prof. dr. R.J.P.M. (Rob) Scholten

Professor Emeritus

  • Department of Epidemiology
  • Julius Center Research Program Methodology

prof. dr. R.J.P.M. (Rob) Scholten


Rob J.P.M. Scholten is Emeritus Professor of Evidence Synthesis in Health Care at the Julius Center for Health Sciences and Primary Care. From 2001 – October 2018, he was the director of The Dutch Cochrane Centre which is hosted by the Julius Center. July 1st, 2020 he officially retired.

Rob did his medical training at the Vrije Universiteit in Amsterdam and in 1993 he obtained his PhD in Clinical Epidemiology at the same university (Thesis ‘The increased incidence of meningococcal disease in the Netherlands: an attempt at an epidemiological explanation’). In 1995 he was formally registered as Clinical Epidemiologist (‘Wetenschappelijk Onderzoeker Epidemioloog’, SMBWO).

From 1993 to 2000 Rob worked as senior researcher of the research programme “Musculoskeletal disorders” of the EMGO-Institute, Amsterdam, and from 2000 to 2013 as Senior Clinical Epidemiologist at The Dutch Cochrane Centre and the department of Clinical Epidemiology, Biostatistics and Bioinformatics of the Academic Medical Center in Amsterdam. In 2001 he became the director of the Dutch Cochrane Centre and in 2010, he was appointed as Professor of Clinical Epidemiology in particular Evidence-based Medicine at the University of Amsterdam. In 2014, the Dutch Cochrane Centre moved to Utrecht and in 2015, Rob was appointed as professor of Evidence Synthesis in Health Care.

Side Activities

    • Former Editor Cochrane Diagnostic Test Accuracy Editorial Team

    • Member of the following Cochrane Methods Groups: GRADEing Methods Group, Screening and Diagnostic Tests Methods Group and Statistics Methods Group

    • Member (review author) of the following Cochrane Review Groups: Heart Group, Gynaecological, Neuro-oncology and Orphan Cancer Group, Back and Neck Group, Dementia and Cognitive Improvement Group, Developmental, Psychosocial and Learning Problems Group, Oral Health Group, Airways Group, Neuromuscular Group, Bone, Joint and Muscle Trauma Group, Methodology Review Group, Metabolic and Endocrine Disorders Group, Common Mental Disorders Group, Upper GI and Pancreatic Diseases Group, Colorectal Group

    • Member of the international GRADE Working Group and core member of the Dutch GRADE Network

Research Output (72)

Cross-sectional associations of amyloid burden with semantic cognition in older adults without dementia:A systematic review and meta-analysis

Vonk Jet M J, Twait Emma L, Scholten Rob J P M, Geerlings Mirjam I 19 okt 2020, In: Mechanisms of Ageing and Development. 192

Potential impact of missing outcome data on treatment effects in systematic reviews:imputation study

Kahale Lara A, Khamis Assem M, Diab Batoul, Chang Yaping, Lopes Luciane Cruz, Agarwal Arnav, Li Ling, Mustafa Reem A, Koujanian Serge, Waziry Reem, Busse Jason W, Dakik Abeer, Schünemann Holger J, Hooft Lotty, Scholten Rob Jpm, Guyatt Gordon H, Akl Elie A 26 aug 2020, In: BMJ (Clinical research ed.). 370

Transparent Reporting of Multivariable Prediction Models in Journal and Conference Abstracts:TRIPOD for Abstracts

Heus Pauline, Reitsma Johannes B, Collins Gary S, Damen Johanna A A G, Scholten Rob J P M, Altman Douglas G, Moons Karel G M, Hooft Lotty 2 jun 2020, In: Annals of Internal Medicine. 173 , p. 42-47 6 p.

GRADE guidelines:21 part 1. Study design, risk of bias and indirectness in rating the certainty across a body of evidence for test accuracy

Schünemann Holger J, Mustafa Reem A, Brozek Jan, Steingart Karen R, Leeflang Mariska, Murad Mohammad Hassan, Bossuyt Patrick, Glasziou Paul, Jaeschke Roman, Lange Stefan, Meerpohl Joerg, Langendam Miranda, Hultcrantz Monica, Vist Gunn E, Akl Elie A, Helfand Mark, Santesso Nancy, Hooft Lotty, Scholten Rob, Rosen Måns, Rutjes Anne, Crowther Mark, Muti Paola, Raatz Heike, Ansari Mohammed T, Williams John, Kunz Regina, Harris Jeff, Rodriguez Ingrid Arévalo, Kohli Mikashmi, Guyatt Gordon H, 11 feb 2020, In: Journal of Clinical Epidemiology. 122 , p. 129-141 13 p.

Prognostic value of radiological recurrence patterns in ovarian cancer

Roze Joline F, Veldhuis Wouter B, Hoogendam Jacob P, Verheijen René H M, Scholten Rob J P M, Zweemer Ronald P 1 jan 2020, In: Gynecologic Oncology. 157 , p. 606-612 7 p.

Meta-Analyses Proved Inconsistent in How Missing Data Were Handled Across Their Included Primary Trials:A Methodological Survey

Kahale Lara A, Khamis Assem M, Diab Batoul, Chang Yaping, Lopes Luciane Cruz, Agarwal Arnav, Li Ling, Mustafa Reem A, Koujanian Serge, Waziry Reem, Busse Jason W, Dakik Abeer, Hooft Lotty, Guyatt Gordon H, Scholten Rob J P M, Akl Elie A 2020, In: Clinical Epidemiology. 12 , p. 527-535 9 p.

A guidance was developed to identify participants with missing outcome data in randomized controlled trials

Kahale Lara A, Guyatt Gordon H, Agoritsas Thomas, Briel Matthias, Busse Jason W, Carrasco-Labra Alonso, Khamis Assem M, Zhang Yuqing, Hooft Lotty, Scholten Rob J P M, Akl Elie A 9 jul 2019, In: Journal of Clinical Epidemiology. 115 , p. 55-63 9 p.

GRADE guidelines:22. The GRADE approach for tests and strategies—from test accuracy to patient-important outcomes and recommendations

Schünemann Holger J., Mustafa Reem A., Brozek Jan, Santesso Nancy, Bossuyt Patrick M., Steingart Karen R., Leeflang Mariska, Lange Stefan, Trenti Tommaso, Langendam Miranda, Scholten Rob, Hooft Lotty, Murad Mohammad Hassan, Jaeschke Roman, Rutjes Anne, Singh Jasvinder, Helfand Mark, Glasziou Paul, Arevalo-Rodriguez Ingrid, Akl Elie A., Deeks Jonathan J., Guyatt Gordon H., 1 jul 2019, In: Journal of Clinical Epidemiology. 111 , p. 69-82 14 p.

Performance of the Framingham risk models and pooled cohort equations for predicting 10-year risk of cardiovascular disease:A systematic review and meta-analysis

Damen Johanna A., Pajouheshnia Romin, Heus Pauline, Moons Karel G.M., Reitsma Johannes B., Scholten Rob J.P.M., Hooft Lotty, Debray Thomas P.A. 13 jun 2019, In: BMC Medicine. 17

Uniformity in measuring adherence to reporting guidelines:The example of TRIPOD for assessing completeness of reporting of prediction model studies

Heus Pauline, Damen Johanna A.A.G., Pajouheshnia Romin, Scholten Rob J.P.M., Reitsma Johannes B., Collins Gary S., Altman Douglas G., Moons Karel G.M., Hooft Lotty 24 apr 2019, In: BMJ Open. 9

All Research Output (72)