, Töyräs Juha, Weinans Harrie, Creemers Laura B, Pouran Behdad 30 sep 2019, In: Acta Biomaterialia. 100 , p. 202-212 11 p.

Complete regeneration of large bone defects in rats with commercially available fibrin loaded with BMP-2

Koolen M, Longoni A, van der Stok J, Van der Jagt O, Gawlitta D, Weinans H 17 sep 2019, In: European Cells & Materials. 38 , p. 94-105 12 p.

All Research Output (162)